[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-hypoxia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-hypoxia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100442999","effect-of-hypoxic-conditioning-on-cerebrovascular-health-in-the-elderly-100442999",false,"NCT05048680","Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly","HYPOXAGE","Inclusion Criteria:\n\n* 60 to 80 years of age;\n* Being physically inactive (less than 150 min\u002Fweek of moderate to intense physical activity);\n* No chronic cardiovascular, respiratory, metabolic or neuromuscular disease counterindicating an exercise training or hypoxic conditioning program;\n* Health coverage;\n* Being able to provide written fully informed consent.\n\nExclusion Criteria:\n\n* Body-mass index \\>30 kg\u002Fm2;\n* Smoking (\\> cigarettes\u002Fday);\n* Alcohol use (\\> 10g\u002Fday);\n* Mental disorder or history of mental disorder;\n* Beta-blockade treatment;\n* Inability or refusal to provide informed consent;\n* No health coverage\n* People exceeding the annual ceiling of allowances received as a result of their participation in other clinical trials;\n* People deprived of freedom by judicial or administrative decision;\n* People subject to legal protection, who cannot be included in clinical trials.",true,"ALL","60 Years","80 Years",{"count":21,"type":22},64,"ESTIMATED","INTERVENTIONAL",[25],"NA","In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional capacities and a sufficient quality of life in the elderly. The alteration of vascular function (at the cerebral and systemic level) with aging is an important feature in the clinical picture including a decrease in physical and cognitive capacities. Although physical activity is recognized as an essential means of combating the effects of aging, optimizing its effects by defining the most effective strategies of practice remains a key objective. Offering alternative interventions to exercise training is also necessary for people who are unwilling or unable to engage in a physical activity program. In this context, hypoxic conditioning, alone or in conjunction with rehabilitative exercise training, is a new therapeutic modality with strong preclinical validity, in particular from a cardiovascular standpoint, and used in other pathologies to improve cardiovascular function and exercise performance and quality of life. Our aim is, therefore, to investigate the effect of hypoxic conditioning (alone or in conjunction with exercise training) on cerebrovascular health in the elderly.",[28,29,30,31,32,33,34],"Hypoxia","Cerebral Hypoxia","Brain Diseases","Exercise","Aging","Cognitive Decline","Healthy Aging","RECRUITING","2026-05-04",{"date":38,"type":39},"2026-05-08","ACTUAL",{"date":41,"type":39},"2021-10-13",{"date":43,"type":22},"2026-09",{"name":45,"class":46},"University Hospital, Grenoble","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":47},"100437076","thrombo-inflammation-biomarkers-trial-in-acute-cerebral-hypoxia-100437076","NCT04971564","Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia","Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia. A Case-control Trial Nested in a Cohort","RADICAL","Inclusion Criteria:\n\n\\- For cases, admitted within the first 36 hours of an acute neurological symptom related to :\n\n* An ischaemic cerebrovascular accident (iCVA) eligible for a mechanical thrombectomy procedure,\n* A subarachnoid haemorrhage (SAH, all aetiologies) : patient presenting with at least a modified Fisher scale 3 or 4,\n* An intra-parenchymal haematoma (IPH) with greatest axis ≥ 20mm or with NIHSS on admission \\>4.\n\nOR\n\n* For control patients, admitted within 7 days of the onset of acute neurological symptomatology related to a clinical diagnosis of transient ischaemic attack (TIA) - based on thorough questioning of the patient on admission - and prior to imaging, with an ABCD2≥ 2 score.\n* Express consent to participate in the study.\n* Member or beneficiary of a social security.\n\nExclusion Criteria:\n\n* Pre-existing functional and\u002For cognitive disability\n* Patient under legal protection.\n* Pregnant or breastfeeding woman.\n* Patient with secondary haemorrhagic transformation.\n\nSecondary exclusion criteria :\n\n* Patients with an ischaemic lesion visible on imaging, unrelated to large vessel occlusion and therefore ineligible for mechanical thrombectomy.\n* Patients diagnosed with an acute non-vascular neurological pathology (migraine, epilepsy, etc.).\n* TIA patients presenting an abnormality on follow-up imaging 24-48 hours after the initial imaging.\n\nExcluded patients will be replaced.","18 Years",{"count":58,"type":22},200,"OBSERVATIONAL","The goal of this trial is to study, in three well-defined clinical situations responsible for cerebral hypoxia, the concentrations of biomarkers of thrombo-inflammation compared to a population of patients without cerebral hypoxia, and to study in patients with cerebral hypoxia the association between these concentrations and the clinical evolution.",[29,62],"Ischemic Stroke","2026-01-21",{"date":65,"type":39},"2026-01-22",{"date":67,"type":39},"2024-03-19",{"date":69,"type":22},"2026-06-22",{"name":71,"class":72},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK"]