[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-aneurysm-unruptured\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-aneurysm-unruptured":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100642008","remifentanil-vs-esmolol-during-intubation-for-cerebral-aneurysm-coil-embolization-100642008",false,"NCT07660861","Remifentanil vs Esmolol During Intubation for Cerebral Aneurysm Coil Embolization","Effects of Remifentanil Versus Esmolol on Optic Nerve Sheath Diameter\u002FEyeball Transverse Diameter Ratio During Endotracheal Intubation in Patients Undergoing Cerebral Aneurysm Coil Embolization: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective cerebral aneurysm coil embolization under general anesthesia\n* Planned endotracheal intubation\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Emergency procedures\n* Hemodynamic instability before induction of anesthesia\n* Severe cardiac conduction abnormalities or clinically significant arrhythmias\n* Contraindication or allergy to remifentanil or esmolol\n* Chronic opioid use or opioid dependence\n* Known orbital disease, ocular trauma, or conditions interfering with optic nerve sheath diameter measurements\n* Anticipated difficult airway\n* Pregnancy\n* Refusal to participate in the study","ALL","18 Years",{"count":19,"type":20},84,"ESTIMATED","INTERVENTIONAL",[23],"NA","Endotracheal intubation may cause significant increases in blood pressure, heart rate, and intracranial pressure, particularly in patients undergoing cerebral aneurysm coil embolization. Remifentanil and esmolol are commonly used agents to attenuate these responses during anesthesia induction.\n\nThis randomized controlled trial aims to compare the effects of remifentanil and esmolol administered before endotracheal intubation on optic nerve sheath diameter\u002Feyeball transverse diameter ratio (ONSD\u002FETD), a noninvasive surrogate marker of intracranial pressure, as well as hemodynamic responses in patients undergoing elective cerebral aneurysm coil embolization.\n\nThe findings may help identify the most effective strategy for minimizing intubation-related intracranial pressure changes and hemodynamic fluctuations in neurointerventional anesthesia practice.",[26,27],"Cerebral Aneurysm Unruptured","Intracranial Pressure",[29,27,30,31,32],"Optic Nerve Sheath Diameter","Remifentanil","Esmolol","Coil Embolization","NOT_YET_RECRUITING","2026-06-16",{"date":36,"type":37},"2026-06-22","ACTUAL",{"date":36,"type":20},{"date":40,"type":20},"2027-07-01",{"name":42,"class":43},"Fatih Sultan Mehmet Training and Research Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":44},"100586364","impact-of-life-size-3d-model-on-patient-anxiety-during-intracranial-aneurysms-embolization-in-interventional-neuroradiology-100586364","NCT06914414","Impact of Life-size 3D Model on Patient Anxiety During Intracranial Aneurysms Embolization in Interventional Neuroradiology.","Interventional Neuroradiology Evaluation of a 3D Silicon Flow Model Representing the Aorto Cervicoencephalic Arterial Tree, Enabling the Patient to Simulate the Entire Procedure During the Preoperative Consultation","ANXIFLOW","Inclusion Criteria:\n\n* Patient (aged 18-70) with cerebral aneurysm pathology\n* Affiliated to the French social security system\n* Patient informed of the study and having signed the informed consent form\n* Patient who speaks and understands French\n\nExclusion Criteria:\n\n* Patient \\> 70 years of age (benefit\u002Frisk balance of preventive treatment against treatment) treatment)\n* Patient under guardianship, curatorship, safeguard of justice or legal protection\n* Mentally handicapped patient\n* Patient with severe psychiatric pathology\n* Patient unable to communicate in French\n* Patients receiving premedication\n* Patient under 18 years\n* Blind patient","70 Years",{"count":55,"type":20},144,[23],"Intracranial aneurysm is a malformation of the cerebral arteries, identifying with a focal dilatation of the wall of an intracranial artery. This pathology is a fragility of the arterial wall which dilates abnormally creating ≪ a pocket ≫ where blood circulates under pressure. Due to their parietal fragility, aneurysms can grow or rupture. In addition, certain factors such as chronic arterial hypertension, smoking and chronic alcohol intoxication favor the risk of aneurysm rupture or growth. Cerebral aneurysm rupture has a serious prognosis: 10% of patients die before reaching hospital, 25% die within 24 hours, and 40-49% die within 3 months. Interventional neuroradiology offers treatment via an endovascular approach, by obstructing the aneurysm with coils and stents navigating within the arteries. This operation is not without risk of death or per-procedural stroke. In France, it is estimated that 5 to 7 patients per 100,000 of the population suffer a ruptured aneurysm, which means around 5,000 new cases every year. This figure does not take into account patients who die before accessing medical services.\n\nInterventional neuroradiology is a little-known discipline. Lack of knowledge about the activity, the professionals involved and the technologies involved, leads to anxiety among patients.\n\nMoreover, neurological pathologies are often physically undetectable. The investigators note a high degree of anxiety among patients on arrival at the department.However, it is difficult to explain the examination without support.That's why it would be interesting to build a simulation tool.\n\nThe investigators note a high degree of anxiety among patients on arrival at the department. However, it is difficult to explain the examination without support. That's why it would be interesting to build a simulation tool.\n\nsimulation tool to help explain the procedure: a 3D printer model of the vessels of a full-scale silicone model called the flow model, to be presented at the paramedical consultation for the experimental group. This will enable the patient to visualize the procedure and play an active role in it. The patient will therefore be able to benefit from all the information the procedure and the practices involved, understanding not only how the puncture is made and where, but also how it is arrived at. the aneurysm and how it is treated. In addition, visualizing the procedure will help patients to avoid the unknown, and make it easier to manage their anxiety.\n\nThe flow model enables visualization of aneurysmal pathology in a simplified, concrete and didactic way for patients and the general public.\n\nAt present, flow models of cerebral aneurysms have already been evaluated by some teams with a view to improving the information provided to the patient, in a non-randomized fashion and partially covering the operation.\n\nTo our knowledge, there is no flow model reproducing the entire endovascular operative pathway from the puncture site (femoral or radial approach), the aorta and the graft to the aorta.\n\nthe aorta, then the cervical arteries through to the cerebral aneurysm, has yet to be created and used.\n\nThe major advantage of this modelization would be to simulate the entire procedure during the consultation, from puncture to placement of the stent and coils occluding the aneurysm. This project is particularly innovative, as it enables the patient to rationalize the procedure, potentially reducing his or her state of anxiety, and putting the patient and paramedical team in a practical situation to face up to the inherent risks of the operation. In addition, flow model simulation will enable the paramedical team to be trained in the practice of interventions. The ANXIFLOW project will therefore form the basis of a new handling training course for the continuing education of radiology technicians.\n\nThis will involve preparing the radiology technicians to assist the doctor, preparing the equipment, disinfecting and laying the operating drapes, and anticipating the doctor's needs: prepared coils, micro-catheters, perfusion bag and purge circuit, etc.",[26],[60,61,62],"aneurysm","anxiety","flow model","2025-04-04",{"date":65,"type":37},"2025-04-06",{"date":67,"type":20},"2025-05-02",{"date":69,"type":20},"2028-05-02",{"name":71,"class":43},"University Hospital, Caen",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":4},"100562271","parent-artery-reconstruction-for-small-unruptured-cerebral-aneurusms-using-flow-diverters-a-multicenter-randomized-trialparat-mt-100562271","NCT06600997","Parent Artery Reconstruction for Small Unruptured Cerebral Aneurusms Using Flow DiverTers: a Multicenter Randomized Trial(PARAT-MT)","Inclusion Criteria:\n\n1. Age 18-75 years.\n2. Previously unruptured saccular cerebral aneurysm arising from intradural segments of the internal carotid artery and intracranial segments of the vertebral artery.\n3. Measuring ≤10mm in maximum diameter\n4. Subjects capable of understanding the study's purpose, willing to participate, and have signed an informed consent form.\n\nExclusion Criteria:\n\n1. Subjects with two or more multiple aneurysms requiring treatment within one year.\n2. Subjects with arteriovenous malformations or moyamoya disease.\n3. Subjects with ruptured, recurrent, or dissecting aneurysms.\n4. Subjects with symptomatic cerebral stenosis \\>70%;\n5. Subjects who have experienced a stroke (cerebral hemorrhage, cerebral infarction) within the past month.\n6. Clinical condition is extremely poor with a modified Rankin score of ≥3.\n7. Subjects planned for surgical\u002Finterventional procedures within three months.\n8. Subjects deemed inappropriate for interventional treatment by the investigator (e.g., no suitable vascular access, excessively tortuous vessels, difficult stent delivery, etc.).\n9. Subjects with severe comorbidities, unsuitable for anesthesia or endovascular surgery (e.g., major cardiac, pulmonary, hepatic, splenic, renal diseases, atrial fibrillation ,brain tumors, severe active infections, disseminated intravascular coagulation, history of severe mental illness).\n10. Subjects unable to tolerate antiplatelet or anticoagulant therapy.\n11. Subjects who has had or are likely to have a severe reaction to contrast media.\n12. Subjects with a history of allergy to nickel-titanium, cobalt-chromium, or platinum-tungsten alloys.\n13. Subjects who have participated in other drug or medical device clinical trials and have not reached the primary endpoint time limit.\n14. Pregnant or breastfeeding women.\n15. Subjects with an expected lifespan of less than 12 months.\n16. Subjects deemed by the investigator to have poor compliance, unable to complete the study as required.","75 Years",{"count":80,"type":20},1008,[23],"A prospective, multicenter, randomized controlled clinical trial with open-label treatment and blinded endpoint assessment.",[26,84],"Cerebral Aneurysm","2025-01-01",{"date":87,"type":37},"2025-01-03",{"date":89,"type":20},"2025-01-15",{"date":91,"type":20},"2031-10-30",{"name":93,"class":43},"Changhai Hospital"]