[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"central-nervous-system-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:central-nervous-system-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":4,"leadSponsor":43,"locationsCount":46},"100117414","comprehensive-multimodal-analysis-of-neuroimmunological-diseases-of-the-central-nervous-system-100117414",false,"NCT00794352","Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System","Comprehensive Multimodal Analysis of Patients With Neuroimmunological Diseases of the CNS","* PATIENT INCLUSION CRITERIA (for in-person and telemedicine sub-cohorts):\n\nPresentation with a clinical syndrome consistent with immune-mediated CNS disorder and\u002For\n\nNeuroimaging evidence of inflammatory and\u002For demyelinating\u002Fdysmyelinating CNS disease\n\nAt least 12 years old at the time of enrollment\n\nWilling to share medical records (including past MRI results) with the study team.\n\nAdults: Able to give informed consent on their own or via a Legally Authorized Representative (LAR) or Durable Power of Attorney (DPA); or Minors: parent or legal guardian able to give consent, with child willing to give assent, if reasonable based on their age and assent capacity\n\nFor in-person sub-cohort: Able to undergo the required procedures, including LP, MRI and clinical\u002Ffunctional evaluations\n\nPATIENT EXCLUSION CRITERIA (for in-person and telemedicine sub-cohorts):\n\nSignificant medical condition that would make participation in research part of evaluation impossible or risky\n\nFor in-person sub-cohort: Medical contraindications for MRI (i.e. any non-organic implant or other device such as a cardiac pacemaker or infusion pump or other metallic implants, objects or body piercings that cannot be removed)\n\nUnwilling to consent for collection of biological samples or their cryopreservation\n\nPATIENT INCLUSION CRITERIA for processing of collected biological samples:\n\nPresentation with a clinical syndrome consistent with immune-mediated CNS disorder and\u002For\n\nNeuroimaging evidence of inflammatory and\u002For demyelinating\u002F dysmyelinating CNS disease\n\nAbility to obtain either direct or surrogate informed consent for sample processing and storage\n\nAged 0+ years\n\nHEALTHY VOLUNTEER (in person) INCLUSION CRITERIA:\n\nAt least 18 years old at the time of enrollment\n\nVital signs are found within normal range at the time of the screening visit\n\nAble to give informed consent\n\nAble and willing to undergo related research procedures, such as blood draw, LP\n\nHEALTHY VOLUNTEER (in person) EXCLUSION CRITERIA:\n\nSystemic inflammatory disorder, or inflammatory or non-inflammatory neurological diseases\n\nPrevious or current history of alcohol and substance abuse\n\nMedical contraindications for MRI (i.e. any non-organic implant or other device such as a cardiac pacemaker or infusion pump or other metallic implants, objects or body piercings that cannot be removed)\n\nMedical contraindication for LP\n\nPsychological contraindications for MRI (i.e. claustrophobia). This will be assessed at the time the medical history is collected\n\nPregnancy or current breastfeeding\n\nAny contraindications to having study procedures done\n\nHistory of auditory disorder (i.e. hearing impairment, known impaired acoustic reflex, tinnitus)\n\nHEALTHY VOLUNTEER SUB-STUDY TO OBTAIN NORMATIVE DATA FOR THE SMARTPHONE APPS:\n\nBecause this sub-study collects no personal identifiable information (PII), there are no inclusion\u002Fexclusion criteria. Participating subjects are self-declared as not having any neurological deficit, which would be the same population that would provide normative data if the apps were freely available via App store.",true,"ALL","1 Month","99 Years",{"count":21,"type":22},2400,"ESTIMATED","OBSERVATIONAL","Inflammatory or degenerative diseases of the brain and spinal cord, such as multiple sclerosis, may be related to problems with an individual s immune system. However, more information is needed on the ways in which the cells of the immune system interact with the central nervous system (CNS). This study will compare tests performed on both healthy volunteers and individuals who have signs or symptoms of immune-related damage to their CNS.\n\nThis study will include two groups of subjects at least 12 years old. Subjects will either have symptoms of immune-related CNS damage, or will be healthy volunteers selected for comparison purposes.\n\nStudy participants will visit the NIH Clinical Center on an outpatient basis for an initial evaluation visit. During the visit, patients will provide a comprehensive medical history and undergo a neurological examination, and will provide blood samples for research purposes. The healthy volunteers will be asked to schedule a return visit for a magnetic resonance imaging (MRI) procedure, and may be asked to undergo other tests requested by the study researchers on an as-needed basis. The group of patients with symptoms of immune-related CNS damage will be asked to undergo a series of tests, including the following:\n\n* MRI procedures, with a minimum of three brain MRIs and one spinal cord MRI taken approximately 4 weeks apart\n* A diagnostic lumbar puncture, performed on an outpatient basis\n* Tests of brain and vision activity\n* Additional blood and tissue samples\n\nPatients with symptoms of immune-related CNS damage may be offered the opportunity to participate in additional followup tests with NIH researchers.\n\n...",[26,27],"Central Nervous System Disease","Multiple Sclerosis",[29,27,30,31,32,33,26,34,35],"Inflammation","Neuroimmunology","Immune Disorder","Neuroimaging","Natural History","Healthy Volunteers","HV","RECRUITING","2026-06-27",{"date":39,"type":40},"2026-06-30","ACTUAL",{"date":42,"type":40},"2008-10-01",{"name":44,"class":45},"National Institute of Allergy and Infectious Diseases (NIAID)","NIH",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":72,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":46},"100644654","impact-of-transcutaneous-spinal-stimulation-on-blood-pressure-and-orthostasis-in-spinal-cord-injury-100644654","NCT07674511","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury: Short and Long-Term Effects","(SCI)","Inclusion Criteria:\n\n* Individuals with a SCI ≥ 1 year after injury\n* Injury level ≥ T6 (thoracic level)\n* AIS grade A-C\n* Cardiovascular dysfunction characterized by one or more of the following:\n\n  1. Persistent hypotension (SBP \\\u003C 90mmHg)\n  2. Orthostatic hypotension (OH, a drop of 20\u002F10 mmHg in SBP\u002FDBP within 5 minutes of standing\u002Fupright positioning).\n\nAdditionally, experiencing orthostatic symptoms in daily life and\u002For requiring medication to manage OH.\n\nExclusion Criteria:\n\n* Current illness (e.g., infection, a pressure injury that might interfere with the intervention)\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* History of seizures\n* pregnancy\n* Insufficient mental capacity to understand and independently provide consent\n* Deemed unsuitable by the study physician","18 Years","75 Years",{"count":58,"type":22},10,"INTERVENTIONAL",[61],"NA","The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.\n\nThe main questions this study attempts to solve:\n\n1. What are the immediate effects of spinal cord transcutaneous stimulation on BP?\n2. Does stimulation produce lasting improvements in BP regulation and subsequently, daily function?",[64,65,66,67,68,69,26,70,71],"Spinal Cord Injuries","Hypotension","Orthostatic Hypotension","Spinal Cord Diseases","Cardiovascular Diseases","Trauma, Nervous System","Nervous System Diseases","Blood Pressure",[73,74,75,76,77],"transcutaneous spinal cord stimulation","spinal stimulations","orthostatic hypotension","blood pressure","neuromodulation","NOT_YET_RECRUITING","2026-06-24",{"date":81,"type":40},"2026-06-29",{"date":83,"type":22},"2026-09",{"date":85,"type":22},"2028-12",{"name":87,"class":88},"Kessler Foundation","OTHER",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":59,"phases":99,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":46},"100597273","long-term-brain-stimulation-of-the-motor-ventral-thalamus-vopvim-to-improve-motor-function-100597273","NCT07056348","Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP\u002FVIM) to Improve Motor Function","Chronic Stimulation of the Motor Ventral Thalamus (VOP\u002FVIM) for Motor Control in Humans","Inclusion Criteria:\n\n* Movement disorder patients ≥18 years of age and \\\u003C 80 years of age, who will be implanted with DBS for treatment of motor symptoms.\n* Subject has provided written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization, where applicable, prior to any study-related procedures.\n\nExclusion Criteria:\n\n* History of seizure disorders\n* Vasovagal response history and loss of consciousness history\n* Severe behavioral or cognitive problems that preclude participation in the study, in the opinion of the investigator would impact participation in the study.\n* Any serious disease or disorder (e.g. cancer, severe cardiac or respiratory disease, neurological conditions other than current movement disorder) or cognitive impairments that could impair ability to participate in this study.\n* Females who are pregnant or breastfeeding.","80 Years",{"count":98,"type":22},60,[61],"This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without stimulation. DBS parameters would be adjusted prior to motor testing. Patients would then participate in multiple sessions performing contralateral upper extremity movement tasks measuring movement speed, grip strength, and strength modulation, facial movement, swallowing, and speech tasks.",[102,103,104,105,26,106,107],"Traumatic Brain Injury","Stroke","Brain Disease","Movement Disorders (Incl Parkinsonism)","Essential Tremor, Movement Disorders","Essential Tremor of Voice","2025-12-08",{"date":110,"type":40},"2025-12-16",{"date":112,"type":40},"2022-05-10",{"date":114,"type":22},"2030-12-31",{"name":116,"class":88},"Jorge Gonzalez-Martinez"]