[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"central-visual-impairment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:central-visual-impairment":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100637773","vision-rehabilitation-training-with-multimodal-feedback-in-central-vision-loss-100637773",false,"NCT07577219","Vision Rehabilitation Training With Multimodal Feedback in Central Vision Loss","Inclusion Criteria:\n\nBilateral central scotomas confirmed via computerized tangent screen Visual acuity between 20\u002F60 and 20\u002F200 (0.5 - 1.00 logMAR) in either eye Stable central vision loss (no change in visual acuity \\>0.2 logMAR in past 6 months) Age 14 years or older, with diagnosis of macular disease Normal cognitive function (Mini-Mental State Examination score ≥24) Ability to provide informed consent and complete study visits No major hearing loss Fluent in English\n\nExclusion Criteria:\n\nUnstable ocular disease (e.g., ongoing treatments and\u002For injections) Peripheral vision loss of less than 40 degrees Conditions affecting oculomotor control independent of CVL","ALL","14 Years",{"count":18,"type":19},12,"ESTIMATED","INTERVENTIONAL",[22],"NA","Central vision loss from macular degeneration creates blind spots that impair reading, face recognition, and navigation. Individuals must learn to use peripheral vision, requiring retraining of eye movements. Our preliminary research using high-speed eye tracking demonstrated that people with larger scotomas have impaired eye movement control, and that single-session visual feedback training showed limited immediate benefit, though combining feedback types showed promise.\n\nThis study will evaluate whether extended binocular training (5 weekly sessions) with multimodal feedback improves eye movement control in 8-15 participants with bilateral central vision loss. Unlike conventional monocular rehabilitation systems, our approach trains both eyes simultaneously using real-time visual and auditory feedback during saccadic and smooth pursuit tasks. Participants will receive gaze-contingent scotoma awareness feedback, preferred retinal locus feedback, and auditory cues while performing eye tracking exercises.\n\nPrimary outcomes include saccadic accuracy (latency, landing error, amplitude) and smooth pursuit parameters (gain, tracking accuracy). Secondary outcomes include contrast sensitivity and self-reported visual function. Success could establish an evidence base for accessible home-based training using virtual reality technology, potentially benefiting millions with macular degeneration.",[25,26,27],"Low Vision","Central Visual Impairment","Macular Degeneration","RECRUITING","2026-05-05",{"date":31,"type":32},"2026-05-11","ACTUAL",{"date":34,"type":32},"2026-01-31",{"date":36,"type":19},"2026-12-01",{"name":38,"class":39},"New England College of Optometry","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":40},"100474148","factors-in-learning-and-plasticity-macular-degeneration-100474148","NCT05454124","Factors in Learning And Plasticity: Macular Degeneration","Characterization of Multiple Factors in Training and Plasticity in Central Vision Loss: Macular Degeneration","FLAP","Inclusion Criteria:\n\n* Aged 18-89\n* Severely impaired vision in both eyes (20\u002F100 or worse)\n* diagnosis of Macular Degeneration by an Ophthalmologist\n* Light sensitivity in the macular retina that is at least 10 dB units worse than in peripheral regions, as demonstrated by a scanning laser ophthalmoscope (MAIA)\n* Medical record review indicating this level of disease severity has been present for at least 2 years\n* Reside within 50 miles of study site\n\nExclusion Criteria:\n\n* Pacemaker or any ferromagnetic metal implanted in their body\n* Metal of any type implanted in their head (limited dental work is acceptable)\n* Claustrophobia\n* Being hearing-impaired\n* Weight over 300 pounds\n* Maximum body girth over 60 inches\n* Previous serious head injury\n* Presence of hallucinations or delusions\n* Excessive old, or colorful tattoos, especially near the head\n* Pregnancy\n* Braces\u002Fpermanent retainer","18 Years","89 Years",{"count":52,"type":19},60,[22],"A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the NEI to support research on visual disorders, mechanisms of visual function, and preservation of sight. The comparison of different training and outcome factors is in line with the NIMH RDOC framework and studies in an aging population are consistent with the mission of the NIA.",[26,27],[57,58,59],"plasticity","central vision loss","perceptual learning","2026-02-04",{"date":62,"type":32},"2026-02-09",{"date":64,"type":32},"2022-11-01",{"date":66,"type":19},"2026-11",{"name":68,"class":39},"University of Alabama at Birmingham",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":15,"minAge":75,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":20,"phases":78,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":40},"100609618","remapping-text-in-sentence-and-word-tasks-to-aid-reading-with-central-vision-loss-100609618","NCT07216924","Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss","Inclusion Criteria:\n\n* Dense bilateral scotomas of at least 2 deg diameter in each eye covering the fovea\n* Bivariate contour ellipse area (BCEA) of less than 10\\^2 is obtained in a simple fixation task\n\nExclusion Criteria:\n\n* Neovascular AMD\n* Any history of visual disorders other than that causing the central vision loss.","16 Years",{"count":77,"type":19},100,[22],"Reading performance in patients with Central Vision Loss will be measured with and without missing text being remapped to different parts of the visual field in a variety of different reading tasks.",[27,26],[82,83],"Reading","Central Field Loss","NOT_YET_RECRUITING","2025-10-13",{"date":87,"type":32},"2025-10-15",{"date":89,"type":19},"2026-06",{"date":91,"type":19},"2032-05",{"name":93,"class":39},"University of Minnesota"]