[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cartilage-degeneration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cartilage-degeneration":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,42,76,101,134,161,184],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100553798","analysis-of-the-pathophysiological-and-functional-state-of-the-knee-joint-100553798",false,"NCT06490770","Analysis of the Pathophysiological and Functional State of the Knee Joint","Gait-MRI-Knee","Inclusion Criteria:\n\n* Knee pain and\u002For loss of functionality\n* Kellgren-Lawrence grade less than or equal to 2\n* Arthroscopic evidence of cartilage tissue lesions\n* Evidence of cartilage and\u002For meniscal tissue degeneration and\u002For subchondral bone marrow lesions\n\nExclusion Criteria:\n\n* History\u002Fevidence of previous partial or total knee prosthesis interventions\n* Inability to provide informed consent\n* Conditions or physical disorders incompatible with the use of MRI and electrical stimulation (implanted active and passive biomedical devices, epilepsy, severe venous insufficiency in the lower limbs)","ALL","18 Years","60 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"NA","Osteoarthritis is the most common degenerative condition affecting the knee joint globally, with an incidence of about 7% of the population. In Italy, it affects approximately 3.9 million people, with a direct treatment cost of around €2.5 billion. At the joint level, osteoarthritis manifests with pain and reduced functionality, worsening as the disease progresses and severely limiting knee movement. Compounding this, osteoarthritis can impact both elderly and younger individuals due to traumatic factors.\n\nDespite its significant impact, effective treatments for osteoarthritis that address its underlying causes are still lacking, focusing mainly on symptom management. Therefore, improving diagnostic and prognostic approaches is crucial to better understand its onset and progression.\n\nMRI is a primary diagnostic tool for assessing the knee joint's pathophysiological state. It uses tissue-specific sequences to investigate joint homeostasis in detail, although it primarily provides insights into morphology, structure, and tissue composition rather than functional changes within the joint. This limitation is noteworthy because joint homeostasis involves complex interactions among biomechanical, structural, and biological processes, which are directly influenced by osteoarthritis.\n\nGait analysis provides valuable diagnostic information on joint function. By integrating sensor measurements and electronic systems with patient-specific musculoskeletal models derived from MRI morphometric data, it is possible to assess the forces and moments within the joint during specific movements.\n\nGiven that osteoarthritis affects the entire joint, employing multidisciplinary approaches can enhance diagnostic precision and provide insights into the progressive impact of degenerative conditions like osteoarthritis on joint health.",[27,28],"Osteoarthritis, Knee","Cartilage Degeneration","RECRUITING","2026-06-30",{"date":32,"type":33},"2026-07-02","ACTUAL",{"date":35,"type":33},"2025-07-09",{"date":37,"type":21},"2027-04",{"name":39,"class":40},"Istituto Ortopedico Rizzoli","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":62,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":41},"100564678","dexa-bone-density-analysis-of-the-corehip-prosthesis-system-100564678","NCT06632301","DEXA Bone Density Analysis of the CoreHip® Prosthesis System","DEXA Bone Density Analysis to Analyze the Loading Concept of the CoreHip® Prosthesis","CODEX","Inclusion Criteria:\n\n* Unilateral hip osteoarthritis\n* Indication for CoreHip Standard hip stem according to preoperative planning\n* Written Informed Consent\n* Age 35-85 years\n* According to the assessment of the study doctor, the patient is therapy compliant and able to attend the follow-up visits\n\nExclusion Criteria:\n\n* Femoral neck fractures\n* Pregnancy\n* BMI \\> 35\n* History of femoral fracture or previous surgery on the same hip\n* Metabolic bone disease, use of steroids or other drugs affecting bone metabolism\n* Intraoperative bone cracks\n* Severe osteoarthritis of the contralateral hip\n* THA of the contralateral side or other event leading to restricted weight bearing during the study period","35 Years","85 Years",{"count":53,"type":21},40,[24],"The goal of this interventional post-market follow-up study is to evaluate radiological changes in the diaphyseal bone density (Gruen Zones 3 and 4) within 24 months postoperative in patients treated with CoreHip® primary cementless stem. The DEXA bone density analysis is used.",[57,28,58,59,60,61],"Primary Osteoarthritis","Osteoarthritis, Hip","Inflammatory Arthritis","Osteonecrosis of Femoral Head","Traumatic Disorder",[63,64],"Total Hip Arthroplasty","DEXA Bone Density Analysis","NOT_YET_RECRUITING","2026-02-24",{"date":68,"type":33},"2026-02-27",{"date":70,"type":21},"2026-06",{"date":72,"type":21},"2028-09",{"name":74,"class":75},"Aesculap AG","INDUSTRY",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":94,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":41},"100403652","multi-vendor-multi-site-novel-accelerated-mri-relaxometry-100403652","NCT04536103","Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry","MVMS_MRI","Inclusion Criteria:\n\nGroup 1\n\n1\\. Age \\> 18\n\nGroup 2\n\n1\\. Age 18-50\n\nGroup 3\n\n1. Age 18-50\n2. Sustain an acute full ACL tear in one knee; the contralateral knee uninjured\n3. Undergo ACL reconstructions and standard rehabilitation\n\nGroup 4\n\n1\\. Age 18-50\n\nExclusion Criteria:\n\nGroup 1\n\n1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.\n2. Pregnancy.\n\nGroup 2\n\n1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.\n2. Pregnancy.\n3. History of osteoarthritis and inflammatory arthritis\n4. Previous injury and\u002For surgery on either knee\n\nGroup 3\n\n1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.\n2. Pregnancy.\n3. Inability to undergo standard pre- and post-injury\u002Foperative rehabilitation\n\nGroup 4\n\n1. Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.\n2. Pregnancy.\n3. History of osteoarthritis and inflammatory arthritis\n4. Previous injury and\u002For surgery on either knee","50 Years",{"count":85,"type":21},88,"OBSERVATIONAL","Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many challenges remain to clinically applying these techniques, including lack of standardized acquisition and quantification methods, and long acquisition times. The study aims to develop novel, fast and reproducible MR T1ρ and T2 relaxation time imaging methods on MR systems from multiple vendors and establish a platform for standardization and cross validation of these measures as a tool for clinical trials using such techniques. Following method validation, patients at risk for osteoarthritis will be tested.",[89,90,91,92,93,28],"Bone Diseases, Infectious","Musculoskeletal Diseases","Joint Diseases","Osteoarthritis","ACL Tear",{"date":68,"type":33},{"date":96,"type":33},"2022-04-01",{"date":98,"type":21},"2026-12-28",{"name":100,"class":40},"Xiaojuan Li",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100605082","early-phase-1-investigating-the-safety-and-regenerative-potential-of-msc-derived-secretome-combined-with-prgf-in-knee-osteoarthritis-100605082","NCT07157891","Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis","PRGFSECKOA","Inclusion Criteria:\n\n* Following is the inclusion criteria for the enrolment of patients affected with damaged cartilage in this study:\n\n  * Diagnosed with primary OA in one or both knees based on American College of Rheumatology criteria\n  * Grade I and II Arthritis\n  * Joint pain ≥ 20mm measured by visual analogue scale\n  * Age ranges from 30-55 years of age\n  * BMI 27.12 ± 4.38\n  * Patients with no previous surgical interventions to lower limb\n  * Willing to participate in the study\n\nExclusion Criteria:\n\n* • Secondary OA due to trauma, infection, rheumatoid arthritis, congenital disease or other inflammatory disorders of the knee\n\n  * Diagnosed with a systemic autoimmune disorder, immunodeficiency or coagulation disorder\n  * Had history of malignancy\n  * History of allergy or allergic constitution\n  * Pregnant or breastfeeding women.","30 Years","55 Years",{"count":20,"type":21},[112],"EARLY_PHASE1","This Phase I\u002FII randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in Growth Factors (PRGF) in patients with knee osteoarthritis (KOA). The study aims to assess whether this cell-free, biologically enriched therapeutic combination can reduce pain, improve joint function, and promote cartilage repair.",[115,116,28],"Osteoarthritis (OA)","Knee Injury",[118,119,120,121,122,123,124],"Mesenchymal Stem Cell Secretome","Plasma Rich in Growth Factors (PRGF)","Platelet-Rich Plasma (PRP)","Knee Osteoarthritis","Intra-articular Injection","Cell-free Therapy","Regenerative Medicine","2025-08-28",{"date":127,"type":33},"2025-09-05",{"date":129,"type":21},"2025-12-10",{"date":131,"type":21},"2028-12-11",{"name":133,"class":40},"University of the Punjab",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":144,"conditions":145,"keywords":147,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":41},"100544412","effect-of-early-gait-training-on-knee-cartilage-degeneration-after-anterior-cruciate-ligament-reconstruction-100544412","NCT06368544","Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n1. Patients with ACL rupture were diagnosed by MRI;\n2. Unilateral ACL rupture for the first time should be performed in our hospital (Department of Sports Medicine, Peking University Third Hospital)The art of reconstruction;\n3. Normal BMI range: 18.5-23.9 kg\u002Fm2;\n4. Within 6 months from the trauma;\n5. The affected knee joint has passed the acute stage, no obvious redness, pain,inflammation, and limited joint motion,basically restore joint motion.\n\nExclusion Criteria:\n\n1. BMI\\\u003C18.5 kg\u002Fm2 or BMI≥24 kg\u002Fm2);\n2. There is a history of contralateral lower limb musculoskeletal system injury and surgery;\n3. ACL injury time \\> 6 months;\n4. Outerbridge damage rating Ⅲ and Ⅳ;\n5. Patients with meniscal tears who are expected to undergo meniscal suture surgery at the time of ACLR surgery;\n6. Serious injury to the posterior cruciate ligament, medial collateral ligament, or lateral collateral ligament;\n7. There is metabolic syndrome (obesity, dyslipidemia, diabetes, etc.), which will involve articular cartilage Epidemic diseases, serious cardiovascular and cerebrovascular diseases, etc.;\n8. Those who do not want to accept this treatment","40 Years",{"count":142,"type":21},60,[24],"A randomized controlled clinical study was conducted to elucidate the relationship between the lower extremity biomechanics of patients undergoing early gait training after ACLR surgery.The relationship between the biochemical characteristics of cartilage and the biomechanical risk index were proposed to providing exercise guidance and training for ACLR people and it is suggested that it can prevent and reduce the risk of cartilage degeneration early after operation.",[146,28],"Anterior Cruciate Ligament Injuries",[148,149,150,151],"anterior cruciate ligament injuries","gait training","Cartilage biochemical characteristics","anterior cruciate ligament reconstruction","2025-07-22",{"date":154,"type":33},"2025-07-25",{"date":156,"type":33},"2024-07-22",{"date":158,"type":21},"2027-12-31",{"name":160,"class":40},"Peking University Third Hospital",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":167,"sex":168,"minAge":169,"maxAge":83,"enrollmentInfo":170,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":41},"100563146","effects-of-60-day-6-head-down-bed-rest-on-cartilage-and-function-of-the-knee-joint-100563146","NCT06612372","Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint","Inclusion Criteria:\n\n* (1) male; (2) age 25-50 years old; (3) height between 160-175 cm, weight ≥50kg, and BMI between 18.5-26 kg\u002Fm²; (4) good general health status.\n\nExclusion Criteria:\n\n* (1) history of alcoholism; (2) smoking ≥5 cigarettes\u002Fday in the 3 months before the test; (3) drug dependence or use of medications affecting bone metabolism within 2 weeks before screening; (4) presence of metal implants, severe vertigo, or severe snoring.",true,"MALE","25 Years",{"count":171,"type":21},26,[24],"Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.",[28,175],"Weightlessness","2024-09-24",{"date":178,"type":33},"2024-09-25",{"date":180,"type":33},"2023-09-10",{"date":182,"type":21},"2024-11-15",{"name":160,"class":40},{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":41},"100535290","efficacy-of-bioceramic-materials-for-bone-defects-repair-100535290","NCT06249906","Efficacy of Bioceramic Materials for Bone Defects Repair","Clinical Study of Bioceramic Materials in Bone Defect Repair","Inclusion Criteria:\n\n1. Patients who voluntarily take the test and sign the informed consent form;\n2. Patients aged 18-65 years old with no history of allergies;\n3. Patients able to communicate well with the investigator and follow the requirements of the entire trial.\n\nExclusion Criteria:\n\n1. Patients who refuse to sign the informed consent form to participate in the trial;\n2. Patients who are not in the age range of 18 to 65 years;\n3. Patients with diseases unsuitbale for the trial: history of allergies, severe cardiopulmonary disease, coagulation dysfunction, Alzheimer's disease, cerebral atrophy, acute phase or sequelae of cerebrovascular disease, cognitive impairment;\n4. Patients in the acute phase of local or systemic bacterial infections;\n5. Patients who cannot cooperate with the operation and evaluate the effect;\n6. Other conditions that are considered inappropriate by the investigator to participate in the study.","65 Years",{"count":193,"type":21},10,[24],"The purpose of this study is to demonstrate the effect of bioceramic implants on the repair of human bone defects, and to explore the application of bioceramic materials in bone defects, bone implantation, and bone fusion. The surface microstructure of β-tricalcium phosphate bioceramic implants can be effectively controlled to guide the regeneration of bones, promote the restoration of bones, accelerate the speed of recovery, and improve bone quality, which is of great clinical and social significance.",[197,28,198,199,200,201],"Bone Lesion","Osteo Arthritis Knee","Bone Fracture","Bone Injury","Bone Loss","2024-03-08",{"date":204,"type":33},"2024-03-12",{"date":206,"type":33},"2024-02-20",{"date":208,"type":21},"2026-12-30",{"name":210,"class":40},"Nanjing First Hospital, Nanjing Medical University"]