[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"central-sensitisation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:central-sensitisation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,47,71,97,120,141,161,186,210,242,274,300,322],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100620521","sedentary-status-and-multidimensional-outcomes-in-fibromyalgia-100620521",false,"NCT07358702","Sedentary Status and Multidimensional Outcomes in Fibromyalgia","Comparison of Body Awareness, Respiratory Muscle Strength, Kinesiophobia, Central Sensitization, Functional Status and Sleep Quality in Sedentary and Non-Sedentary Fibromyalgia Individuals","Inclusion Criteria - Sedentary Fibromyalgia Participants\n\n* Physical activity level below 600 MET-min\u002Fweek according to the International Physical Activity Questionnaire (IPAQ)\n* Diagnosis of fibromyalgia according to the 2016 ACR criteria\n* Age between 18 and 65 years\n* Ability to understand and respond to study assessments\n\nExclusion Criteria - Sedentary Fibromyalgia Participants\n\n* Conditions posing risk during assessments, including unstable angina, decompensated heart failure, or myocardial infarction within the past month\n* Uncontrolled diabetes, hypertension \\>180\u002F110 mmHg, and\u002For severe neuropathy\n* Diagnosed severe cognitive impairment\n* Pregnancy or suspected pregnancy Inclusion Criteria - Non-Sedentary Fibromyalgia Participants\n* Physical activity level above 600 MET-min\u002Fweek according to the IPAQ\n* Diagnosis of fibromyalgia according to the 2016 ACR criteria\n* Age between 18 and 65 years\n* Ability to understand and respond to study assessments\n\nExclusion Criteria - Non-Sedentary Fibromyalgia Participants\n\n* Conditions posing risk during assessments, including unstable angina, decompensated heart failure, or myocardial infarction within the past month\n* Uncontrolled diabetes, hypertension \\>180\u002F110 mmHg, and\u002For severe neuropathy\n* Diagnosed severe cognitive impairment\n* Pregnancy or suspected pregnancy","ALL","18 Years","65 Years",{"count":20,"type":21},66,"ESTIMATED","INTERVENTIONAL",[24],"NA","Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and functional limitations. Pain, fatigue, and fear of movement often lead individuals with FMS to adopt sedentary behaviors, which may further exacerbate symptoms and reduce physical capacity. Factors such as impaired body awareness, reduced respiratory muscle strength, kinesiophobia, central sensitization, poor functional status, and sleep disturbances play an important role in disease severity and quality of life in individuals with FMS.\n\nAlthough physical inactivity is common in fibromyalgia, limited evidence exists regarding the differences in these multidimensional clinical parameters between sedentary and non-sedentary individuals with FMS. Therefore, the aim of this study is to compare body awareness, respiratory muscle strength, kinesiophobia, central sensitization, functional status, and sleep quality between sedentary and non-sedentary individuals diagnosed with fibromyalgia syndrome. The findings of this study may contribute to a better understanding of the impact of sedentary behavior on clinical outcomes in fibromyalgia and help guide more comprehensive and individualized rehabilitation approaches.",[27,28,29,30],"Fibromyalgia","Sedentary Behavior","Kinesiophobia","Central Sensitisation",[32,28,33],"Fibromyalgia Syndrome","Functional Status","NOT_YET_RECRUITING","2026-02-04",{"date":37,"type":38},"2026-02-06","ACTUAL",{"date":40,"type":21},"2026-05-15",{"date":42,"type":21},"2027-01-15",{"name":44,"class":45},"Izmir Democracy University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":46},"100590438","comparison-of-pain-sensitisation-function-and-quality-of-life-according-to-stenosis-degree-in-chronic-neck-pain-100590438","NCT06967415","Comparison of Pain, Sensitisation, Function and Quality of Life According to Stenosis Degree in Chronic Neck Pain","Comparison of Pain, Central Sensitisation, Functional Status and Quality of Life According to Stenosis Degree in Individuals With Chronic Neck Pain","Inclusion Criteria:\n\n* Cases whose stenosis classification can be clearly determined on MRI\n* Individuals with neck pain for at least 3 months\n\nExclusion Criteria:\n\n* Individuals who did not agree to participate in the study\n* Individuals undergoing cervical surgery\n* Individuals with pain so severe that they cannot perform cervical movement\n* Individuals with a diagnosis of vertigo\n* Individuals with sudden hearing loss\n* Individuals with additional neurological disorders\n* Individuals with psychiatric and cognitive disorders that would prevent measurement in the study",true,{"count":56,"type":21},88,[24],"The cervical spine is a structure that bears the weight of the head and has important functions, but is susceptible to mechanical stress and degenerative processes. Cervical stenosis can lead to compression of the nerve roots as a result of narrowing of the spinal canal and symptoms such as pain, numbness and weakness. Central sensitisation (CS) causes even innocuous stimuli to cause pain due to hypersensitivity of the central nervous system and negatively affects the quality of life by increasing pain intensity in individuals with chronic neck pain. Progression of cervical stenosis can lead to symptoms such as walking difficulties, loss of balance and loss of proprioception. Furthermore, CS causes patients to avoid physical activity, increasing muscle weakness and pain, which further reduces quality of life. For this reason, our study will be carried out to determine the effect of cervical stenosis on patients with neck pain whom applied to Izmir Democracy University Physical Medicine and Rehabilitation outpatient clinic and had cervical MRI. Participants' pain status, central sensitisation, sensory loss, range of motion and proprioception will be recorded. Pressure pain threshold will be measured with algometer, sensory loss will be examined with Semmes-Weinstein Monofilament (SWM) Test, joint movements and proprioception will be evaluated with Pa CROM Basic device. In addition, the effects of cervical stenosis on functional status and quality of life will be measured by questionnaires. The data obtained will be compared and analysed with appropriate statistical methods. This study is aimed to contribute to the development of treatment methods and improvement of patient care, and will provide important information in terms of pain management and improvement of quality of life.",[30,60],"Cervical Spine Stenosis",[62],"chronic neck pain","2025-12-30",{"date":65,"type":38},"2026-01-05",{"date":67,"type":21},"2025-12-15",{"date":69,"type":21},"2026-08-15",{"name":44,"class":45},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":46},"100601388","effect-of-boswellia-serrata-on-pain-intensity-central-and-peripheral-sensitization-and-pain-modulation-in-healthy-volunteers-100601388","NCT07109843","Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers","Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers - a Randomized, Double-blind, Placebo-controlled, Cross-over Pilot Trial","BSPP","Inclusion Criteria:\n\n* Age: ≥18 years\n\nExclusion Criteria:\n\n* Not pregnant or breastfeeding\n* No renal or liver insufficiency\n* No neurological\u002Fdermatological\u002Fcardiovascular diseases\n* No chronic pain and\u002For use of analgesics\n* No use of anticoagulants\n* No use of antidepressants\n* No use of MAO inhibitors\n* No use of St. John's Wort\n* No use of medications affecting the CYP mechanism\n* No allergies to Boswellia serrata or capsaicin\"",{"count":80,"type":21},12,[24],"This planned study is based on a randomized, placebo-controlled cross-over design.\n\nBoswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian Ayurvedic medicine system as antioxidants and anti-inflammatory agents for treating conditions such as rheumatoid arthritis, chronic bronchitis, asthma, and chronic inflammatory bowel diseases (ulcerative colitis and Crohn's disease). The β-configured pentacyclic triterpenic acids in B. serrata include 3-acetyl-11-keto-β-boswellic acid (AKBBA), 11-keto-β-boswellic acid (KBBA), β-boswellic acid (BBA), and 3-acetyl-β-boswellic acid (ABBA). These compounds, which constitute approximately 14% of the lipophilic fractions of the B. serrata extract, are the major active components. Boswellia serrata is marketed as a food supplement in accordance with EU Directive 2002\u002F46\u002FEC. Several clinical studies have examined the efficacy of B. serrata in chronic pain conditions.\n\nThe data suggest a clinical analgesic efficacy, without, however, allowing conclusions about the underlying mechanisms. These have not yet been investigated in a human experimental pain model. The aim of the study is to investigate the influence of Boswellia serrata in peripheral and central sensitization, as well as descending inhibitory pathways by Quantitative Sensory Testing (QST). These findings are of great relevance for a better understanding of clinical efficacy.\n\nThe 'Capsaicin Pain Model' is a validated method for inducing short-term peripheral and central sensitization. As a non-invasive human pain model, it is therefore well suited for investigating the analgesic and anti-hyperalgesic effects of drugs.\n\nFurthermore, the influence of Boswellia serrata on mood (depression, anxiety), sleep quality and psychological well-being will be investigated by using the psychological questionnaires Becks-Depression-Inventory, Becks-Anxiety-Inventory, Pittsburgh Sleep Quality Index and World Health Organization Well-Being Index (BDI-II, BAI, PSQI and WHO5) as secondary target variables.",[84,30,85,86],"Chronic Pain","Peripheral Sensitization","Neuroinflammatory Response","RECRUITING","2025-09-23",{"date":90,"type":38},"2025-09-24",{"date":92,"type":38},"2025-09-01",{"date":94,"type":21},"2025-12-31",{"name":96,"class":45},"Medical University of Graz",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":104,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":46},"100589014","relationship-between-central-sensitization-symptoms-and-cognitive-dysfunction-in-fibromyalgia-100589014","NCT06948903","Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Fibromyalgia","Investigation of the Relationship Between Central Sensitization Symptoms and Cognitive Dysfunction in Patients With Fibromyalgia","Inclusion Criteria:\n\n* Being diagnosed with fibromyalgia according to American College of Rheumatology 2016 criteria\n* Being between 18-65 years old\n* Being literate\n* Accepting to participate in the study\n\nExclusion Criteria:\n\n* Concomitant systemic inflammatory disease, central nervous system disease (cortical involvement), active infection and malignancy history\n* History of illness that may lead to cognitive impairment\n* Being \\\u003C18 and \\>65 years old\n* Being illiterate\n* Not accepting to participate in the study",{"count":105,"type":21},100,"OBSERVATIONAL","The aim of the study is to investigate the relationship between central sensitization parameters and cognitive dysfunction in patients with fibromyalgia.The main questions it aims to answer are:\n\nDo central sensitization symptoms affect cognitive dysfunction in patients with fibromyalgia? To what extent do central sensitization symptoms affect objective and subjective cognitive complaints in fibromyalgia patients? How do cognitive complaints relate to other clinical parameters, including disease severity, in these patients?",[27,109,30],"Cognitive Dysfunction",[27,109,30],"2025-09-05",{"date":113,"type":38},"2025-09-12",{"date":115,"type":38},"2023-01-10",{"date":117,"type":21},"2025-10-01",{"name":119,"class":45},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":127,"minAge":17,"maxAge":18,"enrollmentInfo":128,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":135,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":46},"100581498","investigation-of-the-relationship-between-central-sensitization-and-balance-in-fibromyalgia-100581498","NCT06851091","Investigation of the Relationship Between Central Sensitization and Balance in Fibromyalgia","Investigation of the Relationship Between Central Sensitization Parameters and Balance Changes in Patients With Fibromyalgia","Inclusion Criteria:\n\n* Diagnosis of FMS according to the ACR 2016 diagnostic criteria\n* Being between the ages of 18 and 65\n* Being literate\n* Providing informed consent by signing the voluntary consent form\n\nExclusion Criteria:\n\n* Being under 18 years old or over 65 years old\n* Presence of vestibular disorders\n* Having undergone spinal and\u002For extremity surgery (such as for back\u002Fhip\u002Fknee\u002Ffoot) within the last 6 months\n* History of lower extremity amputation\n* Presence of spinal deformities\n* Peripheral arterial disease\n* Vitamin B12 deficiency\n* Any neurological disorder (e.g., stroke, traumatic brain injury, multiple sclerosis, Parkinson's disease, central nervous system malignancies, etc.)\n* Severe cardiopulmonary insufficiency (stage 3-4)\n* Uncontrolled systemic diseases such as hypertension and diabetes\n* Presence of systemic inflammatory diseases, malignancies, or active infections\n* Pregnancy","FEMALE",{"count":129,"type":21},75,"The aim of the study is to investigate the relationship between central sensitization parameters and changes in static and dynamic balance in patients with fibromyalgia.\n\nThe main questions it aims to answer are:\n\n* Do central sensitization parameters differ in patients with fibromyalgia compared to healthy individuals?\n* How is balance performance in these individuals compared to healthy controls?\n* Do central sensitization parameters affect static and dynamic balance in patients with fibromyalgia?\n* Do central sensitization parameters lead to quantitative changes in balance in patients with fibromyalgia?",[32,30,132],"Postural Balance",[27,30,134,132],"Balance Changes",{"date":113,"type":38},{"date":137,"type":38},"2025-02-18",{"date":139,"type":21},"2025-12",{"name":119,"class":45},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":148,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":160,"locationsCount":46},"100575311","investigation-of-central-sensitization-and-associated-factors-in-patients-with-lipedema-100575311","NCT06770634","Investigation of Central Sensitization and Associated Factors in Patients With Lipedema","Investigation of the Prevalence of Central Sensitization and Associated Factors in Patients With Lipedema","Inclusion Criteria:\n\n1. Lipedema; Diagnosis of lipedema Aged between 18 and 65 years Literate Willing to participate in the study\n2. control group; Being completely healthy (no internal\u002Fmetabolic issues such as diabetes, obesity, or hypothyroidism, and no diagnosis of lipedema) BMI ≤ 30 Aged between 18 and 65 years Literate Willing to participate in the study\n\nExclusion Criteria:\n\n1. Lipedema group; Under 18 or over 65 years of age Presence of concurrent lymphedema, chronic venous insufficiency, deep vein thrombosis, polyneuropathy, or fibromyalgia Illiterate Not willing to participate in the study\n2. Control group; Under 18 or over 65 years of age Presence of concurrent lymphedema, chronic venous insufficiency, deep vein thrombosis, polyneuropathy, fibromyalgia, systemic rheumatic diseases, active cancer, infections, or pregnancy Illiterate Not willing to participate in the study",{"count":149,"type":21},50,"This study aims to investigate the presence of central sensitization and its associated parameters in patients with lipedema. Lipedema is a chronic and hereditary condition that primarily affects the lower extremities in women and is often associated with hormonal changes. Symptoms such as pain, swelling, and tenderness are common in lipedema, and these symptoms may be related to central sensitization. Additionally, the ultrasonographic findings and pain sensitivity in lipedema will be compared with those of healthy individuals. This study seeks to contribute to the diagnosis and treatment process of lipedema.",[152,30],"Lipedema",[154,152],"central sensitization",{"date":156,"type":38},"2025-09-08",{"date":158,"type":38},"2024-12-06",{"date":63,"type":21},{"name":119,"class":45},{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":168,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":170,"conditions":171,"keywords":174,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":46},"100601778","symptom-distribution-and-pain-sensitization-in-carpal-tunnel-syndrome-100601778","NCT07114913","Symptom Distribution and Pain Sensitization in Carpal Tunnel Syndrome","Evaluation of Central Sensitization Parameters Based on Extra Median Symptom Distribution in Carpal Tunnel Syndrome: A Cross-sectional Study","Inclusion Criteria:\n\n* Having been diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings\n* Being between 18 and 65 years of age\n* Being literate\n* Agreeing to participate in the study\n\nExclusion Criteria:\n\n* Having a history of concomitant diabetes, systemic inflammatory disease, active infection, or malignancy\n* Being \\\u003C18 and \\>65 years of age\n* Being illiterate\n* Refusing to participate in the study\n* Having a disease associated with neuropathic pain, such as polyneuropathy, radiculopathy, or multiple sclerosis\n* History of injection or surgery for CTS within the last 6 months",{"count":169,"type":21},80,"This study aims to compare central sensitization parameters between carpal tunnel syndrome (CTS) patients with extra median symptom distribution and those with typical, median nerve-related symptoms. Extra median sensory spread, observed in some CTS patients beyond the anatomical boundaries of the median nerve, may reflect central sensitization mechanisms. Using the Central Sensitization Inventory and pressure pain threshold measurements, this study will assess whether extra median symptom patterns are associated with increased central sensitization.",[172,30,173],"Carpal Tunnel Syndrome","Pain, Radiating",[175,154,176,177],"carpal tunnel syndrome","central sensitization inventory","pressure pain threshold","2025-08-06",{"date":180,"type":38},"2025-08-11",{"date":182,"type":38},"2025-06-21",{"date":184,"type":21},"2026-03-01",{"name":119,"class":45},{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":22,"phases":196,"briefSummary":197,"conditions":198,"keywords":199,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":207,"leadSponsor":209,"locationsCount":46},"100584781","the-effect-of-griffonia-simplicifolia-on-pain-intensity-central-and-peripheral-sensitization-painmodulation-in-healthy-volunteers-100584781","NCT06893822","The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers","The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers - A Randomized, Double-blinded, Placebo-controlled, Cross-over Study","Exclusion Criteria:\n\n* pregnancy or breastfeeding.\n* renal or hepatic insufficiency\n* neurological\u002Fdermatological\u002Fcardiovascular diseases\n* chronic pain and\u002For use of analgesics\n* intake of antidepressants\n* intake of MAO inhibitors\n* intake of sleep medication\n* intake of St. John's wort\n* allergy to Griffonia simplicifolia","99 Years",{"count":195,"type":21},20,[24],"This planned study is based on a randomized, placebo-controlled cross-over design.\n\nGriffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid. 5-HTP can cross the blood-brain barrier and is converted to serotonin. Low serotonin levels are associated with depression, anxiety disorders and sleep disorders, among others. Griffonia simplicifolia is marketed as a food supplement in accordance with EU Directive 2002\u002F46\u002FEC. Several clinical studies have examined the efficacy of 5-HTP in chronic pain conditions.\n\nThe data suggest a clinical analgesic efficacy, without, however, allowing conclusions about the underlying mechanisms. These have not yet been investigated in a human experimental pain model. The aim of the study is to investigate the influence of 5-HTP in peripheral and central sensitization, as well as descending inhibitory pathways by Quantitative Sensory Testing (QST). These findings are of great relevance for a better understanding of clinical efficacy.\n\nFor this purpose, \"repetitive phasic heat application\" is a validated method for achieving short-term peripheral and central sensitization. As a non-invasive human pain model, it is therefore well suited for investigating the analgesic and anti-hyperalgesic effects of drugs.\n\nFurthermore, the influence of Griffonia simplicifolia on mood (depression, anxiety), memory, sleep quality and psychological well-being will be investigated by using psychological questionnaires as secondary target variables.",[84,30,85,86],[200,201,202,30],"Griffonia simplicifolia","5-HTP","Peripheral Sensitisation","2025-06-12",{"date":205,"type":38},"2025-06-17",{"date":113,"type":21},{"date":208,"type":21},"2025-12-20",{"name":96,"class":45},{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":54,"sex":127,"minAge":218,"maxAge":219,"enrollmentInfo":220,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":222,"conditions":223,"keywords":226,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":46},"100363639","evaluation-of-central-sensitization-fear-avoidance-and-pain-pressure-threshold-with-chronic-pain-after-hysterectomy-100363639","NCT04014829","Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy","Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain in Post-Hysterectomy Patients: A Collaborative Cohort Study (EPOCH - Enhancing Post-operative Outcomes in Chronic Pain After Hysterectomy)","EPOCH","Inclusion Criteria:\n\n* Age 21 to 80 years old\n* American Society of Anesthesiologists Physical Scale (ASA) I to III\n* Benign gynaecological indications for hysterectomy\n* Elective abdominal or laparoscopic hysterectomy\n\nExclusion Criteria:\n\n* Vaginal hysterectomy\n* Uterine prolapse, endometriosis, malignant disease, or pelvic pain as main indication for surgery\n* History of drug dependence or recreational drug use\n* History of chronic pain syndrome\n* Current chronic daily treatment with corticosteroids, excluding inhaled steroids\n* Allergy to study drugs\n* Major heart surgery\n* Heart transplant\n* Pacemaker inserted\n* Baseline non-sinus cardiac rhythm","21 Years","80 Years",{"count":221,"type":21},436,"Phase 1 (started in July 2019):\n\nCentral Sensitization Inventory (CSI), Fear-Avoidance Components Scale (FACS), pain-pressure threshold are factors associated with chronic post-hysterectomy pain (CPHP), but a complete understanding on the development of CPHP is lacking. The study aims to identify clinically-relevant factors for CPHP that can be reliably assessed preoperatively.\n\n===\n\nPhase 2 (anticipated start May 2022):\n\nIn addition to above factors, the association between heart rate variability (HRV) parameters, anxiety level, anticipated pain, and anticipated analgesia requirement with significant postoperative pain and CPHP will be investigated.",[224,84,30,225],"Hysterectomy","Anxiety Depression",[224,84,227,228,229,230,231],"Fear-Avoidance","Central Sensitization","Pain-Pressure Threshold","Mechanical Temporal Summation","Heart rate variability","2024-11-24",{"date":234,"type":38},"2024-11-26",{"date":236,"type":38},"2019-07-23",{"date":238,"type":21},"2027-12",{"name":240,"class":241},"KK Women's and Children's Hospital","OTHER_GOV",{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":127,"minAge":17,"maxAge":249,"enrollmentInfo":250,"targetDuration":4,"studyType":22,"phases":252,"briefSummary":253,"conditions":254,"keywords":259,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":46},"100553904","myofascial-release-technique-in-women-with-primary-dysmenorrhea-100553904","NCT06492148","Myofascial Release Technique in Women With Primary Dysmenorrhea","Effect of Myofascial Release Technique on Central Sensitization, Myofascial Trigger Point and Menstrual Symptoms in Women With Primary Dysmenorrhea: Sham-Controlled, Randomized Double-Blind Study","Inclusion Criteria:\n\n* Diagnosed with Primary Dysmenorrhea according to the Primary Dysmenorrhea Consensus Guide,\n* Having regular menstruation in the last 6 months (28±7 days)\n* Those who had menstrual pain between 40 mm and 100 mm according to the Visual Analogue Scale (VAS) in the last 6 months\n\nExclusion Criteria:\n\n* Diagnosed with Secondary Dysmenorrhea,\n* Having given birth,\n* Those with serious gastrointestinal, urogynecological, or autoimmune diseases or other chronic pain syndromes,\n* Undergoing urogynecological surgery,\n* Those who are pregnant or suspected of pregnancy,\n* Those who use analgesics or non-pharmacological agents other than NSAIDs for menstrual pain,\n* Those using intrauterine or oral contraceptives,\n* Those taking extra supplements such as magnesium, which may affect treatment","35 Years",{"count":251,"type":21},36,[24],"It has been found that women with dysmenorrhea have active trigger points, particularly in the rectus abdominis, oblique abdominal muscles, quadratus lumborum, and paraspinal muscles. The myofascial release technique is a widely used manual therapy method characterized by the application of low-load, long-duration mechanical forces to manipulate the myofascial complex. This technique aims to restore optimal length, alleviate pain, and improve function. This study aims to examine the effect of the myofascial release technique on central sensitization, myofascial trigger points, and menstrual symptoms in women with primary dysmenorrhea.",[255,30,256,257,258],"Dysmenorrhea Primary","Myofascial Trigger Point Pain","Menstrual Discomfort","Myofascial Release",[260,261,262,263,264],"myofascial release","trigger point","Central sensitization","Dysmenorrhea","sham","2024-11-19",{"date":267,"type":38},"2024-11-21",{"date":269,"type":38},"2024-09-10",{"date":271,"type":21},"2025-09-25",{"name":273,"class":45},"Gazi University",{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":54,"sex":16,"minAge":281,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":22,"phases":285,"briefSummary":287,"conditions":288,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":4},"100544370","phase-4-effect-of-pregabalin-on-shoulder-pain-in-patients-with-central-sensitization-after-arthroscopic-rotator-cuff-repair-100544370","NCT06367998","Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair","The Effect of Pregabalin on Shoulder Pain of Patients With Myofascial Pain Syndrome and Central Sensitization Who Undergo Arthroscopic Rotator Cuff Repair","Inclusion Criteria:\n\n* Age over 19 to under 70\n* Underwent arthroscopic rotator cuff repair due to a tear of the rotator cuff.\n* Clinical diagnosis of myofascial pain syndrome\n* Central sensitization (Central Sensitization Inventory (CSI) score of 40 or above).\n\nExclusion Criteria:\n\n* Previous history of Pregabalin prescription\n* Hypersensitivity reactions or severe complications after taking Pregabalin.\n* Diagnosed with and are being treated for psychiatric disorders\n* Localized infection, sepsis, or previous neurological abnormalities\n* Uncontrolled hypertension (evidenced by a resting blood pressure of more than 100 mmHg)\n* Liver function abnormalities (aspartate aminotransferase or alanine aminotransferase \\>60 IU\u002Flitre).\n* major cardiovascular diseases or renal impairments","20 Years","69 Years",{"count":284,"type":21},76,[286],"PHASE4","This study aims to investigate the effects of Pregabalin intake on shoulder pain management in patients with central sensitization undergoing arthroscopic rotator cuff repair. Although Pregabalin is known to be effective in controlling pain after shoulder arthroscopy, research on its efficacy in pain management for patients with central sensitization is scarce. Utilizing a list that identifies central sensitization, this study will explore whether Pregabalin can reduce postoperative pain in these patients and potentially improve joint mobility, emotional, and physical functioning. A prospective randomized study is planned, with inclusion criteria set for patients aged between 19 and 70 who have undergone arthroscopic rotator cuff repair.\n\nThe study will compare clinical outcomes up to one year postoperatively between two groups of 38 patients each. The case group will receive standard postoperative medications (NSAIDs) plus Pregabalin oral intake from the day before surgery to six weeks postoperatively, while the control group will receive only the standard postoperative medications without Pregabalin.",[289,30,290],"Rotator Cuff Tears","Neuropathic Pain","2024-08-21",{"date":293,"type":38},"2024-08-23",{"date":295,"type":21},"2024-09-01",{"date":297,"type":21},"2026-05-01",{"name":299,"class":45},"The Catholic University of Korea",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":11,"sex":16,"minAge":306,"maxAge":307,"enrollmentInfo":308,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":309,"conditions":310,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":4},"100558592","evaluation-of-the-effect-of-central-sensitivity-on-pain-and-functional-status-after-total-knee-joint-replacement-surgery-100558592","NCT06553118","Evaluation of the Effect of Central Sensitivity on Pain and Functional Status After Total Knee Joint Replacement Surgery","Inclusion Criteria:\n\n* Diagnosis of primary knee osteoarthritis\n* Planning for total joint replacement surgery for the knee\n* Being between the ages of 60-75\n\nExclusion Criteria:\n\n* Having secondary knee osteoarthritis\n* Planning for knee total joint prosthesis revision\n* Having uncontrolled systemic disease (such as diabetes mellitus, hypertension, thyroid disease)\n* Having neuromuscular disease\n* Having a body mass index over 40","60 Years","75 Years",{"count":169,"type":21},"The study is a prospective observational study designed to determine the effects of central sensitization on pain and functional status of patients before and after total knee joint replacement surgery.\n\nThe aim of this study is to evaluate whether there is a difference in preoperative and postoperative pain and functional status between patients with and without central sensitization with knee osteoarthritis.\n\nWhen the literature was reviewed, it was seen that central sensitization was one of the important mechanisms that caused pain in knee osteoarthritis, and it was determined that this had negative consequences in terms of postoperative pain and improvement in functional status. In this study, the effect of central sensitization on the results will be investigated by evaluating pain and functional status before and after knee total joint prosthesis in two groups of knee osteoarthritis patients, with and without central sensitization, and by comparing the groups.",[30,311,312],"Postoperative Pain","Arthritis","2024-08-13",{"date":315,"type":38},"2024-08-15",{"date":317,"type":21},"2024-08-12",{"date":319,"type":21},"2026-02-12",{"name":321,"class":45},"Istanbul University",{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":106,"phases":4,"briefSummary":331,"conditions":332,"keywords":333,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":340,"leadSponsor":342,"locationsCount":46},"100553386","investigating-the-association-between-central-sensitization-and-breathing-pattern-disorders-100553386","NCT06485414","Investigating the Association Between Central Sensitization and Breathing Pattern Disorders","Investigating the Association Between Central Sensitization and Breathing Pattern Disorders : A STROBE-compliant Cross-sectional Study","Inclusion Criteria:\n\n* Adults aged 18 and above.\n* Individuals scoring 40 or above on the Central Sensitization Inventory for Koreans (CSI-K).\n* Individuals who consent to the use and publication of their personal information and wish to participate in assessment measurements.\n\nExclusion Criteria:\n\n* Individuals with pulmonary, cardiac, or respiratory diseases.\n* Individuals with severe hypertension, defined as systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 100 mmHg.\n* Individuals with cognitive impairments.\n* Individuals who express a desire to withdraw from the study during its duration.",{"count":330,"type":21},40,"Breathing pattern disorders can cause mechanical, physiological, and psychological issues in the body, contributing to the initiation and chronicity of pain. Therefore, considering breathing patterns is significant in managing chronic pain, yet direct research on central sensitization and breathing pattern disorders remains scant. This study aims to analyze the correlation between central sensitization and breathing pattern disorders in adults by assessing both respiration and pain.",[30],[154,334,335],"breathing pattern disorders","chronic pain","2024-06-29",{"date":338,"type":38},"2024-07-03",{"date":338,"type":21},{"date":341,"type":21},"2024-08-31",{"name":343,"class":45},"Sahmyook University"]