[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cataract-and-iol-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cataract-and-iol-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,42,63,92,117,142,167,189,213,234],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100637895","vr-for-cataract-anxiety-lowering-management--a-rct-study-100637895",false,"NCT07620821","VR for Cataract Anxiety Lowering Management--A RCT Study","A Randomized Controlled Study of Virtual Reality Simulation of Intraoperative Audiovisual Experience to Reduce Anxiety in Cataract Surgery Patients","VR-CALM","Inclusion Criteria:\n\n1. Diagnosed with cataracts in one or both eyes, and planning to undergo surgical treatment\n2. Voluntarily participate in this trial and sign the informed consent form.\n\nExclusion Criteria:\n\n1. History of previous ophthalmic surgery\n2. Suffering from severe hearing impairment, unable to comprehend VR video content.\n3. Those who suffer from cognitive dysfunction or mental illness and are unable to cooperate in completing the scale assessment.\n4. Suffering from severe macular diseases, glaucoma, or other ocular diseases that may affect surgery or interfere with the assessment of tension level.\n5. Assessed as intolerant to topical anesthesia for the surgery.\n6. History of motion sickness, severe vertigo, or intolerance to VR video viewing (such as claustrophobia).\n7. Other situations where the researcher deems the participant unsuitable for participation in this study.","ALL","20 Years","90 Years",{"count":21,"type":22},260,"ESTIMATED","INTERVENTIONAL",[25],"NA","Cataract is currently the leading cause of blindness globally, and surgery is the only effective treatment. With the advancement of medical technology, cataract surgery is usually performed under topical anesthesia, which means patients will be awake during the procedure, able to see the light from the surgical lamp and hear the sounds of surgical instruments being operated. Some patients may feel nervous or scared due to unfamiliarity with the surgical process, which may lead to increased blood pressure, rapid heartbeat, and even affect their cooperation during the surgery.Virtual reality (VR) technology is a new multimedia technology. By wearing VR glasses, patients can immerse themselves in a virtual world and see and hear realistic scenes. Through this study, the investigators aim to investigate whether allowing cataract patients to \"experience\" a surgical procedure in advance through VR glasses before cataract surgery can help alleviate their nervousness during the actual surgery.",[28,29],"Cataract and IOL Surgery","VR-based Informed Consent","NOT_YET_RECRUITING","2026-05-27",{"date":33,"type":34},"2026-06-02","ACTUAL",{"date":36,"type":22},"2026-06-01",{"date":38,"type":22},"2026-09-30",{"name":40,"class":41},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":15,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":62,"locationsCount":4},"100640192","vr-for-cataract-anxiety-lowering-management-100640192","NCT07586280","VR for Cataract Anxiety Lowering Management","A Non-Randomized Controlled Trial of Virtual Reality Simulation of Intraoperative Audiovisual Experience to Reduce Anxiety in Cataract Surgery Patients","Inclusion Criteria:\n\n1. Diagnosed with cataracts in both eyes, and planning to undergo surgical treatment\n2. Voluntarily participate in this trial and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Having any history of previous ophthalmic surgery.\n2. Suffering from severe hearing impairment, unable to comprehend VR video content.\n3. Those who suffer from cognitive dysfunction or mental illness and are unable to cooperate in completing the scale assessment.\n4. Suffering from severe macular diseases, glaucoma, or other ocular diseases that may affect surgery or interfere with the assessment of tension level.\n5. Assessed as intolerant to surface anesthesia surgery.\n6. History of motion sickness, severe vertigo, or intolerance to VR video viewing (such as claustrophobia).\n7. Other situations where the researcher deems the participant unsuitable for participation in this study.","50 Years","80 Years",{"count":52,"type":22},60,[25],"Cataract is currently the leading cause of blindness globally, and surgery is the only effective treatment. With the advancement of medical technology, cataract surgery is usually performed under topical anesthesia, which means patients will be awake during the procedure, able to see the light from the surgical lamp and hear the sounds of surgical instruments being operated. Some patients may feel nervous or scared due to unfamiliarity with the surgical process, which may lead to increased blood pressure, rapid heartbeat, and even affect their cooperation during the surgery.\n\nVirtual reality (VR) technology is a new multimedia technology. By wearing VR glasses, patients can immerse themselves in a virtual world and see and hear realistic scenes. Through this study, the investigators aim to investigate whether allowing cataract patients to \"experience\" a surgical procedure in advance through VR glasses before cataract surgery can help alleviate their nervousness during the actual surgery.",[29,28],"2026-05-12",{"date":58,"type":34},"2026-05-14",{"date":60,"type":22},"2026-05-01",{"date":38,"type":22},{"name":40,"class":41},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":17,"minAge":71,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":23,"phases":74,"briefSummary":75,"conditions":76,"keywords":77,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100605104","clareon-panoptix-versus-acrysof-panoptix--prospective-study-comparing-contrast-sensitivity-100605104","NCT07158177","Clareon PanOptix Versus AcrySof PanOptix : Prospective Study Comparing Contrast Sensitivity","Clareon PanOptix Versus AcrySof PanOptix : Prospective Study Comparing Contrast Sensitivity. Study of Two Different Material of Intra Ocular Multifocal Lenses Aiming to Compare the Effect on Contrast Sensitivity.","CLAYRE","Inclusion Criteria:\n\n* Patients ≥ 18 years of age\n* Patients presenting for cataract surgery in routine clinical practice and eligible for multifocal IOL implantation (toric and non-toric)\n* Patients with grade 2\u002F3 cataract density and comparable visual acuity in both eyes\n* Patient with a pregnancy test (negative pregnancy test), if applicable\n* Patient with signed consent to participate in the study\n* Patient affiliated to a social security scheme or entitled beneficiary\n\nExclusion Criteria:\n\n* Children \\\u003C 18 years of age\n* Pregnancy or breast-feeding in progress or planned during the study.\n* History of anterior (cornea, anterior chamber, sulcus) or posterior (uveal, vitreoretinal) segment pathology, including retinal vascular occlusive disease, retinal detachment or peripheral retinal laser photocoagulation, AMD, glaucoma.\n* Any inflammation of the anterior or posterior segment, whatever the etiology, and\u002For history of any disease with intraocular inflammatory repercussions.\n* Clinically significant corneal pathology (epithelial, stromal and\u002For endothelial) that could have an impact on visual results.\n* Clinically significant moderate or severe dry eye that could affect study measurements.\n* History of intraocular or corneal surgery (refractive or trauma-related).\n* Presence or history of amblyopia or monofixation syndrome.\n* Subjects with conditions that increase the risk of zonular disruption during the phacoemulsification procedure that may affect the centration or postoperative orientation of the IOL.\n* Any other planned eye surgery, including, but not limited to, limbal relaxing incision (LRI)\u002Fastigmatic keratotomy and laser refractive surgery (LASIK).\n* Irregular astigmatism identified by corneal topography\n* Patients under guardianship, curatorship or safeguard of justice, as well as pregnant or breast-feeding women (article L1121-5 of the CSP).1.1\n* Patient under AME","18 Years",{"count":73,"type":22},40,[25],"Retrospective, comparative, interventional, randomized, single-center study, contralateral (the patient's 2 eyes will be implanted: 1 CPO and the other APO) Patients presenting for cataract surgery with a request for presbyopia correction and managed as part of routine clinical practice.\n\nThe main aim of the study is to demonstrate that contrast sensitivity is better with the Clareon PanOptix (CPO) intraocular lens (IOL) compared with the AcrySof PanOptix (APO) IOL 3 months after implantation.",[28],[78,79,80],"Multifocal Intra Ocular Lens","Presbyopia Correcting Intra Ocular Lens (PCIOL).","Cataract","RECRUITING","2026-03-25",{"date":84,"type":34},"2026-03-30",{"date":86,"type":34},"2025-10-01",{"date":88,"type":22},"2026-10-15",{"name":90,"class":41},"Assistance Publique - Hôpitaux de Paris",1,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":103,"phases":4,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":91},"100627700","postoperative-outcomes-of-a-toric-addon-intraocular-lens-after-keratoplasty-and-cataract-surgery-100627700","NCT07452042","Postoperative Outcomes of a Toric AddOn Intraocular Lens After Keratoplasty and Cataract Surgery","Postoperative Outcomes of a Toric Add-On Intraocular Lens After Keratoplasty and Cataract Surgery","AddOn","Inclusion Criteria:\n\n* Gender: female, male, or diverse\n* Ophthalmological diagnosis: pseudophakic patients after keratoplasty\n* Age: 45 to 90 years\n* Complication-free cataract surgery using phacoemulsification and implantation of a posterior chamber lens.\n* Complication-free keratoplasty and regular postoperative corneal astigmatism \\> 1 diopter (D)\n* Pupil diameter in mydriasis \\> 5.5 mm\n\nExclusion Criteria:\n\n* Uncontrolled glaucoma\n* Proliferative diabetic retinopathy\n* Iris neovascularization\n* History of uveitis or iritis\n* Microphthalmus\n* Recurrent intraocular inflammation of unknown cause\n* Blindness in the other eye\n* Uncontrolled systemic or ocular disease\n* Pregnancy\n* Breastfeeding","45 Years","95 Years",{"count":73,"type":22},"OBSERVATIONAL","The aim of this clinical study is to evaluate a toric add-on intraocular lens (IOL) for the correction of high astigmatism in patients who have undergone keratoplasty and cataract surgery. As this patient group often suffers from significant preoperative residual astigmatism, there is a relevant clinical need for effective and safe refractive treatment options. The implantation of a toric add-on IOL in the ciliary sulcus is intended to significantly reduce postoperative astigmatism and improve visual rehabilitation.\n\nThe study is designed as a prospective, monocentric clinical trial with a limited number of cases, as this is a rare condition with limited availability of suitable patients. It is being conducted in accordance with Section 3 of the Austrian Medical Devices Act (MPG 2021) and is investigating a CE-marked add-on intraocular lens implant used within its intended purpose. The postoperative refractive cylinder serves as the primary endpoint, as it reflects the actual effectiveness of astigmatism correction. The rotational stability of the add-on IOL, which significantly influences refractive precision, is recorded as a secondary endpoint.\n\nAll study participants will be examined pre- and postoperatively in accordance with applicable medical standards. The results should contribute to the optimization of refractive care after keratoplasty and assess the clinical applicability of toric AddOn IOLs in this specific indication.",[28,106,107],"Keratoplasty","Toric Intraocular Lens Stability","2026-02-27",{"date":110,"type":34},"2026-03-05",{"date":112,"type":22},"2026-02",{"date":114,"type":22},"2029-02",{"name":116,"class":41},"Medical University of Vienna",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":125,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":91},"100615600","improving-visual-quality-in-patients-with-irregular-corneas-using-asymmetrical-toric-intraocular-lenses-100615600","NCT07294716","Improving Visual Quality in Patients With Irregular Corneas Using Asymmetrical Toric Intraocular Lenses","VITAL - \"Visual Improvement With Toric Asymmetrical Lenses\": Enhancing Vision in Irregular Corneas","VITAL","Inclusion Criteria:\n\n* Age 21 years or older\n* Scheduled cataract surgery\n* At least 1.75 D of total astigmatism in the CASIA2 measurement\n* At least 0.75 D of asymmetry or higher order irregularity within the 6mm zone of the real (total) index corneal refractive map of the CASIA2 measurements\n\nExclusion Criteria:\n\n* Relevant central corneal scars\n* PEX, previous ocular surgery, severe trauma or any pathology that could lead to an unstable capsular bag\n* Combined surgery (cataract plus glaucoma\u002Fvitreoretinal\u002Fcorneal surgery)\n* Postoperative best corrected distance visual acuity below 0.3 Snellen decimal\n* Pregnancy","21 Years",{"count":127,"type":22},15,[25],"Cataract surgery in patients with irregular corneas presents unique challenges, primarily due to the high variability in keratometry and corneal tomography measurements, which complicates accurate intraocular lens (IOL) calculations. In these patients, therapeutic options are currently limited to either non-toric IOLs and rigid contact lenses postoperatively or conventional toric IOLs for the reduction of total astigmatism within cataract surgery. While conventional toric IOLs may be beneficial in selected cases with a stable astigmatic pattern and clear axis, their effectiveness is largely limited, as significant irregularity and higher order aberrations reduce predictability, accuracy of formulae, and refractive outcomes. Therefore, the development of a reliable method to reduce total astigmatism - including irregular components - would represent a major advancement, potentially improving both visual function and patient quality of life. The aim of this exploratory study is to evaluate the effectiveness of customized toric intraocular lenses (AMILens Individual, AMIPLANT GmbH, Germany) in reducing total corneal astigmatism in patients with a significant irregular astigmatic component. These lenses are designed to address corneal aberrations up to the 6th Zernike order, thereby extending correction beyond the capabilities of conventional toric IOLs. To our knowledge, no clinical study has yet investigated this novel approach.",[131,132,28],"Irregular Astigmatism","Astigmatism","2026-01-22",{"date":135,"type":34},"2026-01-26",{"date":137,"type":34},"2026-01-20",{"date":139,"type":22},"2027-06",{"name":141,"class":41},"Johannes Kepler University of Linz",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":17,"minAge":71,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":164,"locationsCount":91},"100617941","development-of-optical-biometer-100617941","NCT07325162","Development of Optical Biometer","Development of a Next-Generation Optical Biometer for Eyes With Cataract","CH-0203","Inclusion criteria:\n\n* The presence of cataract in at least one eye.\n* Minimally 21 years of age.\n* Provided written informed consent.\n\nExclusion criteria:\n\n* The inability to properly fixate on a fixation target for several seconds\n* The inability to provide informed consent.",{"count":151,"type":22},100,[25],"The Helioscope (Cassini Technologies B.V.) is a novel device under development that aims at combining LED-based corneal topography and SS-OCT to provide accurate and fast measurements of both the corneal shape and the ocular biometry. To that end, the hardware and software of the Cassini color-LED topographer (Cassini Technologies B.V.) is combined with a novel SS-OCT device.\n\nWhile the new Helioscope can largely be evaluated using data acquired with healthy eyes, one of its main use-cases is providing input for IOL power formulae for cataract surgery. Thus, it is essential that the device can perform measurements in eyes with (dense) cataract. As cataract changes the optical properties of the crystalline lens and the OCT measurement is optical, this is not a given. This study therefore seeks a dataset of Helioscope measurements performed in eyes with cataract that can be used to develop the software algorithms of the Helioscope.",[28],[156,157],"Optical Biometer","SS-OCT","2026-01-06",{"date":160,"type":34},"2026-01-08",{"date":162,"type":34},"2025-11-07",{"date":84,"type":22},{"name":165,"class":166},"Cassini Technologies","INDUSTRY",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":71,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":176,"briefSummary":177,"conditions":178,"keywords":179,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":182,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":91},"100617943","hud-surgical-guidance-for-toric-alignment-100617943","NCT07325188","HUD Surgical Guidance for Toric Alignment","Clinical Evaluation of a Novel Intraoperative Guidance System for Accurate Toric IOL Positioning in Cataract Surgery","CG-Toric","Inclusion criteria:\n\n* Patients undergoing uncomplicated cataract surgery with toric IOL implantation,\n* Eyes implanted with a toric IOL.\n\nExclusion criteria:\n\n* Ocular comorbidity likely to impair postoperative visual acuities, or\n* History of ocular trauma or zonular instability, or\n* Previous refractive surgery, or\n* Irregular corneal astigmatism or keratoconus, or\n* Patients with physical or intellectual disabilities that may prevent reliable fixation or comprehension (e.g. Down's Syndrome, Parkinson's Disease), or\n* Patients with unreliable biometry measurements, or\n* Severe dry eye disease or ocular surface disease.",{"count":151,"type":22},[25],"This study aims to assess the accuracy of toric intraocular lens (IOL) alignment axes as calculated and displayed by a novel digital guidance system. In addition, it evaluates the time required to initiate surgical guidance and postoperative refractive astigmatism following toric IOL implantation.\n\nThis single-surgeon, single-site, prospective, non-invasive observational study evaluated the accuracy of toric IOL alignment axes calculated and displayed by the digital guidance system (Cassini Technologies, B.V.) in 100 eyes. The intraoperatively calculated alignment axes were compared to preoperative measurements to assess their accuracy (in degrees). Postoperative outcomes, including residual refractive astigmatism (diopters) and visual acuity (Snellen), were recorded at 1 month postoperatively.",[28],[180,181],"Guidance","Toric IOL",{"date":160,"type":34},{"date":184,"type":34},"2025-11-04",{"date":186,"type":22},"2026-10-31",{"name":188,"class":41},"Gainesville Eye Associates",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":195,"maxAge":4,"enrollmentInfo":196,"targetDuration":4,"studyType":23,"phases":198,"briefSummary":199,"conditions":200,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":91},"100610152","the-impact-of-physiologic-cataract-surgery-on-patient-comfort-and-medication-usage-100610152","NCT07223866","The Impact of Physiologic Cataract Surgery on Patient Comfort and Medication Usage","Inclusion Criteria: Subjects who will require bilateral cataract surgery will be considered. Evaluations will occur in the clinic of the Principal Investigator (PI) Matthew Rauen, MD at the Wolfe Eye Clinic.\n\nInclusion Criteria:\n\n* Visually significant cataract 2-3+ undergoing uncomplicated cataract surgery with similar cataract grade in both eyes\n* Unremarkable ocular health but inclusive of early AMD\n\nExclusion Criteria:\n\n* H\u002Fo ocular surgery including corneal refractive surgery\n* Compromised zonular integrity or stability\n* Uncontrolled diabetes and diabetic retinopathy\n* Small pupils\n* H\u002Fo systemic inflammatory disease\u002Fuveitis\n* H\u002Fo chronic pain medications (including narcotics) and benzodiazepine usage\n* Abnormal liver or renal function","60 Years",{"count":197,"type":22},85,[25],"The study will pertain to investigating the impact of high vs low IOP on the intraoperative experience and comfort for the patient and surgeon. Our hypothesis is that operating at a more physiological IOP using Unity VCS\u002FCS and Centurion with Active Sentry at a higher, or more traditional IOP will result in significantly less discomfort\u002Fpain as assessed by the decreased need for rescue medication and lower VAS scores.",[28,201,202,203],"Cataract Surgery Anesthesia","Cataract Surgery Experience","Nuclear Cataract","2025-11-05",{"date":206,"type":34},"2025-11-10",{"date":208,"type":22},"2025-11-01",{"date":210,"type":22},"2027-01-01",{"name":212,"class":41},"Matthew Rauen",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":17,"minAge":71,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":23,"phases":221,"briefSummary":222,"conditions":223,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":4},"100598361","outcomes-of-combined-cataract-surgery-with-retinal-surgery-for-visually-significant-epiretinal-membrane-with-vivity-versus-monofocal-intraocular-lens-100598361","NCT07070492","Outcomes of Combined Cataract Surgery With Retinal Surgery for Visually Significant Epiretinal Membrane With Vivity Versus Monofocal Intraocular Lens","Inclusion Criteria:\n\n* Adult patients with visually significant epiretinal membrane who are undergoing or have already had pars plana vitrectomy and membrane peel combined with cataract surgery using Clareon Vivity and Clareon Vivity Toric IOLs or monofocal IOL\n* IOL powers between +6D to +30.0D, T3-T6\n\nExclusion Criteria:\n\n* History of ocular or refractive surgery\n* Other ocular or systemic comorbidities that may alter or reduce visual acuity and contrast sensitivity, such as severe dry eye\u002Focular surface disease, glaucoma, macular degeneration, retinopathy, neuro-ophthalmic diseases, strabismus\u002Famblyopia etc.\n* Patients with irregular astigmatism, corneal dystrophies, pupil abnormalities, zonular laxity\n* Intraoperative or postoperative complications",{"count":220,"type":22},36,[25],"To investigate the patient Quality of Life and satisfaction outcomes of combined cataract surgery with retinal surgery for visually significant epiretinal membrane in patients receiving Vivity IOL versus standard monofocal controls.",[28,224],"Epi-retinal Membrane","2025-07-07",{"date":227,"type":34},"2025-07-17",{"date":229,"type":22},"2025-07",{"date":231,"type":22},"2027-07",{"name":233,"class":41},"Debbie Kuo, MD",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":17,"minAge":242,"maxAge":243,"enrollmentInfo":244,"targetDuration":4,"studyType":23,"phases":246,"briefSummary":247,"conditions":248,"keywords":252,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":91},"100596918","head-to-head-comparison-of-five-enhanced-depth-of-focus-iols-and-one-monofocal-iol-100596918","NCT07051720","Head-to-Head Comparison of Five Enhanced Depth of Focus IOLs and One Monofocal IOL","Visual Performance, Patient Satisfaction, and Quality of Vision Outcomes in Presbyopia-Correcting IOLs: A Prospective Clinical Study","AKA-Reports","Inclusion Criteria:\n\n* Bilateral implantation of the same intraocular lens (IOL) model\n* Expected postoperative best-corrected distance visual acuity (BCDVA) of 0.8 (decimal) or better\n* Regular corneal astigmatism less than 1 diopter\n\nExclusion Criteria:\n\n* Endothelial cell density \\\u003C 2,000 cells\u002Fmm²\n* Required IOL power for emmetropia falls outside the available range of +10.0 D to +30.0 D\n* Pupillary abnormalities\n* Intraocular inflammation\n* Recent ocular trauma or ocular surgery that is unresolved\u002Funstable, or which may impair visual outcomes or increase patient risk\n* History of corneal refractive surgery (e.g., LASIK, LASEK, PRK)\n* Irregular astigmatism, as well as corneal abnormalities or opacities\n* Conditions associated with an increased risk of zonular rupture, including capsular or zonular anomalies that may lead to IOL decentration or tilt, such as pseudoexfoliation syndrome, trauma, Marfan syndrome, among others\n* Systemic or ocular diseases, or medications, that may impair vision, increase surgical risk, or confound study outcomes\n* Clinically significant dry eye disease affecting visual function\n* Anticipated need for retinal laser treatment or any other ocular surgical intervention during the study period\n* Pregnancy, planned pregnancy, breastfeeding, or any condition associated with hormonal fluctuations that may induce refractive changes\n* Continuous contact lens wear within the past 4 weeks\n* Inability to understand and\u002For complete study questionnaires\n* Advanced glaucoma with visual field defects\n* Age-related macular degeneration (exudative or geographic form)","22 Years","85 Years",{"count":245,"type":22},180,[25],"Study Goal\n\nThe goal of this clinical trial is to compare how well four different types of artificial lenses (called intraocular lenses or IOLs) help people see after cataract surgery. The main questions it aims to answer are:\n\nWhich lens gives the best vision at different distances (far, middle, and close)? How satisfied are patients with their vision after surgery? How often do patients still need glasses after surgery?\n\nWho Can Participate Adults aged 22 to 85 years who need cataract surgery in both eyes and meet specific health requirements.\n\nStudy Design\n\nResearchers compared six different lens types:\n\nTECNIS Eyhance - designed to improve middle-distance vision AcrySof IQ Vivity - extends the range of clear vision LuxSmart - uses special optics for better depth of focus Rayner EMV - uses gradual light-bending technology for smooth vision transition Eycryl SERT - modifies light focus to extend clear vision range CT ASPHINA 409M - standard single-focus lens (comparison group)\n\nParticipants chose their preferred lens type after learning about each option's benefits and limitations.\n\nWhat Participants Do? Participants will:\n\nHave cataract surgery on both eyes (1-2 weeks apart) Complete vision tests at multiple distances Take contrast sensitivity tests under different lighting conditions Fill out questionnaires about vision quality and daily activities Attend follow-up visits at 1 day, 1 week, 1 month, and 3 months\n\nThis study helps patients and doctors make informed decisions about which type of artificial lens might work best for individual needs and lifestyle.",[28,249,250,251],"IOL Implantation","Presbyopia Correction","Extended Depth of Focus",[253,254,255,256,257,258,259,260,261,262,263,264,265,266],"Cataract surgery","Extended depth-of-focus","EDOF","Intraocular lens","Presbyopia correction","Spectacle independence","Visual outcomes","Patient satisfaction","TECNIS Eyhance","AcrySof IQ Vivity","LuxSmart","CT Asphina","RayOne EMV","Eyecryl SERT","2025-07-01",{"date":269,"type":34},"2025-07-04",{"date":271,"type":34},"2022-04-12",{"date":273,"type":22},"2026-01",{"name":275,"class":41},"Augenklinik Ahaus G + H GmbH & Co. KG"]