[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carpal-tunnel-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carpal-tunnel-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,72,93,124,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100630163","efficacy-of-proximal-median-nerve-release-100630163",false,"NCT07484100","Efficacy of Proximal Median Nerve Release","Efficacy of Operative Versus Conservative Treatment in Proximal Median Nerve Compression","PROMER","Inclusion Criteria:\n\n1. Clinically diagnosed PMNC\n2. If the patient has clinically and electrodiagnostically confirmed carpal tunnel syndrome, at least 6 months must have passed since surgical treatment\n3. Age 18 or over\n4. Ability to understand Finnish\n5. Ability to complete electronic questionnaires independently\n6. Willingness to participate in research and follow research instructions\n7. Provision of informed consent from the participant\n\nExclusion Criteria:\n\n1. Nerve root disorder findings in ENMG\n2. Thoracic outlet syndrome, TOS\n3. Other neurological condition that causes upper limb symptoms such as MS, previous nerve injury\n4. Active rheumatoid arthritis or any other active inflammatory joint disease that affects hand function\n5. Significant compression symptoms of another peripheral nerve in association with PMNC\n6. Other upper extremity operation performed less than 6 months ago\n7. Another disease or condition that accounts for most of the patient's symptoms\n8. Other known reasons that may prevent participation or implementation of treatment during the study","ALL","18 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","A multi-center randomized controlled clinical trial which determines the efficacy of proximal median nerve release in patients with persistent proximal median nerve compression. The primary outcome is patient reported improvement of symptoms on a 7-point Likert scale at 6 months after the randomization to treatment group.",[27,28,29],"Carpal Tunnel Surgery","Median Nerve Compression","Median Nerve Entrapment",[31,32,33,34],"proximal median nerve entrapment","proximal median nerve compression","proximal median nerve release","randomized controlled trial","NOT_YET_RECRUITING","2026-03-17",{"date":38,"type":39},"2026-03-19","ACTUAL",{"date":41,"type":21},"2026-03-01",{"date":43,"type":21},"2041-07",{"name":45,"class":46},"Tampere University Hospital","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100569362","study-of-transaxillary-robotic-thyroidectomy-versus-standard-open-thyroidectomy-prospective-comparative-single-center-study-100569362","NCT06693258","Study of Transaxillary Robotic Thyroidectomy Versus Standard Open Thyroidectomy: Prospective, Comparative Single-Center Study","A Comparative Study of Transaxillary Robotic Thyroidectomy Versus Standard Open Thyroidectomy","CARTO","Inclusion Criteria:\n\n* Subject aged over 20 years\n* Referred for a thyroidectomy (total or partial)\n* Absence of participation in another clinical study\n* Subject affiliated to a social security scheme or beneficiary of such a scheme\n* Accepts the completion of the various study questionnaires\n\nExclusion Criteria:\n\n* Patient under 20 years of age.\n* Patients who have undergone combined radical cervical lymph node dissection\n* Patient with a postoperative wound problem\n* Patient with an underlying systemic disease that may influence the wound healing process\n* Unable to undergo medical follow-up for the study.",{"count":57,"type":21},100,[24],"The aim of our study is to evaluate the two surgical approaches, standard thyroidectomy and robotic thyroidectomy, in terms of postoperative pain management, scar quality, quality of life, as well as the occurrence of postoperative complications (hypocalcemia, compressive cervical hematoma and nerve stimulation)",[27],"RECRUITING","2026-01-02",{"date":64,"type":39},"2026-01-06",{"date":66,"type":39},"2024-11-25",{"date":68,"type":21},"2026-07",{"name":70,"class":46},"Clinique Bizet",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":71},"100599337","effectiveness-of-medical-hypnosis-in-virtual-reality-on-preoperative-anxiety-in-carpal-tunnel-surgery-100599337","NCT07083180","Effectiveness of Medical Hypnosis in Virtual Reality on Preoperative Anxiety in Carpal Tunnel Surgery","Effectiveness of Medical Hypnosis in Virtual Reality on Preoperative Anxiety in Carpal Tunnel Surgery Interventional Study With Minimal Risks and Constraints, Single-center, Prospective","Inclusion Criteria:\n\n* First surgery of carpal tunnel\n\nExclusion Criteria:\n\n* Patients undergoing treatment for anxiety\n* Uncontrolled epilepsy\n* Visual (binocular vision) and\u002For hearing impairments preventing the use of virtual reality\n* Pregnancy \u002F breast-feeding",{"count":80,"type":21},60,[24],"Anxiety is a predominant factor among patients prior to surgery, particularly in the context of outpatient surgery, where the speed of care and same-day discharge can exacerbate this stress. National patient satisfaction surveys, such as e-SATIS CA, show that many patients report significant anxiety before their surgery, which can affect the outcome of the operation and the recovery process. Medical hypnosis has been shown to be an effective way to reduce anxiety in patients before surgery. Indeed, several studies highlight the psychological and physiological benefits of this method for patients who are anxious before minor or major surgery. Hypnosis allows for deep relaxation, helping to better manage the emotions and fears associated with surgery. New technologies, such as virtual reality, are now being integrated into hypnosis practices to improve their effectiveness. Virtual immersion provides distraction and an environment conducive to hypnosis, facilitating induction and further reducing preoperative anxiety. In this context, we wish to conduct a single-center clinical investigation to determine whether the use of the HypnoVR virtual reality headset can help reduce anxiety in patients undergoing outpatient carpal tunnel surgery.",[27],"2025-12-15",{"date":86,"type":39},"2025-12-16",{"date":88,"type":39},"2025-12-08",{"date":90,"type":21},"2027-02-28",{"name":92,"class":46},"Clinique MEGIVAL",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":71},"100610443","phase-2-nac-repair-for-post-surgical-pain-100610443","NCT07227649","NAC-REPAIR for Post-surgical Pain","NAC-REPAIR: N-Acetylcysteine-facilitated Redox-Immune Modulation for Post-surgical Analgesia and Injury Recovery","Inclusion Criteria:\n\n* Elective outpatient hand\u002Fupper-extremity or foot\u002Fankle surgery (single site; same-day discharge)\n* Baseline visit feasible ≤14 days pre-op\n* Can complete surveys\u002Fblood draw\n* Provides informed consent\n* Willing to follow dosing schedule and avoid restricted supplements\u002Fmeds\n\nExclusion Criteria:\n\n* Allergy to NAC\u002Fcapsule components □ NAC or high-dose antioxidants in past 14 days (unwilling to stop)\n* Chronic daily opioids ≥3 months or OUD\u002Fmaintenance therapy □ Pregnant\u002Fbreastfeeding or no contraception as applicable\n* Daily nitrates (nitroglycerin\u002Fisosorbide) □ Planned \\>24h admission, multistage\u002Ftrauma case □ Other interventional study within 30 days\n* Unable to swallow capsules \u002F malabsorption surgery affecting oral meds","75 Years",{"count":102,"type":21},80,[104],"PHASE2","This pilot asks whether peri-operative N-acetylcysteine (NAC) improves recovery after common outpatient hand\u002Ffoot-ankle surgery-specifically, does NAC reduce pain and opioid use and enhance function by modulating redox-inflammatory pathways? Primary objectives are to establish feasibility (accrual, adherence, follow-up), estimate NAC vs placebo effects on pain, function, and opioid consumption, and characterize inflammatory signatures that may predict response.\n\nMethods: a single-site, double-blind, 1:1 randomized trial (N≈80) comparing NAC 1,200 mg twice daily for 14 days (starting pre-op) vs matching placebo; daily e-diaries for POD0-14; standardized outcomes (PROMIS Pain Interference; QuickDASH or FAAM; PGIC; opioid MME); and small blood draws pre-surgery and at two follow-up visits for cytokine profiling.",[27,107,108,109,110,111,112,113,114],"Trigger Finger Disorder","De Quervain Syndrome","Guyon's Canal","Dupuytren Contracture","Morton Neuroma","Tarsal Tunnel Syndrome","Plantar Fasciopathy","Peroneal Nerve Entrapment","2025-11-12",{"date":117,"type":39},"2025-11-14",{"date":119,"type":21},"2026-01-15",{"date":121,"type":21},"2027-07-15",{"name":123,"class":46},"University of Arizona",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":71},"100587884","carpal-tunnel-release-efficacy-trial-100587884","NCT06934187","Carpal Tunnel Release Efficacy Trial","eFficacy Of Carpal tUnnel releaSe (FOCUS) - Protocol for Randomised Controlled Multicentre Triple-Blinded Placebo Surgery Carpal Tunnel Release Trial With Observational Group","FOCUS","Inclusion Criteria:\n\n* CTS diagnosed with ENMG, Symptoms typical for CTS, Ability to understand and answer the questionnaires, ≥ 18 years old.\n\nExclusion Criteria:\n\n* Recurrent CTS; Ongoing systematic steroid treatment, chemotherapy, or immunomodulatory treatment; Pregnancy or breast feeding; Intrinsic muscle atrophy; Peripheral neuropathies; and Profound cognitive impairment",{"count":133,"type":21},96,[24],"Background Carpal tunnel syndrome (CTS) is a prevalent condition that affects 2.7% of the population, especially women. It arises due to compression of the median nerve in the wrist and is linked to factors like diabetes, obesity, and physical workload. Non-surgical treatments such as splinting and corticosteroid injections are often the first approach for mild to moderate CTS but show mixed long-term results. Surgical intervention, carpal tunnel release (CTR), is frequently necessary and has a success rate of 75-88%. CTR is a safe procedure, but like any surgery, it carries risks, including scarring and nerve injury.\n\nRationale Despite its widespread use, the effectiveness of CTR surgery has not been rigorously tested through randomised controlled trials (RCT) against placebo. This leaves a critical gap in understanding whether observed improvements result from surgery or the natural course of CTS, which can sometimes resolve on its own. Previous RCT in hand surgery have faced methodological issues, emphasising the need for high-quality research to validate the benefits of CTR surgery.\n\nObjectives\n\nFOCUS (eFficacy Of Carpal tUnnel release) trial, aims to provide robust evidence of CTR's effectiveness compared to placebo. The null and alternative hypotheses of the trial are as follows:\n\n* Null Hypothesis: The treatment effect of CTR is not superior to placebo surgery.\n* Alternative Hypothesis: The treatment effect of CTR is superior to placebo surgery\n\nTrial Design This multinational, triple-blinded RCT includes two groups: one receiving CTR and the other undergoing placebo surgery. An additional observational cohort will enhance the trial's generalisability. Recruitment begins in Finland, with plans to expand to Denmark, China and Australia. Experienced hand surgeons will perform all procedures, and the study adheres to rigorous international guidelines (SPIRIT).\n\nMethods Eligible participants are screened and randomised 1:1 to receive either CTR or placebo surgery. In CTR, surgeons relieve pressure on the median nerve through a small incision. Placebo surgery involves a similar incision without addressing the nerve compression. Both procedures use the same pre- and post-operative care protocols to maintain participant blinding.\n\nData collection involves comprehensive patient assessments at six months, one, two, and five years. A validated tool, the 6-CTS scale, is the primary outcome measure, while secondary measures include nerve conduction tests, hand strength, and patient-reported satisfaction.\n\nThe study includes 96 participants, allowing for statistical analysis with 80% power to detect meaningful differences in outcomes.Trial is triple-blinded ensuring that participants, outcome assessors, and investigators remain unaware of treatment assignments, minimising bias. Patients will be randomly assigned to 1:1 parallel groups using an internet-based randomisation program.\n\nEthical considerations The trial complies with the Declaration of Helsinki and national regulations. Participants provide informed consent and can withdraw at any time.\n\nData Management and Safety Data is securely stored in compliance with GDPR, and interim analyses are conducted to monitor safety. An independent Data Safety and Monitoring Committee (DSMC) oversees the trial, reviewing any serious adverse events.\n\nExpected Outcomes and Significance\n\nDiscussion The trial seeks to determine whether CTR surgery provides superior outcomes compared to placebo, addressing a critical gap in evidence for this common procedure. By including patient-reported outcomes and rigorous blinding, the study emphasises improvements that matter most to individuals with CTS.\n\nThis research has far-reaching implications for patients, surgeons, and policymakers, offering insights into the value of CTR surgery. The results could refine treatment guidelines, ensuring that surgical interventions are evidence-based and benefit those most in need.\n\nConclusion The FOCUS-trial represents a significant step forward in validating the effectiveness of CTR surgery. By setting a high standard for surgical research, it aims to provide clarity on a widely performed procedure, contributing to improved care and outcomes for individuals with CTS worldwide.",[137,27],"Carpal Tunnel Syndrome (CTS)",[139,140,141,142,143],"Carpal tunnel syndrome","Carpal tunnel release","Placebo surgery","Sham surgery","Randomized controlled trial","2025-09-15",{"date":146,"type":39},"2025-09-19",{"date":148,"type":21},"2026-01",{"date":150,"type":21},"2033-12",{"name":152,"class":46},"Kuopio University Hospital",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":163,"phases":4,"briefSummary":164,"conditions":165,"keywords":166,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":71},"100603272","evaluation-by-clinical-and-hand-ultrasound-in-carpal-tunnel-syndrome-100603272","NCT07134361","Evaluation by Clinical and Hand Ultrasound in Carpal Tunnel Syndrome","Clinical Analysis and Ultrasound Evaluation of the Median Nerve Cross-sectional Area Before and After Carpal Tunnel Release","ECHO-CTS","Inclusion Criteria:\n\n* Clinical diagnosis of primary carpal tunnel syndrome (CTS), confirmed by characteristic symptoms, physical examination findings, and a cross-sectional area superior to 10 mm² in the ultrasonography baseline.\n* Indication for open carpal tunnel release as part of routine clinical care.\n\nExclusion Criteria:\n\n* Secondary CTS due to inflammatory arthritis, prior wrist trauma, or space-occupying lesions.\n* History of previous carpal tunnel release in the affected hand.\n* Concomitant peripheral neuropathies (e.g., diabetic polyneuropathy) or cervical radiculopathy\n* Inability to undergo ultrasound assessment",{"count":162,"type":21},106,"OBSERVATIONAL","Carpal Tunnel Syndrome (CTS) is a common condition where pressure on the median nerve in the wrist causes pain, numbness, and weakness in the hand. Surgery to release the carpal tunnel is often performed to relieve these symptoms.\n\nThis study will evaluate the changes in the median nerve after surgery and how these changes relate to symptom improvement. Investigators will use ultrasound imaging to measure the nerve size before and at three and six months after surgery. Patients will also complete questionnaires about their symptoms and hand function, and undergo tests to assess strength and sensation.\n\nThe investigator's goal is to determine whether changes observed on ultrasound are associated with the rate of patient recovery. This may help doctors better monitor healing and improve care for people with CTS.",[137,27],[167,168,169],"carpal tunnel syndromes","Median Neuropathy","Ultrasonography","2025-08-21",{"date":172,"type":39},"2025-08-28",{"date":174,"type":39},"2025-06-25",{"date":176,"type":21},"2028-12-31",{"name":178,"class":46},"University of Sao Paulo General Hospital"]