[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebellar-atrophy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebellar-atrophy":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100640104","variable-intense-training-for-ataxia-and-locomotion-100640104",false,"NCT07621978","Variable Intense Training for Ataxia and Locomotion","Feasibility and Potential Efficacy of High-intensity Gait Training in Individuals With Cerebellar Damage","VITAL","Inclusion Criteria:\n\n* Ages 18-85\n* \\>6 months following brain injury or diagnosis of cerebellar dysfunction\n* A total score of \\> 4 on items 5-8 on the SARA for the ipsilateral limb\n* Ability to ambulate 10 m at self-selected gait speeds (SSV) \\\u003C1.2 m\u002Fs with no greater than minimal physical assistance permitted for postural stability only, but with below knee bracing and\u002For assistive device as needed\n* Weight \\\u003C 350 pounds\n* Able to follow 1-step command\n* Medical clearance to participate\n\nExclusion Criteria:\n\n* Uncontrolled cardiopulmonary or metabolic disease that limits exercise participation, active heterotopic ossification, recurrent history of lower extremity fractures, previous orthopedic or other peripheral or central neurologic injury that may impair locomotor activities\n* Currently participating in other physical therapy\n* \\>50 units of Botox within the past three months in the lower extremity OR in the lower extremity, but above the knee if the participant wears an ankle-foot-orthosis\n* Individuals deemed not stable between Pre-Baseline Testing and Baseline Testing","ALL","18 Years","85 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar disease",[28,29,30,31],"Cerebellar Disorders","Cerebellar Degeneration","Cerebellar Atrophy","Cerebellar Lesions",[33],"Cerebellar diseases, high-intensity training","NOT_YET_RECRUITING","2026-05-27",{"date":37,"type":38},"2026-06-02","ACTUAL",{"date":40,"type":22},"2026-06-15",{"date":42,"type":22},"2028-12-15",{"name":44,"class":45},"Indiana University","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100605739","development-application-and-mechanistic-investigation-of-a-novel-minimally-invasive-bidirectional-epidural-cerebellar-stimulation-technique-for-cerebellar-cognitive-affective-syndrome-100605739","NCT07166432","Development, Application, and Mechanistic Investigation of a Novel Minimally-Invasive Bidirectional Epidural Cerebellar Stimulation Technique for Cerebellar Cognitive Affective Syndrome","Inclusion Criteria:\n\n* 1\\. Clinically and biochemically confirmed ACTH-dependent or ACTH-independent Cushing syndrome (loss of serum cortisol circadian rhythm, elevated 24-hour urinary free cortisol, and failure to suppress on low-dose dexamethasone suppression test).\n\n  2\\. Cranial MRI demonstrating unequivocal cerebellar atrophy (CCAS imaging criterion: cerebellar hemisphere or vermian volume ≥1.5 SD below age-matched normative data).\n\n  3\\. Established clinical diagnosis of CCAS (meets Schmahmann criteria, CCAS-S total score ≥20).\n\n  4\\. Cerebellar ataxia rating scale (SARATA) ≥10, indicating at least moderate motor ataxia.\n\n  5\\. Positive cognitive impairment screen (MoCA \\\u003C26, or Z-scores ≤-1.5 in at least two cognitive domains).\n\n  6\\. Willingness to undergo minimally invasive epidural cerebellar stimulation and provision of written informed consent.\n\nExclusion Criteria:\n\nPatients with significant systemic disease; occurrence of major complications or irreproducible, critical deviations in data collection or experimental procedures; or any circumstance rendering continued participation inappropriate-including clinical deterioration, serious adverse events, or poor compliance-will result in discontinuation of the subject's enrollment.",{"count":53,"type":22},200,"OBSERVATIONAL","Building on previous findings regarding microglial immune function and the immunosuppressive effects of glucocorticoids, this project centers on the cerebellum's role in cognitive science. Using Cushing's syndrome-induced cerebellar atrophy leading to CCAS as a model, we aim to elucidate the pathogenic mechanisms governed by the neuro-adrenal-immune network and to uncover the molecular basis by which a novel minimally invasive brain-machine fusion system ameliorates cerebellar ataxia and cognitive impairment.",[30,57,58],"Etiology","Physiopathology","RECRUITING","2025-09-03",{"date":62,"type":38},"2025-09-10",{"date":64,"type":38},"2025-06-28",{"date":66,"type":22},"2028-06-01",{"name":68,"class":45},"Peking University First Hospital",1]