[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-oxygen-saturation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-oxygen-saturation":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,55,88,115,146,168],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100613069","phase-4-duration-of-surfactant-administration-and-impact-on-stabilisation-of-vital-parameters-in-very-preterm-neonates-1-minutes-versus-5-minutes-100613069",false,"NCT07261787","Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes","Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minute Versus 5 Minutes - a Prospective Randomised-controlled Phase IV Trial - A Randomised Clinical Trial on Influence of Duration of Surfactant Administration on Stabilisation of Routine Monitoring Parameters and Cerebral Tissue Oxygen Saturation Monitoring in Preterm Neonates \u003C 28 Weeks of Gestational Age","SurfStab I","Inclusion Criteria:\n\n* Preterm neonate \\\u003C28+0 weeks (gestational age up to 27 weeks and 6 days)\n* Indication of surfactant administration via the LISA method\n* Postnatal age \\\u003C 72 hours\n\nExclusion Criteria:\n\n* Invasive ventilation, indication of INSURE procedure\n* Severe pulmonary or cardiac malformation affecting oxygenation or congenital cerebral malformation\n* Preexisiting diagnose of any IVH \\> grade 2 or PVH.","ALL","0 Months","72 Hours",{"count":21,"type":22},76,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA) technique. However, the optimal duration of surfactant instillation during LISA has never been systematically evaluated. Rapid instillation may provoke transient hypoxia and bradycardia, while slower administration might improve physiological stability and cerebral oxygenation.\n\nThis randomised controlled trial investigates whether the duration of surfactant administration (1 minute versus 5 minutes) affects cerebral and systemic oxygen stability in extremely preterm neonates (\\\u003C 28 weeks).",[28,29,30,31,32,33],"Neonates and Preterm Infants","Infant Respiratory Distress Syndrome","Surfactant Deficiency Syndrome Neonatal","Surfactant","Cerebral Oxygenation","Cerebral Oxygen Saturation",[35,36,37,38,39,40,41],"surfactant","surfactant administration","LISA","less-invasive surfactant administration","preterm neonates","cerebral oxygenation","near-infrared spectroscopy","RECRUITING","2026-05-12",{"date":45,"type":46},"2026-05-14","ACTUAL",{"date":48,"type":46},"2026-02-20",{"date":50,"type":22},"2028-12-01",{"name":52,"class":53},"Medical University of Graz","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":4},"100623634","effect-of-perioperative-iv-ibuprofen-on-cerebral-oxygenation-and-postoperative-cognition-during-one-lung-ventilation-100623634","NCT07399184","Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation","Comparison of the Effects of Ibuprofen on Cerebral Oxygenation, Postoperative Cognitive Dysfunction, and Delirium in One-Lung Ventilation","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* American Society of Anesthesiologists (ASA) Physical Status Classification System I-III\n* Patients scheduled for lobectomy or segmentectomy via Video-Assisted Thoracic Surgery (VATS ) with one-lung ventilation\n* New York Heart Association (NYHA) class I-II\n* Patients who have been informed about the study and have provided written informed consent will be included.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 75 years\n* History of alcohol or substance abuse\n* Patients with chronic NSAID use and\u002For NSAID use within the last 30 days, or NSAID allergy\n* Allergy to other drugs used in the study (e.g., bupivacaine)\n* ASA Physical Status IV-V\n* Severe hearing, visual, or speech impairment\n* Dementia, Alzheimer's disease, or psychiatric disorders (psychosis, bipolar disorder, schizophrenia)\n* History of previous head trauma\n* Chronic liver disease\n* Pregnancy\n* History of cerebrovascular disease\n* Moderate-to-severe chronic obstructive pulmonary disease (COPD) (predicted FEV₁ \\\u003C50%)\n* GFR \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients who do not provide written informed consent\n* Conditions that may cause inaccurate cerebral oximetry readings (subdural and\u002For extracranial hematoma, intracranial arteriovenous shunts, hyperbilirubinemia)\n* Patients undergoing emergency surgery\n* Patients in whom surgery is initiated as thoracotomy or converted to thoracotomy\n* Patients unable to complete the preoperative MMSE (total score ≤24) will be excluded.","18 Years","75 Years",{"count":65,"type":22},54,[67],"NA","This study compares the effects of ibuprofen administered during surgery and within the first 24 hours after surgery, versus no ibuprofen, on cerebral oxygenation, postoperative changes in consciousness (postoperative delirium and cognitive dysfunction), length of stay in the intensive care unit, and the incidence of postoperative pain, nausea, vomiting, and pruritus in patients undergoing lung lobectomy or segmentectomy using a closed (video-assisted) method (VATS - video-assisted thoracoscopic surgery), in whom one-lung ventilation is applied.\n\nThe aim of this study is to evaluate the effects of ibuprofen on cerebral oxygenation, postoperative cognitive changes, and delirium in patients undergoing one-lung ventilation.",[70,33,71],"Postoperative Delirium","Postoperative Cognitive Dysfunction (POCD)",[40,73,74,75,76,77],"near infrared spectroscopy","thoracic anesthesia","postoperative delirium","one lung ventilation","ibuprofen","NOT_YET_RECRUITING","2026-02-08",{"date":81,"type":46},"2026-02-10",{"date":83,"type":22},"2026-02-15",{"date":85,"type":22},"2026-09-01",{"name":87,"class":53},"Ondokuz Mayıs University",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":17,"minAge":95,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":23,"phases":98,"briefSummary":99,"conditions":100,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":54},"100601305","intraoperative-infusion-of-either-lidocaine-or-dexmedetomidine-on-regional-cerebral-oxygen-saturation-and-postoperative-delirium-in-elderly-patients-undergoing-abdominal-surgeries-100601305","NCT07108764","Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries","Effect of Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries","Inclusion Criteria:\n\n* Age ≥ 65years old.\n* Both sexes.\n* Physical status classification of II - III according to the American Society of Anesthesiologists (ASA).\n* Undergo elective non-cardiac surgeries.\n\nExclusion Criteria:\n\n* History of mental illness, neurological illness, or scoring less than 8 using the abbreviated mental test (AMT) before operation.\n* Severe hearing or visual impairment that may interfere with communication.\n* Severe renal or hepatic dysfunction.\n* Patients on central nervous system (CNS) medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).\n* Contraindications to lidocaine or dexmedetomidine \\[e.g., allergy, severe bradycardia, atrioventricular (AV) block\\].","65 Years",{"count":97,"type":22},100,[67],"This study aims to compare the effect of intraoperative infusion of either lidocaine or dexmedetomidine on the incidence of postoperative delirium (POD) in elderly patients undergoing major surgeries. It also aims to evaluate the impact of both medications on intraoperative regional cerebral oxygen saturation (rSO₂).",[101,102,103,33,70,104,105],"Intraoperative Infusion","Lidocaine","Dexmedetomidine","Elderly Patients","Abdominal Surgeries","2025-07-31",{"date":108,"type":46},"2025-08-07",{"date":110,"type":46},"2025-04-17",{"date":112,"type":22},"2027-04-01",{"name":114,"class":53},"Tanta University",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":54},"100594234","cerebral-regional-oxygen-saturation-during-tavi---the-cros-tavi-prospective-registry-100594234","NCT07016789","Cerebral Regional Oxygen Saturation During TAVI - The CROS-TAVI Prospective Registry","Cerebral Regional Oxygen Saturation During TAVI: A Prospective Comparison of Balloon-Expandable and Self-Expanding Valves","CROS-TAVI","Inclusion Criteria:\n\nSigned informed consent prior to any study-specific procedures\n\nDiagnosis of severe degenerative aortic valve stenosis with echocardiographic criteria:\n\nMean gradient \\> 40 mm Hg, or\n\nJet velocity \\> 4.0 m\u002Fs, or\n\nAortic valve area (AVA) \\\u003C 0.8 cm² (or AVA index \\\u003C 0.5 cm²\u002Fm²)\n\nSymptomatic aortic stenosis defined as NYHA functional class ≥ II\n\nExclusion Criteria:\n\nSymptomatic carotid artery disease or indication for carotid revascularization\n\nCardiogenic shock or inotropic support required prior to the procedure\n\nActive neurodegenerative disease\n\nContraindications as determined by anesthesiology screening\n\nAge \\\u003C 18 years\n\nContraindications to NIRS monitoring\n\nST-elevation myocardial infarction or cardiogenic shock within 48h before enrollment\n\nEmergency TAVI due to decompensated AV stenosis\n\nMalignancy or comorbidities with life expectancy \\\u003C 12 months\n\nInability to comply with the study protocol\n\nStroke or transient ischemic attack within 6 months\n\nRenal insufficiency (creatinine \\> 3.0 mg\u002FdL) or dialysis dependency\n\nSevere left ventricular dysfunction (LVEF \\\u003C 30%)\n\nSignificant mixed valvular disease (e.g., severe mitral or tricuspid regurgitation)\n\nIntracardiac mass, thrombus, or vegetation\n\nChronic corticosteroid use\n\nParticipation in another investigational drug or device study\n\nActive bacterial endocarditis or other active infections",{"count":124,"type":22},40,[67],"This single-center, non-commercial clinical study investigates how different types of transcatheter aortic valve prostheses affect cerebral oxygen saturation during the procedure (TAVI - Transcatheter Aortic Valve Implantation). The study uses a non-invasive monitoring system (NIRS) to track brain oxygenation (rSO₂) in real time.\n\nThe goal is to understand whether balloon-expandable, intra-annular self-expanding, or supra-annular self-expanding valves lead to different levels or patterns of cerebral oxygenation. This may help identify early warning signs for delayed hemodynamic recovery, stroke, or delirium.\n\nParticipants will be randomly assigned to receive one of:\n\nA balloon-expandable valve (Group A), or\n\nA self-expanding valve (Group B), with further randomization into:\n\nGroup B1: intra-annular valve (NAVITOR)\n\nGroup B2: supra-annular valve (EVOLUT)\n\nThe procedure, follow-up, and data collection will follow standard clinical practice. No experimental devices or drugs are used. Patients will not undergo any additional risk or burden beyond what is normally expected during TAVI.\n\nThe study is being conducted at the Fondazione Policlinico Universitario A. Gemelli IRCCS in Rome, Italy, and aims to enroll 40 patients. No compensation is provided, and participation is voluntary.",[128,129,33,130],"Aortic Stenosis Disease","TAVI(Transcatheter Aortic Valve Implantation)","Hemodynamic Changes",[132,133,33,134,135,136],"TAVI","Aortic Valve Stenosis","NIRS","Balloon-Expandable Valve","Self-Expanding Valve","2025-06-23",{"date":139,"type":46},"2025-06-26",{"date":141,"type":22},"2025-06",{"date":143,"type":22},"2026-06",{"name":145,"class":53},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":155,"phases":4,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":54},"100454522","association-between-local-cerebral-oxygenation-monitoring-and-postoperative-delirium-in-carotid-endarterectomy-100454522","NCT05198635","Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy","Association Between Local Cerebral Oxygen Saturation Monitoring and Postoperative Delirium in Carotid Endarterectomy：A Prospective Cohort Study","Inclusion Criteria:\n\nScheduled carotid endarterectomy; Signed informed consent.\n\nExclusion Criteria:\n\nSevere cognitive impairment(Mini-Mental State Examination, MMSE\\\u003C18); History of psychotropic drugs; Previous intracranial surgery history; Poor hearing or vision; Language barriers",{"count":154,"type":22},140,"OBSERVATIONAL","Postoperative delirium (POD) is a common perioperative complication, which can lead to adverse outcomes. Patients undergoing carotid endarterectomy (CEA) were elderly, complicated with vascular risk factors, cognitive dysfunction, some also had a history of stroke, and the circulation fluctuated greatly during the operation, often resulting in hypoperfusion of cerebral tissue and hypoxia. Therefore, they're the high-risk group of POD. Near-infrared Spectroscopy (NIRS) can continuously and noninvasively monitor local cerebral oxygen saturation (SctO2) to identify the mismatch of oxygen supply and demand in brain tissue. However, for CEA patients, the association between intraoperative SctO2 changes and POD remains unclear. This study intends to explore the association between them and determine the SctO2 threshold for predicting POD. We will monitor SctO2 intraoperatively, follow up and collect data postoperatively.",[33,70,158],"Carotid Endarterectomy","2025-02-12",{"date":161,"type":46},"2025-02-13",{"date":163,"type":46},"2022-02-14",{"date":165,"type":22},"2025-12-31",{"name":167,"class":53},"Beijing Tiantan Hospital",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":175,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":179,"briefSummary":180,"conditions":181,"keywords":183,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":4},"100486546","effect-of-cerebral-oxygen-saturation-monitoring-on-pocd-of-elderly-patients-undergoing-shoulder-arthroscopy-100486546","NCT05615480","Effect of Cerebral Oxygen Saturation Monitoring on POCD of Elderly Patients Undergoing Shoulder Arthroscopy","Effect of Controlled Hypotension Guided by Cerebral Oxygen Saturation Monitoring on Postoperative Cognitive Function of Elderly Patients Undergoing Shoulder Arthroscopy","Inclusion Criteria:\n\n* Patients undergoing elective shoulder arthroscopic surgery under general anesthesia combined with brachial plexus block;\n* ASA grade ≤ grade III;\n* Patients Can communicate normally, can cooperate and complete cognitive function test;\n* Patients volunteered and signed informed consent.\n\nExclusion Criteria:\n\n* BMI \\\u003C 18 or \\> 27 kg \u002F m2;\n* Previous history of dementia, psychosis or other central nervous system diseases or mental diseases, such as cerebral infarction, stroke, Parkinson's disease, etc;\n* Patients taking sedatives or antidepressants;\n* Alcoholics or drug addicts;\n* Illiteracy, severe hearing or visual impairment;\n* Patients with cognitive impairment before operation (MMSE score \\\u003C 23);\n* Patients with peripheral vascular diseases and contraindication of arterial puncture and catheterization;\n* Patients unable to carry out long-term follow-up or poor compliance.","60 Years","79 Years",{"count":178,"type":22},400,[67],"To observe whether adjusting the level of intraoperative controlled hypotension through cerebral oxygen saturation monitoring can improve postoperative cognitive function(POCD) and reduce postoperative neurological complications, a prospective randomized controlled study method will be used in this study. 400 elderly patients undergoing shoulder arthroscopic surgery under general anesthesia combined with brachial plexus block will be selected. They will be randomly divided into control group and experimental group according to whether cerebral oxygen saturation monitoring was used during the operation. The control group maintain the target blood pressure only according to the controlled hypotension guideline, and the experimental group adjust the controlled hypotension level under the guidance of cerebral oxygen saturation monitoring. The general condition, operation, anesthesia and hospitalization related data of the patients will be recorded.",[33,182],"Postoperative Cognitive Function",[184],"controlled hypotension","2023-04-11",{"date":187,"type":46},"2023-04-13",{"date":189,"type":22},"2023-05-15",{"date":191,"type":22},"2026-06-30",{"name":193,"class":53},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University"]