[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-hypoperfusion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-hypoperfusion":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,80,110,142],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100604495","correlation-between-carotid-stump-pressure-and-interhemispheric-rso-asymmetry-during-awake-carotid-endarterectomy-100604495",false,"NCT07150260","Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry During Awake Carotid Endarterectomy","Evaluation of the Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry in Awake Carotid Endarterectomy: A Prospective Cohort Study","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for elective carotid endarterectomy (CEA)\n* Able to tolerate surgery under regional anesthesia (superficial cervical plexus block)\n* Availability of bilateral regional cerebral oxygen saturation (rSO₂) measurements by near-infrared spectroscopy (NIRS)\n* Successful intraoperative carotid stump pressure (SP) measurement after cross-clamping\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Incomplete NIRS or SP recordings\n* Conversion from regional to general anesthesia\n* Intraoperative technical complications preventing monitoring\n* History of prior ipsilateral carotid endarterectomy or carotid artery stenting\n* Recent major stroke with permanent neurological deficit\n* Recent myocardial infarction within the past 3 months\n* History of traumatic brain injury within the past 6 months","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","30 Days","OBSERVATIONAL","This study aims to better understand how well the brain is perfused (supplied with blood and oxygen) during a specific type of surgery called carotid endarterectomy (CEA), which is performed to prevent strokes in people with stenosis of carotid arteries.\n\nDuring this surgery, the surgeon temporarily clamps the carotid artery to remove a blockage, which can reduce blood flow to the brain. Monitoring brain oxygen levels during this time is important to prevent brain injury. Two common monitoring methods are:\n\nStump pressure (SP) - a pressure measurement taken from the carotid artery during surgery.\n\nNear-infrared spectroscopy (NIRS) - a non-invasive technique that tracks brain oxygen levels in real time.\n\nThis study focuses on the relationship between carotid stump pressure and differences in brain oxygenation between the two sides of the brain (interhemispheric asymmetry), as measured by NIRS.\n\nThe study will include patients undergoing awake CEA (under regional anesthesia) at a single center university hospital. Oxygen levels in both hemispheres of the brain will be monitored before and after the carotid artery is clamped after 3 minutes. Stump pressure will also be measured. The researchers will examine whether low stump pressure is linked to greater differences in brain oxygen levels between the two sides.\n\nThe primary goal is to determine whether a large difference in brain oxygenation between the two hemispheres (greater than 10%) is associated with low carotid stump pressure. Secondary goals include identifying a stump pressure threshold that predicts significant asymmetry and analyzing the influence of patient and surgical factors.\n\nThe findings may help improve how surgeons and anesthesiologists monitor and protect the brain during CEA, particularly in patients who are awake and can be observed for neurological changes.",[25,26,27],"Carotid Artery Stenosis Symptomatic","Carotid Endarterectomy (CEA) Surgical Patients","Cerebral Hypoperfusion",[29,30,31,32,33,34],"Carotid stump pressure","Near-infrared spectroscopy","rSO₂ asymmetry","Cerebral oxygenation","Awake carotid endarterectomy","Regional anesthesia","RECRUITING","2026-01-06",{"date":38,"type":39},"2026-01-07","ACTUAL",{"date":41,"type":39},"2025-09-01",{"date":43,"type":20},"2026-10-01",{"name":45,"class":46},"Izmir Katip Celebi University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":60,"conditions":61,"keywords":67,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":47},"100526369","cerebral-autoregulation-in-non-cardiac-surgery-and-relationship-to-postoperative-delirium-state-100526369","NCT06133842","CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State","CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State - CERBERUS Trial","CERBERUS","Inclusion Criteria:\n\n* Age ≥ 60 years\n* Undergoing any non-cardiac surgeries including but not limited to vascular, hepatobiliary, or complex spine surgeries requiring general anesthesia with arterial catheterization for monitoring\n\nExclusion Criteria:\n\n1. Non-English speaking (Justification: cognitive assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)\n2. Cognitive impairment as defined by total MoCA score \\\u003C 10 (justification: baseline cognitive dysfunction will confound primary outcome measure)\n3. Significant visual impairment (justification: will be difficult for patients to draw individual components in MOCA score)\n4. Emergent surgery (justification: insufficient time to initiate intervention)\n5. History of stroke within the last 3 months (justification: cognitive dysfunction secondary to stroke can confound outcome measures",true,"60 Years",{"count":59,"type":20},100,"The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60 undergoing major non-cardiac surgery. The main question\\[s\\] it aims to answer are:\n\n* Is there a way to tailor the blood pressure to be maintained in such patients during surgery for optimal brain health using non-invasive monitors that check the brains electrical activity, the electroencephalogram(EEG) monitor, and the brain's blood oxygen levels, the cerebral oximetry(CO) monitor?\n* How much does this optimal blood pressure level vary between patients?\n\nParticipants will be asked to:\n\n* Complete a questionnaire at the time they enroll into the study, as well as a daily questionnaire to help determine their level of thinking and brain health. This questionnaire will be administered by a member of the study team.\n* They will also have an EEG and CO monitoring sticker placed on their foreheads. This will be connected to a monitor that will collect this data just before, during, and after their surgery. The data collected through these monitors will help us with our study goals.",[62,63,64,65,66,27],"Perioperative\u002FPostoperative Complications","Postoperative Cognitive Dysfunction","Postoperative Delirium","EEG With Periodic Abnormalities","Intraoperative Hypotension",[68,69,70],"EEG","Cerebral Autoregulation","Intraoperative Monitoring","2025-10-27",{"date":73,"type":39},"2025-10-28",{"date":75,"type":39},"2024-04-17",{"date":77,"type":20},"2027-07",{"name":79,"class":46},"Beth Israel Deaconess Medical Center",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":47},"100587475","the-effect-of-controlled-hypotension-100587475","NCT06928870","The Effect of Controlled Hypotension","The Effect of Controlled Hypotension on Cerebral Oxygen Saturation in Spinal Surgery","NIRS","Inclusion Criteria:\n\n* Aged 18-65 years\n* ASA I-III risk group\n* BMI between 18-40\n* Baseline blood pressure below 140\u002F90 mmHg\n* Scheduled to undergo spinal surgery (2-4 level instrumentation)\n\nExclusion Criteria:\n\n* Below 18 or above 65 years old\n* Advanced comorbidities\n* ASA IV or higher\n* Baseline blood pressure above 140\u002F90 mmHg\n* History of bleeding diathesis\n* Use of anticoagulant medications\n* BMI below 18 or above 40\n* History of previous spinal surgery","65 Years",{"count":19,"type":20},"INTERVENTIONAL",[92],"NA","Controlled hypotension is currently used in spinal surgery to reduce bleeding at the surgical site, improve the surgeon's visibility, and decrease intraoperative blood loss. Although controlled hypotension is considered a beneficial method from a surgical perspective, it is important to be cautious about its side effects. One such side effect is cerebral perfusion insufficiency, which can be managed by monitoring cerebral circulation through regional cerebral oxygen saturation (rSO2).\n\nThe aim of this study is to compare the effects of controlled hypotension at specific MAP ranges on cerebral oxygen saturation.",[27,95],"Hypotension",[97,86,98],"cerebral oxygen saturation","controlled hypotension","NOT_YET_RECRUITING","2025-04-14",{"date":102,"type":39},"2025-04-15",{"date":104,"type":20},"2025-04-30",{"date":106,"type":20},"2025-06-30",{"name":108,"class":109},"Ankara Etlik City Hospital","OTHER_GOV",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":120,"conditions":121,"keywords":126,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":47},"100564061","test-of-reproducibility-of-15oh20-pet-assessment-of-brain-perfusion-100564061","NCT06624267","Test of Reproducibility of [15O]H20-PET Assessment of Brain Perfusion","Small Vessel Disease of the Brain and Heart: a Perfusion PET Study of Training Effects","SVAT","Inclusion Criteria:\n\n* Age \\> 60 years\n* No diagnosis of T2D according to WHO\\'s criteria.\n* Speaks and understands Danish (required for reliable cognitive testing)\n* Able to provide informed and written consent\n\nExclusion Criteria:\n\n* Moderate to high intensity training \\>2 times\u002Fweek.\n* Previous AMI, atrial fibrillation, significant cardiac valve disease, HFrEF (LVEF \\<45%), asthma.\n* Previous stroke or significant neurological disease including cognitive dysfunction.\n* Ongoing depression.\n* Hypothyroidism\n* Unable or unwilling to participate in training, e.g., due to injury, arthrosis or lung disease.",{"count":119,"type":20},8,"In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in relation to stroke have improved significantly. Yet, the majority of elderly patients with ischemic heart disease do not have large-vessel heart disease and it seems that small vessel disease (SVD) may explain a large fraction of these cases as well as the cardiovascular morbidity in the elderly. Hence, the current development in diagnostics and treatments of ischemic heart disease does not address the most common subtype of ischemic disease seen in elderly patients.\n\nIt has been suggested that SVD is part of a multisystem disorder and several systematic reviews have addressed the hypothesis of a potential link between small vessel disease of the heart, brain, and kidneys. Cerebral SVD is prevalent in the aging population causing cognitive impairment, dementia, and an increased risk of stroke, and cerebral hypoperfusion is an acknowledged cause of vascular dementia and a possible cause of Alzheimer's disease. Further, cognitive impairment within multiple cognitive domains is highly prevalent in heart failure and is associated to an increased risk of dementia. The link between heart failure and dementia may be due to multisystem SVD, although a direct link between the two is possible.\n\nAmong other known risk factors such as age, hypertension, and female sex, diabetes is a major cause of SVD and is linked to coronary heart disease as well as cognitive impairment. The diagnosis of cerebral SVD relies on MRI detecting infarctions, haemorrhages, microbleeds and ischemic white matter changes, i.e. Fazekas score. In contrast, perfusion PET is used to image myocardial perfusion in patients with coronary SVD; and coronary SVD is recognized as a part of the pathophysiology in angina, coronary artery disease, and heart failure. Perfusion PET before and after adenosine-induced vasodilation allows for measuring, the myocardial flow reserve (MFR), i.e. perfusion capacity, which in the absence of regional perfusion defects, is a measure of coronary SVD. Prof. Eva Prescott have recently shown that reduced MFR obtained by 82Rb PET is a strong predictor of future microvascular events and all-cause mortality.\n\nExercise is well known to improve cognitive health but professor Carl-Johan Boraxbekk has shown that the effect on cognitive performance may be dependent on the initial cerebrovascular status, as patients with moderate to severe white matter changes did not improve after a 6 months physical activation intervention in contrast to patients with mild changes. Yet, it is possible to improve brain function in diabetic patients through either dietary or exercise interventions.\n\nSystemic SVD is measured as cerebral SVD (reduced brain perfusion during acetazolamide-induced vasodilation) and coronary SVD (reduced heart perfusion during adenosine-induced vasodilation). The researchers anticipate that patients with type 2 dabetes have reduced perfusion capacity of the brain and heart correlating to reduced cognition and cardiorespiratory fitness (VO2-max).",[122,123,124,27,125],"Microvascular Disease","Microvascular Complications","Diabetes Mellitus Type 2","Dementia",[127,128,129,130,131,132],"microvascular disease","microvascular complications of the heart","microvascular complications of the brain","microvascular disease patophysiology","diabetes type 2","dementia","2024-10-02",{"date":135,"type":39},"2024-10-04",{"date":137,"type":20},"2024-11",{"date":139,"type":20},"2027-12",{"name":141,"class":46},"University Hospital Bispebjerg and Frederiksberg",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":116,"eligibilityCriteria":148,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":149,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":120,"conditions":151,"keywords":152,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":153,"startDateStruct":154,"completionDateStruct":155,"leadSponsor":156,"locationsCount":47},"100564370","comparison-of-differencens-in-vo2-max-perfusion-of-the-heart-and-brain-and-cognitive-performance-between-patients-with-type-2-diabetes-and-healthy-age-matched-controls-100564370","NCT06628297","Comparison of Differencens in VO2-max, Perfusion of the Heart and Brain and Cognitive Performance Between Patients with Type 2 Diabetes and Healthy Age Matched Controls.","Small Vessel Disease of the Brain and Heart a PET Perfusion Study of Training Effects","Inclusion Criteria for the patients with type 2 diabetes:\n\nDiabetes type II diagnose with one of the following:\n\n* Duration over 5 years\n* Moderate microalbuminuria\n* Non-proliferative diabetic retinopathy\n\n  * Speaks and understands Danish (required for reliable cognitive testing)\n  * Able to provide informed and written consent\n\nExclusion Criteria or the patients with type 2 diabetes:\n\nModerate to high intensity training \\>1 times\u002Fweek.\n\n* Previous AMI, atrial fibrillation, significant cardiac valve disease, HFrEF (LVEF \\<45%), asthma.\n* Previous stroke or significant neurological disease including cognitive dysfunction.\n* Ongoing depression.\n* Hypothyroidism\n* Unable or unwilling to participate in training, e.g., due to injury, arthrosis or lung disease.\n\nInclusion Criteria for the healthy age-matched controls:\n\n* Age \\> 60 years\n* No diagnosis of T2D according to WHO\\'s criteria.\n* Speaks and understands Danish (required for reliable cognitive testing)\n* Able to provide informed and written consent\n\nExclusion Criteria for the healthy age-matched controls:\n\n* Moderate to high intensity training \\>2 times\u002Fweek.\n* Previous AMI, atrial fibrillation, significant cardiac valve disease, HFrEF (LVEF \\<45%), asthma.\n* Previous stroke or significant neurological disease including cognitive dysfunction.\n* Ongoing depression.\n* Hypothyroidism\n* Unable or unwilling to participate in training, e.g., due to injury, arthrosis or lung disease.",{"count":150,"type":20},72,[122,123,125,124,27],[127,128,129,131,132,130],{"date":135,"type":39},{"date":137,"type":20},{"date":139,"type":20},{"name":141,"class":46}]