[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"central-venous-catheter\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:central-venous-catheter":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,53,83,107,135,163,197,223],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100053238","medical-adhesive-and-barrier-products-for-preventing-marsi-in-central-venous-catheter-dressings-100053238",false,"NCT07697430","Medical Adhesive and Barrier Products for Preventing MARSI in Central Venous Catheter Dressings","Effect of Medical Adhesive and Skin Barrier Products Used for Central Venous Catheter Dressings on the Development of Medical Adhesive-Related Skin Injury: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older. Patients admitted to the Chest Diseases Intensive Care Unit who are undergoing insertion of an internal jugular central venous catheter.\n\nCentral venous catheter inserted by a physician using sterile technique in the intensive care unit or operating room.\n\nIntact skin at the catheter insertion site, with no pre-existing skin injury or dermatological disease.\n\nWritten informed consent provided by the participant or a legally authorized representative.\n\nExclusion Criteria:\n\n* Active or congenital dermatological disease. Known allergy or hypersensitivity to the study dressings or skin barrier film. Clinically significant hyperhidrosis. Central venous catheter inserted through a site other than the internal jugular vein (e.g., subclavian or femoral vein).\n\nPatients requiring contact isolation (e.g., scabies) or airborne isolation (e.g., tuberculosis).","ALL","18 Years",{"count":19,"type":20},162,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to compare three different dressing securement strategies used for central venous catheters (CVCs) to determine which is more effective in preventing medical adhesive-related skin injury (MARSI) among adults admitted to a Chest Diseases Intensive Care Unit.\n\nThe main questions it aims to answer are:\n\nDoes the type of dressing securement affect the occurrence of MARSI? Which dressing securement strategy is most effective in preventing CVC-related MARSI?\n\nResearchers will compare:\n\nacrylic adhesive tape, silicone adhesive tape, and barrier film combined with acrylic adhesive tape to determine which dressing securement strategy provides the best protection against CVC-related MARSI.\n\nParticipants will:\n\nbe randomly assigned to one of the three dressing securement strategies, receive the assigned dressing securement throughout the study period, undergo regular skin assessments for signs of MARSI, and be followed for up to 21 days or until catheter removal.",[26,27],"Medical Adhesive Related Skin Injury","Central Venous Catheter",[29,26,27,30,31,32,33,34,35,36,37,38,39],"MARSI","Central Venous Catheter Dressing","Acrylic Adhesive Tape","Silicone Adhesive Tape","Barrier Film","Intensive Care Unit","Nursing","Skin Injury","Randomized Controlled Trial","medical adhesive tapes","Central venous catheter dressing fixation","RECRUITING","2026-07-05",{"date":43,"type":44},"2026-07-13","ACTUAL",{"date":46,"type":44},"2026-06-01",{"date":48,"type":20},"2027-06-01",{"name":50,"class":51},"Azize Özdaş Gündoğan","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":63,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":52},"100615381","central-venous-catheter-placement-with-thoracic-ultrasound-and-intracavity-ecg-positioning-100615381","NCT07291869","Central Venous Catheter Placement With Thoracic Ultrasound and Intracavity ECG Positioning","A Randomised Feasibility Study of Real-time Intracavity ECG and Thoracic Ultrasound for Central Venous Catheter Tip Confirmation in Critical Care","CVC-TIP","Inclusion Criteria:\n\n* Adult (aged ≥ 18 years)\n* Admitted, or planned for admission, to critical care\n* Requiring central venous catheter insertion as a part of their usual care\n* Suitable for both right or left internal jugular vein insertion\n\nExclusion Criteria:\n\n* Previously randomised into CVC-TIP\n* Atrial fibrillation on 12-lead ECG\n* Cardiovascular instability, defined as\n* Noradrenaline dose \\> 0.5mcg\u002Fkg\u002Fmin\n* Rapidly escalating doses of vasopressors \u002F inotropes\n* Difficulty in obtaining thoracic ultrasound images due to either\n* Weight \\> 120kg\n* Existing pneumothorax (either side)\n* Subcutaneous emphysema\n* Wounds \u002F dressing over anterior chest wall\n* Existing pacemaker\n* Non-English speaking participants\n* Death perceived as imminent\n* Any other reason as determined by treating clinician",{"count":62,"type":20},75,[23],"The goal of this interventional study is to assess the feasibility of two bedside techniques for confirming central venous catheter (CVC) placement and detecting complications:\n\n* Intracavity ECG monitoring to confirm internal jugular vein CVC tip position.\n* Thoracic point-of-care ultrasound (POCUS) to rule out pneumothorax following CVC insertion.\n\nParticipants who require an internal jugular CVC as part of their routine care and meet all inclusion and no exclusion criteria will be randomised to receive either:\n\n* Standard care, or\n* The intervention, consisting of intracavity ECG guidance and thoracic POCUS. The CVC will be inserted either on the left or right side of the neck.\n\nAll participants will undergo a post-procedure chest X-ray regardless of study arm, to allow comparison of the intervention methods with standard care.",[27,66,67,68],"Point of Care Ultrasound (POCUS)","Intracavitary Electrocardiogram Guiding","Feasibility Studies",[70,71,72,73],"Intracavity ECG","POCUS","IC-ECG","Thoracic point of care ultrasound","2026-05-28",{"date":76,"type":44},"2026-06-02",{"date":78,"type":44},"2026-05-15",{"date":80,"type":20},"2027-10",{"name":82,"class":51},"York Teaching Hospitals NHS Foundation Trust",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":16,"minAge":17,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":21,"phases":94,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":52},"100640032","the-5050-nitrous-oxide-vs-2-lidocaine-challenge-100640032","NCT07618676","The 50:50 Nitrous Oxide vs 2% Lidocaine Challenge","The 50:50 Nitrous Oxide Challenge: A Prospective Randomised Trial - Needle, Meet Your Match","Inclusion Criteria:\n\n* Subjects who have not previously received Nitrous Oxide.\n* Subjects of both sexes, aged between 18 and 65 inclusive.\n* Subjects who have signed informed consent with full disclosure; no study-related procedure may begin until the subject signs the consent form.\n\nExclusion Criteria:\n\n* Infection at the planned puncture site.\n* Pregnancy.\n* Intracranial hypertension.\n* Vitamin B12 deficiency.\n* Hemodynamic instability.\n* BMI over 35.\n* Glasgow Coma Scale (GCS) score less than 15.\n* Presence of chronic pain.\n* Neurological disorders.\n* Hematologic disorders.\n* More than two attempts at venous puncture (Subject Withdrawal Criterion).\n* Subject experienced an adverse event requiring early discontinuation (Subject Withdrawal Criterion).\n* Withdrawal of consent by the subject (Subject Withdrawal Criterion)",true,"65 Years",{"count":93,"type":20},62,[23],"The main goal of the project is to assess pain levels and patient comfort during the administration of a 50:50 Nitrous Oxide\u002FOxygen gas mixture, in comparison to the same parameters under the standard method used at our institution, which includes injecting a local anaesthetic at the site of planned puncture for central venous catheterisation.",[97,98,27],"Acute Pain","Anxiety","2026-05-25",{"date":46,"type":44},{"date":102,"type":44},"2025-06-06",{"date":104,"type":20},"2026-07-01",{"name":106,"class":51},"Institute for Oncology and Radiology of Serbia",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":21,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":52},"100584041","cvcs-versus-midline-catheters-100584041","NCT06884176","CVCs Versus Midline Catheters","Complication Rates Associated With Central Venous Catheters Versus Midline Catheters: A Randomized Control Trial","Inclusion Criteria:\n\n* Patients over 18 years of age being treated in the Emergency Department at Jacobi Medical Center\n\n  * Have an upper extremity (left or right arm) that can accept a midline catheter\n  * Able to provide consent (patient or health care proxy)\n  * Clinical team believes the patient will require inpatient admission at the time of needing intravenous access\n  * Requires a central line or midline catheter as an expected requirement of care\n* Patients requiring a single vasopressor due to hypotension\n\nExclusion Criteria:\n\n* Patients in cardiac arrest (prior to achieving ROSC)\n* Patients with infection or burns at both upper extremities\n* Patient expected to be discharged from the hospital within 24 hours\n* Prisoner\n* Pregnancy\n* Children less than 18 years of age\n* The patient is known or is suspected to be allergic to materials contained in the device\n* Patients known to have bacteremia\n* Patients with existing central venous catheter\n* Patients without the ability to consent (or no health care proxy to consent)",{"count":115,"type":20},100,[23],"The goal of this clinical trial is to learn if midline catheters can reduce adverse patient outcomes in adult patients requiring a single vasopressor. The main questions the study aims to answer are:\n\n* Do midline catheters reduce the rates of catheter-related bloodstream infections as compared to central venous catheters?\n* Do midline catheters reduce the rates of deep venous thrombosis as compared to central venous catheters? Researchers will compare midline catheters to central venous catheters to see if there is a reduction in these events.\n\nParticipants will be randomized to the midline catheter group or the central venous catheter group. The catheters will be part of standard of care for vasopressor therapy. The participants will be followed for 30 days.",[27,119,120],"Midline Catheter","Complication of Catheter",[122,123,124],"midline catheter","central venous catheter","central line related bloodstream infection","NOT_YET_RECRUITING","2026-04-01",{"date":128,"type":44},"2026-04-02",{"date":130,"type":20},"2026-06",{"date":132,"type":20},"2027-06",{"name":134,"class":51},"Albert Einstein College of Medicine",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":146,"conditions":147,"keywords":151,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":52},"100594075","contact-activation-of-coagulation-in-newly-inserted-central-venous-catheters-100594075","NCT07014722","Contact Activation of Coagulation in Newly Inserted Central Venous Catheters","Contact Activation of Coagulation in Newly Inserted Central Catheters - a Randomized Controlled Trial","CAS-2","Inclusion Criteria\n\nParticipants must meet all of the following criteria to be included in the study:\n\n1. Clinical indication for the placement of a two-lumen central venous catheter with length 150-160 mm.\n2. Age ≥18 years.\n3. Signed informed consent.\n\nExclusion Criteria\n\nParticipants meeting any of the following criteria will be excluded:\n\n1. Current use of anticoagulants or platelet inhibitors, except: Prophylactic low molecular weight heparin (LMWH), double prophylactic dose of LMWH, Acetylsalicylic acid (ASA).\n2. Prothrombin complex (pK\u002FINR) outside the normal range (0.9-1.2), platelet count \\\u003C50 × 10⁹\u002FL or haemoglobin \\\u003C 80 g\u002FL, if already available.\n3. Known coagulopathic conditions, including but not limited to:\n\n   * Activated protein C (APC) resistance,\n   * Hemophilia A or B,\n   * Vitamin K deficiency,\n   * Disseminated intravascular coagulation (DIC),\n   * Antiphospholipid syndrome,\n   * von Willebrand disease, Other known congenital or acquired bleeding disorders.",{"count":144,"type":20},88,[23],"A central venous catheter (CVC) is a thin plastic tube placed into one of the body's large veins, typically in the neck or near the clavicle. CVCs are crucial for administering medications, fluids, and secure blood samples. Although CVCs are an essential tool in healthcare, there are certain risks and complications associated with their use. CVCs can affect the body's coagulation system, potentially leading to the formation of blood clots at the site of the catheter. This can result in serious complications, and in some cases, increased morbidity and mortality. Despite the known risk of blood clot formation with catheter use, it is still do not fully understand why clots occur or how a newly inserted catheter affects the coagulation system.\n\nThe aim of this randomized controlled trial is to compare four different central venous catheters and their impact on the coagulation system.\n\nEighty eight patients ≥18 years of age, who require a CVC and agree to participate in the study will be randomly assigned to one of the four predetermined, commonly used, central venous catheters. Two blood samples will be taken from the newly inserted catheter. The first blood sample (Sample 1) will be collected within seconds after catheter insertion without pre-flushing the catheter with saline. The second blood sample (Sample 2) will be taken after the catheter has been flushed with at least 10 ml saline and the initial blood discarded. All samples will be taken from the distale lumen without any connectors. Samples 1 and 2 will then be analyzed to measure how the coagulation system is affected after contact with the inside surface of the CVC. The blood samples will also be compared between the different catheter types and in overall cohort irrespective of group .\n\nThe study could provide valuable information on how the coagulation system is affected after catheter insertion. This knowledge could help improve preventive measures to reduce the risk of blood clot formation and ensure safer blood sampling for patients with venous catheters.",[27,148,149,150],"Coagulation","Coagulation Activation","Central Venous Catheter Complications",[152,153,123],"coagulation","ROTEM","2026-02-13",{"date":156,"type":44},"2026-02-18",{"date":158,"type":44},"2025-09-10",{"date":160,"type":20},"2026-12-30",{"name":162,"class":51},"Thomas Kander",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":90,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":21,"phases":172,"briefSummary":173,"conditions":174,"keywords":179,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":52},"100619513","central-venous-catheter-care-training-for-pediatric-oncology-nurses-100619513","NCT07345598","Central Venous Catheter Care Training for Pediatric Oncology Nurses","Training in Central Venous Catheter Care: Effects on Knowledge and Infection Prevention Behaviors of Pediatric Oncology Nurses","Inclusion Criteria:\n\n* Provided care to a pediatric oncology patient at least once\n* Performed a procedure via a central venous catheter on a pediatric oncology patient\n* Voluntarily signed the informed consent form\n\nExclusion Criteria:\n\n* Not having previously performed a procedure via a central venous catheter",{"count":171,"type":20},30,[23],"The knowledge level of nurses regarding care techniques plays a crucial role in the prevention of central venous catheter-related infections. This study was designed to evaluate the effect of training on central venous catheter care (CVCC), provided to nurses caring for pediatric oncology patients, on their knowledge level and infection prevention behaviors. The study aims to determine the effectiveness of an educational program intended to enhance nurses' knowledge and practical skills in preventing CVC-related infections, thereby contributing to evidence-based practices that improve patient safety.",[175,176,27,177,178],"Pediatric Cancer","Pediatric Oncology","Central Venous Catheter Placement","Central Venous Catheter Exit Site Infection",[180,181,178,182,183,184,185,186,187],"Pediatric Nursing","Central venous catheter placement","Nurse training","hand hygiene","knowledge","infection prevention","clinical education","quasi-experimental study","2026-01-07",{"date":190,"type":44},"2026-01-15",{"date":192,"type":20},"2026-01-22",{"date":194,"type":20},"2026-06-22",{"name":196,"class":51},"Fenerbahce University",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":21,"phases":207,"briefSummary":208,"conditions":209,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":52},"100584279","peri-procedural-management-of-direct-oral-anticoagulants-for-central-venous-catheters-in-cancer-patients-with-venous-thromboembolism-or-atrial-fibrillation-pilot-study-100584279","NCT06887270","Peri-procedural Management of Direct Oral Anticoagulants for Central VENOus Catheters in CAncer Patients With Venous Thromboembolism or Atrial Fibrillation Pilot Study","Peri-procedural Management of Direct Oral Anticoagulants for Central VENOus Catheters in CAncer Patients With Venous Thromboembolism or Atrial Fibrillation (VENOCAT) Pilot Study","VENO CAT","Inclusion Criteria:\n\n1. Adult patients with VTE or non-valvular AF on prophylactic or therapeutic dose DOAC\n2. Active cancer, defined as diagnosed within the past 6 months; or recurrent, regionally advanced, or metastatic cancer; or for which treatment had been administered within 6 months of port or tunneled CVC insertion; or hematologic cancer not in complete remission\n3. Pending elective radiologically guided insertion of tunneled or port CVC\n4. Able and willing to adhere to peri-procedural DOAC management plan and follow-up\n\nExclusion Criteria:\n\n1. Creatinine clearance (Cockcroft-Gault equation) \\\u003C30 mL\u002Fmin for Dabigatran, Rivaroxaban, or Edoxaban, and \\\u003C25mL\u002Fmin for Apixaban\n2. Diagnosis of VTE within 21 days\n3. Platelet count \\\u003C 50 x 10\\^9\u002FL at time of study entry\n4. Concomitant strong inhibitors or inducers to P-glycoprotein and\u002For CYP-3A4",{"count":206,"type":20},10,[23],"The peri-procedural management of direct oral anticoagulants (DOACs) in persons with cancer (PWC) undergoing tunneled or port central venous catheter (CVC) insertion is a common but understudied clinical problem, with conflicting management advice from guidelines and resultant uncertainty for best practices. Data from prospective studies assessing peri-procedural DOAC management exist; however, these data pertain to procedures in the general population. These management strategies may not be applicable to PWC because (1) although CVC insertion is a low risk, image-guided specialized procedure, (2) PWC are at considerably higher risk of peri-procedural bleeding and thrombosis than non-PWC. It is not surprising, therefore, that guideline recommendations and current practices vary widely. To resolve management uncertainty and establish a standard-of-care, the VENOCAT pilot randomized controlled trial (RCT) is a first step that will assess the feasibility of a definitive trial comparing continued vs. interrupted DOAC management in PWC undergoing tunneled or port CVC insertion. Evidence is needed to standardize clinical practice and reduce the risk of bleeding and thrombotic complications.",[210,211,212,27,213],"Anticoagulant-induced Bleeding","Direct Oral Anticoagulant","Cancer","Periprocedural Complication","2025-03-13",{"date":216,"type":44},"2025-03-20",{"date":218,"type":20},"2025-09",{"date":220,"type":20},"2027-09",{"name":222,"class":51},"University Health Network, Toronto",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":16,"minAge":230,"maxAge":17,"enrollmentInfo":231,"targetDuration":4,"studyType":21,"phases":233,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":52},"100566619","sisipush-evaluation-of-hemolysis-and-iatrogenic-anemia-using-the-push-pull-method-to-obtain-blood-from-pediatric-patients-with-central-venous-catheters-100566619","NCT06657534","SISIPUSH: Evaluation of Hemolysis and Iatrogenic Anemia Using the Push-pull Method to Obtain Blood from Pediatric Patients with Central Venous Catheters","SISIPUSH","Inclusion Criteria:\n\n* hospitalized patient at the Specialist Pediatric Department of Ghent University Hospital\n* age 0-18 years\n* presence of a central venous catheter for diagnostic or therapeutic reasons of the type surgically placed (Hickman, port-a-cath) or non-surgically placed (vena jugularis interna, subclavia, femoralis,...)\n* patent catheter with possibility of infusion of fluids and collection of blood on at least one of the lumens\n* clinical and\u002For radiographic confirmation of correct central position of the catheter tip\n* at least one blood collection per week hospitalization expected or already planned\n\nExclusion Criteria:\n\n* presence of a bloodstream or catheter related infection before or at the time of randomization","0 Years",{"count":232,"type":20},150,[23],"Anemia is frequently observed during hospitalizations, both in adults and children. In addition to the fact that anemia can be caused by an acute or chronic condition, blood samples taken during the hospital stay contribute to additional blood loss (so-called iatrogenic anemia).\n\nFor children, the relative amount of blood taken at each blood collection is greater than in adults. It is therefore expected that in children, due to the lower circulating blood volume, the relative impact of repeated blood sampling is greater and interventions such as sparing the number of blood samples or blood volume can have a relevant impact on the onset of anemia, the need for iron supplements or blood transfusions and the general clinical recovery.\n\nFor children, only limited data are available on the development of iatrogenic anemia during hospital stay. In a study of children in an intensive care unit, a decrease in hemoglobin of 0.7 g\u002Fdl can already be seen with an average stay of 4.5 days (and an average number of blood samples of 2.9) (François et al. Ped Crit Car Med, 2022). The average blood volume lost to blood samples during the stay is 3.9 ml\u002Fkg, which already corresponds to 5% of the total blood volume. Interventions to decrease the frequency of blood sampling or to perform the same analyses on a smaller blood volume (e.g. adapted, smaller blood tubes for children) are therefore useful in preventing the development of anemia during a hospital stay, especially in children.\n\nAlternative methods have been described to save on blood volume when performing blood sampling, especially if these are performed via central venous catheters (surgically or non-surgically placed). To obtain a suitable sample via such catheters, the usual technique is to obtain 5 to 10 ml of blood and discard the volume (so-called \"waste blood\") before the sample for laboratory analysis is obtained (typically only 1-2 ml). A recently published technique is the so-called push-pull method (described by McBride et al, J Infus Nurs 2018), in which blood sampling can be performed without waste blood.\n\nThe push-pull technique has been studied in children, but mainly in oncological and intensive care units. Paired analyses have verified that the technique provides a reliable sample for most blood analyses, including blood count, electrolytes, liver and kidney function parameters, CRP, but also coagulation factors and therapeutic drug monitoring. The occurrence of complications, of which the development of catheter-related bacteremia is of particular importance, is not described. A beneficial effect on anemia onset has not yet been described, usually due to low patient numbers per study (23-35 patients).\n\nIn SISIPUSH, we compare the push-pull technique with the standard-of-care in hospitalised children who undergo blood sampling via a central venous catheter for diagnostic reasons (in the context of routine care). By means of a 1:1 randomization, eligible patients who gave informed consent are assigned to one of the two methods for the remainder of the hospitalization. From the moment of randomization until discharge from the hospital, data will be collected from the medical file that are collected routinely (number of blood samples, hemoglobin values, number of blood transfusions, markers of hemolysis, age and gender, reason for hospitalization, type of catheter) and compared between the two groups. In parallel, nurses score the easy of use and satisfaction with the procedure at each blood sample.",[236,27],"Pediatrics",[238],"push-pull technique","2024-10-23",{"date":241,"type":44},"2024-10-24",{"date":243,"type":44},"2024-10-14",{"date":245,"type":20},"2025-12-31",{"name":247,"class":51},"University Hospital, Ghent"]