[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carpal-tunnel-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carpal-tunnel-syndrome":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,46,0,25,[9,42,76,107,131,164,190,220,244,269,301,327,348,372,396,420,445,466,496,518,543,568,595,623,643],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100641749","effectiveness-of-matrix-rhythm-therapy-on-carpal-tunnel-syndrome-100641749",false,"NCT07660913","Effectiveness of Matrix Rhythm Therapy on Carpal Tunnel Syndrome","Effectiveness of Matrix Rhythm Therapy on Symptom Severity and Function in Carpal Tunnel Syndrome: A Randomized, Placebo-Controlled, Assessor-Blinded Trial","Inclusion Criteria:\n\n* Having a diagnosis of unilateral carpal tunnel syndrome confirmed by an orthopedist based on clinical examination and electromyography (EMG) testing.\n* Being classified with mild-to-moderate carpal tunnel syndrome severity.\n* Having symptoms persisting for at least 12 weeks.\n* Having a Mini-Mental State Examination (MMSE) score greater than 24.\n* Being literate (able to read and write).\n\nExclusion Criteria:\n\n* History of prior carpal tunnel release surgery.\n* History of corticosteroid injection into the affected hand\u002Fwrist.\n* Having received physiotherapy for carpal tunnel syndrome within the last 6 months.\n* Presence of any neurological signs or symptoms in the upper extremity other than carpal tunnel syndrome.\n* History of prior surgery in the hand or wrist region due to other conditions.\n* Diagnosis of any systemic neurological disease.\n* Diagnosis of rheumatic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus).\n* Having ongoing pain in the arm or hand due to any other underlying cause.","ALL","18 Years","60 Years",{"count":21,"type":22},84,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to investigate the effects of matrix rhythm therapy, applied in addition to conventional treatment, on symptom severity, function, grip and pinch strength, and quality of life in patients with carpal tunnel syndrome.",[28],"Carpal Tunnel Syndrome","NOT_YET_RECRUITING","2026-06-16",{"date":32,"type":33},"2026-06-22","ACTUAL",{"date":35,"type":22},"2026-07-01",{"date":37,"type":22},"2027-09-01",{"name":39,"class":40},"Izmir Bakircay University","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":12,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":41},"100641581","combined-manual-therapy-and-percutaneous-neuromodulation-for-moderate-carpal-tunnel-syndrome-100641581","NCT07654621","Combined Manual Therapy and Percutaneous Neuromodulation for Moderate Carpal Tunnel Syndrome","Combined Manual Therapy and Percutaneous Neuromodulation Versus Postsurgical Rehabilitation for Moderate Carpal Tunnel Syndrome: Protocol for a Non-Randomized Controlled Trial","MANUCTS","Inclusion Criteria:\n\n* Adults aged 30 to 50 years.\n* Clinical diagnosis of moderate carpal tunnel syndrome confirmed by nerve conduction studies according to the American Association of Electrodiagnostic Medicine criteria.\n* Symptoms persisting for at least 3 months.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Previous surgery for carpal tunnel syndrome in the affected hand (experimental group only).\n* Severe carpal tunnel syndrome requiring urgent surgical intervention.\n* History of wrist fracture or major upper-limb trauma affecting the study limb.\n* Pregnancy.\n* Diabetes mellitus or other systemic diseases associated with peripheral neuropathy.\n* Cervical radiculopathy or other neurological disorders affecting the upper limb.\n* Rheumatoid arthritis or other inflammatory arthropathies involving the wrist.\n* Previous corticosteroid injection for carpal tunnel syndrome within the last 3 months.\n* Contraindications to percutaneous neuromodulation (e.g., pacemaker, active infection at the treatment site, bleeding disorders, or anticoagulant therapy when considered clinically inappropriate).\n* Inability to comply with the study protocol or follow-up assessments.","30 Years","50 Years",{"count":53,"type":22},150,[25],"Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy and can cause pain, numbness, tingling, and functional impairment of the hand. Although surgical decompression is considered an effective treatment for moderate CTS, there is increasing interest in conservative therapeutic strategies that may improve symptoms and function while avoiding surgery.\n\nThe aim of this multicenter non-randomized controlled trial is to evaluate the effectiveness of a combined intervention consisting of manual therapy and ultrasound-guided percutaneous neuromodulation compared with conventional postsurgical rehabilitation in patients with moderate CTS.\n\nParticipants allocated to the experimental group will receive a standardized multimodal physiotherapy program including manual therapy techniques and ultrasound-guided percutaneous neuromodulation, whereas participants in the control group will undergo standard rehabilitation following carpal tunnel release surgery. The primary outcome will be symptom severity and functional status assessed with the Boston Carpal Tunnel Questionnaire. Secondary outcomes will include pain intensity, nerve conduction parameters, ultrasound measures, hand strength, patient-reported outcomes, and adverse events.\n\nThe findings of this study are expected to provide evidence regarding the potential role of combined conservative treatment as an alternative therapeutic strategy for patients with moderate carpal tunnel syndrome.",[28],[28,58,59,60,61,62,63,64,65,66],"Manual Therapy","Percutaneous Neuromodulation","Physical Therapy","Rehabilitation","Median Nerve","Peripheral Neuropathy","Ultrasound-Guided Intervention","Conservative Treatment","Upper Limb","2026-06-12",{"date":69,"type":33},"2026-06-17",{"date":71,"type":22},"2026-07",{"date":73,"type":22},"2028-01",{"name":75,"class":40},"Universidad Europea de Valencia",{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100638119","finnish-carpal-tunnel-surgery-study-100638119","NCT07614425","Finnish Carpal Tunnel Surgery Study","Finnish Carpal Tunnel Study - a Randomised, Placebo-surgery Controlled Trial","FINCATS","Inclusion Criteria:\n\n* Age 18-75 years\n* Clinical manifestations of carpal tunnel syndrome: paresthesia and \u002For hypoesthesia in the distribution of the median nerve, possibly pain\n* Electrodiagnostically (ENMG or ENEG) verified compression of the median nerve at the carpal tunnel in the wrist, performed no more than a year before recruitment.\n* Duration of symptoms 3 months or longer\n* Patient living independently\n* Patient has not responded to the use of a resting splint supporting the wrist, nor to other possible conservative forms of treatment\n* Patient able and willing to give consent\n* The patient is willing to undergo surgical treatment for carpal tunnel syndrome.\n* The patient has access to a device that can be used to complete electronic symptom questionnaires.\n\nExclusion Criteria:\n\n* Work disability\n* Clinical findings of Abductor Pollicis Brevis atrophy\n* Symptoms and Electrodiagnostic findings of some other peripheral neural entrapment than carpal tunnel syndrome\n* Rheumatoid arthritis or other forms of systemic inflammatory disease\n* Diagnosed dementia\n* Neurologic disorders affecting the function of the hand\n* Other untreated systemic disorders or diseases with poor therapeutic balance: hypertension, epilepsy, pulmonary or cardiac disease, liver or renal insufficiency, diabetes mellitus, hypothyroidism, psychiatric disease\n* Other causes of pain and paresthesia in the hand\n* Previous trauma of the hand or wrist (e.g. distal radius fracture), which has resulted in compromised hand function\n* Previous carpal tunnel release in either hand\n* Previous nerve injury to the upper limb or cervical spine","75 Years",{"count":86,"type":22},180,[25],"Carpal tunnel syndrome (CTS) is a common condition caused by pressure from a ligament on a nerve in the wrist, leading to pain, numbness, and weakness in the hand. Surgery to cut the ligament is often recommended when non-surgical treatments do not provide sufficient symptom relief, but it is unclear how much of the improvement is due to the surgery itself versus natural recovery or placebo effects.\n\nThe FINCATS study will compare standard carpal tunnel surgery with a placebo procedure in which the ligament is not cut. Participants and the healthcare staff caring for them after the procedure will not know which procedure was performed. The study's main question is whether cutting the ligament provides greater symptom relief than a placebo procedure. In addition, eligible patients who are not willing to participate in randomized setting are invited to join a parallel observational group. Participants in this observational group are treated within usual care pathway.\n\nParticipants in both the randomized and observational group will be followed for five years to assess symptom improvement, hand function, pain, quality of life, and any side effects. The goal is to provide reliable evidence to help patients and doctors make informed decisions about treatment.",[28],[91,92,93,94,95],"Randomised controlled trial","Placebo-controlled trial","Surgery","Carpal tunnel syndrome","Carpal tunnel release","RECRUITING","2026-06-01",{"date":99,"type":33},"2026-06-03",{"date":101,"type":22},"2026-06-11",{"date":103,"type":22},"2035-12-31",{"name":105,"class":40},"Helsinki University Central Hospital",2,{"id":108,"slug":109,"hasResults":12,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":117,"conditions":118,"keywords":119,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":41},"100534471","validity-and-reliability-of-thai-version-clinical-questionnaire-for-diagnosis-of-carpal-tunnel-syndrome-100534471","NCT06239259","Validity and Reliability of Thai Version Clinical Questionnaire for Diagnosis of Carpal Tunnel Syndrome","Validity and Reliability of Thai Version of Kamath and Stothard Clinical Questionnaire for Diagnosis of Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Patients aged 18 years and older who are admitted to Siriraj Hospital with signs and symptoms consistent with carpal tunnel disease.\n* Diagnosis of carpal tunnel disease was confirm with electrodiagnostic study and electromyography\n* Must be able to communicate in Thai.\n\nExclusion Criteria:\n\n* Patients diagnosed with other neurological diseases such as cerebrovascular disease, cervical radiculopathy, diabetic neuropathy, tumors of the nerve endings in the arm, and other peripheral neuropathy.\n* Pregnancy or breastfeeding\n* History of recieving chemotheraphy agent\n* Patient who recieved surgical treatment for carpal tunnel syndrome.",{"count":115,"type":22},80,"OBSERVATIONAL","The Kamath and Stothard clinical questionnaire for diagnosing carpal tunnel syndrome (CTS) is a valid score for diagnosis of CTS. However it haven't been translated in to Thai version and the validity and accuracy of the Thai the Thai version have not been yet verified.\n\nThe research team recognizes the importance and potential benefits of adapting this assessment for use within the Thai population.Therefore, we aim to conduct this research to translate the questionnaire from the original English to Thai and to assess its validity and reliability for diagnosing patients with Carpal Tunnel Syndrome.",[28],[28,120,121],"Diagnosis","Content validity","2026-05-18",{"date":124,"type":33},"2026-05-20",{"date":126,"type":33},"2023-07-06",{"date":128,"type":22},"2026-12-31",{"name":130,"class":40},"Siriraj Hospital",{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":41},"100637199","hydrodissection-with-neuroprolotherapy-versus-open-release-for-carpal-tunnel-syndrome-100637199","NCT07576803","Hydrodissection With Neuroprolotherapy Versus Open Release for Carpal Tunnel Syndrome","Ultrasound-Guided Hydrodissection Combined With Neuroprolotherapy Versus Open Carpal Tunnel Release in Patients With Carpal Tunnel Syndrome: A Randomized, Parallel-Group, Non-Inferiority Trial","HN-CTS","Inclusion Criteria:\n\n* Adults aged 18 years or olde\n* Clinical diagnosis of carpal tunnel syndrome\n* Presence of symptoms for at least 3 months\n* Failure of conservative treatment, including splinting, medication, or physical therapy\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Previous carpal tunnel surgery in the affected limb\n* Severe thenar muscle atrophy\n* Cervical radiculopathy or proximal nerve compression\n* Pregnancy\n* Coagulopathy or current use of anticoagulants contraindicating procedures\n* Local infection at the intervention site\n* Inability to comply with follow-up","70 Years",{"count":141,"type":22},72,[25],"This study is a randomized controlled, parallel-group, non-inferiority trial designed to compare ultrasound-guided hydrodissection combined with neuroprolotherapy versus open carpal tunnel release in patients with carpal tunnel syndrome. Participants will be randomly allocated in a 1:1 ratio using a computer-generated sequence, with allocation concealment ensured by sequentially numbered, sealed, opaque envelopes. Outcome assessment and statistical analysis will be performed by blinded evaluators.\n\nThe experimental group will undergo a single session of ultrasound-guided hydrodissection with perineural injection of a solution composed of zero point nine percent sodium chloride and five percent dextrose, combined with local anesthetic and betamethasone, aiming to promote mechanical release of the median nerve and modulation of the inflammatory process. The control group will undergo standard open carpal tunnel release through surgical division of the transverse carpal ligament under sterile conditions.\n\nParticipants will be assessed at baseline, and at 1, 3, and 6 months after intervention. The primary outcome is the change in the Boston Carpal Tunnel Questionnaire score at 3 months. A non-inferiority margin of 0.5 points will be adopted. Secondary outcomes include pain intensity measured by visual analog scale, grip strength, pinch strength, median nerve cross-sectional area assessed by ultrasound, time to return to work, and procedure-related complications.\n\nStatistical analysis will follow the intention-to-treat principle, with complementary per-protocol analysis. Between-group comparisons will be conducted using analysis of covariance adjusted for baseline values, and repeated measures will be analyzed using mixed-effects models. The hypothesis is that the minimally invasive intervention is non-inferior to surgical decompression, with potential advantages in recovery and morbidity.",[28,145],"Median Neuropathy",[147,148,149,28,150,151,152,153,154],"Hydrodissection","Perineural injection","Ultrasound-guided procedure","Median nerve decompression","Minimally invasive treatment","Open carpal tunnel release","Nerve entrapment","Functional outcomes","2026-05-04",{"date":157,"type":33},"2026-05-08",{"date":159,"type":22},"2026-05-02",{"date":161,"type":22},"2027-08-31",{"name":163,"class":40},"Universidade Federal de Pernambuco",{"id":165,"slug":166,"hasResults":12,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":174,"conditions":175,"keywords":178,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":41},"100467324","association-between-radial-artery-intervention-and-development-of-neuropathy-in-the-hand---a-prospective-study-100467324","NCT05365282","Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study","Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study - The ACCESS IV Study","ACCESS-IV","Inclusion Criteria:\n\n* The patient must be able to give informed consent\n\nExclusion Criteria:\n\n* Pregnancy\n* Negative Barbeau test",{"count":173,"type":22},400,"Evaluation of potential nerve damage after radial CAG\u002FPCI.",[176,177,28],"Ischemic Heart Disease","Nerve Injury",[179,176,180],"Transradial access","Hand Dysfunction","2026-04-22",{"date":183,"type":33},"2026-04-23",{"date":185,"type":33},"2024-01-01",{"date":187,"type":22},"2028-12-01",{"name":189,"class":40},"Aarhus University Hospital Skejby",{"id":191,"slug":192,"hasResults":12,"nctId":193,"briefTitle":194,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":12,"sex":17,"minAge":196,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":23,"phases":200,"briefSummary":201,"conditions":202,"keywords":207,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":41},"100617852","efficacy-of-combining-ultrasound-guided-needle-release-of-transverse-carpal-ligament-and-median-nerve-dextrose-water-hydrodissection-for-carpal-tunnel-syndrome-100617852","NCT07324005","Efficacy of Combining Ultrasound-Guided Needle Release of Transverse Carpal Ligament and Median Nerve Dextrose Water Hydrodissection for Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* age between 20 to 80 years old\n* diagnosed with CTS on the basis of clinical condition and an electrophysiological analysis\n* the NRS of pain or paresthesia≧3\n* with symptoms lasting for a minimum of 3 months.\n\nExclusion Criteria:\n\n* history of polyneuropathy, thoracic outlet syndrome, brachial plexopathy, or inflammatory arthropathy\n* onset of CTS during pregnancy, hypothyroidism, or systemic infection\n* previous corticosteroid injection or wrist surgery for CTS\n* hypersensitivity to dextrose injection\n* the anatomic structure of the wrist is not suitable for needle release of TCL.","20 Years","80 Years",{"count":199,"type":22},102,[25],"Carpal tunnel syndrome (CTS) is a common musculoskeletal disorder, which is caused by compression of the median nerve as it travels through the wrist. There are several treatments for CTS, including conservative and surgical options. Though local corticosteroid injection has been considered more effective than physical therapy for treatment of CTS and has significant short-term benefits, long term benefits are not evidenced. Several studies in recent years reported significantly superior longer-term benefit of D5W and PRP compared with corticosteroid injections and other conservative managements. In addition, percutaneous release of the transverse carpal ligament (TCL) was developed to treat CTS in recent years. Because the effectiveness of the recently developed techniques in treating CTS has not been well established, the investigators aim to investigate whether combining US-guided partial release of the transverse carpal ligament with a needle plus D5W hydrodissection is more beneficial for CTS comparing to either treatment alone.",[28,203,204,205,206],"Dextrose","Carpal Tunnel Release","Ultrasound","Nerve Hydrodissection Therapy",[28,208,209,210,211],"dextrose","carpal tunnel release","ultrasound","nerve hydrodissection therapy","2026-04-21",{"date":183,"type":33},{"date":215,"type":33},"2026-01-01",{"date":217,"type":22},"2030-12-31",{"name":219,"class":40},"Shin Kong Wu Ho-Su Memorial Hospital",{"id":221,"slug":222,"hasResults":12,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":23,"phases":228,"briefSummary":229,"conditions":230,"keywords":231,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":41},"100616938","a-study-to-see-whether-taking-a-mix-of-vitamins-can-help-adults-recover-better-after-surgery-for-carpal-tunnel-syndrome-100616938","NCT07312123","A Study to See Whether Taking a Mix of Vitamins Can Help Adults Recover Better After Surgery for Carpal Tunnel Syndrome","Effect of Oral Alpha-Lipoic Acid, Vitamin E, and Vitamin B Combination on Symptoms and Function in Carpal Tunnel Syndrome Following Carpal Tunnel Surgery","Inclusion Criteria:\n\n* Age more than 18 years old\n* Subjects with symptoms and physical examination of CTS\n* Patients with CTS going for CT release\n\nExclusion Criteria:\n\n* Pregnant or breast-feeding women\n* Patients with history of trauma in the dominant hand",{"count":21,"type":22},[25],"Carpal Tunnel Syndrome (CTS) is a common condition that causes numbness, tingling, pain, and weakness in the hand due to compression of the median nerve at the wrist. It can affect daily activities, work performance, and quality of life. While surgery is effective in severe cases, many patients with mild to moderate CTS are initially treated with non-surgical options such as splinting and medications. However, the effectiveness of oral supplements for CTS remains uncertain.\n\nThis clinical study aims to evaluate whether an oral combination of alpha-lipoic acid, Vitamin E, and Vitamin B complex can safely reduce symptoms and improve hand function in patients with Carpal Tunnel Syndrome. These supplements are believed to have antioxidant, anti-inflammatory, and nerve-protective properties, which may help reduce nerve irritation and improve nerve recovery.\n\nParticipants in this study will be randomly assigned to receive either the oral supplement combination or a comparator treatment. The study is single-blinded, meaning participants will not know which treatment they are receiving. Symptoms such as pain, numbness, and hand function will be assessed over a defined follow-up period using clinical evaluation and standardized questionnaires.\n\nThe main hypothesis of this study is that patients receiving the oral combination of alpha-lipoic acid, Vitamin E, and Vitamin B will experience greater improvement in symptoms and functional outcomes compared to those who do not receive the combination, without significant side effects.\n\nThe results of this study may help determine whether this oral supplement combination can be used as an effective and safe conservative treatment option for patients with Carpal Tunnel Syndrome, potentially reducing the need for invasive procedures.",[28],[232,233,234,235],"carpal tunnel syndrome","median nerve compression","vitamin e","peripheral nerve entrapment","2026-04-20",{"date":183,"type":33},{"date":239,"type":33},"2025-12-08",{"date":241,"type":22},"2027-01-31",{"name":243,"class":40},"Hospital Universiti Sains Malaysia",{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":23,"phases":252,"briefSummary":254,"conditions":255,"keywords":256,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":106},"100352336","phase-4-exparel-and-education-to-avoid-opioids-after-carpal-tunnel-release-100352336","NCT03867539","Exparel and Education to Avoid Opioids After Carpal Tunnel Release","Inclusion Criteria:\n\n* carpal tunnel syndrome diagnosed either by physical exam or EMG\n* age \\>18.\n\nExclusion Criteria:\n\n* allergy to bupivacaine\n* pre-operative opioid usage within the last six months\n* patients allergic to Percocet or acetaminophen\n* patients taking tricyclic antidepressants (interaction with bupivacaine)\n* vulnerable populations (prisoners or pregnant women)",{"count":251,"type":22},64,[253],"PHASE4","This trial seeks to use the long acting local anesthetic Exparel, in conjunction with opioid education, to attempt to avoid any post-operative opioid use following carpal tunnel surgery. This group will be compared with a \"standard\" group that receives non-liposomal bupivacaine, opioid education, and opioids.",[28],[257,258,259],"hand","exparel","opioid crisis","2026-04-02",{"date":262,"type":33},"2026-04-08",{"date":264,"type":33},"2019-02-15",{"date":266,"type":22},"2027-12-31",{"name":268,"class":40},"Kettering Health Network",{"id":270,"slug":271,"hasResults":12,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":277,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":278,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":280,"conditions":281,"keywords":284,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":4},"100632031","median-nerve-cross-sectional-area-and-body-weight-in-carpal-tunnel-syndrome-100632031","NCT07508397","Median Nerve Cross-Sectional Area and Body Weight in Carpal Tunnel Syndrome","The Relationship Between Ultrasonographic Median Nerve Cross-Sectional Area and Electrophysiological Severity in Carpal Tunnel Syndrome Diagnosis: The Masking Role of Body Weight","CTS-US-WEIGHT","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years.\n* Clinical diagnosis of Carpal Tunnel Syndrome (CTS) based on symptoms (numbness, tingling, nocturnal pain in the median nerve distribution).\n* Electrophysiological confirmation of CTS according to the American\n* Association of Neuromuscular \\& Electrodiagnostic Medicine (AAEM) criteria.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Secondary causes of CTS (e.g., Diabetes Mellitus, Hypothyroidism, Rheumatoid -Arthritis, Chronic Renal Failure).\n* Coexisting neurological conditions (e.g., Cervical Radiculopathy,\n* Polyneuropathy, Brachial Plexopathy).\n* History of previous wrist surgery, trauma, or local corticosteroid injection within the last 6 months.\n* Pregnancy or lactation.\n* Congenital anatomical variations such as a bifid median nerve or persistent median artery (detected during USG).",true,{"count":279,"type":22},120,"This study aims to evaluate the diagnostic accuracy of ultrasonographic measurements of the median nerve in patients with Carpal Tunnel Syndrome (CTS). While ultrasound is a common diagnostic tool, various physical factors can influence its results. The researchers will investigate how a patient's absolute body weight and Body Mass Index (BMI) affect the size of the median nerve cross-sectional area across different stages of disease severity. The goal is to determine if absolute body weight plays a 'masking' role that could lead to more precise diagnostic interpretations in clinical practice.",[28,282,283],"Entrapment Neuropathies","Median Nerve Compression",[285,62,286,287,288,289,290,291],"Ultrasonography","Cross-Sectional Area","Body Weight","Body Mass Index (BMI)","Electromyography","Diagnostic Accuracy","Physical and Rehabilitation Medicine","2026-03-30",{"date":260,"type":33},{"date":295,"type":22},"2026-04-01",{"date":297,"type":22},"2026-09-01",{"name":299,"class":300},"Kayseri City Hospital","OTHER_GOV",{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":308,"targetDuration":4,"studyType":23,"phases":310,"briefSummary":311,"conditions":312,"keywords":316,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":41},"100534824","comparison-of-ultrasound-guided-injection-with-median-nerve-decompression-surgery-in-carpal-tunnel-syndrome-100534824","NCT06243848","Comparison of Ultrasound-Guided Injection With Median Nerve Decompression Surgery in Carpal Tunnel Syndrome","Comparison of Ultrasound-Guided Injection With Traditional Median Nerve Decompression Surgery in Patients With Carpal Tunnel Syndrome: Randomized Controlled Study","Inclusion Criteria:\n\n* The presence of symptoms such as nocturnal, posture-related, or movement-related paresthesias, along with possible pain, in the area supplied by the median nerve in the hand, lasting for more than 3 months.\n* Confirmation of mild, moderate or severe CTS through electrophysiological testing.\n* Numbness and loss of sensation in the hand's regions innervated by the median nerve, as well as weakness in the thenar muscles innervated by the median nerve.\n* Positive results on either the Phalen test and\u002For Tinel sign.\n\nExclusion Criteria:\n\n* Individuals who may exhibit symptoms mimicking carpal tunnel syndrome, such as cervical radiculopathy, polyneuropathy, brachial plexopathy, or thoracic outlet syndrome.\n* Patients who have received a previous injection into the carpal tunnel within the past 6 months.\n* Thenar muscle atrophy.\n* A history of prior carpal tunnel surgery.\n* Regular usage of systemic nonsteroidal anti-inflammatory drugs and corticosteroids.\n* Pregnancy\n* Patients diagnosed with rheumatoid arthritis, systemic lupus erythematosus, gout, systemic sclerosis, dermatomyositis, or polymyositis.\n* Malignancy.\n* Active infections",{"count":309,"type":22},60,[25],"The aim of this study is to compare ultrasound-guided perineural injection of the median nerve with classic minimal incision surgical technique for median nerve decompression in patients diagnosed with mild, moderate, and severe carpal tunnel syndrome.",[313,314,28,315,93],"Musculoskeletal Diseases","Median Nerve Disease","Ultrasound-Guided Injection",[28,315,317],"Median Nerve Decompression","2026-03-10",{"date":320,"type":33},"2026-03-12",{"date":322,"type":33},"2024-01-25",{"date":324,"type":22},"2026-05-24",{"name":326,"class":40},"Afyonkarahisar Health Sciences University",{"id":328,"slug":329,"hasResults":12,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":4,"eligibilityCriteria":333,"healthyVolunteers":277,"sex":17,"minAge":196,"maxAge":197,"enrollmentInfo":334,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":335,"conditions":336,"keywords":338,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":347,"locationsCount":41},"100496326","the-relationship-between-ultrasonographic-findings-and-sleep-quality-in-carpal-tunnel-syndrome-100496326","NCT05742776","The Relationship Between Ultrasonographic Findings and Sleep Quality in Carpal Tunnel Syndrome","The Relationship Between Ultrasonographic Findings and Sleep Quality in Patients With Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Patients diagnosed with CTS according to the criteria of the American Academy of Neurology\n\nExclusion Criteria:\n\n* Patients with radiculopathy, brachial plexopathy, thoracic outlet syndrome and traumatic nerve injury that may affect the median nerve\n* History of Carpal tunnel surgery\n* Pregnancy\n* Malignancy\n* Thyroid diseases\n* Amyloidosis\n* Systemic lupus erythematosus, Rheumatoid arthritis, Systemic sclerosis, Gout, Dermatomyositis, Polymyositis\n* Obstructive sleep apnea",{"count":279,"type":22},"The aim of our study is to determine the relationship between disease severity and sleep quality in CTS patients and to compare the findings with healthy controls.",[313,314,28,205,337],"Sleep Quality",[28,339,340],"Ultrasonographic evaluation","Pittsburgh Sleep Quality Index","2026-03-06",{"date":343,"type":33},"2026-03-09",{"date":345,"type":33},"2023-02-23",{"date":35,"type":22},{"name":326,"class":40},{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":355,"targetDuration":357,"studyType":116,"phases":4,"briefSummary":358,"conditions":359,"keywords":360,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":41},"100419093","corticosteroid-injection-effectiveness-in-carpel-tunnel-patients-with-negative-or-mild-emg-studies-100419093","NCT04737239","Corticosteroid Injection Effectiveness in Carpel Tunnel Patients With Negative or Mild EMG Studies","Corticosteroid Injection Effectiveness in Carpel Tunnel Patients With Negative or Mild EMG","Inclusion Criteria:\n\n* Patients who speak English\n* Patients who are 18 years or older\n* Patients who are clinically diagnosed with CTS\n* Patients who have a negative or mild EMG study\n* Patients who receive a corticosteroid injection after obtaining a negative or mild EMG study\n\nExclusion Criteria:\n\n* Patients who do not speak English\n* Patients who are younger than 18 years of age\n* Patients who have experienced previous trauma to the wrist\n* Patients who have had previous treatment for CTS including but not limited to corticosteroid injection or surgery\n* Patients with a moderate or severe EMG study",{"count":356,"type":22},300,"1 Year","Carpal Tunnel Syndrome (CTS) is the most common nerve entrapment syndrome worldwide. There are currently no studies examining the effectiveness of corticosteroid injections in patients with normal (negative) EMG studies. The purpose of this study is to gain a better understanding of the duration of symptom improvement post corticosteroid injection in patients with negative or mild EMG studies. The Boston Carpal Tunnel Questionnaire will be given to patients undergoing corticosteroid injections for the treatment of carpal tunnel syndrome to assess their response to the injection. Investigators will collect data retrospectively. The Boston Carpal Tunnel Questionnaire (BCTQ) is administered as per standard protocol to all patients with CTS who have a negative or mild EMG study. The BCTQ assesses the patient's self-reported symptom severity and functional status. Investigators will analyze this data with respect to demographics as well as numbness in the median n. distribution, nocturnal numbness, weakness\u002Fatrophy of the thenar musculature, Tinel's sign, Phalen's test, loss of 2-point discrimination, Quick-Dash score, and grip strength score.\n\nThe primary outcome will be the Boston Carpal Tunnel Questionnaire outcome score under the different EMG conditions.The secondary outcomes will be numbness in the median n. distribution, nocturnal numbness, weakness\u002Fatrophy of the thenar musculature, Tinel's sign, Phalen's test, loss of 2-point discrimination, QuickDash score, and grip strength score. Both outcomes will be examined in patients with negative or mild EMG readings. This information will allow orthopedic physicians to gain a better understanding of the duration of symptom improvement post-corticosteroid injection, allowing them to fine tune their treatment plans for CTS patients.",[28],[361,362],"corticosteroid injection","electromyography","2026-02-26",{"date":365,"type":33},"2026-03-02",{"date":367,"type":33},"2020-12-23",{"date":369,"type":22},"2026-12-22",{"name":371,"class":40},"Henry Ford Health System",{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":378,"eligibilityCriteria":379,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":380,"targetDuration":4,"studyType":23,"phases":382,"briefSummary":383,"conditions":384,"keywords":385,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":41},"100532123","carpal-arch-space-augmentation-casa-clinical-trial-100532123","NCT06208709","Carpal Arch Space Augmentation (CASA) Clinical Trial","Biomechanical Treatment of CTS Via Carpal Arch Space Augmentation: A Pilot Clinical Trial","CASA","Inclusion Criteria\n\n* 18 and older\n* Diagnosed with right-handed or bilateral CTS. Participants will be treated only in the right hand.\n\nExclusion Criteria\n\n* History of musculoskeletal or neurological conditions that may confound Carpal Tunnel Syndrome symptoms, including but not limited to:\n\n  1. Diagnosed or suspected arthritis in the test wrist, hand, or finger joints\n  2. Prior neck trauma, whiplash injury, or any condition suggestive of cervical radiculopathy\n  3. Current or prior treatment from a healthcare provider such as neurologist, physical therapist, physiatrist, rheumatologist, neurosurgeon, orthopedic surgeon or chiropractor for cervical radiculopathy or other musculoskeletal problem involving the neck, shoulder, and or upper extremity\n* History of traumatic or chronic symptomatic neuromusculoskeletal disorders involving the upper extremity to be tested.\n* The following diseases: uncontrolled diabetes, thyroid disease, rheumatoid arthritis, gout, lupus, renal failure, hemodialysis, sarcoidosis, amyloidosis, additional systemic diseases that may have an effect on the peripheral median nerve.\n* Positive diagnosis of cervical disorders affecting the same side of the body as the test hand such as radiculopathy, spondylosis, tumor, and multiple sclerosis\n* Symptomatic joint diseases in the test hand (e.g., Osteoarthritis)\n* Osteoporosis in the test hand\n* History of carpal tunnel release in the test hand\n* History of corticosteroid injection treatments for CTS in the test hand within the 3 months preceding study initiation\n* Women who are currently pregnant\n* Patients who have carpal tunnel release surgery scheduled for the next 12 weeks in their test hand.\n* Patients who have taken pain medication, including over-the-counter products, within 2 weeks prior to initiation of the study.\n* Will not participate in other CTS treatment or therapies during this study",{"count":381,"type":22},116,[25],"This research proposes to evaluate the effectiveness of a novel device designed for the treatment of carpal tunnel syndrome. The device applies a small cyclic force to the wrist. The cycles include a small time period of force is applied, followed by a brief period of no force. The device is intended to be worn during hours of sleep. The efficacy of the treatment is evaluated based on patient reported outcomes. Treatment efficacy will also be evaluated based on comparisons to patient reported outcomes for a SOC treatment.",[28],[386,232],"cts","2026-02-20",{"date":389,"type":33},"2026-02-23",{"date":391,"type":33},"2024-04-23",{"date":393,"type":22},"2026-07-31",{"name":395,"class":40},"University of Arizona",{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":197,"enrollmentInfo":402,"targetDuration":4,"studyType":23,"phases":404,"briefSummary":405,"conditions":406,"keywords":408,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":412,"lastUpdatePostDateStruct":413,"startDateStruct":414,"completionDateStruct":416,"leadSponsor":418,"locationsCount":41},"100378335","noninvasive-brain-stimulation-for-treating-carpal-tunnel-syndrome-100378335","NCT04206215","Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome","Inclusion Criteria:\n\n1. Able to provide informed consent to participate in the study\n2. Subjects between 18 to 80 years old\n3. Having symptomatic CTS spreading within or beyond the median nerve distribution (demonstrating 'extra-median spread'), involving at least 1 wrist, with chronic pain as defined by International Association for the Study of Pain (existing pain for at least 6 months and having pain on at least half the days in the past 6 months with an average of at least a 3 on a 0-10 VAS scale).\n4. Pain resistant to first line therapies of chronic pain (pain still present at lower levels most of the time following therapy)\n5. Must have the ability to feel pain as self-reported.\n\nExclusion Criteria:\n\n1. Subject is pregnant\n2. Contraindications to tDCS+TUS:\n\n   1. intracranial metal implant\n   2. implanted brain medical devices\n3. History of alcohol or drug abuse within the past 6 months as self-reported\n4. Use of carbamazepine within the past 6 months as self-reported\n5. Suffering from major depression (with a PHQ-9 score of ≥20)\n6. History of neurological disorders involving stroke, brain tumors, or epilepsy with residual neurological symptoms as self-reported (note patients will also be evaluated via EEG at baseline about 1 week prior to stimulation and any patient showing abnormal EEG activity will be removed))\n7. History of unexplained fainting spells as self-reported\n8. History of head injury resulting in more than a momentary loss of consciousness as self-reported and with current neurological deficits\n9. History of intracranial neurosurgery as self-reported",{"count":403,"type":22},95,[25],"The purpose of this study is to assess the effects of tDCS in combination with TUS for the treatment of pain in subjects with Carpal Tunnel Syndrome. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.",[407,28],"Chronic Pain",[409,410,411],"transcranial Direct Current Stimulation","Transcranial Ultrasound","Noninvasive brain stimulation","2026-02-18",{"date":387,"type":33},{"date":415,"type":33},"2021-04-16",{"date":417,"type":22},"2027-02-28",{"name":419,"class":40},"Spaulding Rehabilitation Hospital",{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":427,"enrollmentInfo":428,"targetDuration":4,"studyType":23,"phases":429,"briefSummary":430,"conditions":431,"keywords":432,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":436,"lastUpdatePostDateStruct":437,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":41},"100624779","high-intensity-laser-therapy-in-carpal-tunnel-syndrome-clinical-sonographic-and-electrophysiological-outcomes-100624779","NCT07414069","High-Intensity Laser Therapy in Carpal Tunnel Syndrome: Clinical, Sonographic, and Electrophysiological Outcomes","Evaluation of the Clinical, Sonographic, and Electrophysiological Efficacy of High-Intensity Laser Therapy (HILT) in Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Clinical symptoms consistent with carpal tunnel syndrome\n* Electrophysiologically confirmed mild or moderate carpal tunnel syndrome\n* Ability to comply with the study protocol and follow-up assessments\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Severe carpal tunnel syndrome on electrophysiological examination\n* Previous surgical treatment for carpal tunnel syndrome\n* Local causes of carpal tunnel syndrome (e.g., mass lesions, ganglion cysts, tumors)\n* Systemic conditions associated with carpal tunnel syndrome (e.g., diabetes mellitus, hypothyroidism, pregnancy, acromegaly)\n* History of corticosteroid injection for carpal tunnel syndrome within the last 6 months\n* Presence of polyneuropathy, radiculopathy, or other upper extremity peripheral nerve disorders\n* Contraindications to electrophysiological testing or laser therapy\n* Inability to complete follow-up assessments","65 Years",{"count":115,"type":22},[25],"Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy of the upper extremity and is characterized by pain, paresthesia, and functional impairment resulting from increased pressure within the carpal tunnel. Although conservative treatment approaches such as splinting and pharmacological therapy are commonly used, High-Intensity Laser Therapy (HILT) has emerged as a non-invasive modality with potential analgesic, anti-inflammatory, and biostimulatory effects. However, evidence regarding its efficacy remains limited, particularly from sham-controlled studies incorporating objective outcome measures. This prospective, randomized, double-blind, sham-controlled clinical trial aims to evaluate the clinical, sonographic, and electrophysiological effectiveness of HILT in patients with mild-to-moderate CTS. Eligible patients aged 18 to 65 years with electrophysiologically confirmed mild-to-moderate CTS will be randomized into two groups: a HILT group and a sham HILT group. Both groups will receive standard wrist splinting as part of conservative management. Clinical outcomes will be assessed using Visual Analog Scale (VAS) scores for pain, Boston Carpal Tunnel Questionnaire (BCTQ) scores for symptom severity and functional status, and grip strength measurements. Objective evaluations will include median nerve sensory and motor nerve conduction studies and ultrasonographic measurement of the median nerve cross-sectional area at the proximal carpal tunnel level. Assessments will be performed at baseline and at 1 and 3 months after treatment. This study aims to provide robust and objective evidence regarding the therapeutic effectiveness of HILT in the conservative management of carpal tunnel syndrome.",[28],[28,433,434,435,62],"High-Intensity Laser Therapy","HILT","Entrapment Neuropathy","2026-02-12",{"date":438,"type":33},"2026-02-17",{"date":440,"type":33},"2025-11-02",{"date":442,"type":22},"2026-04-30",{"name":444,"class":40},"Ankara City Hospital Bilkent",{"id":446,"slug":447,"hasResults":12,"nctId":448,"briefTitle":449,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":451,"targetDuration":4,"studyType":23,"phases":453,"briefSummary":454,"conditions":455,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":457,"lastUpdatePostDateStruct":458,"startDateStruct":460,"completionDateStruct":462,"leadSponsor":464,"locationsCount":41},"100499437","effect-of-cooling-therapy-for-post-operative-pain-in-open-carpal-tunnel-release-100499437","NCT05783245","Effect of Cooling Therapy for Post-Operative Pain in Open Carpal Tunnel Release","Inclusion Criteria:\n\n1. Age 18 or older\n2. Indicated for open carpal tunnel release\n3. Able and willing to complete online questionnaires\n\nExclusion Criteria:\n\n1. Prior carpal tunnel surgery for ipsilateral extremity\n2. Additional procedures to be performed on ipsilateral or contralateral extremity\n3. Current opioid or narcotic pain medication usage",{"count":452,"type":22},128,[25],"This study seeks to perform an appropriately-powered study to evaluate any clinical difference between continuous cooling therapy and traditional ice for treatment of post-operative pain in open CTR surgery.",[28,456],"Perioperative\u002FPostoperative Complications","2026-02-04",{"date":459,"type":33},"2026-02-05",{"date":461,"type":33},"2023-06-01",{"date":463,"type":22},"2026-09-30",{"name":465,"class":40},"University of Chicago",{"id":467,"slug":468,"hasResults":12,"nctId":469,"briefTitle":470,"officialTitle":471,"acronym":472,"eligibilityCriteria":473,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":474,"enrollmentInfo":475,"targetDuration":4,"studyType":23,"phases":477,"briefSummary":479,"conditions":480,"keywords":482,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":4},"100538744","phase-2-4ap-for-carpal-tunnel-syndrome-cts-100538744","NCT06294821","4AP for Carpal Tunnel Syndrome (CTS)","4-Aminopyridine to Delay Carpal Tunnel Release or Resolve Carpal Tunnel Syndrome","CTS","Inclusion Criteria:\n\n* Patients diagnosed with non-traumatic carpal tunnel syndrome without any other confounding diagnosis (e.g. cubital tunnel syndrome, cervical nerve compression)\n* Standard of care EDX testing within 6 months of study enrollment\n* Cognitive ability to report sensory and motor deficit during examination.\n* Able to complete twice daily dosing of 4-AP for the entire 6 week treatment period.\n* Adults subject aged 18-90\n* Ability to give written informed consent.\n* Capable of safely undergoing electrodiagnostic testing (EDX).\n* Availability for all study visits.\n\nExclusion Criteria:\n\n* Inability to complete twice daily dosing during 6 week treatment period.\n* History of multiple sclerosis, stroke or any other diagnosed neurological disorder\n* History of hypersensitivity to AMPYRA® or 4-aminopyridine\n* Current use of aminopyridine medications, including other compounded 4-AP\n* Suspected renal impairment based on the Choyke questionnaire.","90 Years",{"count":476,"type":22},160,[478],"PHASE2","The investigators have found recent promising data supporting the use of a currently FDA approved drug, 4-aminopyridine, in the treatment of nerve injury including compression neuropathy. The purpose of this research is determine whether 4-aminopyridine can treat carpal tunnel syndrome or delay the need for formal surgical release in patients with known carpal tunnel syndrome who would otherwise undergo surgery.",[481,28],"Compression Neuropathy",[483,232,484,485,472,95,486],"4 aminopyridine","CTR","4AP","compression neuropathy","2026-01-22",{"date":489,"type":33},"2026-01-26",{"date":491,"type":22},"2026-11",{"date":493,"type":22},"2028-07",{"name":495,"class":40},"John Elfar",{"id":497,"slug":498,"hasResults":12,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":4,"eligibilityCriteria":502,"healthyVolunteers":12,"sex":17,"minAge":196,"maxAge":503,"enrollmentInfo":504,"targetDuration":4,"studyType":23,"phases":506,"briefSummary":507,"conditions":508,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":516,"locationsCount":41},"100620565","effects-of-neurodynamic-and-carpal-bone-mobilization-in-mild-to-moderate-carpal-tunnel-syndrome-100620565","NCT07359274","Effects of Neurodynamic and Carpal Bone Mobilization in Mild-to-Moderate Carpal Tunnel Syndrome","Clinical and Morphological Effects of Neurodynamic Mobilization and Carpal Bone Mobilization Techniques in Patients With Mild-to-Moderate Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Diagnosis of mild-to-moderate carpal tunnel syndrome confirmed by electrodiagnostic testing\n* CTS symptoms for at least 3 months\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Previous carpal tunnel surgery\n* Diabetes mellitus or polyneuropathy\n* Cervical radiculopathy\n* Pregnancy or breastfeeding\n* Central nervous system disorders","55 Years",{"count":505,"type":22},93,[25],"Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by compression of the median nerve at the wrist. Conservative interventions such as splinting and manual therapy are frequently used in individuals with mild-to-moderate CTS. Neurodynamic mobilization and carpal bone mobilization aim to improve neural and soft tissue mobility; however, their comparative effects on clinical outcomes and median nerve morphology are not fully understood.\n\nThis interventional, non-randomized clinical study aims to compare the clinical and ultrasonographic effects of neurodynamic mobilization plus splinting, carpal bone mobilization plus splinting, and splinting alone in patients with mild-to-moderate CTS. Ninety-three participants diagnosed with mild-to-moderate carpal tunnel syndrome based on electrodiagnostic criteria will be included. Participants will be allocated into three parallel groups without randomization. All participants will receive a neutral-position wrist splint as standard conservative care.\n\nTwo intervention groups will additionally receive either neurodynamic mobilization exercises or carpal bone mobilization techniques administered by a physiotherapist for four weeks. Clinical outcomes and median nerve morphology will be evaluated at baseline and immediately after the intervention period.\n\nThe primary outcome is the change in the Boston Carpal Tunnel Questionnaire score. Secondary outcomes include pain intensity, neuropathic pain, functional disability, muscle strength, pressure pain threshold, and ultrasonographic measurements of the median nerve.",[28,509],"Splints","2026-01-13",{"date":487,"type":33},{"date":513,"type":22},"2026-01-15",{"date":515,"type":22},"2027-03-15",{"name":517,"class":40},"Kutahya Health Sciences University",{"id":519,"slug":520,"hasResults":12,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":524,"eligibilityCriteria":525,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":526,"targetDuration":4,"studyType":23,"phases":528,"briefSummary":529,"conditions":530,"keywords":531,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":541,"locationsCount":41},"100618695","ultrasound-guided-carpal-tunnel-infiltration-comparison-between-the-manual-method-and-a-robot-assisted-method-100618695","NCT07334964","Ultrasound-Guided Carpal Tunnel Infiltration: Comparison Between the Manual Method and a Robot-Assisted Method","Ultrasound-Guided Carpal Tunnel Infiltration: Comparison Between the Manual Method and a Robot-Assisted Method - A Pilot, Comparative, Randomized Study","ICCERO","Inclusion Criteria:\n\n1. Age ≥ 18 and ≤ 75 years.\n2. Clinical diagnosis of carpal tunnel syndrome.\n3. Indication for corticosteroid injection as determined by investigator.\n4. Moderate to severe carpal tunnel syndrome defined by a pain score on the Visual Analogue Scale (VAS) ≥ 4 (at baseline and on day 0).\n5. Signed informed consent.\n\nExclusion Criteria:\n\n1. Known allergy to corticosteroids or povidone-iodine (Betadine)\n2. Probable or ongoing systemic or local infection\n3. History of injection in the affected wrist within the last 6 months\n4. Thenar eminence atrophy\n5. Trauma requiring surgery or immobilization\n6. History of carpal tunnel surgery\n7. Protected person (under guardianship or curatorship)\n8. Person under judicial protection\n9. Person deprived of liberty\n10. Person not affiliated with a social security scheme\n11. Pregnant or breastfeeding woman\n12. Person participating in a drug trial",{"count":527,"type":22},20,[25],"This study aims to assess the feasibility, safety, and accuracy of a robotic arm-assisted carpal tunnel injection in comparison with the conventional ultrasound-guided method, prior to conducting a larger-scale study.\n\nThe use of a robotic arm to maintain the ultrasound probe in position could provide valuable assistance to the physician. The procedure would no longer require the involvement of a third person in addition to the physician. To date, no study has compared these two approaches.",[28],[232,532,533],"robot-assited-ultrasonography","carpal tunnel injection","2026-01-06",{"date":536,"type":33},"2026-01-12",{"date":538,"type":33},"2025-11-25",{"date":540,"type":22},"2027-02-25",{"name":542,"class":40},"Centre Hospitalier Régional d'Orléans",{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":427,"enrollmentInfo":551,"targetDuration":4,"studyType":23,"phases":553,"briefSummary":554,"conditions":555,"keywords":556,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":41},"100612390","acute-effects-of-warm-whirlpool-bath-therapy-on-forearm-and-hand-muscle-stiffness-and-pain-in-carpal-tunnel-syndrome-100612390","NCT07252960","Acute Effects of Warm Whirlpool Bath Therapy on Forearm and Hand Muscle Stiffness and Pain in Carpal Tunnel Syndrome","Acute Effects of Warm Whirlpool Bath Therapy on Forearm and Hand Muscle Stiffness and Pain in Patients With Carpal Tunnel Syndrome: A Randomised Controlled Trial","CTS-WB","Inclusion Criteria:\n\n* Being apparently healthy without a known chronic systemic disease\n* Physically active participants, regardless of gender\n* Adults aged 18-65 years diagnosed with carpal tunnel syndrome\n* No history of other chronic musculoskeletal or neurological disorders\n* Not having any acute upper limb injury\n\nExclusion Criteria:\n\n* Having a previous surgery on the affected wrist or hand\n* Systemic conditions affecting nerve function, such as diabetes mellitus or thyroid disease\n* Having a cardiovascular disease or uncontrolled hypertension\n* Being younger than 18 or older than 65 years\n* Being pregnant",{"count":552,"type":22},24,[25],"Carpal tunnel syndrome (CTS) is a common entrapment neuropathy that causes pain, paresthesia and functional limitations in the hand and wrist. Hydrotherapy methods such as warm whirlpool baths are frequently used in physiotherapy practice to reduce pain and improve soft-tissue properties, but their acute effects on forearm and hand muscle stiffness in CTS have not been clearly quantified.\n\nThis randomized controlled trial aims to investigate the acute effects of a single session of warm whirlpool bath therapy on forearm and hand muscle stiffness and pain intensity in adults with CTS. Participants diagnosed with CTS will be randomly allocated to an experimental group receiving a 20-minute warm whirlpool bath or to a resting control group. Muscle stiffness of selected forearm and hand muscles will be assessed using the MyotonPRO device, and pain intensity will be recorded with a numeric rating scale, immediately before and after the intervention. It is hypothesized that warm whirlpool bath therapy will produce a greater reduction in muscle stiffness and pain compared with rest alone.",[28],[94,557,558],"Muscle stiffness","Whirlpool bath therapy","2025-11-19",{"date":561,"type":33},"2025-11-28",{"date":563,"type":22},"2025-11-30",{"date":565,"type":22},"2025-12-10",{"name":567,"class":40},"Erzurum Technical University",{"id":569,"slug":570,"hasResults":12,"nctId":571,"briefTitle":572,"officialTitle":573,"acronym":574,"eligibilityCriteria":575,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":576,"targetDuration":4,"studyType":23,"phases":578,"briefSummary":579,"conditions":580,"keywords":581,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":586,"lastUpdatePostDateStruct":587,"startDateStruct":589,"completionDateStruct":591,"leadSponsor":593,"locationsCount":41},"100467870","carpal-tunnel-release-under-local-anaesthesia-with-or-without-distal-median-nerve-block-100467870","NCT05372393","Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block","Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block - a Protocol of a Double Blinded Randomised Controlled Trial","PERSONNEL","Inclusion Criteria:\n\n* ≥18 years of age\n* CTS verified by nerve conduction studies\n* Symptoms suitable for CTS\n\nExclusion Criteria:\n\n* Recurrent CTS\n* Peripheral neuropathies\n* Known allergy to the trial drugs\n* Profound cognitive impairment\n* Pregnancy",{"count":577,"type":22},118,[25],"Carpal tunnel syndrome (CTS) is the most commonly appearing entrapment neuropathy of the upper extremity. Treatment options include both non-operative and operative methods. Surgical treatment, carpal tunnel release (CTR), involves division of the transverse carpal ligament. Surgery can be performed under axillary or intravenous block, or general anaesthesia. There are no prior randomised controlled trials (RCT) comparing local infiltration anaesthesia to local infiltration anaesthesia augmented with a distal median nerve block in CTR.\n\nThe aim of this trial is to investigate whether adding a distal median nerve block to local anaesthesia reduces the patient's perceived pain level for up to 72 hours after CTR, compared to using only local anaesthesia, i.e., an anaesthesia mixture injected solely in and around the planned incision and nerve release. The null hypothesis is that the use of distal median nerve block with local anaesthesia does not reduce pain after CTR compared to pure local anaesthesia.\n\nPERSONNEL (carPal tunnEl ReleaSe lOcal iNfiltratioN mEdian bLockade) is a double-blinded, i.e., patient and investigators, RCT in patients with CTS. Patients will be randomly divided into two parallel trial groups, 1:1 in size to each other. Fifty-nine patients will be needed for each group to have adequate power. The primary outcome is the pain level perceived by the patient after the procedure during the first 72 hours using the Visual Analogue Scale (VAS). Secondary outcomes include patient-rated outcome measures, safety, the entire consumption of pain killers after the surgery during the first 72 hours postoperatively, pain of performing the anaesthesia, and pain during and after the operation.\n\nNo trial comparing local anaesthesia to local anaesthesia augmented with distal median nerve block has been published before. There is also no trial noting individual tolerance to pain. The quality of the median nerve block at the wrist has been achieved by using sensory or sensory-motor nerve stimulation and has been proven effective. This increases trust in the effectiveness of the treatment method, but it still needs to be adequately proven which is the goal of this trial.",[28],[232,209,582,583,584,585],"local anaesthesia","surgery","wide-awake local anaesthesia with no tourniquet","nerve block","2025-09-15",{"date":588,"type":33},"2025-09-19",{"date":590,"type":33},"2022-09-21",{"date":592,"type":22},"2026-04",{"name":594,"class":40},"Kuopio University Hospital",{"id":596,"slug":597,"hasResults":12,"nctId":598,"briefTitle":599,"officialTitle":600,"acronym":601,"eligibilityCriteria":602,"healthyVolunteers":277,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":603,"targetDuration":4,"studyType":23,"phases":605,"briefSummary":606,"conditions":607,"keywords":610,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":614,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":621,"locationsCount":106},"100472378","absorbable-versus-non-absorbable-sutures-for-wound-closure-in-carpal-tunnel-release-100472378","NCT05431101","abSorbable vErsus Non-absorbable SuturEs for Wound Closure in Carpal Tunnel Release","Absorbable Versus Non-absorbable Sutures for Wound Closure in Carpal Tunnel Release: a Randomized Controlled Trial","SENSE","Inclusion Criteria:\n\n• indication for carpal tunnel release\n\nExclusion Criteria:\n\n* carpal tunnel syndrome which has yet been operated\n* injection with corticosteroids",{"count":604,"type":22},2604,[25],"Carpal Tunnel Syndrome is a prevalent condition, up to 9% in women and 0.6% in men. Surgical decompression in the most effective treatment. After surgery, approximately 1,8% of the patients develop a wound infection. Possibly, the type of sutures used can influence the prevalence of wound infection. In this RCT the incidence of infection is investigated between the use of absorbable versus non-absorbable sutures in carpal tunnel release.",[28,608,609],"Wound Infection","Suture, Complication",[232,611,612,613],"wound infection","absorbable sutures","non-absorbable sutures","2025-08-19",{"date":616,"type":33},"2025-08-26",{"date":618,"type":33},"2022-05-01",{"date":620,"type":22},"2028-04-01",{"name":622,"class":40},"Gelre Hospitals",{"id":624,"slug":625,"hasResults":12,"nctId":626,"briefTitle":627,"officialTitle":628,"acronym":4,"eligibilityCriteria":629,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":427,"enrollmentInfo":630,"targetDuration":4,"studyType":23,"phases":632,"briefSummary":633,"conditions":634,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":41},"100564902","effectiveness-of-desensitisation-and-pain-neuroscience-education-in-patients-with-carpal-tunnel-syndrome-with-nosiplastic-pain-100564902","NCT06635213","Effectiveness of Desensitisation and Pain Neuroscience Education in Patients With Carpal Tunnel Syndrome With Nosiplastic Pain","Determination of the Effectiveness of Desensitisation and Pain Neuroscience Training in Patients With Carpal Tunnel Syndrome With Nosiplastic Pain Phenotype","Inclusion Criteria:\n\n* Being diagnosed with CTS\n* Being suitable for the nosiplastic pain phenotype\n* Being between the ages of 18-65\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Having systemic inflammatory disease\n* Having a disease that may cause polyneuropathy such as diabetes mellitus\n* Having a pacemaker\n* Having a disease affecting the central nervous system\n* Having cervical radiculopathy\n* History of previous operation or local steroid injection due to CTS\n* Hypersensitivity to heat and cold",{"count":631,"type":22},40,[25],"The aim of our study was to determine the effectiveness of desensitisation and pain neuroscience education in a group of patients with mixed phenotype pain (neuropathic and nosiplastic).",[28],"2025-08-11",{"date":637,"type":33},"2025-08-12",{"date":639,"type":33},"2024-10-25",{"date":641,"type":22},"2027-06-10",{"name":517,"class":40},{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":4,"eligibilityCriteria":649,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":427,"enrollmentInfo":650,"targetDuration":4,"studyType":116,"phases":4,"briefSummary":651,"conditions":652,"keywords":655,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":41},"100601778","symptom-distribution-and-pain-sensitization-in-carpal-tunnel-syndrome-100601778","NCT07114913","Symptom Distribution and Pain Sensitization in Carpal Tunnel Syndrome","Evaluation of Central Sensitization Parameters Based on Extra Median Symptom Distribution in Carpal Tunnel Syndrome: A Cross-sectional Study","Inclusion Criteria:\n\n* Having been diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings\n* Being between 18 and 65 years of age\n* Being literate\n* Agreeing to participate in the study\n\nExclusion Criteria:\n\n* Having a history of concomitant diabetes, systemic inflammatory disease, active infection, or malignancy\n* Being \\\u003C18 and \\>65 years of age\n* Being illiterate\n* Refusing to participate in the study\n* Having a disease associated with neuropathic pain, such as polyneuropathy, radiculopathy, or multiple sclerosis\n* History of injection or surgery for CTS within the last 6 months",{"count":115,"type":22},"This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms. Extra median sensory spread, observed in some CTS patients beyond the anatomical boundaries of the median nerve, may reflect central sensitization mechanisms. Using the Central Sensitization Inventory and pressure pain threshold measurements, this study will assess whether extra median symptom patterns are associated with increased central sensitization.",[28,653,654],"Central Sensitisation","Pain, Radiating",[232,656,657,658],"central sensitization","central sensitization inventory","pressure pain threshold","2025-08-06",{"date":635,"type":33},{"date":662,"type":33},"2025-06-21",{"date":664,"type":22},"2026-03-01",{"name":666,"class":40},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey"]