[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cataract-bilateral\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cataract-bilateral":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100598664","comparative-study-of-high-frequency-pulsed-vacuum-technology-versus-phacoemulsification-for-cataract-surgery-100598664",false,"NCT07074431","\"Comparative Study of High-frequency Pulsed Vacuum Technology Versus Phacoemulsification for Cataract Surgery","PULSEM","Inclusion Criteria:\n\n* Adult patient\n* Patient with bilateral cataracts\n* Grade 1 to 3 cataracts\n* Indication for bilateral cataract surgery\n* Patient informed of the study and having given their written and signed informed consent\n* Patient affiliated with a social security scheme or beneficiary of such a scheme\n\nExclusion Criteria:\n\n* Refusal of consent\n* Cataract grade \\> 3\n* Unilateral and\u002For combined cataract surgery\n* Uveitic cataract\n* Glaucoma\n* Patient with ocular comorbidity\n* Patient with cognitive impairment preventing them from responding to satisfaction questionnaires\n* Patient unable to read, write, or understand French\n* Pregnant or breastfeeding patient as defined in Article L1121-5 of the French Public Health Code\n* Vulnerable patient as defined in Article L1121-6 of the French Public Health Code\n* Adult patient under guardianship, curatorship, or legal protection\n* Patient unable to give personal consent","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","Cataracts are cloudings of the lens, primarily due to aging. Surgery is the primary treatment for cataracts. The most commonly used surgical technique is phacoemulsification, which involves fragmenting the lens using a high-frequency ultrasound probe and removing the fragments. Phacoemulsification is more common due to its advantages.\n\nRecently, a new approach has emerged, using high-frequency pulsed vacuum technology for cataract ablation. This less invasive approach is expected to allow for faster patient recovery and reduce surgical risks. High-frequency pulsed vacuum utilizes the pulse-pulse principle by interrupting the vacuum every tenth of a second. This interruption creates an impact moment between the cataract material and the cannula tip, dissecting the cataract without damaging the surrounding delicate tissue. High-frequency pulsed vacuum maintains anterior chamber stability while creating sufficient dissection to aspirate the cataract material. This energy also cools the tip, allows for better vacuum control, and significantly reduces turbulence within the eye. More importantly, high-frequency pulsed vacuum disrupts endothelial cells less and causes less edema than mechanical ultrasound.\n\nThis technique therefore appears ideal for treating patients with at-risk corneas (low endothelial cell count, risk of decompensation and corneal transplantation).\n\nThe objective of the study is to demonstrate the benefits of this approach using high-frequency pulsed vacuum technology through a randomized, comparative, crossover study.",[26],"Cataract Bilateral","RECRUITING","2026-03-26",{"date":30,"type":31},"2026-03-31","ACTUAL",{"date":33,"type":31},"2025-12-12",{"date":35,"type":20},"2027-01",{"name":37,"class":38},"Clinique Victor Pauchet","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":39},"100628994","this-clinical-trial-compares-two-phacoemulsification-systems-used-in-a-bilateral-cataract-surgery-subjects-in-order-to-study-cde-and-ultrasound-time-during-cataract-removal-100628994","NCT07468877","This Clinical Trial Compares Two Phacoemulsification Systems Used in a Bilateral Cataract Surgery Subjects in Order to Study CDE and Ultrasound Time During Cataract Removal","Cumulative Dissipated Energy (CDE) and Total Phacoemulsification Energy (Joules) of Unity VCS\u002FCS With 4D Phaco Compared to Centurion System With OZil","CDE","Inclusion Criteria:\n\n* Healthy patients 18 years or older undergoing uncomplicated sequential bilateral cataract surgery with phacoemulsification and IOL implantation\n* Expected to undergo sequential cataract surgery in both eyes\n* Must have bilateral nuclear sclerosis cataracts classified using LOCS III as grade 3 or above (see appendix III)\n* Both eyes will be operated on by the same surgeon\n* Have the ability to consent for study and procedure planned\n\nExclusion Criteria:\n\n* Patients under 18 years of age.\n* Complex cataract cases involving zonulopathy (e.g., pseudoexfoliation syndrome, traumatic zonular weakness) that may require use of zonular support devices during surgery (e.g. capsular hooks) and\u002For implantation of capsular tension rings or other zonular support devices, and in the investigator's judgment, may interfere with the surgical procedure or study outcome measures.\n* Require mechanical pupil expanding devices (e.g., iris hooks, Malyugin rings, etc.)\n* Undergoing femtosecond laser-assisted lens fragmentation.\n* Surgical complications, in the opinion of the investigator, occurring either intraoperatively or postoperatively (including capsule tears, iris trauma, or decentered intraocular lens) and not attributable to the study device or study design.\n* Prior ocular surgery (including intraocular, oculoplastic, corneal or refractive surgical procedure) performed within the last 3 months or at any time that in the investigator's clinical judgment, if it interferes with the outcome measures of this study.\n* Presence of endothelial cell dystrophies and\u002For corneal comorbidities.\n* History of intraocular inflammation (e.g., uveitis, iritis).\n* History of retinal edema or presence of a clinically significant epiretinal membrane that, in the investigator's clinical judgment, may interfere with the outcome measures of this study.\n* History of retinal surgery (e.g.retinal detachment repair, membrane peel) involving vitrectomy.\n* Dense brunescent cataract that in the investigator's clinical judgment, may interfere with the outcome measures of this study.",{"count":49,"type":20},30,[23],"This clinical trial compares two phacoemulsification systems used in a bilateral cataract surgery subjects, in order to study CDE and Ultrasound time during cataract removal",[53,54,26],"Nuclear Sclerosis of the Lens","Phacoemulsification Cataract Surgery",[56,57,58,59,60],"Phacoemolsification","Unity VCS\u002FCS","Centurion","Nuclear Sclerosis of the lens","Cataract","2026-03-16",{"date":63,"type":31},"2026-03-18",{"date":65,"type":31},"2026-02-13",{"date":67,"type":20},"2027-02-13",{"name":69,"class":38},"Nicole Fram M.D.",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":95},"100572768","medico-economic-evaluation-of-immediately-sequential-bilateral-cataract-surgery-compared-with-delayed-sequential-cataract-surgery-in-france-100572768","NCT06737562","Medico-economic Evaluation of Immediately Sequential Bilateral Cataract Surgery Compared With Delayed Sequential Cataract Surgery in France","Medico-economic Evaluation of Immediately Sequential Bilateral Cataract Surgery Compared With Delayed Sequential Cataract Surgery in France: a Multicenter Randomized Controlled Trial","SIMCAT","Inclusion Criteria:\n\n* Age greater than or equal to 18 years\n* Indication for non-combined cataract surgery under local anaesthesia in both eyes\n* Patient scheduled for outpatient cataract surgery\n* Availability of a caregiver\u002Faccompanying person on the day of surgery and for the 1st day post-surgery\n* Resident in France\n* Speak and understand French\n* Consent to participate in the study\n* Affiliated or beneficiary of social security\n\nExclusion Criteria:\n\n* Women of childbearing age\n* Surgery scheduled under general anesthesia or combined with other eye surgeries\n* Ocular tone \\> 24 mm Hg in at least one eye on day of inclusion\n* Presence of risk factors for refractive error :\n\nPresence of keratoconus confirmed by corneal topography Extreme axial eye length (\\\u003C 21 mm or \\> 27 mm) High myopia with posterior staphyloma History of corneal surgery (LASIK, surface laser, radial keratotomy)\n\n\\- Presence of risk factors for endophthalmitis : Ocular, periocular or adnexal infections Immunosuppression Uncontrolled diabetes\n\n* Presence of risk factors for intraoperative complications Ocular, adnexal or anatomical abnormalities History of retinal detachment Lens dislocation or iridodonesis Black cataract or posterior polar cataract History of perforating or blunt ocular trauma\n* Presence of risk factors for corneal edema (e.g. Fuchs' endothelial dystrophy)\n* Presence of vision-related comorbidities (glaucoma, AMD, amblyopia, uveitis, etc.)\n* Presence of diabetes with diabetic retinopathy or macular edema\n* Patient unable to participate in follow-up (e.g., response to questionnaires)\n* Presence of cognitive disorders that could affect the smooth running of surgery or response to questionnaires",{"count":79,"type":20},242,[23],"Cataracts are defined as opacification of all or part of the crystalline lens, resulting in reduced vision. It is a common disease in France, affecting more than one in five people over the age of 65, and almost two in three over the age of 85. Cataract treatment is exclusively surgical. In the case of bilateral cataracts, which account for 70% of cases, Delayed Sequential Bilateral Cataract Surgery (DSBCS), which involves operating on both eyes with an interval of a few weeks, is the reference treatment in France. The practice of DSBCS has long been justified by the need to reduce the risk of post-operative complications, essentially refractive error and bilateral endophthalmitis. Today, thanks to numerous technological advances in cataract surgery and new intraoperative standards, these complications have become exceptional. Since 2009, the International Society of Bilateral Cataract Surgeons (ISBCS) has issued a guide to best practice (the ''ISBCS General Principles for Excellence in ISBCS''), enabling surgery on both eyes to be performed on the same day in complete safety. As a result, Immediate Sequential Bilateral Cataract Surgery (ISBCS), which involves operating on both eyes on the same day, could be performed with no additional risk compared to SDBCS, while providing the same level of postoperative visual acuity. In view of these factors, we hypothesize that CCBIS would be an efficient alternative to DSBCS in cases of bilateral cataract, for the patient and his family, the hospital and the health insurance company. In addition, its adoption would reduce delays in access to treatment, thus promoting better access to care in the situation of growing demand for this treatment, particularly in areas with fewer medical facilities.\n\nThe aim of thisproject is to evaluate the associated costs and quality of life in comparison with CCBSD, based on a prospective, multicenter, randomized controlled trial.",[26,83,84],"Bilateral Cataracts","Bilateral Cataract","2025-12-02",{"date":87,"type":31},"2025-12-03",{"date":89,"type":31},"2025-07-03",{"date":91,"type":20},"2029-07",{"name":93,"class":94},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",4]