[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carotid-endarterectomy-cea-surgical-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carotid-endarterectomy-cea-surgical-patients":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100604495","correlation-between-carotid-stump-pressure-and-interhemispheric-rso-asymmetry-during-awake-carotid-endarterectomy-100604495",false,"NCT07150260","Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry During Awake Carotid Endarterectomy","Evaluation of the Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry in Awake Carotid Endarterectomy: A Prospective Cohort Study","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for elective carotid endarterectomy (CEA)\n* Able to tolerate surgery under regional anesthesia (superficial cervical plexus block)\n* Availability of bilateral regional cerebral oxygen saturation (rSO₂) measurements by near-infrared spectroscopy (NIRS)\n* Successful intraoperative carotid stump pressure (SP) measurement after cross-clamping\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Incomplete NIRS or SP recordings\n* Conversion from regional to general anesthesia\n* Intraoperative technical complications preventing monitoring\n* History of prior ipsilateral carotid endarterectomy or carotid artery stenting\n* Recent major stroke with permanent neurological deficit\n* Recent myocardial infarction within the past 3 months\n* History of traumatic brain injury within the past 6 months","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","30 Days","OBSERVATIONAL","This study aims to better understand how well the brain is perfused (supplied with blood and oxygen) during a specific type of surgery called carotid endarterectomy (CEA), which is performed to prevent strokes in people with stenosis of carotid arteries.\n\nDuring this surgery, the surgeon temporarily clamps the carotid artery to remove a blockage, which can reduce blood flow to the brain. Monitoring brain oxygen levels during this time is important to prevent brain injury. Two common monitoring methods are:\n\nStump pressure (SP) - a pressure measurement taken from the carotid artery during surgery.\n\nNear-infrared spectroscopy (NIRS) - a non-invasive technique that tracks brain oxygen levels in real time.\n\nThis study focuses on the relationship between carotid stump pressure and differences in brain oxygenation between the two sides of the brain (interhemispheric asymmetry), as measured by NIRS.\n\nThe study will include patients undergoing awake CEA (under regional anesthesia) at a single center university hospital. Oxygen levels in both hemispheres of the brain will be monitored before and after the carotid artery is clamped after 3 minutes. Stump pressure will also be measured. The researchers will examine whether low stump pressure is linked to greater differences in brain oxygen levels between the two sides.\n\nThe primary goal is to determine whether a large difference in brain oxygenation between the two hemispheres (greater than 10%) is associated with low carotid stump pressure. Secondary goals include identifying a stump pressure threshold that predicts significant asymmetry and analyzing the influence of patient and surgical factors.\n\nThe findings may help improve how surgeons and anesthesiologists monitor and protect the brain during CEA, particularly in patients who are awake and can be observed for neurological changes.",[25,26,27],"Carotid Artery Stenosis Symptomatic","Carotid Endarterectomy (CEA) Surgical Patients","Cerebral Hypoperfusion",[29,30,31,32,33,34],"Carotid stump pressure","Near-infrared spectroscopy","rSO₂ asymmetry","Cerebral oxygenation","Awake carotid endarterectomy","Regional anesthesia","RECRUITING","2026-01-06",{"date":38,"type":39},"2026-01-07","ACTUAL",{"date":41,"type":39},"2025-09-01",{"date":43,"type":20},"2026-10-01",{"name":45,"class":46},"Izmir Katip Celebi University","OTHER"]