[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-oxygenation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-oxygenation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,45,76,114,136,161,196,224,255,282,312,338,374,400],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100638571","hfno-flow-rates-and-cerebral-oxygenation-during-deep-sedation-for-cystoscopy-100638571",false,"NCT07630038","HFNO Flow Rates and Cerebral Oxygenation During Deep Sedation for Cystoscopy","Effect of Different Flow Rates of High-Flow Nasal Oxygen on Peripheral and Cerebral Oxygenation and Ventilation During Procedural Sedation for Cystoscopy: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled to undergo elective cystoscopy under procedural sedation in an operating room setting\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known neurological disorders\n* History of ischemic or hemorrhagic stroke\n* Peripheral artery disease\n* Vasculitis\n* Severe heart failure\n* Uncontrolled hypertension\n* Uncontrolled diabetes mellitus\n* Advanced-stage chronic obstructive pulmonary disease\n* Severe anemia (hemoglobin \\\u003C8 g\u002FdL)\n* Skin lesions that could interfere with near-infrared spectroscopy (NIRS) measurements\n* History of head trauma\n* History of cranial surgery\n* Nasal deformity or nasal obstruction",true,"ALL","18 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","For Patients and Families\n\nThis study aims to investigate how high-flow oxygen therapy affects oxygen levels, especially brain oxygenation, during cystoscopy procedures performed under sedation. The goal is to improve patient safety and comfort by ensuring better oxygen delivery during the procedure. Different oxygen flow rates will be compared, while patients' breathing, oxygen levels, and vital signs are continuously monitored throughout the procedure. All methods used in the study are consistent with routine anesthesia practices, and patient safety remains the highest priority.\n\nFor Healthcare Professionals\n\nThis prospective randomized controlled study evaluates the effects of different high-flow nasal oxygen (HFNO) flow rates on cerebral oxygenation, peripheral oxygenation, and ventilation parameters in patients undergoing cystoscopy under procedural sedation. The primary aim is to determine the contribution of HFNO to sedation safety and to provide clinical evidence regarding the optimal flow rate. In addition, hypoxemia incidence, airway intervention requirements, hemodynamic variables, and sedation depth are being analyzed.",[27,28,29,30],"Deep Sedation","High Flow Nasal Canula","Cerebral Oxygenation","PSI",[28,27,32,30],"rSO2","NOT_YET_RECRUITING","2026-06-01",{"date":36,"type":37},"2026-06-05","ACTUAL",{"date":34,"type":21},{"date":40,"type":21},"2026-10-01",{"name":42,"class":43},"Firat University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100637544","manual-versus-autoflow-ventilation-during-anesthesia-inducton-in-geriatric-patients-100637544","NCT07582913","Manual Versus Autoflow Ventilation During Anesthesia Inductıon in Geriatric Patients","Effects of Manual Versus Autoflow Ventilation During Anesthesia Induction on Cerebral and Peripheral Oxygenation in Geriatric Patients","Inclusion Criteria:\n\n* Patients aged 65 years and older.\n* Patients scheduled to undergo elective surgery requiring endotracheal intubation under general anesthesia.\n* Patients with an American Society of Anesthesiologists (ASA) physical status of I, II, or III.\n* Volunteer patients who are willing to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Patients with severe heart failure or severe pulmonary disease.\n* Patients with a presence or history of brain tumors or cerebrovascular accidents (CVA\u002Fstroke).\n* Patients with impaired cooperation or cognitive dysfunction (e.g., dementia, delirium, Alzheimer's disease).\n* Patients with a known history or preoperative prediction of a difficult airway.\n* Patients with a known allergy to the monitoring sensor materials.","65 Years",{"count":54,"type":21},106,[24],"The objective of this study is to compare the effects of manual ventilation and AutoFlow ventilation, administered during the induction of general anesthesia, on cerebral (s-rSO₂) and peripheral (somatic) oxygenation (p-rSO₂) in geriatric patients.",[29,58,59,60,61],"Peripheral Oxygenation","Geriatrics","Ventilation","Near-Infrared Spectroscopy",[59,61,63,64,65,66],"Cerebral Oximetry","Cerebral Autoregulation","Mask Ventilation","Autoflow","RECRUITING","2026-05-13",{"date":70,"type":37},"2026-05-15",{"date":68,"type":37},{"date":73,"type":21},"2026-12-05",{"name":75,"class":43},"Ankara City Hospital Bilkent",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":90,"conditions":91,"keywords":97,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":44},"100613069","phase-4-duration-of-surfactant-administration-and-impact-on-stabilisation-of-vital-parameters-in-very-preterm-neonates-1-minutes-versus-5-minutes-100613069","NCT07261787","Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes","Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minute Versus 5 Minutes - a Prospective Randomised-controlled Phase IV Trial - A Randomised Clinical Trial on Influence of Duration of Surfactant Administration on Stabilisation of Routine Monitoring Parameters and Cerebral Tissue Oxygen Saturation Monitoring in Preterm Neonates \u003C 28 Weeks of Gestational Age","SurfStab I","Inclusion Criteria:\n\n* Preterm neonate \\\u003C28+0 weeks (gestational age up to 27 weeks and 6 days)\n* Indication of surfactant administration via the LISA method\n* Postnatal age \\\u003C 72 hours\n\nExclusion Criteria:\n\n* Invasive ventilation, indication of INSURE procedure\n* Severe pulmonary or cardiac malformation affecting oxygenation or congenital cerebral malformation\n* Preexisiting diagnose of any IVH \\> grade 2 or PVH.","0 Months","72 Hours",{"count":87,"type":21},76,[89],"PHASE4","Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA) technique. However, the optimal duration of surfactant instillation during LISA has never been systematically evaluated. Rapid instillation may provoke transient hypoxia and bradycardia, while slower administration might improve physiological stability and cerebral oxygenation.\n\nThis randomised controlled trial investigates whether the duration of surfactant administration (1 minute versus 5 minutes) affects cerebral and systemic oxygen stability in extremely preterm neonates (\\\u003C 28 weeks).",[92,93,94,95,29,96],"Neonates and Preterm Infants","Infant Respiratory Distress Syndrome","Surfactant Deficiency Syndrome Neonatal","Surfactant","Cerebral Oxygen Saturation",[98,99,100,101,102,103,104],"surfactant","surfactant administration","LISA","less-invasive surfactant administration","preterm neonates","cerebral oxygenation","near-infrared spectroscopy","2026-05-12",{"date":107,"type":37},"2026-05-14",{"date":109,"type":37},"2026-02-20",{"date":111,"type":21},"2028-12-01",{"name":113,"class":43},"Medical University of Graz",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":44},"100628588","cerebral-oxygen-consumption-response-to-increased-oxygen-supply-and-postoperative-delirium-in-older-surgical-patients-100628588","NCT07463586","Cerebral Oxygen Consumption Response to Increased Oxygen Supply and Postoperative Delirium in Older Surgical Patients","Association Between Cerebral Oxygen Consumption Responsiveness to Increased Oxygen Supply and Postoperative Delirium: A Prospective Observational Study Using Functional Near-Infrared Spectroscopy","Inclusion Criteria:\n\n* Patients undergoing elective laparoscopic surgery under general anesthesia\n* Age 65 years or older\n\nExclusion Criteria:\n\n* Diagnosis of dementia or presence of delirium before surgery\n* Loss of capacity to provide informed consent\n* Moderate or severe cerebrovascular stenosis diagnosed before surgery\n* Moderate or severe obstructive or restrictive pulmonary dysfunction identified on preoperative pulmonary function testing\n* Requirement for supplemental oxygen therapy before surgery\n* History of neurological disorders (e.g., Parkinson's disease, stroke) or prior brain surgery\n* Severe hepatic dysfunction (AST or ALT \\> 120 IU\u002FL)\n* Severe renal dysfunction (estimated GFR \\\u003C 15 mL\u002Fmin\u002F1.73 m²)\n* Persistent severe hemodynamic instability (mean arterial pressure \\\u003C 60 mmHg)\n* Skin conditions preventing placement of the forehead fNIRS sensor\n* Combined surgical procedures performed concurrently\n* Planned postoperative admission to the intensive care unit",{"count":122,"type":21},80,"OBSERVATIONAL","The goal of this observational study is to learn whether the brain's ability to use oxygen during surgery is associated with postoperative delirium in adults aged 65 years and older undergoing general anesthesia.\n\nThe main question it aims to answer is:\n\n\\- Does reduced cerebral oxygen consumption responsiveness during surgery increase the risk of postoperative delirium in older patients?\n\nParticipants who are undergoing elective laparoscopic surgery under general anesthesia as part of their routine medical care will have brain oxygen levels measured during surgery using a non-invasive forehead sensor, and will be assessed for delirium for up to three days after surgery.",[126,29],"Delirium - Postoperative","2026-03-29",{"date":129,"type":37},"2026-04-02",{"date":131,"type":37},"2026-03-11",{"date":133,"type":21},"2028-05",{"name":135,"class":43},"Seoul National University Bundang Hospital",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":145,"conditions":146,"keywords":150,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":44},"100630708","effect-of-glycemic-control-on-intraoperative-nirs-and-postoperative-recovery-in-diabetic-patients-100630708","NCT07491185","Effect of Glycemic Control on Intraoperative NIRS and Postoperative Recovery in Diabetic Patients","Effects of Intraoperative Near-Infrared Spectroscopy and Postoperative Recovery on Glycemic Control Levels in Patients With Diabetes Mellitus: A Prospective Study","NIRS-DM","Inclusion Criteria:\n\n* Age ≥18 years\n* Patients scheduled for elective urologic surgery under general anesthesia\n* ASA physical status I-III\n* Patients with diabetes mellitus or non-diabetic control patients\n* Availability of preoperative HbA1c measurement\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* ASA physical status \\>III\n* Emergency surgery\n* History of cerebrovascular disease or neurological disorder\n* Previous brain or neurological surgery\n* Inability to communicate or refusal to participate\n* Intraoperative hemodynamic instability\n* Inadequate NIRS monitoring data",{"count":122,"type":21},"This prospective observational study aims to evaluate the effect of glycemic control level on intraoperative cerebral oxygenation measured by near-infrared spectroscopy (NIRS) and postoperative recovery in patients with diabetes mellitus undergoing elective urologic surgery under general anesthesia.\n\nPatients will be grouped according to HbA1c levels to assess the relationship between long-term glycemic control and intraoperative regional cerebral oxygen saturation, hemodynamic parameters, and postoperative recovery scores.",[147,148,29,149],"Diabetes Mellitus","Glycemic Control","Anesthesia",[147,148,61,151],"Postoperative Recovery","2026-03-18",{"date":154,"type":37},"2026-03-24",{"date":156,"type":37},"2025-11-01",{"date":158,"type":21},"2027-03",{"name":160,"class":43},"Ege University",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":169,"targetDuration":4,"studyType":22,"phases":170,"briefSummary":171,"conditions":172,"keywords":176,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":44},"100624025","oxygen-reserve-index-guided-oxygen-titration-during-surgery-in-the-beach-chair-position-100624025","NCT07404267","Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position","The Utility of Oxygen Reserve Index Guidance in Inspiratory Oxygen Titration for Patients Undergoing Surgery in the Beach Chair Position: A Prospective Comparative Study","ORI-BCP","Inclusion Criteria:\n\n* Adult patients aged 18 to 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective orthopedic surgery in the beach chair position\n* Body mass index (BMI) \\\u003C35 kg\u002Fm²\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 or ≥65 years\n* Finger deformities preventing the use of Oxygen Reserve Index (ORi) monitoring\n* Severe anemia (hemoglobin \\\u003C8 g\u002FdL)\n* Pregnancy\n* Refusal or inability to provide informed consent\n* History of stroke or significant vascular pathology\n* Severe cardiac or respiratory disease",{"count":122,"type":21},[24],"This study aims to evaluate whether guidance by the Oxygen Reserve Index (ORi) improves inspiratory oxygen fraction (FiO₂) titration compared with conventional pulse oximetry (SpO₂)-guided oxygen administration in adult patients undergoing surgery in the beach chair position.\n\nOxygen therapy is routinely used during general anesthesia to prevent hypoxemia; however, excessive oxygen administration may result in hyperoxia, which has been associated with adverse cardiovascular and pulmonary effects. Standard pulse oximetry may not adequately detect hyperoxia when oxygen saturation values are high.\n\nIn this prospective comparative study, patients will receive oxygen titration guided either by SpO₂ alone or by combined ORi and SpO₂ monitoring. The primary outcome is the incidence of intraoperative hyperoxemia, assessed by arterial blood gas analysis. Secondary outcomes include intraoperative oxygenation parameters and hemodynamic variables.",[173,174,175,29],"Hyperoxemia","Intraoperative Oxygen Therapy","Beach Chair Position",[177,178,179,180,181,182,183,184,185,186],"Oxygen Reserve Index","ORİ","FiO2 titration","Hyperoxia","Pulse oximetry","Arterial blood gas","Near-infrared spectroscopy","General anesthesia","Beach chair position","Orthopedic surgery","2026-02-09",{"date":189,"type":37},"2026-02-11",{"date":191,"type":21},"2026-02-15",{"date":193,"type":21},"2026-07-31",{"name":195,"class":43},"Fatih Sultan Mehmet Training and Research Hospital",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":204,"conditions":205,"keywords":210,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":223},"100613726","evaluation-of-cerebral-oxygenation-during-orthopedic-surgeries-performed-in-the-beach-chair-position-under-general-anesthesia-100613726","NCT07270341","Evaluation of Cerebral Oxygenation During Orthopedic Surgeries Performed in the Beach Chair Position Under General Anesthesia","Inclusion Criteria:\n\n* Patients scheduled for orthopedic surgery in the semi-sitting position\n* ASA physical status I-III\n* Voluntary participation with informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* Patients who do not provide consent\n* History of cerebral ischemia\n* History of head trauma\n* Previous neurosurgical intervention\n* Documented carotid stenosis ≥90%\n* Previous neck surgery",{"count":203,"type":21},40,"The goal of this observational study is to determine the correlation between cerebral oxygenation values measured by near-infrared spectroscopy (NIRS) and other routine monitoring parameters in patients placed in the semi-sitting position.\n\nThe primary questions investigated are :\n\nDo NIRS values correlate with heart rate, invasive mean arterial pressure, and end-tidal carbon dioxide?\n\nDo NIRS values reflect changes observed in arterial blood gas analysis?\n\nAre cerebral perfusion-related parameters associated with patients' comorbidities such as diabetes, obesity, and hypertension?\n\nResearchers will compare routine noninvasive monitoring (heart rate, blood pressure, peripheral oxygen saturation) with invasive arterial monitoring and NIRS to assess whether NIRS provides additional information for evaluating cerebral perfusion.\n\nParticipants will be monitored for:\n\nHeart rate\n\nInvasive mean arterial pressure\n\nEnd-tidal carbon dioxide\n\nArterial blood gas changes\n\nCerebral oxygenation with NIRS\n\nPatients' comorbidities (e.g., diabetes, obesity, hypertension) will also be recorded, and their association with perfusion-related parameters will be analyzed.",[206,29,207,208,209],"Cerebral Perfusion","Hemodynamic Monitoring","Semi-sitting Position","Orthopedic Surgical Procedures",[211,212,213,103],"cerebral perfusion","semi-sitting position","orthopedic surgery","2025-12-05",{"date":216,"type":37},"2025-12-08",{"date":218,"type":37},"2024-10-01",{"date":220,"type":21},"2026-05-30",{"name":222,"class":43},"Akdeniz University",2,{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":232,"enrollmentInfo":233,"targetDuration":4,"studyType":22,"phases":235,"briefSummary":236,"conditions":237,"keywords":239,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":223},"100576023","phase-4-effect-of-volatile--based-versus-total-intravenous-anesthesia-on-brain-homeostasis-and-neurocognitive-outcome-100576023","NCT06779890","Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive Outcome","Effect of Volatile-based Versus Total Intravenous Anesthesia on Cerebral Homeostasis and Neucognitive Function in Patients Undergoing Elective Craniotomy for Brain Tumor Excision.","TIVolBrain","Inclusion Criteria:\n\n* ASA-PS 1-3 (American Society of Anesthesiologists Physical Status classification)\n* Elective or semi-elective craniotomy for brain tumor resection\n* Signed informed consent\n\nExclusion Criteria:\n\n* History of craniotomy at the same site\n* Morbid obesity\n* Delirious person before surgery\n* Cognitive disturbances\n* Preoperative heart rate (HR) \\\u003C45 beats\u002Fmin or second or third degree AV block\n* Treatment with a-methyldopa, clonidine or other a2-adrenergic agonist\n* Pregnancy\n* Liver or renal failure","80 Years",{"count":234,"type":21},84,[89],"The brain is a metabolic active organ with constant energy demands. Brain oxygen supply is secured via cerebral circulation. Brain tumor surgery is commonly associated with the tumor's underlying pathophysiology including brain swelling or edema. During craniotomy for brain tumor resection maintenance of cerebral hemodynamic stability is of paramount importance. Neuroinflammation is also a normal response to trauma, such as in the case of brain tumor surgery. The role of neuroinflammation in postoperative brain function is well documented and the aim is to limit it through an appropriate anesthetic approach.\n\nAnesthetic agents used during surgery affect brain homeostasis. The anesthetic agent of choice for neurosurgery should deliver smooth and hemodynamically stable anesthesia, good operating conditions, and allow early neurological assessment. Also, the ideal anesthetic agent should preserve cerebral perfusion and neuroprotection.\n\nThe two most common categories of anesthetic agents used nowadays for elective craniotomy are intravenous and inhalational agents.\n\nPropofol is the intravenous anesthetic agent of choice. The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gamma-aminobutyric acid (GABA). Propofol causes a decrease in cerebral metabolic rate (CMR), intracranial pressure (ICP), cerebral perfusion pressure (CPP), and cerebral blood flow (CBF). It also is known for its antiemetic properties.\n\nVolatile agents commonly used in neuroanesthesia clinical practice are sevoflurane and desflurane. Both of these agents decrease CMR while maintaining stable CPP. CBF alteration is dose-dependent. Desflurane evokes a greater cerebral vasodilation effect than sevoflurane. Sevoflurane is a well-known neuroprotective anesthetic agent traditionally used in neurosurgery. Both desflurane and sevoflurane are associated with early emergence.\n\nThus, this study aimed to explore the effect of volatile-based versus total intravenous anesthesia on cerebral homeostasis and neurocognitive function in patients undergoing elective craniotomy for brain tumor excision aiming to provide a basis for clinical rational drug use in patients undergoing craniotomy resection of supratentorial lesions.",[238,29],"Brain Edema Caused by Drugs",[240,241,242,243,244,245],"sevoflurane","desflurane","total intravenous anesthesia","brain edema","brain oxygenation","neurocognitive outcome","2025-09-30",{"date":248,"type":37},"2025-10-01",{"date":250,"type":37},"2025-05-12",{"date":252,"type":21},"2026-09-30",{"name":254,"class":43},"Georgia Tsaousi",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":262,"minAge":18,"maxAge":52,"enrollmentInfo":263,"targetDuration":4,"studyType":22,"phases":265,"briefSummary":266,"conditions":267,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":44},"100597736","sevoflurane-with-or-without-intravenous-lidocaine-infusion-versus-propofol-anesthesia-on-intracranial-pressure-and-cerebral-oxygenation-during-laparoscopic-hysterectomy-100597736","NCT07062367","Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy","Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I and Ⅱ.\n* Body mass index (BMI) ≤35.\n* Females scheduled for laparoscopic hysterectomy.\n\nExclusion Criteria:\n\n* Patients' refusal to participate in the study.\n* Hypersensitivity and allergy to drugs of the study.\n* Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery\n* Any central nervous system or cardiovascular disease, severe hepatic or renal impairment\n* Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery\n* If peak inspiratory pressure (PIP) exceeds 35.","FEMALE",{"count":264,"type":21},90,[24],"This study will be conducted to evaluate the effects of different anesthetic modalities \\[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).",[268,269,270,271,29,272],"Sevoflurane","Lidocaine","Propofol","Intracranial Pressure","Laparoscopic Hysterectomy","2025-07-02",{"date":275,"type":37},"2025-07-14",{"date":277,"type":37},"2025-02-01",{"date":279,"type":21},"2027-02-01",{"name":281,"class":43},"Tanta University",{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":17,"minAge":290,"maxAge":291,"enrollmentInfo":292,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":294,"conditions":295,"keywords":298,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":44},"100584235","mri-assesment-of-cerebral-blood-flow-in-anesthetized-children-100584235","NCT06886698","MRI Assesment of Cerebral Blood Flow in Anesthetized Children","Arterial Spin Label Assessment of Cerebral Blood Flow in Anesthetized Children","BAMBI","Inclusion Criteria:\n\n* children aged 6 months to 12 years\n* Planned to undergo MRI brain\n* Exclusion Criteria:\n* known brain tumor\n* vascular malformation in the brain\n* hydrocephalus","6 Months","12 Years",{"count":293,"type":21},30,"Children undergoing magnetic resonance imaging (MRI) of the brain often need to be sedated to complete the examination, as it is difficult to remain still for a long period, which is required to obtain usable images. During sedation, most patients typically experience a drop in blood pressure, including children. Maintaining an adequate blood pressure under anesthesia is important, as blood pressure is routinely used as a measure to ensure sufficient blood circulation to the body's organs, including the brain. Ensuring adequate blood flow to the brain is one of the cornerstones of all anesthesia, including in children. Therefore, low blood pressure during anesthesia is often treated with standardized interventions, such as blood pressure-raising interventions. These treatments generally restore blood pressure to normal, but how this affects blood flow to the brain in children is not fully known.\n\nWith the help of modern MRI technology (so-called Arterial Spin Labeling, ASL), blood flow in the brain can be measured quickly and completely safely with high precision.\n\nIn similar situations with adult patients, it has been observed that while blood pressure-raising interventions successfully normalize low blood pressure, MRI scans show that blood flow to the brain paradoxically decreases despite the increase in blood pressure. It is believed that this may be due to the brain's blood vessels constricting.\n\nThe investigators now wish to examine this relationship in sedated children undergoing planned brain MRI for certain diagnoses. The investigators hypothesis is that standardized measures intended to raise blood pressure (i.e., the routine treatment used regardless of whether a patient participates in the study or not) normalizes low blood pressure (when deemed necessary to treat according to routine) but does not necessarily lead to improved blood flow to the brain.\n\nPrimary research question: How does routine treatment of low blood pressure affect cerebral blood flow in sedated children?",[296,29,297],"Blood Flow","Blood Pressure",[299,300,301,302],"anesthesia","bloodflow","brain","children","2025-03-24",{"date":305,"type":37},"2025-03-25",{"date":307,"type":21},"2025-04-15",{"date":309,"type":21},"2026-09-15",{"name":311,"class":43},"Karolinska Institutet",{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":4,"eligibilityCriteria":318,"healthyVolunteers":11,"sex":17,"minAge":319,"maxAge":4,"enrollmentInfo":320,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":44},"100484575","respiratory-support-and-brain-health-in-preterm-infants-100484575","NCT05589831","Respiratory Support and Brain Health in Preterm Infants","Respiratory Support and Brain Health in Preterm Infants: a Prospective Crossover Study","Inclusion Criteria:\n\n* Preterm infants born between 22+0 and 31+6 weeks' GA\n* Weight \\> 500 g at the time of approach for consent\n* A minimum of 3 days of age\n* Clinically stable for \\> 24 hours while receiving NIPPV or NIV-NAVA\n\nClinical stability will be defined as meeting all the following criteria for a 24 hour period prior to recruitment:\n\n1. differences in maximum and minimum fractions of inspired oxygen (FiO2) of \\\u003C20%\n2. differences in maximum and minimum MAP \\\u003C4 cm H2O\n3. no active infection\n4. no hypotension\n5. no use of cardioactive medications or medical therapy for patent ductus arteriosus.\n\nExclusion Criteria:\n\n* Infants with IVH of grade 3 or 4\n* Birth weight \\\u003C 3rd percentile\n* Genetic or congenital abnormalities","3 Days",{"count":321,"type":21},50,"Premature babies often require breathing support during their neonatal intensive care unit stay. This is because their lungs are not fully developed to perform the work of breathing on their own. Although breathing support can be provided via a breathing tube, it is preferable to provide breathing support non-invasively from a breathing machine which is then connected to a mask or prongs placed on the baby's nose. In premature babies born under 32 weeks gestation, a commonly used mode of non-invasive breathing support is called Non-Invasive Positive Pressure Ventilation (NIPPV). In this mode, the breathing machine provides 2 levels of support: one is the constant distending pressure to keep the lungs open and the other provides additional 'breaths' on top of that distending pressure. This is to mimic regular breathing. These breaths are set at a fixed rate and pressure. Although NIPPV protects the lungs from injury caused by a breathing tube, the breaths are not in sync with the baby's own breathing effort. Another mode of non-invasive breathing support recently being used in premature infants called Neurally Adjusted Ventilatory Assist (NAVA). When NAVA is provided non-invasively using a mask or prongs similar to NIPPV, it is called Non-invasive NAVA (NIV-NAVA). During NIV-NAVA a special feeding tube is used that detects the baby's own breathing movement from the electrical signal of the baby's diaphragm and feeds back to the machine which then provides a 'top-up' to the baby's own breath. This top-up breath also provides only as much pressure as the baby needs on top on their own breathing effort. Therefore, this is thought to be in sync with the baby's own breathing effort. However, it is not known if this mode of ventilation leads to improved sleep, improved brain oxygen levels, reduced discomfort and improved functioning of the diaphragm. The investigators aim to examine these indices in this research project.",[324,29],"Sleep",[326,327,328,329],"Neurally Adjusted Ventilatory Assist","Non-Invasive Positive Pressure Ventilation","Preterm Neonates","Amplitude integrated electroencephalography","2025-03-19",{"date":303,"type":37},{"date":333,"type":37},"2023-07-04",{"date":335,"type":21},"2026-01",{"name":337,"class":43},"Mount Sinai Hospital, Canada",{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":16,"sex":17,"minAge":346,"maxAge":52,"enrollmentInfo":347,"targetDuration":4,"studyType":22,"phases":349,"briefSummary":350,"conditions":351,"keywords":354,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":4},"100583289","investigating-the-combined-effects-of-intermittent-hypoxia-and-exercise-on-cognitive-and-cerebral-function-in-middle-aged-adults-100583289","NCT06874387","Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults","Towards a Better Understanding of the Combination of Intermittent Hypoxia and Physical Exercise: Comparison of Effects on Cognitive and Cerebral Capacities in Middle-Aged Adults","HYPOX-AGE","* Inclusion Criteria:\n\n  * Adults aged 50 to 65 years (male and female)\n  * Montreal Cognitive Assessment (MoCA) score ≥ 24\n  * No participation in any structured exercise intervention in the last 6 months\n  * No exposure to altitudes above 1,500 m in the preceding 3 months\n  * No chronic kidney, cardiovascular, metabolic, neurological, or orthopedic -disease\n  * No history of significant respiratory conditions (e.g., asthma, exercise-induced -bronchospasm, dyspnea on exertion)\n  * No current immunosuppressive treatment (e.g., corticosteroids, antidepressants)\n  * No history of cancer or arthritis treatments\n  * No recent blood donation (within the last 2 months)\n  * Must be covered by a Social Security system or equivalent\n  * Signed informed consent after receiving clear and transparent study information\n  * Eligibility confirmed by a medical doctor during the inclusion process\n* Exclusion Criteria:\n\n  * Active smoking\n  * Major cardiovascular complications within the last 3 months (e.g., myocardial i-infarction, unstable angina, severe arrhythmias)\n  * Severe hypertension (≥180 mmHg systolic or ≥110 mmHg diastolic)\n  * Chronic respiratory insufficiency (e.g., COPD, sleep apnea)\n  * Diabetes mellitus\n  * Need for continuous or intermittent oxygen therapy\n  * Participation in another clinical study at the same time\n  * Use of corticosteroids or other systemic immunosuppressants\n  * Any condition compromising safety or study compliance, as determined by the medical team\n  * Pregnancy or breastfeeding\n  * Legal or administrative protections (e.g., individuals under guardianship, persons deprived of liberty)\n  * High baseline physical activity levels (PASE score \\>90 indicating moderate-to-intense physical activity)","50 Years",{"count":348,"type":21},176,[24],"This study investigates whether intermittent hypoxia (IH) and physical activity (PA), either alone or in combination (simultaneously or sequentially), can improve cognitive function and brain health in middle-aged adults (50-65 years old). The hypothesis is that (1) each intervention alone (IHT or PA) provides cognitive benefits and (2) combining IHT with PA may yield additive or synergistic effects, particularly when administered simultaneously rather than sequentially. By comparing these distinct interventions, the study aims to determine which approach best preserves or enhances cognitive performance in middle-aged adults. Findings from this research may inform non-pharmacological strategies to promote healthy aging and reduce the risk of age-related cognitive decline.",[352,353,29],"Cognitive Ability, General","Brain Health",[355,356,357,358,359,353,360,361,362,363,364],"intermittent Hypoxia Training","Hypoxic Conditioning","Physical Activity","Exercise Intervention","Cognitive Function","Non-Pharmacological Interventions","Middle-Aged Adults","Healthy Aging","Cognitive Decline Prevention","Neuroplasticity","2025-03-07",{"date":367,"type":37},"2025-03-13",{"date":369,"type":21},"2025-04-01",{"date":371,"type":21},"2026-12-30",{"name":373,"class":43},"Ayoub Boulares",{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":17,"minAge":381,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":22,"phases":384,"briefSummary":385,"conditions":386,"keywords":389,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":397,"locationsCount":44},"100583057","low-and-moderete-flow-anaesthesia-on-haemodynamics-100583057","NCT06871371","Low and Moderete Flow Anaesthesia on Haemodynamics","The Comparison of the Effects of Low and Medium Flow Anesthesia on Haemodynamics, Arrhytmia Risk and Cerebral Oxygenation in Laparoscopic Cholecystomy Cases","Inclusion Criteria:\n\n* being ASA1-2 status\n* between the ages of 18-70\n* who are planned for laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Patients who refuse to give informed consent\n* Pregnant and breastfeeding patients\n* Morbidly obese patients (Body mass index over 40)\n* Patients with uncontrolled diabetes mellitus, with serious cardiovascular, pulmonary, renal, hepatic disease, obstructive sleep apnea, with electrolyte imbalance- Those with a history of alcohol or drug abuse, with perioperative hemodynamic instability\n* Patients using drugs known to prolong myocardial repolarization\n* inability to increase SPO2 above 95 despite necessary intervention","17 Years","70 Years",{"count":87,"type":21},[24],"The study topic investigates the potential advantages of low-flow anesthesia in terms of physiological protection and resource saving.",[387,388,29],"Hemodynamics Instability","Arrhythmias Cardiac",[390],"Low-Medium Flow Anesthesia, Hemodynamics, Oxygenation","2025-03-06",{"date":393,"type":37},"2025-03-11",{"date":395,"type":21},"2025-03-15",{"date":307,"type":21},{"name":398,"class":399},"Umraniye Education and Research Hospital","OTHER_GOV",{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":406,"eligibilityCriteria":407,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":408,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":410,"conditions":411,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":44},"100417994","neurocognitive-outcomes-for-icu-patients-with-acute-kidney-injury-100417994","NCT04722939","Neurocognitive Outcomes for ICU Patients With Acute Kidney Injury","Identifying Neurocognitive Outcomes and Cerebral Oxygenation in Critically Ill Adults on Acute Kidney Replacement Therapy in the Intensive Care Unit","INCOGNITOAKI","Inclusion Criteria:\n\n* age greater than or equal to 18 years\n* admitted to the Kingston Health Sciences Intensive Care Unit\n* diagnosis of severe AKI requiring Kidney Replacement Therapy (KRT) (defined by the presence of either a twofold increase in serum creatinine from baseline, serum creatinine level greater than or equal to 354 micromol\u002FL with an increase of 27 micromol\u002FL from baseline, or urine output \\\u003C6 mL\u002Fkg in the preceding 12 hours)\n* within 12 hours of initiation of KRT via intermittent hemodialysis (iHD) or continuous kidney replacement therapy (CKRT).\n\nExclusion Criteria:\n\n* acquired or congenital neurological disorders\n* any contraindication to testing with cerebral oximetry, Kinarm, or MRI (e.g., claustrophobia, limb amputation, paresis, neuromuscular disorders, etc.)\n* KRT via PD\n* failure to consent\n* life expectancy less than 24 hours\n* clinical suspicion of renal obstruction\n* rapidly progressive glomerulonephritis or interstitial nephritis\n* prehospitalization eGFR \\\u003C30 mL\u002Fmin\u002F1.73m2.",{"count":409,"type":21},104,"Introduction. Initiation of acute kidney replacement therapy (KRT) is common in critically ill adults admitted to the intensive care unit (ICU), and is associated with increased morbidity and mortality. KRT has been linked to poor neurocognitive outcomes, leading to a reduced quality of life, as well as increased utilization of healthcare resources. Adults initiated on dialysis in the ICU may be particularly at risk of neurocognitive impairment, as survivors of critical illness are already predisposed to developing cerebrovascular disease and cognitive dysfunction over the long-term relative to healthy controls. Regional cerebral oxygen saturation (rSO2) may provide a critical early marker of long-term neurocognitive impairment in patients in this population. The INCOGNITO-AKI study aims to understand cerebral oxygenation in patients undergoing KRT, either continuous or intermittent, in the ICU. These findings will be correlated with long-term cognitive and functional outcomes, as well as structural brain pathology.\n\nMethods and analysis. 108 patients scheduled to undergo treatment for acute kidney injury with KRT in the Kingston Health Sciences Centre ICU will be recruited into this prospective observational study. Enrolled patients will be assessed with intradialytic cerebral oximetry using near infrared spectroscopy (NIRS). Delirium will be assessed daily with the Confusion Assessment Method-Intensive Care Unit (CAM-ICU) and delirium severity quantified as cumulative CAM-ICU-7 scores. Neurocognitive impairment will be assessed at 3- and 12-months after hospital discharge using the Kinarm and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Structural brain pathology on MRI will also be measured at the same timepoints. Driving safety, adverse events, and medication adherence will be assessed at 12-months to evaluate the impact of neurocognitive impairment on functional outcomes.\n\nEthics and dissemination. This study has been approved by the Queen's University Health Sciences and Affiliated Teaching Hospitals Research Ethics Board (Approval number: DMED-2424-20). Results will be presented at critical care scientific conferences and a lay summary will be provided to patients and families in their preferred format.",[412,413,414,415,29,64],"Delirium","Acute Kidney Injury","Critical Illness","Cognitive Impairment","2023-12-19",{"date":418,"type":37},"2023-12-26",{"date":420,"type":37},"2021-01-15",{"date":422,"type":21},"2027-01-01",{"name":424,"class":43},"Dr. Gordon Boyd"]