[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carpal-tunnel-syndrome-cts\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carpal-tunnel-syndrome-cts":26},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,40,0,25,[9,39,74,98,121,149,174,218,244,272,291,324,350,379,405,431,466,489,513,542,567,590,612,634,657],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100053342","diagnostic-value-of-digital-infrared-thermographic-imaging-in-diagnosing-carpal-tunnel-syndrome-100053342",false,"NCT07699289","Diagnostic Value of Digital Infrared Thermographic Imaging in Diagnosing Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* 18 years old or more\n* Were referred to the department of rehabilitation for electrodiagnostic evaluation of the disease not involved in the index hand\n* The hand of interest has cumulative score of less than 12 from CTS-6 scale\n\nExclusion Criteria:\n\n* History of hand surgery in the index hand\n* Having a condition which may alter surface temperature of the hand, for example, infection, scar in the interested area, arthritis, other peripheral neuropathy, uncontrolled diabetes mellitus, uncontrolled thyroid disease, stroke, and vascular disease\n* Having hand deformities that render collecting DITI information to calculate the parameters of interest impossible, for example, amputation of any part of the hand\n* Current medication affecting sympathetic tone\n* Severe tremors or inability to maintain standardized positioning\n* Electrodiagnosis result other than normal or carpal tunnel syndrome in the hand of interest",true,"ALL","18 Years",{"count":20,"type":21},144,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this observational study is to evaluate skin temperature patterns measured by infrared thermography in patients with carpal tunnel syndrome (CTS). The main questions it aims to answer are: Are skin temperature patterns associated with CTS as determined by 6-item CTS scale?\n\nParticipants diagnosed with CTS as part of their routine clinical care will undergo infrared thermal imaging and electrodiagnostic evaluation according to the study protocol. The relationship between thermographic findings and electrodiagnostic severity will be analyzed.",[26],"Carpal Tunnel Syndrome (CTS)","NOT_YET_RECRUITING","2026-07-07",{"date":30,"type":31},"2026-07-13","ACTUAL",{"date":33,"type":21},"2026-09-01",{"date":35,"type":21},"2027-11-30",{"name":37,"class":38},"Mahidol University","OTHER",{"id":40,"slug":41,"hasResults":12,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100637823","mede-study-comparing-median-nerve-decompression-at-the-carpal-tunnel-alone-versus-median-nerve-decompression-at-both-the-carpal-tunnel-and-lacertus-fibrosis-in-adults-with-carpal-tunnel-syndrome-100637823","NCT07594821","MeDe Study: Comparing Median Nerve Decompression at the Carpal Tunnel Alone Versus Median Nerve Decompression at Both the Carpal Tunnel and Lacertus Fibrosis in Adults With Carpal Tunnel Syndrome","MeDe Study: A Randomized Controlled Trial Comparing Median Nerve Decompression at the Carpal Tunnel Alone Versus Median Nerve Decompression at Both the Carpal Tunnel and Lacertus Fibrosis in Adults With Carpal Tunnel Syndrome","MeDe","Inclusion Criteria:\n\n* Patients being at least 18 years or older\n* CTS confirmed by EMG or nerve ultrasound\n* Patient opts for surgical treatment\n\nExclusion Criteria:\n\n* Previous surgical decompression of the median nerve at the ipsilateral wrist or forearm\n* Severe thenar atrophy: Examination of the thenar is based on clinical observation. The presence of thenar muscle atrophy is scored as none, mild, or severe.\n* Simultaneous nerve decompression in the ipsilateral arm (e.g. cubital tunnel, Guyon and radial nerve release.\n* Neurological disorders affecting peripheral nerves (e.g. spinal cord compression or injury, muscular dystrophy, dystonia, ALS)\n* Malunion of the distal radius\n* Impaired hand function\n* Pregnancy\n* Inability to complete study forms due to insufficient comprehension of the Dutch language",{"count":48,"type":21},110,"INTERVENTIONAL",[51],"NA","Carpal tunnel syndrome (CTS) is a condition that can cause pain, numbness, or tingling in the hand and wrist. The most common surgery for CTS is called carpal tunnel release, which aims to relieve pressure on the main nerve in the wrist.\n\nHowever, after this surgery, some patients (up to 4 out of 10) still have symptoms, and about 1 in 8 may need another surgery. One reason symptoms can continue is that the nerve may also be compressed higher up in the arm, near a ligament called the Lacertus fibrosus. Releasing this area might help, but it is often not checked or treated during the first surgery because current tests (like physical exams, nerve studies, and ultrasounds) cannot reliably detect it.\n\nThis study is comparing two approaches for people with CTS:\n\n1. Standard surgery - only releasing the carpal tunnel.\n2. Extended surgery - releasing both the carpal tunnel and the Lacertus fibrosus.\n\nThe goal is to see which surgery helps patients feel better and have fewer symptoms in the hand and wrist after treatment.",[26,54],"Lacertus Syndrome",[56,57,58,59,60,61,62],"carpal tunnel syndrome","proximal median nerve compression","lacertus syndrome","double crush","nerve decompression","carpal tunnel release","lacertus release.","RECRUITING","2026-06-25",{"date":66,"type":31},"2026-06-26",{"date":68,"type":31},"2026-05-06",{"date":70,"type":21},"2028-02",{"name":72,"class":38},"Maasstad Hospital",2,{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":49,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100641428","comparative-efficacy-of-neuromobilization-tendon-gliding-exercises-and-combined-techniques-in-mild-to-moderate-carpal-tunnel-syndrome-100641428","NCT07653789","Comparative Efficacy of Neuromobilization, Tendon Gliding Exercises, and Combined Techniques in Mild to Moderate Carpal Tunnel Syndrome","Comparative Efficacy of Neuromobilization Techniques, Tendon Gliding Exercises, and Combined Techniques in the Management of Mild to Moderate Carpal Tunnel Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Symptoms of CTS (pain, paresthesia in the area of hand innervated by the median nerve)\n\n  * First and Second Trimester Pregnant women.\n  * Mild to Moderate CTS patients.\n  * Individuals experiencing wrist pain for a duration of at least 6-8 weeks without a history of trauma or specific diagnosis (e.g., fracture, arthritis).\n  * Pain rated between 3 and 5 on (NPRS).\n  * Present neurological disorders (e.g., carpal tunnel syndrome, cervical radiculopathy).\n  * No prior physical therapy treatment for wrist pain in the last 3-6 months\n\nExclusion Criteria:\n\n* • History of traumatic injury, fracture, or surgery to the wrist or hand.\n\n  * Diagnosis of systemic diseases affecting the wrist (e.g., rheumatoid arthritis, gout, or diabetes-related neuropathy).\n  * Any skin condition or infection around the wrist that would contraindicate physical therapy.\n  * Third Trimester Pregnant women\n  * Individuals with serious cardiovascular or metabolic disorders.\n  * patients currently undergoing other treatments specifically targeting CTS (e.g., steroid injections)","45 Years",{"count":83,"type":21},52,[51],"focuses on the comparative efficacy of Neuromobilization techniques, tendon gliding exercises, and their combined application in the management of mild to moderate Carpal Tunnel Syndrome through a randomized controlled trial (RCT)",[87,26],"CTS","2026-06-16",{"date":90,"type":31},"2026-06-17",{"date":92,"type":21},"2026-06-03",{"date":94,"type":21},"2026-09-10",{"name":96,"class":38},"Ibadat International University, Islamabad",1,{"id":99,"slug":100,"hasResults":12,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":106,"targetDuration":108,"studyType":23,"phases":4,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":97},"100626255","the-effect-of-local-corticosteroid-injection-in-carpal-tunnel-syndrome-patients-with-type-2-diabetes-100626255","NCT07433257","The Effect of Local Corticosteroid Injection in Carpal Tunnel Syndrome Patients With Type 2 Diabetes","The Effect of Local Corticosteroid Injection on Electrophysiological and Ultrasonographic Findings in Carpal Tunnel Syndrome Patients With Type 2 Diabetes","Inclusion Criteria\n\n* Carpal Tunnel Syndrome with Type 2 Diabetes Mellitus Group (Group 1):\n\n  * Age between 18 and 75 years\n  * Presence of clinical symptoms compatible with carpal tunnel syndrome (e.g., pain, paresthesia, numbness) for at least 3 months\n  * Patients diagnosed with mild-to-moderate carpal tunnel syndrome based on electrophysiological findings\n  * Diagnosis of type 2 diabetes mellitus\n  * Regulated blood glucose levels, defined as hemoglobin A1c (HbA1c) \\\u003C 7%\n* Idiopathic Carpal Tunnel Syndrome Group (Group 2):\n\n  * Age between 18 and 75 years\n  * Presence of clinical symptoms consistent with carpal tunnel syndrome (e.g., pain, paresthesia, numbness) for at least 3 months\n  * Patients diagnosed with mild-to-moderate carpal tunnel syndrome based on electrophysiological findings\n  * No diagnosis of diabetes mellitus\n\nExclusion Criteria\n\n* Severe carpal tunnel syndrome based on electrophysiological findings\n* Presence of polyneuropathy, cervical radiculopathy, brachial plexopathy, or thoracic outlet syndrome\n* Uncontrolled blood glucose levels in the diabetic group (hemoglobin A1c ≥ 7%)\n* Presence of another systemic disease, other than diabetes mellitus, that may cause carpal tunnel syndrome\n* Presence of a rheumatological disease\n* History of wrist surgery\n* Less than 6 months since a local corticosteroid injection for carpal tunnel syndrome\n* Less than 3 months since completion of a physical therapy program for carpal tunnel syndrome\n* Infection at the intended injection site\n* Presence of malignancy\n* Pregnancy","75 Years",{"count":107,"type":21},60,"12 Weeks","Our study was planned as a prospective observational study aiming to compare the post-intervention recovery process between patients with carpal tunnel syndrome (CTS) and diabetes mellitus and patients with idiopathic carpal tunnel syndrome without diabetes mellitus. Patients who presented to the Physical Medicine and Rehabilitation outpatient clinic with clinical symptoms consistent with carpal tunnel syndrome and who were diagnosed with mild to moderate carpal tunnel syndrome based on electrophysiological findings and who received corticosteroid + local anesthetic injection will be included in the study. Data from patients who meet the inclusion and exclusion criteria will be included in the study. Patients' demographic and clinical data will be recorded. Records will be taken before treatment and at 4 and 12 weeks after treatment.",[26,111],"Type 2 Diabetes Mellitus (T2DM)","2026-05-23",{"date":114,"type":31},"2026-05-27",{"date":116,"type":31},"2026-03-01",{"date":118,"type":21},"2026-07-31",{"name":120,"class":38},"Haydarpasa Numune Training and Research Hospital",{"id":122,"slug":123,"hasResults":12,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":49,"phases":130,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":4},"100634840","effects-of-peripheral-repetitive-peripheral-magnetic-stimulation-on-individuals-with-elbow-or-wrist-chronic-pain-100634840","NCT07544914","Effects of Peripheral Repetitive Peripheral Magnetic Stimulation on Individuals With Elbow or Wrist Chronic Pain","Effects of Peripheral Repetitive Peripheral Magnetic Stimulation on Individuals With Elbow or Wrist Chronic Pain, A Pilot Randomized Controlled Trial","rPMS","Inclusion Criteria:\n\n* Clinical diagnosis or self-reported history consistent with either medial or lateral epicondylitis or carpal tunnel syndromes.\n* Presence of chronic pain in the target area (mentioned above) at the time of enrollment.\n* Ability to understand the study procedures and provide informed consent.\n\nExclusion Criteria:\n\n* Contraindications to peripheral magnetic stimulation, including implanted electronic medical devices or metallic implants in locations deemed unsafe for stimulation.\n* Open wounds, active skin conditions, or other local conditions at the stimulation site.\n* Current neurological, musculoskeletal, or systemic medical conditions that, in the opinion of the investigators, would interfere with safe participation or interpretation of study outcomes.\n* Current upper-limb injury or condition other than tennis\u002Fgolfer elbow or carpal tunnel syndromes that could confound pain or perfusion measurements.\n* Pregnancy.\n* Inability to tolerate the stimulation or measurement procedures.\n* Inability to adequately understand study instructions or provide informed consent.",{"count":5,"type":21},[51],"This pilot, randomized, sham-controlled, single-blind study will evaluate the effectiveness of repetitive peripheral magnetic stimulation (rPMS) in reducing pain in adults with tennis\u002Fgolfer's elbow or carpal tunnel syndrome. Approximately 40 participants will be randomly assigned to active or sham stimulation delivered over two consecutive days. Outcomes, including pressure pain threshold, subjective pain ratings, and local tissue oxygenation (fNIRS), will be assessed at baseline, immediately post-intervention, and during follow-up up to 6 months to evaluate both clinical effects and underlying physiological mechanisms.",[133,134,26],"Tennis Elbow Syndrome","Golfer's Elbow",[127,136,137,138,139],"elbow","wrist","chronic pain","NIRS","2026-04-21",{"date":142,"type":31},"2026-04-27",{"date":144,"type":21},"2026-05-01",{"date":146,"type":21},"2027-12-30",{"name":148,"class":38},"University of Manitoba",{"id":150,"slug":151,"hasResults":12,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":157,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":159,"conditions":160,"keywords":161,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":4},"100626248","ultrasound-evaluation-in-carpal-tunnel-syndrome-100626248","NCT07433166","Ultrasound Evaluation in Carpal Tunnel Syndrome","Prospective Evaluation of Median Nerve Cross-Sectionall Area and Power Doppler Signal Changes in Patients With Carpal Tunnel Syndrome","CTS-PD","Inclusion Criteria:\n\n* clinically and electrophysiologically confirmed carpal tunnel syndrome\n* symptom duration \\> 3 months\n* written informed consent\n\nExclusion Criteria:\n\n* previous wrist surgery\n* cervical radiculopathy\n* inflammatory arthritis\n* pregnancy",{"count":158,"type":21},100,"This prospective cohort study aims to evaluate median nerve cross-sectional area and intraneural vascularity using power Doppler ultrasonography in patients with carpal tunnel syndrome. Ultrasonographic findings will be compared between diabetic and non-diabetic patients. Clinical severity and electrophysiological findings will be correlated with ultrasonographic parameters.",[26],[162,163,164],"carpal tunnel","ultrasound","power doppler","2026-04-04",{"date":167,"type":31},"2026-04-09",{"date":169,"type":21},"2026-05",{"date":171,"type":21},"2027-01",{"name":173,"class":38},"SB Istanbul Education and Research Hospital",{"id":175,"slug":176,"hasResults":12,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":183,"conditions":184,"keywords":203,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":97},"100633082","early-functional-response-as-a-predictor-of-clinical-outcomes-in-hand-rehabilitation-a-prospective-feasibility-study-using-a-digital-monitoring-system-100633082","NCT07522060","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Clinician-Developed Digital Monitoring System","HANDREHPREDICT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Hand or upper extremity pathology requiring rehabilitation, including but not limited to: flexor or extensor tendon injuries, peripheral nerve injuries or compression syndromes (including carpal tunnel syndrome, cubital tunnel syndrome), distal radius fractures, metacarpal or phalangeal fractures, joint injuries and instabilities, arthropathy (osteoarthritis, rheumatoid arthritis), trapeziometacarpal osteoarthritis, trigger finger, Dupuytren's disease, DeQuervain tenosynovitis, lateral epicondylitis and post-surgical upper extremity conditions\n* Under clinical responsibility of the principal investigator at the Faculty of Physical Therapy and Rehabilitation, Hacettepe University\n* Expected to attend minimum 8 rehabilitation sessions\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* • Active psychiatric illness precluding participation or completion of assessment tools\n\n  * Severe cognitive impairment precluding understanding of patient-reported outcome measures\n  * Literacy difficulties preventing self-completion of questionnaires\n  * Concurrent enrollment in another interventional clinical study\n  * Refusal to provide written informed consent",{"count":107,"type":21},"This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later. In rehabilitation practice, clinicians make numerous decisions each session regarding exercise type, frequency, duration, and treatment approach. Most of these decisions are currently made without systematic longitudinal data. This study addresses three fundamental questions using data collected during routine clinical care: (1) Can the rate of improvement in the first weeks of treatment predict functional status months later, across both session-based and milestone-based time points? (2) Are there meaningfully different recovery profiles among hand rehabilitation patients? (3) Is there measurable variation in clinical decision-making among patients with similar profiles, and does this variation relate to outcomes? A digital patient monitoring platform developed by the principal investigator, a physiotherapist and academic researcher specializing in hand rehabilitation serves as the data collection infrastructure. The platform records standard clinical assessment measures in a structured format and has been in active clinical use at Hacettepe University prior to this study. For research purposes, the system has been expanded to include structured capture of patient-reported outcomes, patient global impression of change, treatment protocol coding, home exercise adherence, and automated calculation of early response metrics.\n\nThis is a 12-month prospective observational cohort study enrolling a minimum of 60 patients. Data are stored securely on the university's institutional network. Patients are anonymized using identification codes. The study is subject to Hacettepe University Ethics Committee approval and participant informed consent. Findings are expected to generate evidence supporting data-driven clinical decision-making in rehabilitation and to provide a feasibility foundation for a larger multi-center study.",[185,186,187,188,189,190,191,192,193,26,194,195,196,197,198,199,200,201,202],"Hand","Hand Therapy","Upper Extremity","Prediction Models","Hand Injuries","Hand Injuries and Disorders","Hand Arthritis","Tendon Injuries","Wrist Fractures","Peripheral Nerve Injuries","Upper Extremity Injuries","Wrist Injuries","Finger Injuries","Trigger Finger","Trapeziometacarpal (TMC) Arthrosis","DeQuervain's Tenosynovitis","Cubital Tunnel Syndrome","Postoperative Rehabilitation",[204,205,206,207,208],"digital health monitoring","real-world evidence","clinical decision support","upper extremity rehabilitation","early response prediction","2026-04-03",{"date":211,"type":31},"2026-04-13",{"date":213,"type":21},"2026-06-15",{"date":215,"type":21},"2027-06-01",{"name":217,"class":38},"Hacettepe University",{"id":219,"slug":220,"hasResults":12,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":49,"phases":228,"briefSummary":229,"conditions":230,"keywords":231,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":243},"100561731","evaluation-of-dynavisc-in-pain-reduction-following-revision-surgery-for-persistent-or-recurrent-carpal-tunnel-syndrome-100561731","NCT06593977","Evaluation of Dynavisc in Pain Reduction Following Revision Surgery for Persistent or Recurrent Carpal Tunnel Syndrome","A Multicenter, Evaluator-Blinded, Randomized Evaluation of DYNAVISC in Pain Reduction Following Revision Surgery for Persistent or Recurrent Carpal Tunnel Syndrome","Inclusion criteria\n\n* Signed and dated informed consent form;\n* Stated willingness to comply with all study procedures and availability for the duration of the study;\n* Aged 18-65 years of age;\n* In good general health;\n* Patients experiencing recurrence or persistence of pain in the ipsilateral hand after previous carpal tunnel release for surgical treatment of primary carpal tunnel syndrome;\n* All of the following physical examination tests must be performed; at least one must be positive:\n\n  1. Physical examination demonstrates positive Phalen test;\n  2. Physical examination demonstrates positive Tinel's test;\n  3. Physical examination demonstrates positive monofilament test;\n* ENMG demonstrates median nerve velocity and deviation consistent with the diagnosis of carpal tunnel syndrome.\n\nExclusion criteria\n\n* Inability to understand the clinical trial and\u002For sign the Informed Consent;\n* Unable or unwilling to attend all of the study prescribed visits and data collection forms;\n* Active infection requiring medication;\n* Drug requiring diabetes mellitus;\n* Collagenopathies;\n* Hypothyroidism requiring medication;\n* Rheumatoid arthritis requiring medication;\n* Autoimmune disease requiring medication;\n* Cervical nerve compression;\n* Hematopoietic disorders;\n* Lacertus fibrosis;\n* Psychiatric disorder requiring medical treatment;\n* Subject of workers compensation claim;\n* History of cancer, except for basal or squamous cell skin cancer;\n* Known allergic reactions to components of DYNAVISC;\n* Actively participating in another clinical trial.","65 Years",{"count":227,"type":21},50,[51],"The trial will evaluate the efficacy of DYNAVISC in subjects with a diagnosis of persistent or recurrent carpal tunnel syndrome. This is a prospective, multicenter, randomized, evaluator-blinded clinical trial. Results will be stratified based on the method used for median nerve coverage: Group 1 (standard of care surgery followed by DYNAVISC surrounding the median nerve, n=25 participants), Group 2 (standard of care surgery followed by coverage of the median nerve with a hypothenar fat pad flap, n=25",[26],[162,232],"revision","2026-03-31",{"date":235,"type":31},"2026-04-06",{"date":237,"type":21},"2026-03-26",{"date":239,"type":21},"2027-10",{"name":241,"class":242},"FzioMed","INDUSTRY",4,{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":225,"enrollmentInfo":251,"targetDuration":4,"studyType":49,"phases":253,"briefSummary":254,"conditions":255,"keywords":259,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":97},"100631309","glucocorticoid-ozone-and-5-dextrose-local-injection-for-pain-relief-in-carpal-tunnel-syndrome-100631309","NCT07498998","Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome","A Comparative Study Between Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Adults aged 18-65 years with a clinical diagnosis of mild to moderate Carpal Tunnel Syndrome .\n* Clinical diagnosis of mild to moderate Carpal Tunnel Syndrome , as classified by Bland neurophysiological classification scale: Mild Carpal Tunnel Syndrome : Slow Distal Sensory Latency(≥3.6 ms), Normal Distal Motor Latency(\\\u003C 4.5 ms)\n* Moderate Carpal Tunnel Syndrome : Slow Distal Sensory Latency (≥ 3.6 ms), Slow Distal Motor Latency (4.5 - 6.4 ms)\n* Failure to respond to conservative treatments (e.g., splinting, activity modification, or oral medications) for at least 6 weeks.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Severe Carpal Tunnel Syndrome requiring surgical intervention, as defined by the Bland neurophysiological classification scale: Severe Carpal Tunnel Syndrome: Absent Distal Sensory Latency and Slow Distal Motor Latency (4.5 - 6.4 ms)\n* Previous corticosteroid injection for Carpal Tunnel Syndrome within the last 6 months.\n* History of wrist trauma, surgery or anatomical abnormalities.\n* Systemic conditions such as diabetes mellitus, thyroid dysfunction or rheumatoid arthritis.\n* Pregnancy or lactation.\n* Contraindications to any of the study interventions (e.g., allergy to glucocorticoids or ozone).\n* Infection at wrist.",{"count":252,"type":21},105,[51],"This study aims to compare the efficacy and outcomes of perineural injection with 5% dextrose, local ozone and glucocorticoid injection in the management of carpal tunnel syndrome.",[26,256,257,258],"Glucocorticoid","Pain","Dextrose",[260,261,262,56],"glucocorticoid","Ozone","5% dextrose","2026-03-24",{"date":265,"type":31},"2026-03-27",{"date":267,"type":21},"2026-07-30",{"date":269,"type":21},"2026-08-30",{"name":271,"class":38},"Tanta University",{"id":273,"slug":274,"hasResults":12,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":279,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":281,"conditions":282,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":286,"completionDateStruct":287,"leadSponsor":289,"locationsCount":97},"100631109","median-and-ulnar-nerve-function-in-tattoo-artists-100631109","NCT07496398","Median and Ulnar Nerve Function in Tattoo Artists","Occupational Hand-Arm Vibration Exposure and Its Effects on Median and Ulnar Nerve Function in Tattoo Artists: A Case-Control Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Professional tattoo artists with at least 1 year of occupational experience (case group)\n* Healthy individuals without occupational vibration exposure (control group)\n* Voluntary participation and provision of informed consent\n* No upper extremity trauma or surgery within the last 6 months\n\nExclusion Criteria:\n\n* Diagnosis of diabetes mellitus\n* Diagnosis of peripheral neuropathy\n* History of cervical radiculopathy or cervical disc herniation\n* History of upper extremity surgery or injury\n* Presence of rheumatologic or systemic inflammatory diseases\n* Pregnancy\n* Substance or alcohol abuse\n* Engagement in a second occupation involving repetitive hand use or vibration exposure",{"count":280,"type":21},20,"This case-control study aims to investigate the effects of occupational hand-arm vibration exposure on median and ulnar nerve functions in tattoo artists. Chronic exposure to vibration generated by tattoo machines may lead to neurosensory impairment, reduced tactile sensitivity, and decreased hand strength. Objective assessments including nerve provocation tests, sensory threshold evaluation, two-point discrimination, vibration perception, grip and pinch strength measurements, and validated patient-reported outcome questionnaires will be used. Findings will be compared with age- and sex-matched healthy controls.",[283,26,201],"Peripheral Neuropathy Pain","2026-03-23",{"date":265,"type":31},{"date":116,"type":31},{"date":288,"type":21},"2026-08-01",{"name":290,"class":38},"Gazi University",{"id":292,"slug":293,"hasResults":12,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":12,"sex":17,"minAge":298,"maxAge":299,"enrollmentInfo":300,"targetDuration":4,"studyType":49,"phases":302,"briefSummary":303,"conditions":304,"keywords":309,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":97},"100591199","effectiveness-of-kinesiotaping-and-peloidotherapy-in-carpal-tunnel-syndrome-100591199","NCT06977321","Effectiveness of Kinesiotaping and Peloidotherapy in Carpal Tunnel Syndrome","A Comparative Evaluation of the Effectiveness of Kinesiotaping and Peloidotherapy in Patients With Idiopathic Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Being between the ages of 18-65\n* Agreeing to participate voluntarily in the study\n* Being diagnosed with mild or moderate idiopathic chronic CTS as a result of anamnesis, clinical examination and nerve conduction study\n\nExclusion Criteria:\n\n* Presence of predisposing etiological factors for CTS such as diabetes mellitus, chronic kidney and liver disease, acromegaly, rheumatological diseases, acute trauma, hypothyroidism, etc.\n* Being diagnosed with severe CTS\n* Having a history of previous wrist surgery or trauma\n* Having atrophy in the thenar region or weakness in the thenar muscles\n* Having cervical radiculopathy, thoracic outlet syndrome, polyneuropathy, brachial neuropathy or proximal median nerve neuropathy\n* Having had steroid injections in the last 3 months and taking oral steroid medications\n* Being pregnant\n* Having an open wound or rash in the wrist and its surroundings that would prevent treatment\n* Patients who are receiving or will receive another\u002Fadditional treatment for CTS\n* Patients with a bifid median nerve, persistent median artery, ganglion cyst, tenosynovitis, or tendinitis in the wrist.","18 Months","65 Months",{"count":301,"type":21},90,[51],"Patients diagnosed with mild and moderate idiopathic CTS will be randomly divided into three groups. Patients who received 15 sessions of peloid therapy along with a home exercise program will constitute the first group. The second group will consist of patients who received a total of 6 sessions of kinesiotaping twice a week along with a home exercise program. Patients who were given only a home exercise program will be included in the third group. \"Patients will be evaluated in detail in terms of clinical examination and outcomes three weeks after the end of treatment and again at three months.",[26,305,306,307,308],"Kinesio Taping","Exercise","Pain Management","Peloidotherapy",[310,308,311,312,313,163],"carpal tunnel syndrome (CTS)","exercise","pain","kinesio taping","2026-03-19",{"date":316,"type":31},"2026-03-20",{"date":318,"type":31},"2025-05-17",{"date":320,"type":21},"2026-05-15",{"name":322,"class":323},"Konya Beyhekim Training and Research Hospital","OTHER_GOV",{"id":325,"slug":326,"hasResults":12,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":4,"eligibilityCriteria":330,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":331,"targetDuration":4,"studyType":49,"phases":332,"briefSummary":334,"conditions":335,"keywords":336,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":97},"100629441","phase-3-hyaluronic-acid-injection-in-idiopathic-carpal-tunnel-syndrome-is-it-effective-as-local-corticosteroids-100629441","NCT07474714","Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids","Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids? A Comparative Follow up Study","Inclusion Criteria:\n\n1. Numbness or pain in the Median Nerve (MN) distribution.\n2. Nerve conduction studies (NCS) consistent with CTS as per the AANEM guidelines.\n3. An MN cross-sectional area (CSA) at the wrist \\>12 mm²\n\nExclusion Criteria:\n\n1. Patients with severe symptoms (indication for surgery).\n2. Patients who show improvement on medical treatment.\n3. Patients with previous surgical or injectional CTS treatment.\n4. Coexistence of brachial plexopathy, or thoracic outlet syndrome.\n5. Patients with infection at the site of injection.",{"count":107,"type":21},[333],"PHASE3","This study compares the effectiveness of two types of local injections-Hyaluronic Acid (HA) and corticosteroids-for treating mild to moderate idiopathic Carpal Tunnel Syndrome (CTS). Sixty adult patients will be assigned to receive one of the two injections under ultrasound guidance. The goal is to see if HA is as effective as the standard corticosteroid treatment in improving symptoms and nerve function over a 3-month follow-up period.",[26],[26,337,338,339,340],"Hyaluronic Acid","Corticosteroid Injection","Ultrasound-Guided Injection","Median Nerve","2026-03-14",{"date":343,"type":31},"2026-03-17",{"date":345,"type":21},"2026-02",{"date":347,"type":21},"2026-09",{"name":349,"class":38},"Minia University Hospital",{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":225,"enrollmentInfo":357,"targetDuration":4,"studyType":49,"phases":359,"briefSummary":360,"conditions":361,"keywords":364,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":4},"100628170","comparison-of-wrist-splint-positions-in-carpal-tunnel-syndrome-100628170","NCT07458152","Comparison of Wrist Splint Positions in Carpal Tunnel Syndrome","Evaluation of the Effectiveness of Splint Use in Different Wrist Positions in the Treatment of Carpal Tunnel Syndrome: A Single-Blind, Randomized, Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of mild to moderate carpal tunnel syndrome confirmed by electrophysiological studies performed within the last year.\n* Clinical findings consistent with carpal tunnel syndrome.\n* Age between 18 and 65 years.\n\nExclusion Criteria:\n\n* \\\u003C18 years or \\>65 years\n* Thenar atrophy\n* Surgery history for CTS\n* Steroid injection for CTS\n* Physical treatment for CTS in the last 6 months\n* Cervical radiculopathy\n* Tenosynovitis\n* Peripheral polyneuropathy\n* Another compressive neuropathy in the ipsilateral upper extremity\n* History of trauma\u002Ffracture to the hand-wrist region\n* Pregnancy\n* Metabolic disease\n* Rheumatic\u002Fautoimmune disease\n* Kidney failure",{"count":358,"type":21},108,[51],"Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome. It develops as a result of the compression of the median nerve while passing through the osteofibrous structure of the carpal tunnel located at the wrist. Sensory symptoms are the most prominent feature of CTS. These symptoms are observed as pain, paresthesia, and decreased sensory sensitivity. As motor symptoms, thumb abduction and opposition are primarily affected. In advanced cases, atrophy develops in the thenar muscles. Patients may describe weakness as difficulty in writing, opening jars, buttoning, or grasping objects. The diagnosis is made by fulfilling both clinical and electrophysiological diagnostic criteria. CTS has both conservative and surgical treatment options. Conservative treatment includes splinting, physical therapy modalities, and injection options, and it is preferred in mild and moderate cases. Among non-surgical treatment options, splint use is a commonly applied intervention; however, there is no consensus regarding its effectiveness, the optimal wrist position during use, or the duration and frequency of splint application. A total of 108 hands from patients aged 18 to 55 years diagnosed with CTS will be included in this study and randomized into three groups. All groups will be given an education and exercise program. The first group will use a wrist splint fixed at 15° flexion; the second group at neutral position; and the third group at 20° extension, to be worn only at night for eight weeks. Patients will be evaluated before treatment, immediately after treatment, and two months after the end of treatment using measures of pain- numbness severity, functional status, motor and sensory examination findings, and nerve conduction studies. What makes this study unique is that it evaluates the effects of splints that stabilize the wrist at different angles together with electrophysiological findings. A review of the literature shows that while some studies have examined and compared the effects of splints fixed at different wrist angles on symptoms, functional status, and physical examination findings, there is no study that evaluates these effects along with electrophysiological findings. Therefore, this study, which will compare the effectiveness of splints at different angles, is expected to contribute to the literature. The expected outcomes of this research are that one or more types of splints used in the conservative treatment of CTS will provide improvements in symptom severity, functional status, sensory and motor physical examination findings, and electrophysiological evaluation findings at the end of treatment.",[26,362,363],"Peripheral Neuropathies","Median Nerve Entrapment",[365,366,367,368,369],"Splints","Electromyography","Wrist splinting","Rehabilitation","Wrist posture","2026-03-10",{"date":372,"type":31},"2026-03-12",{"date":374,"type":21},"2026-03",{"date":376,"type":21},"2029-01",{"name":378,"class":38},"Istanbul University",{"id":380,"slug":381,"hasResults":12,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":225,"enrollmentInfo":386,"targetDuration":4,"studyType":49,"phases":387,"briefSummary":388,"conditions":389,"keywords":392,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":97},"100626463","magnetotherapy-in-carpal-tunnel-syndrome-randomized-controlled-study-100626463","NCT07435961","Magnetotherapy in Carpal Tunnel Syndrome: Randomized Controlled Study","Evaluation of the Effectiveness of Magnetotherapy in Patients With Carpal Tunnel Syndrome: A Placebo-Controlled, Triple-Arm, Randomized, Double-Blind Study","Inclusion Criteria:\n\n* Adults aged between 18 and 65 years.\n\nClinical diagnosis of carpal tunnel syndrome (CTS) based on physical examination findings, including positive Tinel and\u002For Phalen tests and hypoesthesia in the 3rd to 5th digits.\n\nElectrophysiologically confirmed mild-to-moderate carpal tunnel syndrome based on electromyography (EMG) findings.\n\nExclusion Criteria:\n\n* Severe carpal tunnel syndrome confirmed electrophysiologically by electromyography (EMG).\n\nHistory of previous surgical intervention for carpal tunnel syndrome.\n\nPresence of other peripheral nerve entrapments (e.g., ulnar nerve entrapment, radial nerve entrapment).\n\nElectrophysiologically confirmed polyneuropathy or cervical radiculopathy\u002Fcervical discopathy.\n\nRheumatologic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus).\n\nDiabetes mellitus (Type 1 or Type 2).\n\nPregnancy.\n\nPresence of electronic implants such as cardiac pacemaker, cochlear implant, or implantable defibrillator.\n\nActive acute infection.\n\nHistory of malignancy.\n\nReceipt of physical therapy or rehabilitation for the wrist or surrounding area within the past 6 months.\n\nCorticosteroid injection to the wrist within the past 6 months.\n\nHyperthyroidism or adrenal gland hyperfunction.\n\nOpen growth plates (epiphyseal plates not closed).\n\nParoxysmal neurological disorders (e.g., epilepsy).\n\nMyasthenia gravis.\n\nRegular use of pain medications such as pregabalin, duloxetine, or non-steroidal anti-inflammatory drugs (NSAIDs).",{"count":107,"type":21},[51],"This study is designed to investigate the effectiveness of low-frequency pulsed electromagnetic field therapy in individuals diagnosed with mild-to-moderate carpal tunnel syndrome (CTS). This double-blind, randomized controlled trial will randomly assign participants into three groups:\n\nGroup 1: Active magnetotherapy\n\nGroup 2: Placebo magnetotherapy (treatment using an identical device that does not generate a magnetic field)\n\nGroup 3: Routine (conservative) treatment group\n\nAll participants will receive a standard nighttime wrist splint and a standardized nerve and tendon gliding exercise protocol. Magnetic field applications will be administered five days per week for a total of 15 sessions. Assessments will be conducted at baseline (T0), at the end of treatment (T1 - Week 3), at 1 month (T2), and at 3 months (T3).\n\nThe primary outcome measures include the Boston Carpal Tunnel Questionnaire (BCTQ), pain intensity assessed by the Visual Analog Scale (VAS), functional status measured by QuickDASH, median nerve cross-sectional area assessed by ultrasonography, sensory function evaluated using the Semmes-Weinstein monofilament test, grip strength measured by dynamometry, and clinical test results (Tinel and Phalen tests). Secondary outcomes include sleep quality assessed by the Pittsburgh Sleep Quality Index (PSQI) and patient satisfaction.\n\nThis study aims to contribute to the scientific evidence regarding the effectiveness of magnetotherapy as a non-invasive treatment option for carpal tunnel syndrome.",[390,26,391],"Magnetotherapy","Median Nerve Compression",[393,394,395],"median nerve compression","carpal tunnel syndrome(cts)","magnetotherapy","2026-02-21",{"date":398,"type":31},"2026-02-27",{"date":400,"type":21},"2026-02-01",{"date":402,"type":21},"2026-11-01",{"name":404,"class":38},"Fatih Sultan Mehmet Training and Research Hospital",{"id":406,"slug":407,"hasResults":12,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":411,"eligibilityCriteria":412,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":413,"targetDuration":4,"studyType":49,"phases":415,"briefSummary":416,"conditions":417,"keywords":418,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":427,"leadSponsor":429,"locationsCount":97},"100626216","comparing-efficacy-of-osteopathic-manipulation-vs-wrist-immobilization-for-carpal-tunnel-syndrome-100626216","NCT07432750","Comparing Efficacy of Osteopathic Manipulation vs. Wrist Immobilization for Carpal Tunnel Syndrome","Comparing Efficacy of Osteopathic Manipulation vs. Wrist Immobilization for Carpal Tunnel Syndrome Using Magnetic Resonance Imaging and Patient Perception","OMM","Inclusion Criteria:\n\n* Patients who have been diagnosed with mild\u002Fmoderate carpal tunnel syndrome\n* Patients who are over the age of 18 and patients who score at least a 3 in at least one category in both subsections of the Boston Carpal Tunnel Questionnaire.\n* Exclusion criteria:\n* Patients who are under the age of 18\n* Patients who are pregnant\n* Patients who have found no benefit to their Carpal Tunnel Syndrome Symptoms with bracing\n* Patients who have previously undergone Carpal Tunnel Release\n* Patients who have been diagnosed with osteoporosis, osteomyelitis, underlying bone diseases, severe rheumatoid arthritis or other inflammatory arthritis.\n* Patients with magnetic resonance imaging specific contraindications include patients with metallic implanted devices or retained metallic foreign bodies, patients with severe and uncontrolled claustrophobia and patients who are pregnant",{"count":414,"type":21},10,[51],"Carpal Tunnel Syndrome (CTS) can be defined as disruption of the median nerve and is characterized by pain, numbness and tingling of the lateral 3.5 digits of the hand. In severe cases, motor function can also be disrupted. There are many factors that can contribute to the development of CTS: inflammation, compression, bony abnormality, mechanical injury, or certain lifestyle choices. Abnormalities have been proven to be tangibly visible with ultrasound in prior research projects in the form of decreased cross sectional area of the carpal tunnel, flattening of the median nerve, retinacular bowing and increased median nerve intensity. Although CTS has proven to be multifactorial, the standard of care for patients with CTS has historically been wrist immobilization and\u002For surgical release by endoscopic or open approach. This is despite evidence that osteopathic manipulation techniques have been effective in improving quality of life for patients with CTS.\n\nPatients will not be harmed if they are not bracing, as standard of care may include multiple things: bracings vs. OMM vs. surgical release.\n\nOur study will take place over the course of 10 weeks. Patients who have been previously diagnosed with mild or moderate carpal tunnel syndrome by a physician previously will be randomly placed into one of two groups: osteopathic manipulative medicine or bracing. If placed in the bracing category, patients will be given a brace and asked to wear it nightly. If placed in the osteopathic manipulative medicine category, patients will be asked to present to the clinic one time a week for 6 weeks. Each time the patient presents to clinic, they will be treated for 30 minutes.\n\nfor 30 minutes of osteopathic manipulative medicine for 6 consecutive weeks.\n\nAt the first presentation, patients will obtain a magnetic resonance image of the affected wrist, from which a cross sectional area will be determined. Repeat magnetic resonance image will be obtained at the conclusion of treatment.\n\nAdditionally, at the first presentation, 3 weeks into the study, at the end of the study and 4 weeks after the study is completed, each subject will complete the Boston Carpal Tunnel Questionnaire. Descriptive and repeated measures statistical analysis will be performed.",[26],[411,419,420,421,422],"OMT","Osteopathic","Osteopathic Manipulation","Osteopathic Manipulative Medicine","2026-02-18",{"date":425,"type":31},"2026-02-25",{"date":374,"type":21},{"date":428,"type":21},"2027-02-28",{"name":430,"class":38},"New York Institute of Technology",{"id":432,"slug":433,"hasResults":12,"nctId":434,"briefTitle":435,"officialTitle":435,"acronym":4,"eligibilityCriteria":436,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":437,"enrollmentInfo":438,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":440,"conditions":441,"keywords":448,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":463,"leadSponsor":465,"locationsCount":97},"100625239","turkish-adaptation-of-the-cts-6-evaluation-tool-a-validation-and-reliability-study-100625239","NCT07420049","Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study","1\\) INCLUSION CRITERIA:\n\nParticipants aged 18-60 years will be categorized into three groups:\n\n1. Healthy Control Group\n2. Group Presenting with CTS-like Symptoms\n3. Group Diagnosed with CTS Based on Defined Criteria\n\na) Healthy Control Group: Participants in this group will have no clinical symptoms consistent with CTS based on specified clinical criteria and will be considered normal according to the defined electrophysiological criteria.\n\nb) Group Presenting with CTS-like Symptoms: Participants in this group may exhibit symptoms similar to clinically defined CTS; however, electrophysiological evaluations will show normal findings according to the defined criteria.\n\nb.1) Clinical Findings \u002F Symptoms:\n\nb.1.1) Symptoms:\n\n(A) Sensory symptoms in any of the 1st, 2nd, 3rd, or the radial part of the 4th finger\n\n(B) Symptoms alleviated by shaking, squeezing, or other hand movements\n\n(C) Pain or paresthesia associated with gripping or hand use\n\n(D) Nocturnal paresthesia causing awakening from sleep\n\nb.1.2) Diagnostic Tests \u002F Signs:\n\n1. Tinel Sign\n2. Phalen Test\n3. Reverse Phalen Test\n4. Carpal Tunnel Compression Test\n5. Flick Sign\n\n   A clinical diagnosis of CTS will require symptoms persisting for at least three months, with at least one of the B, C, or D symptoms in addition to symptom A, plus at least one positive diagnostic test or sign.\n\n   b.2) Electrophysiological Evaluation:\n\n   b.2.1) Mild CTS:\n\n   Median-to-ulnar sensory distal latency difference ≥ 0.4 ms at the 4th finger\n\n   Median nerve sensory distal latency ≥ 2.8 ms at the 2nd finger\n\n   Median nerve conduction velocity \\\u003C 50 m\u002Fs\n\n   Sensory nerve action potential ≥ 12 µV\n\n   b.2.2) Moderate CTS:\n\n   Median nerve distal motor latency at Abductor Pollicis Brevis (APB) 4 ms ≤ x \\\u003C 6.5 ms\n\n   Median nerve conduction velocity \\\u003C 50 m\u002Fs\n\n   Compound Muscle Action Potential (CMAP) ≥ 5 mV\n\n   b.2.3) Severe CTS:\n\n   Median nerve distal motor latency at APB ≥ 6.5 ms\n\n   Median nerve conduction velocity \\\u003C 50 m\u002Fs and\u002For CMAP \\\u003C 5 mV\n\n   c) Group Diagnosed with CTS Based on Defined Criteria: Participants in this group meet the clinical diagnostic criteria for CTS and additionally fulfill electrophysiological evaluation criteria for mild, moderate, or severe CTS.\n\n2\\) EXCLUSION CRITERIA:\n\n2.a) Participants Diagnosed with CTS Based on Defined Criteria:\n\nHistory of cardiac pacemaker\n\nHistory of lymphedema in the affected extremity\n\nHistory of cervical radiculopathy\n\nPresence of ipsilateral upper extremity tenosynovitis\n\nPresence of another compressive neuropathy in the ipsilateral upper extremity\n\nHistory of peripheral polyneuropathy\n\nPresence of metabolic disease\n\nHistory of fracture in the hand, wrist, or forearm\n\nCurrent pregnancy\n\nOpen wound on the wrist\n\nUncontrolled medical conditions (including endocrinological, cardiovascular, pulmonary, hematological, hepatic, renal, active systemic inflammatory disease, and\u002For malignancy)\n\nHistory of inflammatory rheumatologic or autoimmune disease\n\nAge \\\u003C18 years or \\>60 years\n\nTrauma to the wrist or median nerve within the last 3 months\n\nReceived any injection in the wrist\n\nUndergone any surgical procedure on the wrist\n\nMental or cognitive incapacity preventing understanding or completion of questionnaires\n\n2.b) Participants Presenting with CTS-like Symptoms:\n\nMental or cognitive incapacity preventing understanding or completion of questionnaires\n\nAge \\\u003C18 years or \\>60 years\n\nCTS diagnosis confirmed based on clinical and electrophysiological criteria\n\n2.c) Healthy Control Group Participants:\n\nMental or cognitive incapacity preventing understanding or completion of questionnaires\n\nAge \\\u003C18 years or \\>60 years\n\nPresence of any clinical symptoms potentially related to CTS based on defined clinical criteria\n\nElectrophysiological findings consistent with CTS","60 Years",{"count":439,"type":21},126,"The purpose of this study is to develop the Turkish version of the CTS-6 Evaluation Tool and to comprehensively assess its validity and reliability in the Turkish population. The CTS-6 Evaluation Tool is a widely used and reliable instrument for the assessment of diagnosis and symptom severity in patients with carpal tunnel syndrome.\n\nIn this study, the CTS-6 will undergo translation and cultural adaptation to ensure linguistic and cultural appropriateness for the Turkish population. The goal is to produce a valid, reliable, and practical tool that can be used efficiently in clinical settings. The adapted version is intended to be applicable across multiple medical specialties involved in the diagnosis and management of carpal tunnel syndrome in Turkey. The results are expected to provide a trustworthy Turkish version of the CTS-6 suitable for both clinical practice and research purposes.",[26,363,442,443,444,445,446,447],"Peripheral Nerve Disease","Peripheral Nerve Disorder","Reliability and Validity","Cross-cultural Adaptation","TURKISH VALIDITY AND RELIABILITY STUDY OF CTS-6 EVALUATİON TOOL","Diagnostic Tool",[449,450,451,452,453,454,447,455,456,457,458],"CTS-6 Evaluation Tool","CTS-6","Cross-cultural adaptation","Carpal Tunnel Syndrome","median nerve entrapment","reliability and validity","Peripheral nerve disease","Peripheral nerve disorders","Turkish version","Turkish Validity and Reliability Study of CTS-6 Evaluation Tool","2026-02-12",{"date":461,"type":31},"2026-02-19",{"date":116,"type":21},{"date":464,"type":21},"2026-07-01",{"name":378,"class":38},{"id":467,"slug":468,"hasResults":12,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":4,"eligibilityCriteria":472,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":473,"targetDuration":4,"studyType":49,"phases":474,"briefSummary":475,"conditions":476,"keywords":477,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":486,"leadSponsor":487,"locationsCount":73},"100624529","investigation-of-the-effectiveness-of-cervicothoracic-exercises-in-individuals-with-carpal-tunnel-syndrome-100624529","NCT07410819","Investigation of the Effectiveness of Cervicothoracic Exercises in Individuals With Carpal Tunnel Syndrome","Karpal Tünel Sendromu Olan Bireylerde Servikotorakal Egzersizlerin Etkinliğinin Araştırılması","Inclusion Criteria:\n\n* Age over 18\n* Symptom duration of at least 12 weeks,\n* Information about carpal tunnel syndrome received from a physician,\n* Positive Tinel or Phalen test in carpal compression test,\n* Pain intensity, Visual Analog Scale, at least 40 mm out of 100 mm\n\nExclusion Criteria:\n\n* Any sensory or motor deficit in the ulnar or radial nerve\n* History of previous surgery or injection in the wrist\n* Trauma to the neck, shoulder, or upper extremity\n* Pregnancy\n* Concurrent cervical radiculopathy or polyneuropathy",{"count":107,"type":21},[51],"This randomized, parallel-group controlled clinical trial aims to investigate the effects of adding cervicothoracic exercises to conventional physiotherapy on pain, functional status, grip strength, and range of motion in individuals with carpal tunnel syndrome (CTS). CTS is a common compressive neuropathy of the median nerve, characterized by pain, numbness, tingling, nocturnal symptoms, and reduced hand function. Sixty adults diagnosed with CTS will be randomly allocated into two groups (n=30 each): a conventional physiotherapy group and a cervicothoracic exercise plus conventional physiotherapy group.\n\nThe conventional physiotherapy program includes transcutaneous electrical nerve stimulation (TENS), therapeutic ultrasound, median nerve mobilization, wrist range-of-motion exercises, and strengthening exercises. The intervention group will receive the same conventional physiotherapy program in addition to cervicothoracic exercises targeting cervical mobility, scapular stabilization, and thoracic spine mobility. The intervention will be applied five days per week for six weeks.\n\nOutcome measures will be assessed at baseline and at the end of week 6. Primary outcomes include pain intensity measured by the Visual Analog Scale (VAS), functional status assessed using the Boston Carpal Tunnel Questionnaire (BCTQ), and grip strength measured with a Jamar hand dynamometer. Secondary outcomes include upper extremity function evaluated using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and wrist and finger range of motion measured with a goniometer. Data will be analyzed using appropriate statistical methods, with statistical significance set at p\\\u003C0.05. This study aims to determine whether adding cervicothoracic exercises to conventional physiotherapy provides additional clinical benefits in CTS rehabilitation.",[26],[452,306,478,479,480],"Hand Grip Strength","Servicothoracic Exercises","Wrist Pain","2026-02-08",{"date":483,"type":31},"2026-02-13",{"date":485,"type":31},"2025-10-01",{"date":320,"type":21},{"name":488,"class":38},"Medipol University",{"id":490,"slug":491,"hasResults":12,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":4,"eligibilityCriteria":495,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":496,"targetDuration":4,"studyType":49,"phases":498,"briefSummary":499,"conditions":500,"keywords":501,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":73},"100615557","comparison-of-rest-splints-vs-high-intensity-laser-therapy-in-carpal-tunnel-syndrome-100615557","NCT07294157","Comparison of Rest Splints vs High-Intensity Laser Therapy in Carpal Tunnel Syndrome","Comparison of the Effects of Rest Splints and High-Intensity Laser Therapy on Pain, Function, Nerve Conduction Studies, and Grip Strength in Patients With Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Patients aged 18-75 years who have been diagnosed with carpal tunnel syndrome based on their medical history, physical examination, clinical findings, and electromyography(EMG) results, who have applied to the outpatient clinic for physical therapy, and who have no contraindications for treatment will be included in the study after obtaining their consent.\n\nExclusion Criteria:\n\n* Diabetes Mellitus\n* Hypothyroidism\n* Acromegaly\n* Rheumatic Diseases\n* Polyneuropathy\n* Ipsilateral brachial plexopathy and traumatic nerve injury in the upper extremity\n* Previous injection into the carpal tunnel within the last 6 months and physical therapy\n* Pregnancy\n* History of malignant tumors\n* Patients with cochlear implants\n* Acquired Immunodeficiency Syndrome\n* History of neck and\u002For shoulder surgery\n* Corticosteroid consumption, analgesic medication use\n* Epilepsy\n* Skin lesion",{"count":497,"type":21},78,[51],"The aim of this study is to compare the effectiveness of rest splints and high-intensity laser therapy(HILT) added to physical therapy programs for patients with carpal tunnel syndrome in terms of pain, function, nerve conduction studies, and grip strength.",[26],[452,502,503],"Physical Therapy Modalities","Electromyography veya Nerve Conduction","2026-01-12",{"date":506,"type":31},"2026-01-13",{"date":508,"type":31},"2025-12-15",{"date":510,"type":21},"2026-09-15",{"name":512,"class":38},"Afyonkarahisar Health Sciences University",{"id":514,"slug":515,"hasResults":12,"nctId":516,"briefTitle":517,"officialTitle":518,"acronym":4,"eligibilityCriteria":519,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":520,"targetDuration":4,"studyType":49,"phases":522,"briefSummary":523,"conditions":524,"keywords":525,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":540,"locationsCount":97},"100616182","the-effectiveness-of-pain-neuroscience-education-for-patients-with-carpal-tunnel-syndrome-100616182","NCT07302282","The Effectiveness of Pain Neuroscience Education for Patients With Carpal Tunnel Syndrome","The Effectiveness of Pain Neuroscience Education for Patients With Mild to Moderate Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Being 18 years of age or older\n* Having a diagnosis of mild or moderate CTS confirmed by ENMG\n* Having complaints of pain and numbness in the first three fingers of the hand for at least 3 months\n\nExclusion Criteria:\n\n* Presence of severe CTS findings on electrophysiological examination\n* Presence of metabolic diseases such as uncontrolled diabetes and hypothyroidism\n* Presence of inflammatory rheumatic disease (e.g., rheumatoid arthritis)\n* Presence of other neuromuscular diseases affecting the hand and wrist (Polyneuropathy, Cervical radiculopathy, peripheral nerve damage, Brachial plexus damage, other entrapment neuropathies, etc.)\n* History of hand and wrist trauma\n* History of neck and wrist surgery\n* History of steroid injection into the carpal tunnel within the last 3 months\n* History of physical therapy application to wrist within the last 3 months\n* Deformity preventing the use of a splint on the wrist\n* Previous participation in a program for the psychological management of chronic pain\n* Cognitive dysfunction preventing cooperation with tests",{"count":521,"type":21},48,[51],"The goal of this clinical trial is to investigate the effects of Pain Neuroscience Education applied in the treatment of mild and moderate carpal tunnel syndrome (CTS).\n\nThe main question it aims to answer is: Does PNE have a therapeutic effect on carpal tunnel syndrome in clinical and ultrasonographic terms? Researchers will compare whether PNE creates a synergistic effect alongside home based exercise programs and splint application in mild to moderate CTS, and will objectively demonstrate potential benefits such as relief from pain and numbness.",[26],[526,527,528,529,306,530,531,532],"Median Neuropathy","Mononeuropathies","Nerve Compression Syndromes","Education","Pain neuroscience education","Carpal tunnel syndrome","Median nerve gliding exercise","2026-01-02",{"date":535,"type":31},"2026-01-06",{"date":537,"type":31},"2025-12-29",{"date":539,"type":21},"2026-08-17",{"name":541,"class":38},"Karamanoğlu Mehmetbey University",{"id":543,"slug":544,"hasResults":12,"nctId":545,"briefTitle":546,"officialTitle":547,"acronym":548,"eligibilityCriteria":549,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":550,"targetDuration":4,"studyType":49,"phases":551,"briefSummary":552,"conditions":553,"keywords":554,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":565,"locationsCount":97},"100618138","effects-of-repetitive-peripheral-magnetic-stimulationrpms-on-ctscarpal-tunnel-syndrome-100618138","NCT07327723","Effects of Repetitive Peripheral Magnetic Stimulation(rPMS) on CTS(Carpal Tunnel Syndrome)","The Effects of Repetitive Peripheral Magnetic Stimulation on Clinical and Electrophysiological Parameters in Patients With Carpal Tunnel Syndrome: A Double-Blind, Randomized, Sham-Controlled Trial","rPMS CTS","Inclusion Criteria\n\n* Voluntary participation with signed informed consent\n* Presence of symptoms consistent with carpal tunnel syndrome (CTS) (pain and\u002For paresthesia in the median nerve distribution), clinical signs (i.e., positive Tinel's and\u002For Phalen's test results), and electrodiagnostic findings (demonstrating mild to moderate CTS based on sensory or motor conduction studies of the median nerve)\n\nExclusion Criteria:\n\n* Electrodiagnostic evidence of severe CTS\n* Abnormal ulnar nerve conduction findings\n* History of surgery for CTS\n* History of physical therapy or injection for CTS within the past 6 months\n* History of wrist fracture\n* Presence of other conditions causing similar symptoms, such as polyneuropathy, cervical radiculopathy, ulnar neuropathy, brachial plexopathy, or thoracic outlet syndrome\n* Central nervous system disorders (e.g., stroke, multiple sclerosis, Parkinson's disease)\n* Pregnancy\n* Presence of risk factors for CTS such as rheumatologic diseases, chronic kidney disease, diabetes mellitus, or hypothyroidism\n* Malignancy\n* Contraindications to rPMS (e.g., pacemaker, cochlear implant)",{"count":5,"type":21},[51],"Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, resulting from compression of the median nerve at the wrist. It is particularly common in middle-aged women. In the early stages, these patients frequently experience pain and numbness in the hand, especially in the first three fingers, and paresthesias, which often worsen at night. As the disease progresses, muscle weakness and atrophy of the thenar muscles can occur, severely impacting patients' daily activities and functionality. Clinical evaluation and patient complaints are crucial for diagnosis. Electrophysiological assessment tools such as nerve conduction studies and electromyography (EMG) are highly sensitive and considered the gold standard for confirming the diagnosis, assessing nerve damage, and determining the severity of this damage. In addition to electrophysiological assessment, ultrasonographic evaluation offers an important opportunity to observe structural changes in the median nerve associated with CTS.\n\nIn cases of mild to moderate CTS, nonsurgical treatments are the primary options for reducing symptoms; splinting, tendon-nerve gliding exercises, and physical therapy modalities are commonly preferred. Repetitive peripheral magnetic stimulation (rPMS) is a non-invasive method that can be applied to various tissues, such as spinal nerves, peripheral nerves, or muscles, and is used to reduce pain and improve motor function. While its potential benefits for many neurological diseases and musculoskeletal problems have been demonstrated in recent years, there are limited studies on the effectiveness of rPMS in patients with CTS. The primary objective of this study is to evaluate the effectiveness of rPMS on pain in individuals diagnosed with mild to moderate CTS. Secondarily, the effects of rPMS on symptom severity, functional status, nerve conduction parameters, and median nerve ultrasonographic findings will be analyzed. The findings of our study suggest that objective evaluation of rPMS treatment will contribute to supporting the clinical practice of this treatment option in patients with CTS with more comprehensive data.",[26],[452,555,556,163,557],"Repetitive Peripheral Magnetic Stimulation","electrodiagnosis","functional status","2025-12-25",{"date":560,"type":31},"2026-01-08",{"date":562,"type":21},"2026-01-01",{"date":564,"type":21},"2027-01-15",{"name":566,"class":38},"Ankara University",{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":225,"enrollmentInfo":574,"targetDuration":4,"studyType":49,"phases":575,"briefSummary":576,"conditions":577,"keywords":578,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":73},"100583920","efficacy-of-corticosteroid-injection-and-nerve-hydrodissection-in-carpal-tunnel-syndrome-100583920","NCT06882603","Efficacy of Corticosteroid Injection and Nerve Hydrodissection in Carpal Tunnel Syndrome","Comparison of the Efficacy of Corticosteroid Injection and Saline Nerve Hydrodissection on Electrophysiological Study, Pain, Function and Sonographic Findings in the Treatment of Carpal Tunnel Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Female and male patients aged 18-65 who applied to Ahi Evran University Physical Medicine and Rehabilitation Polyclinic and diagnosed with carpal tunnel syndrome through clinical and EMG\n2. Patients who can understand the information form correctly and are cooperative\n3. Patients who consented to participate in the study according to the informed consent form\n\nExclusion Criteria:\n\n1. Cervical radiculopathy\n2. Polyneuropathy\n3. Brachial plexopathy\n4. Systemic corticosteroid use\n5. History of fracture and trauma in the forearm and wrist on the treated side 6- Inflammatory rheumatic disease\n\n7- Pregnant and breastfeeding patients 8- Systemic diseases such as renal failure, peptic ulcer, diabetes, hypothyroidism, coagulation disorders 9- Patients who have undergone carpal tunnel syndrome surgery 10- Thoracic outlet syndrome 11- Thenar atrophy, severe carpal tunnel syndrome 12- Patient is unwilling or states that they cannot participate for any reason",{"count":301,"type":21},[51],"The subject of the study is to use current treatment methods in patients with nerve compression in the wrist and compare their effects. The purpose of the study is to determine the most appropriate method by comparing the benefits of cortisone and serum injection in addition to exercise therapy in volunteers like you who have nerve compression in the wrist and have pain and numbness.",[26],[579,580],"steroid injection","nerve hydrodissection","2025-12-09",{"date":583,"type":31},"2025-12-10",{"date":585,"type":31},"2025-10-14",{"date":587,"type":21},"2026-05-05",{"name":589,"class":38},"Kirsehir Ahi Evran Universitesi",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":594,"acronym":4,"eligibilityCriteria":595,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":596,"enrollmentInfo":597,"targetDuration":4,"studyType":49,"phases":599,"briefSummary":601,"conditions":602,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":606,"completionDateStruct":608,"leadSponsor":610,"locationsCount":4},"100614767","phase-4-does-it-matter-the-volume-of-injectate-on-the-outcome-of-ultrasound-guided-perineural-injection-for-carpal-tunnel-syndrome-100614767","NCT07283874","Does it Matter the Volume of Injectate on the Outcome of Ultrasound-guided Perineural Injection for Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Adult patients aged 20-80 years old 2. Patients diagnosed with idiopathic CTS. 3. Abnormal electrophysiological analysis showing mild to moderate CTS 4. Symptoms and signs including:\n\n  1. pain or paraesthesia in the median nerve innervated area (at least two digits with such symptoms between the thumb and the 4th digit) for more than 6 months not responding to conservative management including (vitamin B complex, nonsteroidal anti-inflammatory drugs, oral steroids, and\u002For night splint)\n  2. positive Phalen test, Tinel sign, or flick sign\n  3. The patient's initial examination was based on the American Academy of Orthopaedic Surgeons Clinical Practice Guideline recommendations prior to their inclusion and confirmed by nerve conduction studies\n\nExclusion Criteria:\n\n* 1- Age less than 20 years 2- severe CTS (abductor policies brevis muscle atrophy with distal latency time \\>6.5 MS).\n\n  3- MN electrophysiology study revealing absent potentials. 4- its cross-sectional area (CSA) \\>15 mm2 by sonographic checkup. 5- previous surgery of carpal tunnel. 6- previous wrist injection within 3 months 7- history of peripheral nerve injuries (brachial plexopathy, cervical radiculopathy or thoracic outlet syndrome) 8- CTS due to systemic causes, for example, endocrinal and\u002For pregnancy, rheumatoid arthritis, gouty or psoriatic osteoarthritis.\n\n  9- concurrent use of antihistaminic, or cortisone. 10- Participant refusal. 11- local infection. presence of coagulopathy, and\u002For allergy to the included medications were also points for patients' exclusion from the study","80 Years",{"count":598,"type":21},35,[600],"PHASE4","Carpal tunnel syndrome (CTS) is an entrapment neuropathy affecting the median nerve with a lifetime prevalence of about 8% in the adult population. Carpal tunnel syndrome (CTS) occurs with the symptoms of intermittent nocturnal paresthesia and dysesthesia, followed by loss of sensation, weakness, and thenar muscle atrophy in later stages.\n\nAlthough the etiology of CTS is multifactorial, compression of the median nerve in a space-limited osteofibrous canal at wrist level was proposed.\n\nThe gold standard of diagnosis is electrophysiological study, but ultrasonography was applied in recent decades for a better approach to the morphology change of the median nerve.Nerve hydrodissection (HD) is a widely used technique that involves the injection of fluid to separate the nerve from the surrounding structures.\n\nHD is now considered a novel approach for the treatment of CTS with safe and outstanding long-term effects. A potential benefit of HD is to release the pressure on the \"free nerves supplying the main nerves,\" called \"nervi nervorum.\" Early, the compression of the vasa nervorum would affect venous outflow, causing the accumulation of toxins in the affected part. Then, the lymphatic drainage, located outside the epineurium, would undergo compressive effects.\n\nHD can also decrease the gliding resistance of the median nerve within the carpal tunnel, which is considered a principal patho-mechanical cause of nerve injury.\n\nHydrodissection HD of the entrapped median nerve is considered a safe and efficacious approach for treatment of mild to moderate CTS and could be offered to patients with severe CTS if surgery is refused or can't be done due to other medical comorbidities. The use of US-guided HD could improve symptom severity, functional status, and the US parameters of nerve entrapment. HD has a long-term efficacy outcome; 88.6% of patients reported an effective outcome, and this may vary according to the initial severity status.\n\nDifferent types of injectants are available and studied, with no clear indication of use for each type. However, PRP, D5W, and HA were more efficient than NS as regards subjective and objective improvement. PRP and HA were more effective for long-term nerve recovery, while HA was preferred for the earliest response. So, we recommend making the choice based on every patient's severity scale and electrophysiological scales, which means that for patients with mild forms and severe pain.\n\nInjection of a large volume could be a better option in order to dissect a larger area, provide a better environment for the nerve repair mechanisms, and release the vascular and neural compressive elements.",[26],"2025-12-07",{"date":605,"type":31},"2025-12-16",{"date":607,"type":21},"2025-12",{"date":609,"type":21},"2027-12",{"name":611,"class":38},"Assiut University",{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":4,"eligibilityCriteria":618,"healthyVolunteers":12,"sex":17,"minAge":619,"maxAge":596,"enrollmentInfo":620,"targetDuration":4,"studyType":49,"phases":622,"briefSummary":623,"conditions":624,"keywords":625,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":627,"lastUpdatePostDateStruct":628,"startDateStruct":629,"completionDateStruct":630,"leadSponsor":632,"locationsCount":97},"100613670","pulsed-radiofrequency-versus-hyaluronidase-hydrodissection-for-treatment-of-carpal-tunnel-syndrome-100613670","NCT07269613","Pulsed Radiofrequency Versus Hyaluronidase Hydrodissection for Treatment of Carpal Tunnel Syndrome","Comparison of Ultrasound Guided Pulsed Radiofrequency Versus Hyaluronidase Hydrodissection for Treatment of Carpal Tunnel Syndrome, a Prospective, Randomized, Controlled Clinical Study","Inclusion Criteria:\n\n1. Adults aged 20-80 years\n2. Clinical diagnosis of CTS with symptoms for at least 3 months\n3. Electrophysiological evidence of mild to moderate CTS\n4. No previous intervention for CTS in the affected hand\n\nExclusion Criteria:\n\n1. Previous wrist surgery or trauma\n2. Medical history of polyneuropathy, thoracic outlet syndrome, or brachial plexopathy\n3. Coagulopathy or local infection at injection site\n4. Pregnancy or breastfeeding","20 Years",{"count":621,"type":21},56,[51],"The aim of this study is to compare the clinical efficacy and safety of ultrasound-guided pulsed radiofrequency and hyaluronidase hydrodissection in the treatment of carpal tunnel syndrome. This research seeks to evaluate both techniques in terms of pain relief, functional improvement, nerve conduction parameters, and potential complications, in order to identify the more effective minimally invasive approach for managing carpal tunnel syndrome.",[26],[626],"pulsed radiofrequency versus hyaluronidase hydrodissection for treatment of carpal tunnel syndrome","2025-12-06",{"date":581,"type":31},{"date":607,"type":21},{"date":631,"type":21},"2026-07",{"name":633,"class":38},"Sohag University",{"id":635,"slug":636,"hasResults":12,"nctId":637,"briefTitle":638,"officialTitle":639,"acronym":640,"eligibilityCriteria":641,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":225,"enrollmentInfo":642,"targetDuration":4,"studyType":49,"phases":644,"briefSummary":645,"conditions":646,"keywords":648,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":649,"lastUpdatePostDateStruct":650,"startDateStruct":652,"completionDateStruct":654,"leadSponsor":655,"locationsCount":97},"100612966","immediate-effects-of-paraffin-wax-therapy-on-forearm-and-hand-muscle-stiffness-and-pain-in-carpal-tunnel-syndrome-100612966","NCT07260448","Immediate Effects of Paraffin Wax Therapy on Forearm and Hand Muscle Stiffness and Pain in Carpal Tunnel Syndrome","Immediate Effects of Paraffin Wax Therapy on the Forearm and Hand Muscles' Stiffness and Pain in Patients With Carpal Tunnel Syndrome: A Randomised Controlled Trial","Paraffin-CTS","Inclusion Criteria:\n\n* Clinically diagnosed carpal tunnel syndrome.\n* Age between 18 and 65 years.\n* Apparently healthy, without a known chronic systemic disease (other than CTS).\n* No history of other chronic musculoskeletal or neurological disorders.\n\nExclusion Criteria:\n\n* Previous surgery on the affected wrist or hand.\n* Systemic conditions affecting nerve function (e.g., diabetes mellitus, thyroid disease)\n* Cardiovascular disease or uncontrolled hypertension.",{"count":643,"type":21},24,[51],"This randomized controlled trial aims to investigate the immediate effects of paraffin wax therapy on muscle stiffness and pain among patients diagnosed with Carpal Tunnel Syndrome (CTS). The intervention involves immersing the hand and forearm in paraffin wax at 42-44 °C for 20 minutes. Stiffness will be measured using the MyotonPro device, and pain will be evaluated using standard visual scales.",[26,647],"Muscle Stiffness",[452],"2025-12-02",{"date":651,"type":31},"2025-12-03",{"date":653,"type":21},"2025-11-25",{"date":627,"type":21},{"name":656,"class":38},"Erzurum Technical University",{"id":658,"slug":659,"hasResults":12,"nctId":660,"briefTitle":661,"officialTitle":662,"acronym":4,"eligibilityCriteria":663,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":664,"targetDuration":4,"studyType":49,"phases":665,"briefSummary":666,"conditions":667,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":668,"lastUpdatePostDateStruct":669,"startDateStruct":670,"completionDateStruct":672,"leadSponsor":673,"locationsCount":97},"100612018","pilot-study-aimed-at-describing-in-myography-the-collapse-of-the-muscular-response-visualized-in-the-scratch-collapse-test-in-carpal-tunnel-syndrome-100612018","NCT07248124","Pilot Study, Aimed at Describing in Myography, the Collapse of the Muscular Response Visualized in the Scratch Collapse Test, in Carpal Tunnel Syndrome.","Pilot Study, Aimed at Describing in Myography, the Collapse of the Muscular Response Visualized in the Scratch Collapse Test, in Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Patient over 18 years old\n* Patient with clinical unilateral carpal tunnel syndrome diagnosed by history, clinical examination and electromyography,\n* Patient who has been informed and has given their free, informed, and written consent,\n* Patient affiliated with or beneficiary of a social security scheme.\n\nExclusion Criteria:\n\n* Other associated canal syndrome on either side (ulnar, defilement, lacertus),\n\n  * Rotator cuff pathology, insufficiency or rupture of the infraspinatus,\n  * Associated cervical pathology,\n  * Neuropathy, central or peripheral neurological disease,\n  * Diabetic patient,\n  * Patient with cognitive impairments that prevent the understanding of the study information,\n  * Refusal to participate in the study,\n  * Pregnant, parturient, or breastfeeding woman,\n  * Patient under legal protection,\n  * Patient not receiving health protection,\n  * Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision",{"count":7,"type":21},[51],"The Scratch Collapse Test (SCT) is a neurocutaneous reflex used to detect peripheral nerve compression in nerve tunnel syndromes. It first involves applying a sensory stimulus to the skin over the suspected nerve compression point, then bilaterally testing the strength of a specific muscle in the patient. Compression is then manifested by a transient loss of strength in the muscle on the affected side, while it is preserved on the healthy side. This loss of strength is transient and disappears after a few seconds. This test can be performed during a patient's clinical examination, with the physician assessing strength or, conversely, muscle collapse. However, while several articles have described the relevance of this test, as well as its sensitivity and specificity, no study has specifically investigated and measured this observed loss of eccentric muscle tone and its unilateral and transient nature, even though the phenomenon of CSP (cutaneous silent period) has been described.\n\nWe therefore propose to analyze the myographic tracing obtained in patients diagnosed with unilateral carpal tunnel syndrome. A transient loss of muscle tone is expected by selective needle myography on the pathological side after cutaneous sensory stimulation of the wrist, while cutaneous sensory stimulation on the healthy side does not alter the tracings obtained by myography.",[26],"2025-11-21",{"date":653,"type":31},{"date":671,"type":31},"2025-11-04",{"date":587,"type":21},{"name":674,"class":38},"Elsan"]