[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cataract-surgery-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cataract-surgery-anesthesia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,77,106,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100617946","phase-4-study-of-remimazolam-for-cataract-surgery-100617946",false,"NCT07325227","Study of Remimazolam for Cataract Surgery","Remimazolam for Sedation in Cataract Surgery, A Phase IV, On-label, Blinded Study","Inclusion Criteria:\n\n* Subject is planning to have cataract surgery in both eyes\n* The surgeon estimates that each cataract surgery are estimated to take less than 30 minutes\n* Subject is aged 55 to 90 years old\n* Surgeries will take place on the main campus of Mass Eye and Ear at 243 Charles St., Boston for at least the first year. In the future, surgeries may also occur at Mass Eye and Ear Longwood Surgical Ambulatory Care Center.\n* Subject is able to understand the consent form and sign the consent\n* ASA 1-3 (possible breakdown numbers of 5, 10, 10, 5)\n\nExclusion Criteria • Subject does not speak or read English\n\n* Subject has a history of difficulty with sedation during procedures\n* The surgeon estimates that one of the planned cataract surgeries is estimated to take longer than 30 minutes\n* Subject uses concomitant home narcotic or anxiolytic\n* Subject uses O2\n* Subject has a history of cognitive decline\n* A history of severe hepatic impairment",true,"ALL","55 Years","90 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The goal of this clinical trial is to learn if the use of the sedative remimazolam improves the safety of patients having cataract surgery by decreasing the number of sedation-related complications during and after surgery, and shortening post-surgical cognitive recovery time.",[28],"Cataract Surgery Anesthesia",[30,31],"remimazolam","cataract surgery","NOT_YET_RECRUITING","2026-04-28",{"date":35,"type":36},"2026-04-29","ACTUAL",{"date":33,"type":22},{"date":39,"type":22},"2028-06-01",{"name":41,"class":42},"Fred E, Shapiro","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":43},"100583294","phase-4-an-extension-test-of-whether-to-use-oral-anti-anxiety-drugs-alprazolam-when-patients-choose-second-eye-cataract-surgery-after-unblinding-and-analyze-their-anxiety-satisfaction-and-pain-satisfaction-100583294","NCT06874452","An Extension Test of Whether to Use Oral Anti-anxiety Drugs (Alprazolam) When Patients Choose Second Eye Cataract Surgery After Unblinding, and Analyze Their Anxiety, Satisfaction and Pain Satisfaction","Pain, Anxiety and Anesthetic Satisfaction for Patient With Different State Anxiety Underwent Cataract Surgery With Topical Anesthesia. An Extension Test of Whether to Use Oral Anti-anxiety Drugs (Alprazolam) When Patients Choose Second Eye Cataract Surgery After Unblinding, and Analyze Their Anxiety, Satisfaction and Pain Satisfaction.","Inclusion Criteria:\n\n1. Age between 18 and 80 years old.\n2. Enrolled in \"Anxiety and surgery satisfaction for cataract patient with different state anxiety\" (Research Ethics Committee Case No.: 202302067MINB).\n3. Plan to undergo phacoemulsification and intraocular lens implantation surgery with topical anesthetic on the second eye at the Department of Ophthalmology.\n4. Subject who does not have side effect from XANAX.\n\nExclusion Criteria:\n\n1. Presence of any surgery contraindications.\n2. Presence of any medication contraindications.\n3. Inability to provide clear and complete answers to relevant questionnaires, or expression of no preoperative anxiety during the outpatient visit, or scores below 21 on the STAI-S or STAI-T assessment.\n4. Regular use of anti-anxiety medications, sleeping pills, or analgesics before the procedure.\n5. Pregnancy or breastfeeding during the preoperative period.\n6. Severe corneal diseases, overripe cataracts, small pupils, or lens dislocation leading to difficulties in conventional surgery.\n7. Patients under surface anesthesia who cannot fully cooperate with the surgical procedure.\n8. Pregnant or uncertain pregnancy status (women under 55 years old to be verbally asked by research team members).","18 Years","80 Years",{"count":54,"type":22},250,[25],"Phacoemulsification is one of the most used surgical methods for cataract surgery today, and the surgeries are under the anesthetic and sedative to make it comfortable and safe for patients. The most important issue is which method is the best for reducing the patient's anxiety, pain, and discomfort during surgery. Previous studies have analyzed the impact of intravenous injection of sedative on the quality of phacoemulsification surgery; however, the impact of oral anti-anxiety drugs (Alprazolam) on cataract surgery has not been intensively studied. Therefore, the purpose of this study is to investigate the impact of Alprazolam on satisfaction in cataract surgery. Oral sedation is more convenient and safer than intravenous sedation. Therefore, the investigators will further analyze whether patients using oral anti-anxiety drugs will have an improvement in the pain, anxiety, overall satisfaction, and side effects related to nausea and dizziness in the phacoemulsification surgery. This study will detailed record the patient's status in various aspects using questionnaire scales and scores. Through this research, the investigators will have the opportunity to comprehensively improve the surgical quality of cataract patients in a safe and convenient manner. The investigators plan to collect data from patients who participated in the study \"Anxiety and surgery satisfaction for cataract patient with different state anxiety\" (Research Ethics Committee Case No.: 202302067MINB) from October 2023 to August 2025, and plan to undergo phacoemulsification and intraocular lens implantation surgery in their second eye with local anesthetic at the Department of Ophthalmology, National Taiwan University Hospital. The sample size of 250 participants was determined based on the type of intervention, expected effect size, outcome variability, desired statistical significance, trial power, and experiences from similar studies. Vulnerable populations and those with any relevant contraindications will be excluded during the enrollment process. All medical records and surgical process data, including privacy-related information, will only be accessible to professional medical personnel for analysis. The focus of this study will be on intraoperative satisfaction, pain scores, relevant discomfort symptoms during the surgery, and postoperative anxiety assessment scales.",[58,28,59,60],"Ophthalmology","Oral Anxiolytic","Satisfaction Survey",[62,63,64,65,66],"oral anti-anxiety drugs","oral anxiolytic","ophthalmology","cataract surgery anesthesia","satisfaction survey","RECRUITING","2026-04-21",{"date":70,"type":36},"2026-04-24",{"date":72,"type":36},"2025-03-25",{"date":74,"type":22},"2027-12-31",{"name":76,"class":42},"National Taiwan University Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":105},"100595739","phase-4-the-use-of-sublingual-melatonin-premedication-in-geriatric-cataract-surgery-100595739","NCT07036367","The Use of Sublingual Melatonin Premedication in Geriatric Cataract Surgery","Inclusion Criteria:\n\n* • Age ≥ 60 years\n\n  * American Society of Anesthesiologists (ASA) physical status I-III\n  * Scheduled for unilateral cataract surgery under local anesthesia\n  * Ability to understand and complete study-related questionnaires\n\nExclusion Criteria:\n\n* • Known allergy or hypersensitivity to melatonin\n\n  * Chronic use of sedatives, hypnotics, or anxiolytics\n  * History of sleep disorders or psychiatric illness\n  * Visual or hearing impairment that would hinder communication\n  * Emergency surgery or anticipated intraoperative complications","60 Years",{"count":85,"type":22},60,[25],"Cataract surgery is routinely performed with anesthesia care, whereas anesthesia care for other elective, low-risk, outpatient procedures is applied more selectively. We hypothesize that sublingual melatonin will provide superior anxiolysis and sedation while maintaining a high safety profile and minimizing hemodynamic disturbances.",[28],[90,91,92,93,94,95],"Melatonin","Geriatric","Cataract Surgery","Premedication","Sedation","anxiety","2026-01-04",{"date":98,"type":36},"2026-01-07",{"date":100,"type":36},"2025-09-01",{"date":102,"type":22},"2026-06-15",{"name":104,"class":42},"Al-Azhar University",2,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":43},"100610152","the-impact-of-physiologic-cataract-surgery-on-patient-comfort-and-medication-usage-100610152","NCT07223866","The Impact of Physiologic Cataract Surgery on Patient Comfort and Medication Usage","Inclusion Criteria: Subjects who will require bilateral cataract surgery will be considered. Evaluations will occur in the clinic of the Principal Investigator (PI) Matthew Rauen, MD at the Wolfe Eye Clinic.\n\nInclusion Criteria:\n\n* Visually significant cataract 2-3+ undergoing uncomplicated cataract surgery with similar cataract grade in both eyes\n* Unremarkable ocular health but inclusive of early AMD\n\nExclusion Criteria:\n\n* H\u002Fo ocular surgery including corneal refractive surgery\n* Compromised zonular integrity or stability\n* Uncontrolled diabetes and diabetic retinopathy\n* Small pupils\n* H\u002Fo systemic inflammatory disease\u002Fuveitis\n* H\u002Fo chronic pain medications (including narcotics) and benzodiazepine usage\n* Abnormal liver or renal function",{"count":113,"type":22},85,[115],"NA","The study will pertain to investigating the impact of high vs low IOP on the intraoperative experience and comfort for the patient and surgeon. Our hypothesis is that operating at a more physiological IOP using Unity VCS\u002FCS and Centurion with Active Sentry at a higher, or more traditional IOP will result in significantly less discomfort\u002Fpain as assessed by the decreased need for rescue medication and lower VAS scores.",[118,28,119,120],"Cataract and IOL Surgery","Cataract Surgery Experience","Nuclear Cataract","2025-11-05",{"date":123,"type":36},"2025-11-10",{"date":125,"type":22},"2025-11-01",{"date":127,"type":22},"2027-01-01",{"name":129,"class":42},"Matthew Rauen",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":23,"phases":138,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":149,"leadSponsor":151,"locationsCount":4},"100579263","virtual-reality-and-its-use-in-reducing-perioperative-stress-in-cataract-surgery-100579263","NCT06822023","Virtual Reality and Its Use in Reducing Perioperative Stress in Cataract Surgery","Inclusion Criteria:\n\n1. Patients listed for cataract surgery under local anaesthetic (topical or regional) with sedation planned.\n2. First eye cataract procedures will only be included.\n3. Capacity to give informed consent, cognitive and linguistic ability sufficient to understand and fill out questionnaire\n\nExclusion Criteria:\n\n1. Epilepsy\n2. severe vertigo\n3. poor visual acuity (below 6\u002F60 best corrected in the best seeing eye)\n4. significant hearing impairment\n5. recent facial injury\u002Fburn.",{"count":137,"type":22},75,[115],"This project is to evaluate the benefits of utilising virtual reality (VR) headsets with the aim of reducing peri-operative anxiety in cataract surgery and hence reducing the need for sedation in patients with significant stress levels noted during preassessment. This is a novel study, and with the increased use of VR technology throughout medicine, we may be able to offer our patients alternative management modalities to reduce stress and reduce need for medications with their subsequent potential side effects. It may also improve the quality of care provided and patients' experience with the cataract extraction procedure and might reduce the social care burden associated with standard sedation procedures. All patients will need to fill a quick preoperative anxiety and information scale questionnaire to assess their level of anxiety utilising The Amsterdam Preoperative Anxiety and Information Score.\n\nPatients will be randomised into 2 groups:\n\n1. Conventional group: patients will be prepared as per the standard routine clinical and further explanation of the procedure will be given. Before proceeding to the anaesthetic room, the patients will complete the anxiety score questionnaire again and given the option to proceed with sedation or opt out.\n2. Interventional Group: patients will be prepared as per the standard routine clinical care; they will then be wearing the VR mask for 10 minutes. Before proceeding to the anaesthetic room, patients will complete the anxiety score questionnaire again and given the option to proceed with sedation or opt out.\n\nPost operation, a record will be taken of the surgeon's decision on whether they want the second eye cataract surgery to be done under sedation (this is already standard practice at our centre). Finally, the patient will be asked to fill in one final grading score on whether they are happy with their decision to take\u002Fnot take sedation.",[141,142,28,92],"Virtual Reality","Eye Disease",[144],"cataract surgery, sedation, anxiety, virtual reality","2025-02-06",{"date":147,"type":36},"2025-02-12",{"date":147,"type":22},{"date":150,"type":22},"2025-12-01",{"name":152,"class":42},"South Tyneside and Sunderland NHS Foundation Trust"]