[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carotid-plaque\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carotid-plaque":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100498016","ct-evaluation-of-carotid-plaque-components-100498016",false,"NCT05764772","CT Evaluation of Carotid Plaque Components","Validation of Photon Counting\u002FSpectral Computed Tomography Angiography of Carotid Plaque Composition in Patients With Ischemic Stroke","Inclusion Criteria:\n\n* Patients with symptomatic carotid stenosis with ipsilateral ischemic infarcts attributable to the carotid disease\n* At least 1mm of noncalcified plaque on same side of stroke\n* Brain MRI documenting ischemic infarct in distribution attributable to ipsilateral carotid disease\n* Patients planned to undergo carotid endarterectomies\n* Patients must be able to read and understand English\n* Participants must sign the informed consent form\n\nExclusion Criteria:\n\n* Exclusion Criteria\n\n  * Patients less than 18 years old\n  * Women who are pregnant and\u002For nursing","ALL","18 Years",{"count":19,"type":20},70,"ESTIMATED","1 Year","OBSERVATIONAL","The goal of this observational study is to validate the diagnostic performance of photon counting\u002Fspectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the reference standard.\n\nThe main question\\[s\\] it aims to answer are:\n\n1. Presence or absence of calcium, hemorrhage, and lipid plaque components as determined on CT will be confirmed with carotid MRI, segmentation quantitative (e.g., volume) output from segmentation software, or histologic staining.\n2. Volumes of hemorrhage, lipid, and calcium components will be measured to determine plaque phenotype and correlated with ipsilateral intracranial stroke burden.\n\nParticipants will be asked to do the following:\n\nAim 1:\n\n* 1 Photon counting\u002Fspectral CT angiography of the neck\n* 1 Research Carotid\u002FNeck MRI of the carotid arteries (if eligible)\n\nAim 2:\n\n* 1 Research Carotid\u002FNeck MRI of the carotid arteries (if eligible)\n* 1 Photon counting\u002Fspectral CT angiography of the neck\n* 1 Carotid plaque tissue from participants surgery will be retrieved, imaged, and stained (if eligible)",[25],"Carotid Plaque","RECRUITING","2025-11-19",{"date":29,"type":30},"2025-11-25","ACTUAL",{"date":32,"type":30},"2023-10-01",{"date":34,"type":20},"2028-12",{"name":36,"class":37},"University of Pennsylvania","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":50,"studyType":22,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":38},"100552452","evaluation-of-vulnerability-of-carotid-plaques-and-prediction-of-cardio-cerebrovascular-event-using-ultrasonic-imaging-100552452","NCT06473272","Evaluation of Vulnerability of Carotid Plaques and Prediction of Cardio-Cerebrovascular Event Using Ultrasonic Imaging","A Multi-center Prospective Cohort Study on the Evaluation of Vulnerability of Carotid Artery Plaques and Prediction of Cardio-Cerebrovascular Event Risk Using Ultrasonic Imaging","Inclusion Criteria:\n\n1. Patients who fully understand the purpose and significance of this experiment, voluntarily participate, and voluntarily sign the informed consent form;\n2. Patients over 40 years old;\n3. Patients with carotid plaque thickness ≥ 1.5 mm on conventional ultrasound, undergoing routine duplex ultrasound, contrast-enhanced ultrasound, ultrasound elastography, and three-dimensional ultrasound imaging.\n\nExclusion Criteria:\n\n1. Patients with severe cardiopulmonary insufficiency; allergy to sulfur hexafluoride; pregnant or lactating women; those with advanced tumors;\n2. Poor quality of ultrasound images;\n3. Patients who have previously undergone carotid artery stenting or endarterectomy on the same side as the carotid plaque.","40 Years","100 Years",{"count":49,"type":20},600,"36 Months","This study included patients with carotid artery atherosclerotic plaques to conduct multimodal ultrasound examinations, aiming to establish a plaque vulnerability assessment model based on ultrasonic imaging indicators, clinical history, and laboratory indicators. Based on the occurrence of cardiovascular and cerebrovascular events during the 3-year follow-up period, the correlation between the vulnerability of carotid plaques and the occurrence of cardiovascular and cerebrovascular events was explored. Furthermore, a cardiovascular and cerebrovascular risk prediction model for patients with plaques was established by combining multi-dimensional data indicators such as patients\\' clinical data and ultrasonic multimodal imaging data, forming a risk warning tool suitable for clinical use and providing a reference for risk management in patients with carotid artery plaques.\n\nResearch Objectives：\n\n1. To establish a plaque vulnerability assessment model based on ultrasonic imaging indicators of plaques, clinical indicators of patients, and laboratory indicators.\n2. To establish a cardiovascular and cerebrovascular risk prediction model for patients with carotid plaques by combining clinical indicators of patients and ultrasonic multimodal imaging data.\n3. To screen ultrasonic imaging indicators for predicting cardiovascular and cerebrovascular events.",[25,53,54],"Ischemic Stroke","Cardiovascular Events","2024-12-03",{"date":57,"type":30},"2024-12-06",{"date":59,"type":30},"2024-07-01",{"date":61,"type":20},"2027-12-31",{"name":63,"class":37},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100561171","phase-4-effect-of-small-interfering-rna-inclisiran-on-carotid-plaques-as-assessed-by-carotid-ultrasound-100561171","NCT06586684","Effect of Small Interfering RNA Inclisiran on Carotid Plaques As Assessed by Carotid Ultrasound","The Effect of Small Interfering RNA Inclisiran on Carotid Plaques in Patients with Atherosclerosis: a Real-world Study Using Carotid Ultrasound.","Inclusion Criteria:\n\n* Patients with carotid plaques as indicated by ultrasound\n* Men and women aged 18-75 years;\n* LDL-C \\>3.4 mmol\u002FL without regular statin therapy or LDL-C \\>1.8 mmol\u002FL after 4 weeks of statin lipid-lowering therapy.\n\nExclusion Criteria:\n\n* \\- Known allergies or contraindications to PCSK9 inhibitors and\u002For statin therapy;\n* Prior use of PCSK9 inhibitors;\n* Prior history of hemorrhagic stroke;\n* Prior coronary artery bypass grafting or coronary intervention;\n* Inability to perform OCT imaging or unclear imaging;\n* Severe renal insufficiency (creatinine clearance \\< 30 mL\u002Fmin);\n* Severe hepatic dysfunction;\n* Baseline triglycerides \\> 5.6 mmol\u002FL;\n* Pregnant or lactating women;\n* Life expectancy not exceeding 1 year;\n* In the judgment of the investigator, unsuitable for this study for any reason.","75 Years",{"count":73,"type":20},40,"INTERVENTIONAL",[76],"PHASE4","Current understanding suggests that the majority of cardiovascular events are driven by vulnerable plaques. Nonetheless, the impact of PCSK9 inhibitors on the stability of carotid plaques remains insufficiently elucidated, with a notable scarcity of relevant clinical studies. This investigation seeks to address this gap through a real-world study conducted among patients with arterial sclerosis in Asia. The primary aim is to evaluate the effects of small interfering RNA (inclisiran) on carotid plaque characteristics as assessed by ultrasound, thereby contributing valuable data to inform clinical practice.",[25,79,80],"Hyperlipidemia","Echocardiography",[82,83,80,84],"inclisiran","carotid plaque","hyperlipidmia","NOT_YET_RECRUITING","2024-09-04",{"date":88,"type":30},"2024-09-19",{"date":90,"type":20},"2024-09-20",{"date":92,"type":20},"2026-09-30",{"name":94,"class":37},"First Affiliated Hospital of Xinjiang Medical University"]