[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carotid-endarterectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carotid-endarterectomy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,68,97,125,146],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100547351","association-between-local-cerebral-oxygenation-monitoring-and-postoperative-stroke-in-carotid-endarterectomy-100547351",false,"NCT06406842","Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy","Perioperative Application of Hemodynamic Management Based on Regional Cerebral Oxygen Saturation Monitoring of Cerebral Autoregulation in Carotid Endarterectomy","Inclusion Criteria:\n\n* Patients scheduled for elective carotid endarterectomy\n* ASA Ⅱ or Ⅲ\n* aged 18-80 years old\n\nExclusion Criteria:\n\n* preoperative moderate and severe cognitive impairment\n* preoperative psychotropic medication history within one year\n* history of neurosurgery\n* have speech or language impairments","ALL","18 Years","80 Years",{"count":20,"type":21},560,"ESTIMATED","INTERVENTIONAL",[24],"NA","Carotid endarterectomy (CEA) is used to treat symptomatic extracranial internal carotid artery stenosis. The occult stroke of CEA patients evaluated by magnetic resonance imaging 3 days after operation was as high as 17%. Cerebral blood flow autoregulation (CA) is the ability of the brain to maintain the relative stability of cerebral blood flow, and cerebral oxygen index (COx) can be used to reflect CA. A negative value of cerebral oxygen index or a value near zero indicates that CA is complete, and cerebral oxygen index close to 1 indicates that CA has lost its ability. In theory, real-time monitoring of CA function by cerebral oxygen index and individualized management strategy with this goal can potentially reduce perioperative ischemic brain injury. The purpose of this study is to explore the influence of the management strategy of monitoring CA function based on regional cerebral oxygen saturation on the postoperative neurological complications of CEA patients.",[27,28],"Carotid Endarterectomy","Cerebral Autoregulation","RECRUITING","2025-09-02",{"date":32,"type":33},"2025-09-08","ACTUAL",{"date":35,"type":33},"2024-07-08",{"date":37,"type":21},"2026-12",{"name":39,"class":40},"Beijing Tiantan Hospital","OTHER",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100585114","carotid-endarterectomy-and-stenting-timing-100585114","NCT06898151","Carotid Endarterectomy and Stenting Timing","Carotid Endarterectomy and Stenting Timing：The CEST Trial","CEST","Inclusion Criteria:\n\n* Age ≥18 years;\n* Diagnosed with symptomatic carotid stenosis, defined as the occurrence of sudden-onset neurological symptoms within the territory of the responsible artery within 180 days before randomization (e.g., contralateral hemiparesis, slurred speech\u002Fdifficulty in expression, ipsilateral monocular vision loss, etc.);\n* Stenosis located in the extracranial segment of the internal carotid artery (with or without involvement of the adjacent common carotid artery);\n* Degree of stenosis in the responsible carotid artery confirmed to be ≥50% and ≤99% by CTA\u002FMRA\u002FDSA, based on NASCET criteria;\n* Brain MRI within 72 hours before randomization indicating an acute infarction in the responsible vascular territory, characterized by high signal on DWI and low signal on ADC;\n* Modified Rankin Scale (mRS) score \\\u003C3;\n* Written informed consent obtained from the patient or their legal representative.\n\nExclusion Criteria:\n\n* Progressive neurological deterioration within 72 hours before randomization, defined as an increase in mRS score by ≥2 points or NIHSS score by ≥4 points;\n* Brain MRI within 72 hours before randomization indicating a large infarction (infarct size \\> 1\u002F2 of the middle cerebral artery territory);\n* MRI evidence of hemorrhagic cerebrovascular diseases (e.g., brain tumor, brain abscess, vascular malformations) or other non-ischemic cerebrovascular diseases (e.g., multiple sclerosis);\n* Non-atherosclerotic carotid stenosis (e.g., carotid artery dissection, carotid web, floating thrombus, fibromuscular dysplasia, Takayasu arteritis, etc.);\n* Need for simultaneous surgical intervention for tandem lesions in the ipsilateral carotid artery or other vascular surgeries;\n* History of cerebrovascular surgery within 6 months before randomization;\n* Coexisting cerebrovascular stenosis requiring revascularization within 3 months after randomization;\n* History of spontaneous intracranial hemorrhage within 12 months before randomization;\n* Clear indication for anticoagulation therapy (suspected cardiac embolic source such as atrial fibrillation, known mechanical heart valve, or suspected infective endocarditis);\n* Laboratory abnormalities, including white blood cell count \\\u003C 2×10⁹\u002FL, hematocrit \\\u003C 30%, platelet count \\\u003C 100×10⁹\u002FL, INR \\> 1.5, or heparin-induced thrombocytopenia;\n* Inability to use antiplatelet therapy due to specific reasons, such as active gastrointestinal ulcers, gastrointestinal bleeding within the past 3 months, known severe allergy, severe renal insufficiency (creatinine \\>1.5 times the normal upper limit), hepatic dysfunction (ALT or AST \\>2 times the normal upper limit), or severe heart failure (NYHA Class III-IV);\n* Presence of other severe diseases that may affect adherence to the study protocol, such as severe infection, advanced chronic obstructive pulmonary disease (COPD), active malignant tumors, dementia, psychiatric disorders, or uncontrolled severe hypertension;\n* Pregnant or breastfeeding women who are not in menopause;\n* Participation in another investigational device or drug trial that may interfere with this study;\n* Any other medical condition or history that, in the investigator's judgment, may affect the efficacy or safety assessment of the study.",{"count":51,"type":21},268,[24],"To compare the safety and efficacy of carotid revascularization performed within 48 hours versus after 14 days in patients with symptomatic carotid stenosis accompanied with MRI-confirmed acute infarction (high signal on diffusion-weighted imaging accompanied by low apparent diffusion coefficient signal) in the responsible vascular territory.",[27,55],"Carotid Stenting",[57],"Timing of carotid artery revascularization","2025-08-11",{"date":60,"type":33},"2025-08-15",{"date":62,"type":33},"2025-03-07",{"date":64,"type":21},"2027-09-01",{"name":66,"class":40},"Xuanwu Hospital, Beijing",1,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100579685","blood-flow-evaluation-after-carotid-surgical-treatment-100579685","NCT06827509","Blood Flow Evaluation After Carotid Surgical Treatment","Blood Flow Evaluation After Carotid Surgical Treatment: Carotid Endarterectomy With Patch Repair Versus Eversion Technique","BEAT","Inclusion Criteria:\n\n* Presence of carotid artery stenosis (≥50%) according to conventional clinically performed imaging (duplex\u002FCT(A)\u002FMR(A)) for which patient underwent uncomplicated CEA with either a patch plasty or the eversion technique\n* ≥18 years old;\n* Able to provide signed or oral informed consent\n* Carotid artery \\\u003C25mm below skin\n\nExclusion Criteria:\n\n* Carotid bifurcation with depth of center bulb lumen ≥2.5cm\n* Restenosis after carotid revascularisation at side of interest\n* Participating in another clinical study, interfering on outcomes",{"count":77,"type":21},40,"OBSERVATIONAL","Approximately 20% of strokes originate from the rupture of an atherosclerotic plaque in the carotid artery. Surgical revascularization, i.e. carotid endarterectomy (CEA), is the treatment of choice for patients with a symptomatic carotid stenosis each year about 3,000 procedures are performed in the Netherlands. Currently, two surgical procedures are performed in clinical practice. Most frequently an endarterectomy is performed using a length incision over the artery, followed by a patch plasty (CEAP), in order to reduce the risk of restenosis. As an alternative the eversion technique (ET) was introduced, in which transversal arteriotomy is performed and the plaque is removed from within. After reconstruction with a patch a \\>50% restenosis has been described in 6-36% of patients during long-term follow-up. When using the eversion technique this is seen in 1.7-2.5%, while also the risk on adverse events seem to be lower. One of the drivers for atherosclerosis in general is a disturbance of local blood flow. This may lead to turbulence, recirculation and stasis of blood. The subsequent low Wall Shear Stress may lead to the ne formation of plaque that in turn may become instable and cause recurrent ischemic events. Recently, a breakthrough was achieved in the imaging options of flow in the carotid arteries, using Vector Flow Imaging. Using a fully programmable ultrasound machine, over 10,000 frames per second can be captured, in comparison to about 50 in regular ultrasound. This enables the tracking of particles that, after processing will provide the needed flow information. A recent study, comparing flow before and after CEAP has shown that there is significant recirculation after reconstruction. This raises the question whether this would be more optimal after ET, which would support the potential lower incidence of recurrent stenosis.",[27],[82,83,84,85,86],"Ultrafast ultrasound flow imaging","Velocity vector imaging","Carotid endarterectomy","Patch repair","Eversion technique","NOT_YET_RECRUITING","2025-08-04",{"date":90,"type":33},"2025-08-05",{"date":92,"type":21},"2025-09-01",{"date":94,"type":21},"2026-04-01",{"name":96,"class":40},"Rijnstate Hospital",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":67},"100581439","phase-2-evaluate-the-precision-of-abl-101-perfluorocarbon-and-fluorine-19-mri-for-the-mapping-of-atherosclerotic-plaque-composition-and-inflammation-in-patients-undergoing-carotid-endarterectomy-100581439","NCT06850324","Evaluate the Precision of ABL-101 Perfluorocarbon and Fluorine-19 MRI for the Mapping of Atherosclerotic Plaque Composition and Inflammation in Patients Undergoing Carotid Endarterectomy","A Proof of Concept Study to Evaluate the Precision of ABL-101 Perfluorocarbon and Fluorine-19 Magnetic Resonance Imaging in Mapping of Atherosclerotic Plaque Composition and Inflammation in Patients Undergoing Carotid Endarterectomy","PARFUME","Inclusion Criteria:\n\n1. Written Informed Consent signed by the patient if capable of discernment or by the legally authorized representative if the patient is considered non capable of discernment or authorisation received from independent physician,\n2. Age ≥ 18 years old,\n3. Symptomatic atherosclerotic stenosis of the internal carotid artery ≥ 50% or asymptomatic atherosclerotic stenosis of the internal carotid artery ≥ 60% confirmed on at least two non-invasive imaging studies (Doppler, CT angiography, or MR angiography),\n4. Planned for an elective or semi-urgent carotid endarterectomy (CEA) in 2 days at the earliest based on the current institutional and international guidelines.\n\nExclusion Criteria:\n\n1. Known thrombocytopenia (platelet count \\\u003C150x109\u002FL) or history of platelet function disorder,\n2. MRI with gadolinium-based contrast agents within 24 hours of the MRI scan of this trial,\n3. Known allergy to ABL-101 or any of its constituents (including egg phospholipids),\n4. Known current infection,\n5. Any current medical condition causing impaired immunity (e.g. HIV infection, hyposplenism) or use of systemic immunosuppressant medication except for inhaled, nasal intra-articular or topical corticosteroids) on an ongoing basis or within the preceding 30 days,\n6. Women who are pregnant or breast feeding,\n7. Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, advanced cardiac failure, etc.), Known or suspected non-compliance, drug or alcohol abuse,\n8. Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.,\n9. Participation in another study with investigational drug within the 30 days preceding and during the present study,\n10. Previous enrolment into the current study,\n11. Enrolment of the investigator, his\u002Fher family members, employees and other dependent persons,\n12. Inability to undergo MR imaging (e.g. incompatible implants, claustrophobia, etc.),\n13. Any incapacitated patient that is not expected to recover to a point where they will personally be capable of discernment and able to provide informed consent.\n14. A priori refusal to receive information concerning fortuitous discoveries which may contribute to the prevention, diagnosis and treatment of the disease.",{"count":106,"type":21},18,[108],"PHASE2","This study is aimed at patients suffering from carotid atherosclerosis. In the presence of atherosclerosis of the carotid arteries, one of the treatments that can be proposed is carotid endarterectomy, the aim of which is to remove the atherosclerotic plaque that obstructs the carotid artery and therefore increases the risk of developing a stroke. The risk of rupture of these plaques is primarily assessed by anatomical medical imaging: the degree of stenosis (narrowing) that the plaque causes most often informs the decision whether or not to proceed with surgery. However, it is well established that the degree of stenosis is not a very precise decision criterion: some plaques would never have ruptured, while others have ruptured even though no surgical intervention had been performed. It has since been discovered that the degree of inflammation is a much more accurate predictor of future rupture, but there is currently no reliable non-invasive imaging marker to measure plaque inflammation.\n\nIn this study, the investigators therefore evaluate a new marker, the perfluorocarbon ABL-101, for non-invasive imaging of inflammation in atherosclerotic plaque. To assess the marker's effectiveness in quantifying inflammation in plaque, the plaque will be analyzed microscopically after removal to obtain a more accurate measure of the degree of inflammation. This will enable us to assess the effectiveness of the non-invasive marker injection method versus the more invasive microscopic analysis of the removed plaque.\n\nABL-101 consists of a perfluorocarbon (PFC) emulsion, a liquid mixture in which PFC particles are dispersed. PFCs are chemical compounds containing only carbon and fluorine, and are known for their ability to transport large quantities of oxygen. Totally inert, PFCs cannot be broken down by the body and are eliminated naturally. Due to their small size, these particles are also captured by certain immune system cells and, combined with 19F-MRI, constitute a marker of inflammation.",[111,27],"Atherosclerotic Disease, Carotid",[113,27,114,115],"Mapping of Atherosclerotic Plaque Composition and Inflammation","ABL-101 Perfluorocarbon","Fluorine-19 Magnetic Resonance Imaging","2025-02-26",{"date":118,"type":33},"2025-02-27",{"date":120,"type":21},"2025-07-01",{"date":122,"type":21},"2028-06-30",{"name":124,"class":40},"Ruud van Heeswijk",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":67},"100454522","association-between-local-cerebral-oxygenation-monitoring-and-postoperative-delirium-in-carotid-endarterectomy-100454522","NCT05198635","Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy","Association Between Local Cerebral Oxygen Saturation Monitoring and Postoperative Delirium in Carotid Endarterectomy：A Prospective Cohort Study","Inclusion Criteria:\n\nScheduled carotid endarterectomy; Signed informed consent.\n\nExclusion Criteria:\n\nSevere cognitive impairment(Mini-Mental State Examination, MMSE\\\u003C18); History of psychotropic drugs; Previous intracranial surgery history; Poor hearing or vision; Language barriers",{"count":133,"type":21},140,"Postoperative delirium (POD) is a common perioperative complication, which can lead to adverse outcomes. Patients undergoing carotid endarterectomy (CEA) were elderly, complicated with vascular risk factors, cognitive dysfunction, some also had a history of stroke, and the circulation fluctuated greatly during the operation, often resulting in hypoperfusion of cerebral tissue and hypoxia. Therefore, they're the high-risk group of POD. Near-infrared Spectroscopy (NIRS) can continuously and noninvasively monitor local cerebral oxygen saturation (SctO2) to identify the mismatch of oxygen supply and demand in brain tissue. However, for CEA patients, the association between intraoperative SctO2 changes and POD remains unclear. This study intends to explore the association between them and determine the SctO2 threshold for predicting POD. We will monitor SctO2 intraoperatively, follow up and collect data postoperatively.",[136,137,27],"Cerebral Oxygen Saturation","Postoperative Delirium","2025-02-12",{"date":140,"type":33},"2025-02-13",{"date":142,"type":33},"2022-02-14",{"date":144,"type":21},"2025-12-31",{"name":39,"class":40},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":153,"enrollmentInfo":154,"targetDuration":156,"studyType":78,"phases":4,"briefSummary":157,"conditions":158,"keywords":159,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":67},"100389200","predictors-of-post-clamping-neurologic-deficits-during-carotid-endarterectomy-with-regional-anesthesia-100389200","NCT04347785","Predictors of Post-clamping Neurologic Deficits During Carotid Endarterectomy With Regional Anesthesia","Preoperative, Intraoperative and Postoperative Predictors of Post-clamping Neurologic Deficits During Carotid Endarterectomy With Regional Anesthesia","Inclusion Criteria:\n\n* carotid endarterectomy under regional anesthesia\n* Postclamping carotid deficit\n\nExclusion Criteria:\n\n* carotid stenting","100 Years",{"count":155,"type":21},206,"10 Years","Patients undergoing carotid endarterectomy may suffer from neurologic deficits (ND) during the carotid cross-clamping due to cerebral hypoperfusion. An associated risk of postoperative stroke incidence is also well established.\n\nThe aim of this study is to evaluate the predictive factors associated with ND during CEA performed with RA. The perioperative implications of the ND were also evaluated.",[27],[160,161],"Carotid Stenosis","regional anesthesia","2020-04-13",{"date":164,"type":33},"2020-04-15",{"date":166,"type":33},"2011-01-01",{"date":168,"type":21},"2030-12-31",{"name":170,"class":40},"Universidade do Porto"]