[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-autoregulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-autoregulation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,39,63,99,129,153,180],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100559539","feasibility-of-using-neurasignal-transcranial-doppler-robot-100559539",false,"NCT06565442","Feasibility of Using NeuraSignal Transcranial Doppler Robot","Feasibility of Using NeuraSignal Transcranial Doppler Robot for Generating Cerebral Autoregulation Curves in Neuro ICU Patients Admitted for Blood Pressure Management After Spinal Surgery","Inclusion Criteria:\n\n* 18-89\n* Patients admitted to the Neuro ICU for blood pressure management (MAP management) after spinal surgery\n\nExclusion Criteria:\n\n* Patients under 18 years (or bodyweight \\\u003C50kg if age unknown),\n* prisoners\n* pregnant women,\n* non-English speaking,\n* patients enrolled in concurrent\n* ongoing interventional trial\n* students of UAB\n* employees of UAB\n* targeting specific populations\n* patients with previously diagnosed brain pathology\n* patients with open wounds over temporal bones precluding transcranial doppler","ALL","18 Years","89 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine the feasibility of using the NeuraSignal transcranial doppler robot in a neuro ICU setting to measure cerebral blood flow correlated with arterial blood pressure to generate individualized cerebral autoregulatory curves",[25],"Cerebral Autoregulation","NOT_YET_RECRUITING","2026-05-04",{"date":29,"type":30},"2026-05-08","ACTUAL",{"date":32,"type":21},"2026-06-15",{"date":34,"type":21},"2027-12-15",{"name":36,"class":37},"University of Alabama at Birmingham","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":62},"100635698","ultra-early-identification-of-futile-recanalization-after-reperfusion-therapy-in-acute-ischemic-stroke-based-on-cerebral-autoregulation-100635698","NCT07556068","Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation","Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation Monitoring: a Multicenter, Prospective, Observational Study","CAREFUL-CA","Inclusion Criteria:\n\n1. Age ≥ 18\n2. Clinical signs consistent with acute ischemic stroke with large vessel occlusion in the anterior circulation (intracranial segment of the internal carotid artery, middle cerebral artery M1 segment) demonstrated with CTA\u002FMRA\u002FDSA.\n3. NIHSS score ≥ 6 obtained prior to endovascular treatment.\n4. Modified Rankin Scale ≤ 1 prior to qualifying stroke.\n5. Acute ischemic stroke, undergone endovascular treatment within 24 hours of onset (time of stroke is the last known normal for wake-up stroke or with unknown onset time).with reaching the goal of mTICI grade 2b-3\n6. For patients with symptom onset within 6 hours: ASPECTS ≥ 3; for patients with symptom onset between 6 and 24 hours: age ≤ 80 years and ASPECTS ≥ 3.\n7. Patient\u002FLegally Authorized Representative has signed the Informed Consent Form.\n\nExclusion Criteria:\n\n1. Baseline CT\u002FMRI confirms the presence of multiple vascular territory acute strokes.\n2. Baseline CT\u002FMRI confirms the presence of arterial dissection.\n3. Evidence of intracranial hemorrhage or hemorrhagic transformation before thrombectomy.\n4. Known allergies or intolerances to antiplatelet agents, anticoagulation drugs, iodinated contrast and\u002For anesthetics.\n5. Severe infection (e.g. sepsis) or multiple organ failure.\n6. Known hereditary or acquired hemorrhagic diathesis or coagulation factor deficiency; oral anticoagulant therapy with INR \\> 3; or use of a factor Xa inhibitor within the preceding 48 hours with an abnormal aPTT.\n7. Baseline platelet count \\\u003C 50 × 10\\^9\u002FL.\n8. Blood glucose concentration\\\u003C50 mg\u002FdL (2.7 mmol\u002FL) or \\>400 mg\u002FdL (22.2 mmol\u002FL).\n9. Refractory hypertension that is difficult to control by medication (Defined as persistent systolic blood pressure\\>185 mmHg or diastolic blood pressure\\>110 mmHg).\n10. Severe cardiomyopathy with heart failure (LVEF ≤ 30% or NYHA class IV), acute myocardial infarction, or unstable angina.\n11. Untreated moderate or severe coronary artery stenosis, or previous coronary artery bypass surgery.\n12. Current hemodialysis or peritoneal dialysis; known severe renal insufficiency with estimated glomerular filtration rate \\\u003C 30 mL\u002Fmin or serum creatinine \\> 220 μmol\u002FL (2.5 mg\u002FdL).\n13. Known intracranial aneurysm, and cerebral arteriovenous malformation.\n14. Malignant brain tumor or CNS infection.\n15. Pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations (e.g., dementia or mental illness)\n16. Female who is pregnant or lactating at time of admission.\n17. Anticipated life expectancy \\\u003C 6 months.\n18. Current participation in another investigational drug or device study.\n19. local skin damage or other conditions that cannot cooperate with electrode sticking.\n20. severe agitation or other conditions affecting data collection.",{"count":48,"type":21},129,"This multicenter, prospective, observational diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90 days post-enrollment. The study aims to determine whether impaired cerebral autoregulation during thrombectomy can serve as an ultra-early biomarker for predicting futile recanalization in patients with acute ischemic stroke.",[51,25],"Acute Ischemic Stroke","RECRUITING","2026-04-30",{"date":55,"type":30},"2026-05-06",{"date":57,"type":30},"2026-04-20",{"date":59,"type":21},"2026-10-20",{"name":61,"class":37},"Beijing Shijitan Hospital, Capital Medical University",4,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":71,"targetDuration":4,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":38},"100621941","hyper-mind---hyperoxia-effects-on-cerebral-hemodynamics-100621941","NCT07377162","HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics","HYPERMIND - Hyperoxia Effects on Cerebral Hemodynamics","HYPER-MIND","Inclusion Criteria\n\n* Adult patients aged ≥18 years\n* Admitted to the intensive care unit (ICU)\n* Intubated and mechanically ventilated for ≤72 hours\n* Receiving volume-controlled mechanical ventilation\n* Arterial partial pressure of carbon dioxide (PaCO₂) between 35 and 45 mmHg\n* Invasive arterial blood pressure monitoring in place\n* Adequate transcranial Doppler (TCD) acoustic window\n* Clinically judged to be suitable for a brief normobaric hyperoxic stimulus\n* Expected to receive one or two hyperoxic steps based on baseline FiO₂ requirements: a) Baseline FiO₂ \\\u003C 0.5: two-step hyperoxic stimulus (FiO₂ 0.5 followed by FiO₂ 1.0); b) Baseline FiO₂ ≥ 0.5: one-step hyperoxic stimulus (FiO₂ 1.0)\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Pregnancy\n* Extracorporeal membrane oxygenation (ECMO)\n* Continuous renal replacement therapy (CRRT)\n* Contraindications to hyperoxia, as judged by the treating physician\n* Severe hemodynamic instability requiring changes in vasopressor dose during the recording period\n* Inability to obtain a reliable transcranial Doppler signal through the temporal acoustic windows\n* Any clinical condition deemed by the treating physician to pose unacceptable risk during hyperoxic exposure",{"count":72,"type":21},80,"INTERVENTIONAL",[75],"NA","This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU). Many ICU patients receive more oxygen than strictly necessary, and high blood oxygen levels (hyperoxemia) are very common. However, the immediate effects of short hyperoxic exposures on cerebral circulation and autoregulation remain poorly understood.\n\nIn this study, patients who already require mechanical ventilation for medical reasons will undergo a brief and controlled increase in the oxygen delivered through the ventilator (FiO₂). During this time, we will continuously monitor blood flow in one of the main brain arteries using a non-invasive ultrasound technique called transcranial Doppler (TCD). The goal is to evaluate how cerebral blood flow, pulsatility, and autoregulatory capacity change during and after a short hyperoxic stimulus.\n\nNo additional invasive procedures are required beyond standard ICU monitoring, except for the temporary adjustment of the ventilator's oxygen settings and arterial blood gas sampling, which are part of usual care in critically ill patients. Participation does not provide direct clinical benefit but may help improve future oxygen management in ICU patients. The study involves minimal risk, as short hyperoxic exposures are already common in routine care and will be interrupted immediately in case of any adverse event.",[78,79,25,80,81],"Hyperoxemia","Cerebrovascular Circulation","Critical Illness","Mechanical Ventilation",[83,84,85,86,80,87,88,89],"hyperoxemia","brain hemodynamics","tcd","cerebral autoregulation","intensive care unit","hyperoxia","oxygen","2026-01-22",{"date":92,"type":30},"2026-01-29",{"date":94,"type":30},"2024-01-01",{"date":96,"type":21},"2028-12-31",{"name":98,"class":37},"Erasme University Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":106,"sex":16,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":73,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":38},"100606771","remote-ischaemic-conditioning-in-the-older-person-and-effects-on-dynamic-cerebral-autoregulation-100606771","NCT07179887","Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation","RICE-DCA","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study\n* Participant aged 65 - 85\n* Participant is able to perform RIC independently at home\n\nExclusion Criteria:\n\n* Active cardiovascular or cerebrovascular disease (acute event within the last 12 months)\n* Atrial fibrillation or other significant arrhythmias\n* Peripheral Vascular Disease\n* Haemostatic disorders\n* Soft tissue injury or fracture to the upper limb\n* Pregnant or breast feeding\n* History or current psychiatric illness\n* History or current neurological condition (e.g. epilepsy)\n* Inability to identify temporal window for transcranial doppler ultrasound at screening visit\n* Any condition or presentation under current investigation that is deemed by the study clinician to exclude the participant from the study.\n* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance",true,"65 Years","85 Years",{"count":110,"type":21},45,[75],"Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy in a variety of clinical settings. However, the ideal protocol of RIC \\[dose\\] is unknown. Dynamic Cerebral Autoregulation (dCA) has been shown to increase in response to RIC.\n\nThe goal of this trial is to study whether an increase in RIC protocol intensity results in a larger effect on biomarkers of vascular health such as dCA.\n\nParticipants shall:\n\nReceive RIC daily, RIC thrice weekly or sham RIC thrice weekly for 6 weeks Visit the School of Medicine at baseline and at 6 weeks for measurement of biomarkers of vascular health including blood pressure, indices od dCA and blood plasma samples",[25,114,115],"Blood Pressure","Dynamic Cerebral Autoregulation",[117,115,118,119],"Remote Ischaemic Conditioning","Vascular Health","Randomised Controlled Trial","2025-09-15",{"date":122,"type":30},"2025-09-18",{"date":124,"type":30},"2025-08-27",{"date":126,"type":21},"2027-09-30",{"name":128,"class":37},"University of Nottingham",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":73,"phases":139,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":152},"100547351","association-between-local-cerebral-oxygenation-monitoring-and-postoperative-stroke-in-carotid-endarterectomy-100547351","NCT06406842","Association Between Local Cerebral Oxygenation Monitoring and Postoperative Stroke in Carotid Endarterectomy","Perioperative Application of Hemodynamic Management Based on Regional Cerebral Oxygen Saturation Monitoring of Cerebral Autoregulation in Carotid Endarterectomy","Inclusion Criteria:\n\n* Patients scheduled for elective carotid endarterectomy\n* ASA Ⅱ or Ⅲ\n* aged 18-80 years old\n\nExclusion Criteria:\n\n* preoperative moderate and severe cognitive impairment\n* preoperative psychotropic medication history within one year\n* history of neurosurgery\n* have speech or language impairments","80 Years",{"count":138,"type":21},560,[75],"Carotid endarterectomy (CEA) is used to treat symptomatic extracranial internal carotid artery stenosis. The occult stroke of CEA patients evaluated by magnetic resonance imaging 3 days after operation was as high as 17%. Cerebral blood flow autoregulation (CA) is the ability of the brain to maintain the relative stability of cerebral blood flow, and cerebral oxygen index (COx) can be used to reflect CA. A negative value of cerebral oxygen index or a value near zero indicates that CA is complete, and cerebral oxygen index close to 1 indicates that CA has lost its ability. In theory, real-time monitoring of CA function by cerebral oxygen index and individualized management strategy with this goal can potentially reduce perioperative ischemic brain injury. The purpose of this study is to explore the influence of the management strategy of monitoring CA function based on regional cerebral oxygen saturation on the postoperative neurological complications of CEA patients.",[142,25],"Carotid Endarterectomy","2025-09-02",{"date":145,"type":30},"2025-09-08",{"date":147,"type":30},"2024-07-08",{"date":149,"type":21},"2026-12",{"name":151,"class":37},"Beijing Tiantan Hospital",2,{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":106,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":163,"conditions":164,"keywords":167,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":38},"100493544","cardiovascular-and-cerebrovascular-control-in-healthy-subjects-100493544","NCT05706532","Cardiovascular and Cerebrovascular Control in Healthy Subjects","Cardiovascular and Cerebrovascular Control in Healthy Adult Subjects","CardioSan","Inclusion Criteria:\n\n* age \\>18\n* sinus rhythm\n* informed consent signed\n\nExclusion Criteria:\n\n* age \\\u003C18\n* presence of autonomic nervous system diseases or dysfunctions",{"count":162,"type":21},60,"The aim of the study is to evaluate autonomic function and cerebrovascular control in 60 healthy subjects by means of noninvasive analysis of time series variability.\n\nTo this extent, heart period, systolic and mean arterial blood pressure, cerebral blood velocity, peripheral resistances, respiration will be recorded from subjects during an orthostatic challenge.\n\nThe interactions between autonomic cardiovascular function, cerebrovascular and peripheral control will be evaluated exploiting the most advanced signal processing techniques.",[165,166,25],"Healthy","Autonomic Nervous System",[168,169,86,170],"autonomic nervous system","heart rate variability","peripheral resistances","2025-03-25",{"date":173,"type":30},"2025-03-28",{"date":175,"type":30},"2023-05-29",{"date":177,"type":21},"2027-10",{"name":179,"class":37},"IRCCS Policlinico S. Donato",{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":190,"conditions":191,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":38},"100417994","neurocognitive-outcomes-for-icu-patients-with-acute-kidney-injury-100417994","NCT04722939","Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury","Identifying Neurocognitive Outcomes and Cerebral Oxygenation in Critically Ill Adults on Acute Kidney Replacement Therapy in the Intensive Care Unit","INCOGNITOAKI","Inclusion Criteria:\n\n* age greater than or equal to 18 years\n* admitted to the Kingston Health Sciences Intensive Care Unit\n* diagnosis of severe AKI requiring Kidney Replacement Therapy (KRT) (defined by the presence of either a twofold increase in serum creatinine from baseline, serum creatinine level greater than or equal to 354 micromol\u002FL with an increase of 27 micromol\u002FL from baseline, or urine output \\\u003C6 mL\u002Fkg in the preceding 12 hours)\n* within 12 hours of initiation of KRT via intermittent hemodialysis (iHD) or continuous kidney replacement therapy (CKRT).\n\nExclusion Criteria:\n\n* acquired or congenital neurological disorders\n* any contraindication to testing with cerebral oximetry, Kinarm, or MRI (e.g., claustrophobia, limb amputation, paresis, neuromuscular disorders, etc.)\n* KRT via PD\n* failure to consent\n* life expectancy less than 24 hours\n* clinical suspicion of renal obstruction\n* rapidly progressive glomerulonephritis or interstitial nephritis\n* prehospitalization eGFR \\\u003C30 mL\u002Fmin\u002F1.73m2.",{"count":189,"type":21},104,"Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality. KRT has been linked to poor neurocognitive outcomes, leading to a reduced quality of life, as well as increased utilization of healthcare resources. Adults initiated on dialysis in the ICU may be particularly at risk of neurocognitive impairment, as survivors of critical illness are already predisposed to developing cerebrovascular disease and cognitive dysfunction over the long-term relative to healthy controls. Regional cerebral oxygen saturation (rSO2) may provide a critical early marker of long-term neurocognitive impairment in patients in this population. The INCOGNITO-AKI study aims to understand cerebral oxygenation in patients undergoing KRT, either continuous or intermittent, in the ICU. These findings will be correlated with long-term cognitive and functional outcomes, as well as structural brain pathology.\n\nMethods and analysis. 108 patients scheduled to undergo treatment for acute kidney injury with KRT in the Kingston Health Sciences Centre ICU will be recruited into this prospective observational study. Enrolled patients will be assessed with intradialytic cerebral oximetry using near infrared spectroscopy (NIRS). Delirium will be assessed daily with the Confusion Assessment Method-Intensive Care Unit (CAM-ICU) and delirium severity quantified as cumulative CAM-ICU-7 scores. Neurocognitive impairment will be assessed at 3- and 12-months after hospital discharge using the Kinarm and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Structural brain pathology on MRI will also be measured at the same timepoints. Driving safety, adverse events, and medication adherence will be assessed at 12-months to evaluate the impact of neurocognitive impairment on functional outcomes.\n\nEthics and dissemination. This study has been approved by the Queen's University Health Sciences and Affiliated Teaching Hospitals Research Ethics Board (Approval number: DMED-2424-20). Results will be presented at critical care scientific conferences and a lay summary will be provided to patients and families in their preferred format.",[192,193,80,194,195,25],"Delirium","Acute Kidney Injury","Cognitive Impairment","Cerebral Oxygenation","2023-12-19",{"date":198,"type":30},"2023-12-26",{"date":200,"type":30},"2021-01-15",{"date":202,"type":21},"2027-01-01",{"name":204,"class":37},"Dr. Gordon Boyd"]