[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"carpal-tunnel\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:carpal-tunnel":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,68,92],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100643249","concordance-for-transthyretin-amyloidosis-between-synovial-biopsy-and-anterior-carpal-ligament-biopsy-100643249",false,"NCT07644325","Concordance for Transthyretin Amyloidosis Between Synovial Biopsy and Anterior Carpal Ligament Biopsy","Assessment of Diagnostic Concordance for Transthyretin Amyloidosis Between Synovial Biopsy and Anterior Carpal Ligament Biopsy in Patients Who Underwent Endoscopic Carpal Tunnel Syndrome Surgery","ATTR2026","Inclusion Criteria:\n\n* Adult patient with Health Insurance\n* Clinical diagnosis + carpal tunnel EMG\n* Validated indication for carpal tunnel surgery\n* Signed informed consent\n* Patient at risk for postoperative complications (bilateral carpal tunnel syndrome, heart failure, atrial fibrillation, elderly patients)\n\nExclusion Criteria:\n\n* Need for open carpal tunnel surgery.\n* Pregnant women\n* Adults under guardianship","ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","INTERVENTIONAL",[24],"NA","Transthyretin amyloidosis (ATTR) is an underdiagnosed condition that can present early as carpal tunnel syndrome, sometimes preceding cardiac involvement by several years. The recent emergence of new treatments underscores the importance of early diagnosis. Synovial biopsy performed during open carpal tunnel surgery is considered the gold standard for local screening, but it is less accessible, more difficult, and riskier to perform via endoscopy-a minimally invasive surgical technique that is currently the standard at our center and is becoming increasingly widespread.\n\nThe anterior annular ligament of the carpus constitutes an alternative tissue to the synovium, easily accessible via endoscopy, safe, and standardizable.\n\nIn this study, the systematic performance of an annular ligament biopsy in conjunction with a synovial biopsy during endoscopic carpal tunnel surgery would allow for the evaluation of the diagnostic concordance of the ligament biopsy by comparing it to the results obtained using the gold standard method. This strategy would also provide an opportunity to analyze the feasibility of systematic screening for ATTR on the ligament during endoscopic procedures.\n\nThis approach could offer a practical and innovative method for the early identification of at-risk patients and facilitate appropriate and timely management of the condition.",[27,28],"Carpal Tunnel","Transthyretin Amyloidosis","RECRUITING","2026-06-08",{"date":32,"type":33},"2026-06-12","ACTUAL",{"date":35,"type":33},"2026-05-27",{"date":37,"type":21},"2027-05-27",{"name":39,"class":40},"Clinique Saint Jean, France","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":41},"100526359","dexmedetomidine-ozone-and-dexamethasone-local-injection-in-carpal-tunnel-syndrome-for-pain-relief-100526359","NCT06133712","Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Pain Relief","A Comparative Study Between Dexmedetomidine, Ozone and Dexamethasone Local Injection in Carpal Tunnel Syndrome for Long- Term Pain Relief","Inclusion Criteria:\n\n* Age from 20 to 60 years.\n* Both sexes.\n* Patients with ultrasonographic evidence of mild-to-moderate carpal tunnel syndrome (CTS).\n* Inclusion criteria will include numbness and pain in the median nerve (MN) distribution persisting for minimum of 3 months , nerve conduction studies (NCS) consistent with carpal tunnel syndrome (CTS) as per the American Association of Neuromuscular and Electro diagnostic Medicine (AANEM) guidelines, and an median nerve (MN) cross-sectional area (CSA)at the wrist \\>12 mm2 suggesting mild-to-moderate CTS forms.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Patients with severe symptoms and signs of CTS as identified per the American Association of Neuromuscular and Electro diagnostic Medicine (AANEM) guidelines,\\[14\\] as this is an indication for surgery,\n* Patients who show improvement on medical treatment,\n* Previous surgical or injectional CTS treatment,\n* Pregnancy ,co existence of brachial plexopathy, or thoracic outlet syndrome, polyneuropathy, radiculopathy and peripheral nerve lesion in upper limb.\n* Severe cardiovascular disease\n* Morbid obese patients (body mass index (BMI) of \\>35 kg\u002Fm2)\n* Infection at site of injection.\n* Bleeding diathesis.\n* History of thyroid deficiency, uncontrolled diabetes mellitus , rheumatoid arthritis and history of glucose-6-phosphate dehydrogenase (G6PD) deficiency\n* History of Ozone or Dexmedetomidine allergy.\n* End stage renal and hepatic disease.\n* History of inflammatory joint , connective tissue disorders, , burns, any local tissue contractures and history of wrist trauma.\n* Patients who will not consent to completing The visual analogue scale (VAS) for pain or nerve conduction study before and after injection.","20 Years","60 Years",{"count":52,"type":21},135,[24],"The aim of the present study is to compare the analgesic efficacy of Dexmedetomidine, Ozone and Dexamethasone regional injection in carpal tunnel syndrome.",[27,56,57,58],"Dexmedetomidine","Ozone","Dexamethasone","2025-05-22",{"date":61,"type":33},"2025-05-29",{"date":63,"type":33},"2023-11-01",{"date":65,"type":21},"2025-12-01",{"name":67,"class":40},"Tanta University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":80,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":41},"100592726","short--to-medium-term-outcome-of-minimally-invasive-carpal-tunnel-release-100592726","NCT06997172","Short- to Medium-term Outcome of Minimally Invasive Carpal Tunnel Release","Determining the Short- to Medium-term Outcome After Minimally Invasive Sonography Guided Release of the Carpal Tunnel Compared to Standard-of-care Open and Endoscopic Techniques: a Randomized Controlled Superiority Trial With an Internal Pilot-phase","Inclusion Criteria:\n\n* Patient aged 18 years or older\n* Electroneurographically proven carpal tunnel syndrome\n* Informed Consent for trial participation\n\nExclusion Criteria:\n\n* Revision surgery\n* Inability to give informed consent, whether it be due to an insurmountable language barrier or another reason",{"count":76,"type":21},61,[24],"The aim of the study is to determine whether minimally invasive, ultrasound-guided thread carpal tunnel release leads to faster functional recovery compared to standard open and endoscopic techniques in patients with carpal tunnel syndrome.",[27],[81],"Percutaneous sonography guided release","NOT_YET_RECRUITING","2025-05-21",{"date":85,"type":33},"2025-05-30",{"date":87,"type":21},"2025-05",{"date":89,"type":21},"2026-09",{"name":91,"class":40},"University Hospital, Basel, Switzerland",{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":105,"conditions":106,"keywords":112,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":41},"100397853","phase-4-the-acts-trial-n-acetylcysteine-nac-and-night-splinting-as-a-non-operative-treatment-for-carpal-tunnel-syndrome-100397853","NCT04460521","The ACTS Trial: N-acetylcysteine (NAC) and Night-splinting as a Non-operative Treatment for Carpal Tunnel Syndrome","The Use of N-acetylcysteine Supplementation in Addition to Night Splinting for Treatment of Mild to Moderate Carpal Tunnel Syndrome: A Randomized, Double-blind, Placebo-controlled Trial","ACTS","Inclusion Criteria:\n\n1. The patient has a confirmed diagnosis of mild to moderate idiopathic unilateral or bilateral CTS as determined by both clinical exam findings and electrodiagnostic nerve conduction studies (median nerve distal motor latency ≥ 4.3 milliseconds and\u002For median nerve sensory distal latency ≥ 3.5 milliseconds at the wrist) performed within the preceding year prior to enrollment\n2. Symptoms of CTS must have been present for ≥ 6 weeks\n3. The patient must be ≥ 18 years of age.\n\nExclusion Criteria:\n\n1. Any previous carpal tunnel release procedure on the ipsilateral limb\n2. Any previous corticosteroid injection in the last 6 months on the ipsilateral limb\n3. Severe CTS\u002Fsigns of median nerve denervation with axonal loss determined by constant wrist or hand pain, constant parasthesias in the median nerve distribution, or thenar muscle atrophy in the ipsilateral limb\n4. Any known or suspected allergy to NAC\n5. Any current medications which preclude use of NAC including antibiotics or nitroglycerin\n6. Breastfeeding patients or patients with nephrolithiasis\n7. Any history of proximal ipsilateral neck or proximal limb injury\n8. Secondary CTS related to pregnancy\n9. Unable for financial reasons to obtain a night splint (i.e. lack of insurance coverage or lack of financial means).",true,{"count":102,"type":21},240,[104],"PHASE4","Carpal tunnel syndrome (CTS) is the most common nerve compression syndrome worldwide, causing significant chronic pain, functional impairment, and lowered quality of life for individuals of various backgrounds. CTS is caused by chronic compression of the median nerve in the carpal tunnel of the wrist, causing numbness and pain in the palm, thumb, index, and middle fingers and eventual weakness of the hand. Many different treatments for CTS have been proposed and studied, including but not limited to non-operative treatments such as wrist splinting, steroid injections, and lifestyle modifications as well as operative treatments, such as surgical carpal tunnel release (CTR). To date, very few oral medications have been shown to be effective as conservative treatments for CTS. In this study the investigators will examine whether there is any benefit to using oral N-acetylcysteine (NAC) as an adjunctive treatment for mild to moderate CTS in addition to a standard 8-week trial of night splinting. NAC has been used in humans for various purposes, is extremely safe and has very few side effects, and has been shown to have anti-inflammation properties which may help treat CTS. The investigators will study this by performing a randomized controlled trial, comparing patients receiving oral NAC and standard night splinting to patients receiving an identical placebo and standard night splinting. Both patient groups will be assessed using a questionnaire to assess for severity of their CTS symptoms both before and after the 8-week treatment. The primary objective will be to determine whether supplementation with oral NAC in addition to night splinting has any significant impact on patient-reported symptoms and functional impairment when compared to night splinting alone. The investigators will also measure secondary outcomes including whether patients decide to have surgery for their CTS after treatment and\u002For continued use of other treatments. This study has the potential to have a significant positive impact on patients by identifying a safe, inexpensive, accessible, and well tolerated conservative treatment for mild to moderate carpal tunnel syndrome, and potentially preventing the need for additional, more invasive treatments such as surgery.",[107,108,109,110,27,111],"Carpal Tunnel Syndrome","Hand Injuries and Disorders","Nerve Compression","Splints","Carpal Tunnel Release",[113,114,115,116,117,118,119,120,121,122],"Wrist splint","Carpal tunnel syndrome","Carpal tunnel release","Compression neuropathy","NAC","Conservative treatment","Hand surgery","Plastic surgery","N-acetylcysteine","Night splint","2024-08-21",{"date":125,"type":33},"2024-08-23",{"date":127,"type":33},"2022-04-01",{"date":129,"type":21},"2026-10-01",{"name":131,"class":40},"Emily Krauss"]