[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebellar-degeneration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebellar-degeneration":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100640104","variable-intense-training-for-ataxia-and-locomotion-100640104",false,"NCT07621978","Variable Intense Training for Ataxia and Locomotion","Feasibility and Potential Efficacy of High-intensity Gait Training in Individuals With Cerebellar Damage","VITAL","Inclusion Criteria:\n\n* Ages 18-85\n* \\>6 months following brain injury or diagnosis of cerebellar dysfunction\n* A total score of \\> 4 on items 5-8 on the SARA for the ipsilateral limb\n* Ability to ambulate 10 m at self-selected gait speeds (SSV) \\\u003C1.2 m\u002Fs with no greater than minimal physical assistance permitted for postural stability only, but with below knee bracing and\u002For assistive device as needed\n* Weight \\\u003C 350 pounds\n* Able to follow 1-step command\n* Medical clearance to participate\n\nExclusion Criteria:\n\n* Uncontrolled cardiopulmonary or metabolic disease that limits exercise participation, active heterotopic ossification, recurrent history of lower extremity fractures, previous orthopedic or other peripheral or central neurologic injury that may impair locomotor activities\n* Currently participating in other physical therapy\n* \\>50 units of Botox within the past three months in the lower extremity OR in the lower extremity, but above the knee if the participant wears an ankle-foot-orthosis\n* Individuals deemed not stable between Pre-Baseline Testing and Baseline Testing","ALL","18 Years","85 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar disease",[28,29,30,31],"Cerebellar Disorders","Cerebellar Degeneration","Cerebellar Atrophy","Cerebellar Lesions",[33],"Cerebellar diseases, high-intensity training","NOT_YET_RECRUITING","2026-05-27",{"date":37,"type":38},"2026-06-02","ACTUAL",{"date":40,"type":22},"2026-06-15",{"date":42,"type":22},"2028-12-15",{"name":44,"class":45},"Indiana University","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":5},"100631394","spatiotemporal-entrainment-neuromodulation-targeting-cerebello-cerebral-circuits-to-enhance-cognitive-and-social-rehabilitation-in-cerebellar-diseases-100631394","NCT07500103","Spatiotemporal Entrainment Neuromodulation Targeting Cerebello-Cerebral Circuits to Enhance Cognitive and Social Rehabilitation in Cerebellar Diseases","Spatiotemporal Entrainment as Innovative Neuromodulation Targeting Cerebello-cerebral Circuits for Enhancing Rehabilitation Outcomes of Cognitive and Social Skills in Progressive and Acquired Cerebellar Diseases","SINCRO","Inclusion Criteria for patients with cerebellar malformation include:\n\n* Documented malformations confined to the cerebellum confirmed by a 3T brain MRI scan;\n* Age ranging from 12 to 32 years old;\n* IQ \\>= 50;\n* Absence of extra-cerebellar malformations on conventional brain MRI scan.\n\nInclusion Criteria for patients with degenerative cerebellar atrophy include:\n\n* Evidence of diffuse cerebellar atrophy;\n* More than 6 months of illness;\n* IQ \\>=75;\n* Absence of any cortical lesion on conventional brain MRI scans\n\nExclusion Criteria for both groups include:\n\n* Presence of severe motor and visual impairments, as well as neurodevelopmental (i.e., autism), neurological or psychiatric disorders that could interfere with task execution and protocol compliance;\n* Presence of any contraindication for tACS.","12 Years",{"count":56,"type":22},60,[25],"The cerebellum is increasingly recognized for its crucial role in high-level cognitive processes, particularly in the domain of social cognition and action prediction. Disruptions in cerebellar circuits can lead to significant impairments in anticipating others' intentions and behaviors, affecting daily social interactions. This randomized, double-blind, sham-controlled trial protocol investigates the combined effects of personalized cerebellar High-Definition transcranial Alternating Current Stimulation (HD-tACS) and Immersive Virtual Reality (IVR) training on social prediction abilities. The study involves two clinical populations: adolescents and young adults with congenital cerebellar malformations (CM) and adults with acquired neurodegenerative cerebellar atrophy (CA). Participants undergo eight daily sessions of IVR training designed to enhance internal models of social events through interactive scenarios. Simultaneously, they receive either active or sham HD-tACS delivered at their Individual Gamma Frequency (IGF), determined via baseline EEG. The primary outcomes include behavioral responses to context-based social prediction tasks (action intentions, emotions, and personality traits). Secondary outcomes encompass electrophysiological measures, neuropsychological functioning, and adaptive behavior. By integrating neuromodulation with embodied virtual experiences, the project aims to facilitate cerebello-cerebral plasticity and provide a novel transdiagnostic rehabilitative approach for socio-cognitive impairments.",[29,60],"Cerebellar Malformation",[62,63,64,65],"Cerebellum","Social prediction","tACS","Virtual Reality","RECRUITING","2026-03-25",{"date":69,"type":38},"2026-03-30",{"date":71,"type":38},"2025-01-15",{"date":73,"type":22},"2027-04",{"name":75,"class":45},"I.R.C.C.S. Fondazione Santa Lucia"]