[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"central-respiratory-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:central-respiratory-depression":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100548693","exploration-of-mechanisms-for-weaning-failure-100548693",false,"NCT06424314","Exploration of Mechanisms for Weaning Failure","Changes in Respiratory Mechanics in Patients With Failed Ventilator Withdrawal","Inclusion Criteria:\n\n* Invasive mechanical ventilation for at least 48 hours\n\nExclusion Criteria:\n\n* neuromuscular disease；Postoperative patients or patients with traumatic brain injury",true,"ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT).\n\nThe participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .",[25,26,27,28],"Weaning Failure","Central Respiratory Depression","Diaphragm Injury","Phrenic Nerve Disorder","RECRUITING","2024-07-08",{"date":32,"type":33},"2024-07-09","ACTUAL",{"date":32,"type":33},{"date":36,"type":21},"2025-12-01",{"name":38,"class":39},"The First Affiliated Hospital of Guangzhou Medical University","OTHER"]