[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebellar-ataxia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebellar-ataxia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,70,98,122,150],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100353218","retraining-reaching-in-cerebellar-ataxia-100353218",false,"NCT03879018","Retraining Reaching in Cerebellar Ataxia","Inclusion Criteria:\n\n* Cerebellar damage from stroke, tumor or degeneration\n* Age 22-80\n\nExclusion Criteria:\n\n* Clinical or MRI evidence of damage to extracerebellar brain (e.g. multiple system atrophy)\n* Extrapyramidal symptoms, peripheral vestibular loss, or sensory neuropathy\n* Dementia ( Mini-Mental State exam \\> 22)\n* Pain that interferes with the tasks\n* Vision loss that interferes with the tasks","ALL","22 Years","80 Years",{"count":19,"type":20},18,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to test for benefits of reinforcement based training paradigm versus standard practice over weeks for improving reaching movements in people with ataxia.",[26],"Cerebellar Ataxia",[26],"RECRUITING","2026-06-29",{"date":31,"type":32},"2026-07-01","ACTUAL",{"date":34,"type":32},"2019-08-01",{"date":36,"type":20},"2027-01-01",{"name":38,"class":39},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":58,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":40},"100643273","individualized-neuro-modulation-paired-with-cerebellar-therapy-100643273","NCT07642856","Individualized Neuro-Modulation Paired With Cerebellar Therapy","IMPACT","Inclusion Criteria:\n\n* Age 18-75 years\n* Males and Females\n* Disorders that predominantly affect the cerebellum: damage from stroke, tumor or degeneration (genetic or non-genetic causes, congenital hypoplasia).\n\nExclusion Criteria:\n\n* Diagnoses or impairments that interfere with task execution or data interpretation.\n* Heart pacemaker or other MRI-incompatible implanted metal device\n* Metallic foreign body in their eye or head\n* Experience with severe claustrophobia\n* Experience discomfort from the MRI scan, such as excessive heating of tattoos\n* Seizures or history of seizure disorder\n* Alcohol or substance use disorder (self-report)\n* Diagnosed history of severe psychiatric disorder such as depression, schizophrenia (self-report)\n* Metallic foreign body in their eye or head (except the mouth e.g. dental fillings)\n* Specific medications: tricyclic anti-depressants or neuroleptic medication\n* Any medical condition (including orthopedic, pain, cardiopulmonary or other) that limits safe participation in exercise training","18 Years","75 Years",{"count":51,"type":20},30,[23],"The purpose of this project is to evaluate feasibility and preliminary efficacy of pairing personalized transcranial direct current stimulation (tDCS) with individualized rehabilitation therapy in people with cerebellar damage.",[26,55,56,57],"Cerebellar Diseases","Cerebellar Stroke","Cerebellar Tumor",[59,60,61],"non-invasive brain stimulation","rehabilitation","physical therapy","2026-06-08",{"date":64,"type":32},"2026-06-11",{"date":66,"type":20},"2026-06-30",{"date":68,"type":20},"2032-12-02",{"name":38,"class":39},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":78,"maxAge":48,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":40},"100609202","rtms-for-cerebellar-ataxia-in-children-100609202","NCT07211490","rTMS for Cerebellar Ataxia in Children","Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Cerebellar Ataxia: A Randomized Controlled Trial","rTMS CA","Inclusion Criteria:\n\n* Patients aged ≥ 4 years old - 18 years old fulfilling the following criteria: 1) diagnosis of cerebellar ataxia based on clinical history and neurological examination; 2) cerebellar lesion seen by MRI; 3) IQ ≥ 50 to ensure sufficient cognitive capacity for comprehending and adhering to motor training protocols.\n\nExclusion Criteria:\n\n* Patients will be excluded if they have: 1) Sensory ataxia with etiologies involving the peripheral nerves or posterior columns of the spinal cord, 2) Any contra-indications to rTMS, 3) Severe spasticity (defined as a score of 4 in the Modified Ashworth Scale) and contractures, 4) Uncontrollable epilepsy defined as the occurrence of seizures despite the use of at least one anti-epileptic drug (AED) in adequate dose, 5) History of Botulinum toxin A injection or upper limb casting in previous 6 months, and 6) Cerebellar ataxia resulting from genetic conditions.","4 Years",{"count":80,"type":20},20,[23],"Dysfunction of the cerebellum can result in cerebellar ataxia (CA), typically marked by symptoms such as movement incoordination, gait instability, articulation disorder, oculomotor and swallowing difficulties. Children affected by paediatric cerebellar ataxia (PCA) often suffer from an array of motor symptoms, affecting their quality of life and psychosocial well-being. It was estimated that PCA affects 26\u002F100,000 children worldwide for both genetic and acquired causes. Epidemiological data on PCA, however, are absent in the Hong Kong population.\n\nPCAs comprise a varied group of cerebellar development disorders, marked by impaired balance and motor coordination (e.g., dysmetria and tremor) when performing voluntary movement. Clinical symptoms in children with PCA are related to lesioned localization - focal disorder of the cerebellar vermis leads to truncal instability, head titubation, and nystagmus; while lesioned cerebellar hemispheres results in ataxia gait (wide-staggering gait, tend to fall towards the affected side). These clinical symptoms result in functional difficulties involving balance and walking, reaching, grasping and manipulation, oculomotor and speech domains. Abnormalities of motor excitability have been reported in patients with cerebellar lesions - the motor threshold was found to be raised in the motor cortex contralateral to a hemi-cerebellar lesion.\n\nWith no effective pharmacological treatments available, rehabilitation serves as the primary treatment approach. Even though adaptive learning is affected by cerebellar lesion, motor learning is still possible via exercise interventions. Interventions may include compensatory (educate strategies to compensate for impairment) or restorative approaches (improve functions through training). While exercise interventions have been explored as a potential therapeutic approach for paediatric patients with cerebellar lesions or degeneration, the current evidence lacks robust, high-quality randomized controlled trials (RCTs) to substantiate their efficacy.\n\nExisting evidence shows that cerebellar outputs project to several cortical areas, including the primary motor cortex (M1). CA patients with lesions in structures of the cerebellar efferent pathway exhibit reduced inhibition in the motor cortex. Selective modulation of the efferent pathways may offer an additional means of modulating cortical activity, thus improve motor coordination abilities in CA patients. With the development of non-invasive brain stimulation (NIBS) techniques, more research has been conducted using NIBS as treatment modalities for patients with CA. The most used NIBS techniques include repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). Repetitive transcranial magnetic stimulation (rTMS) enables to modulate cortical excitability focally in conscious subjects; low-frequency stimulation (e.g., 1 Hz) is known to suppress cortical excitability, while higher frequencies (\\> 5 Hz) induce facilitation. These changes in excitability occur not only at the site of stimulation but also at other distant interconnected sites of a network. Both the excitatory stimulation and inhibitory stimulation approaches were adopted in existing adult studies. Paediatric patients with cerebellar lesions-caused by stroke, tumour, or genetic conditions-are thought to share the same pathophysiological basis as adults. Using contra-lesional inhibitory rTMS, França et al. demonstrated that the intervention is safe and feasible for adult patients with CA, showing a reduction in ataxic symptoms. Despite promising results in the adult population, it is still unclear whether rTMS can relieve ataxic symptoms and improve motor performance in children with CA.\n\nTo date, no studies have been published on the effects of rTMS on improving ataxic symptoms in children with cerebellar ataxia. However, emerging evidence suggests its potential utility. Using rTMS of 1 Hz to stimulate the cerebellar hemisphere ipsilateral to the ataxic side combined with mirror therapy, Cha et al. demonstrated that there was improvement in functional mobility as measured by 6-minute walk test and the timed up and go test. Supporting the feasibility of rTMS in paediatric motor rehabilitation, our pilot RCT (HKWC UW 23-492) found that contra-lesional inhibitory rTMS over M1 combined with motor training is safe and effective in improving motor performance in children with cerebral palsy. Comparative studies in older adults suggest that cerebellar rTMS was more effective than M1 rTMS for motor learning and the consolidation, likely due to the unique role of cerebellum in the integration and processing of multimodal sensory inputs to refine motor planning. These findings highlight the cerebellum as a promising neuromodulatory target for motor rehabilitation, warranting further investigation in paediatric cerebellar ataxia.",[26],[85,86,87],"TMS","Cerebellar ataxia","Children","NOT_YET_RECRUITING","2025-10-02",{"date":91,"type":32},"2025-10-08",{"date":93,"type":20},"2025-10-01",{"date":95,"type":20},"2028-03-31",{"name":97,"class":39},"The University of Hong Kong",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":15,"minAge":48,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":121},"100578931","evaluation-of-urinary-dysfunction-in-canvas-patients-100578931","NCT06817707","Evaluation of Urinary Dysfunction in CANVAS Patients","UROCANVAS","Inclusion Criteria:\n\n* 18 years old and more\n* genetic confirmation of CANVAS (presence of pathogenic penta nucleotide expansion in both alleles of the replication factor C subunit 1(RFC1) gene or pathological penta nucleotide expansion in the heterozygous state associated with a truncating mutation on the second allele of the RFC1 gene)\n* Able to undergo renovesical ultrasound and urinary flow measurement;\n* Having given informed consent in writing;\n* Negative pregnancy test for people on childbearing age;\n* Social security affiliated\n\nExclusion Criteria:\n\n* Presenting another urological pathology of base, not related to CANVAS;\n* Having undergone a urological intervention within the 6 months preceding the screening visit;\n* Presenting a condition that is incompatible with the proper conduct of the study as determined by the physician;\n* Protected by law under guardianship or curators, or not able to participate in a clinical study pursuant to article L. 1121-16 of the French Public Health Code\n* Pregnant or breastfeeding women for women of childbearing age",{"count":106,"type":20},40,[23],"The investigator wishes to evaluate the prevalence of urinary symptoms in patients diagnosed with Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS).\n\nAs much as one third of patients living with CANVAS experience symptoms of urinary system dysfunction. The primary objective of this study is to evaluate the incidence of urinary symptoms in these patients, as well as the potential complications that might occur at the level of the upper and lower urinary system. The investigator also wishes to analyse the connection between the severity of the neurological deficits, the presence of dysautonomia and the presence of urinary dysfunction. To that end, the data collected in the study will concern : a detailed neurological examination including SARA (Scale for the assessement and rating of ataxia) scale assessement, laboratory tests of the renal function, dysautonomia tests with Sudoscan and research of orthostatic hypotension, urinary function questionnaires, dysautonomia questionnaire, urodynamic tests and urinary system ultrasound.",[26,110,111],"Neuropathy","Vestibular Areflexia","2025-03-25",{"date":114,"type":32},"2025-03-26",{"date":116,"type":32},"2025-03-21",{"date":118,"type":20},"2027-03",{"name":120,"class":39},"Centre Hospitalier Universitaire de Nice",3,{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":129,"sex":15,"minAge":130,"maxAge":49,"enrollmentInfo":131,"targetDuration":4,"studyType":21,"phases":132,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":40},"100473362","home-exercise-for-individuals-with-neurodegenerative-disease-100473362","NCT05443906","Home Exercise for Individuals with Neurodegenerative Disease","Study of Adapted Exercise and Mindfulness Interventions to Improve Motor Function and Sleep Quality in Individuals with Neurodegenerative Disease","Inclusion Criteria:\n\n* The eligibility criteria for males is X-linked adrenoleukodystrophy as determined by biochemical determination or genetic testing.\n* The eligibility criteria for females is X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis.\n* The Leukoenceophalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion is a confirmed DARS2 mutation through genetic analysis.\n* For people with cerebellar ataxia, people with diagnoses of cerebellar damage from stroke, tumor or degeneration will be included. Those with a genetically confirmed cerebellar disorder will be asked to provide their genetic testing to note their particular type of ataxia.\n* We will also include patients with other neurodegenerative diseases similar to these disorders as determined by chart review and clinical exam.\n\nHealthy Volunteers\n\n* Able to stand for 30 seconds without upper extremity support\n* Ambulatory (including use of a cane or a walker)\n* Able to walk for 2 minutes\n\nExclusion Criteria:\n\n* Other medical or psychological conditions which in the clinical judgement of the investigator would interfere with acquiring the study information or performing the exercises safely including but not limited to:\n\nUncontrolled hypertension, orthopedic conditions, diabetes, seizure disorder, peripheral vestibular loss, severe aphasia, dementia, pregnancy",true,"5 Years",{"count":51,"type":20},[23],"The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.",[135,136,137,138,139,140,26,141],"Neurodegenerative Diseases","Leukodystrophy","Ataxia","LBSL","Leukoencephalopathy with Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)","Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation","Adrenomyeloneuropathy","2025-03-06",{"date":144,"type":32},"2025-03-10",{"date":146,"type":32},"2023-02-13",{"date":148,"type":20},"2027-07-30",{"name":38,"class":39},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":129,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":159,"phases":4,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":40},"100363284","a-registered-cohort-study-on-cerebellar-ataxia-in-the-organization-in-south-east-china-for-cerebellar-ataxia-research-osccar-100363284","NCT04010214","A Registered Cohort Study on Cerebellar Ataxia in the Organization in South-East China for Cerebellar Ataxia Research (OSCCAR)","A Registered Cohort Study on Cerebellar Ataxia","Inclusion Criteria:\n\n* Patients with cerebellar ataxia based on the diagnoses of tow neurologists\n* Relatives of patients with cerebellar ataxia\n* Unrelated healthy controls\n* Participants or legal guardian(s) willing and able to complete the informed consent process\n\nExclusion Criteria:\n\n* Participants are unable to comply with trial procedures and visit schedule",{"count":158,"type":20},1500,"OBSERVATIONAL","Cerebellar ataxia is a form of ataxia originating in the cerebellum. Cerebellar ataxia can occur as a result of many diseases and may present with symptoms of an inability to coordinate balance, gait, extremity and eye movements. To understand the clinical and genetic characteristics of cerebellar ataxia, we establish a registered cohort to follow up Chinese patients with cerebellar ataxia.",[26],"2023-07-11",{"date":164,"type":32},"2023-07-12",{"date":166,"type":32},"2019-07-01",{"date":168,"type":20},"2059-12",{"name":170,"class":39},"Ning Wang, MD., PhD."]