[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-palsy-infantile\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-palsy-infantile":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,49,117,151,181,209,237,264,294,318],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100578123","motor-voice-assessment-in-infants-mami-100578123",false,"NCT06807203","Motor-voice Assessment in Infants (MAMI)","Spontaneous Motor-voice Assessment in Infants Using Video and Audio Recordings.","MAMI","Inclusion Criteria:\n\n* gestational age of 24 0\u002F7 - 41 6\u002F7,\n* admitted to the NICU,\n* medically stable by 40 weeks of gestation (including off ventilator support),\n* born to mothers 18 - 43 years old at the time of birth,\n* one parent fluent in English.\n\nExclusion Criteria:\n\n* diagnosis of a genetic syndrome (e.g. Trisomy 21),\n* musculoskeletal deformity,\n* failed hearing screen.","ALL","10 Days",{"count":20,"type":21},46,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants.. The main questions it aims to answer are:\n\nIdentify voice factors among infants with newborn-detectable risk. Identify association between individual characteristics (Gestational age at birth, global function, motor-function) and voice factors.\n\nExamine unique features of voice production that are present in infants with high-risk for Cerebral Palsy (CP).\n\nParticipants will be asked to upload a 3-minute videos of their child at term-age, 3.5-, and 9-months of age.\n\nAt the 3.5-month and 9-month time point parents can choose to attend an optional in-person assessment with their child.",[25,26,27,28,29],"Cerebral Palsy Infantile","Pre-Term","Motor Delay","Neurodevelopmental Disorders","Autism Spectrum Disorder",[31,32,33,34,35],"Digital health,","Motor assessment,","voice assessment,","cognition","neurodevelopment,","RECRUITING","2026-03-24",{"date":39,"type":40},"2026-03-27","ACTUAL",{"date":42,"type":40},"2025-10-22",{"date":44,"type":21},"2030-01-28",{"name":46,"class":47},"Ohio State University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":61,"conditions":62,"keywords":83,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":48},"100630855","intensive-multimodal-neurorehabilitation-targeting-neuroplasticity-in-pediatric-neurodevelopmental-and-chromosomal-disorders-100630855","NCT07493096","Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders","Functional and Neurodevelopmental Outcomes Following Intensive Multimodal Neurorehabilitation in Pediatric Patients With Neurodevelopmental Disorders, Including Chromosomal Abnormalities","GEN-HOPE","Inclusion Criteria:\n\n* Pediatric participants between approximately 4 and 12 years of age at the time of enrollment.\n* Diagnosed with or presenting with neurodevelopmental, neurologic, or genetic conditions, including but not limited to:\n\n  * cerebral palsy\n  * autism spectrum disorder\n  * developmental delay\n  * hypoxic ischemic encephalopathy (HIE)\n  * traumatic brain injury\n  * sensory processing disorder\n  * chromosomal or genetic abnormalities\n  * Demonstrate functional impairments in one or more neurodevelopmental domains, including:\n* motor coordination or motor planning\n* sensory processing\n* attention or executive functioning\n* oculomotor or visual processing\n* communication\n* emotional or behavioral regulation\n* activities of daily living\n* Enrolled in and able to participate in a two-week intensive therapy program consisting of approximately 2.5 hours per day\u002F 5 days per week\n\n  * Able to complete baseline and post-program clinical assessment using clinician-observed or caregiver-reported measures.\n  * Parent or legal guardian able to provide informed consent and participate in reporting functional outcomes when applicable.\n\nExclusion Criteria:\n\n* Medical instability or acute medical condition that would prevent safe participation in an intensive therapy program.\n* Severe uncontrolled seizure activity or other neurologic condition that would interfere with participation in structured therapeutic activities, as determined by the treating clinician.\n* Behavioral or psychological conditions that would prevent safe engagement in the therapy environment despite appropriate support.\n* Inability to attend or complete the full two-week intensive program.\n* Lack of sufficient baseline or post-intervention data to assess change in functional performance.\n* Concurrent participation in another structured intervention or clinical study that would confound interpretation of functional outcomes, at the discretion of the investigator.","4 Years","12 Years",{"count":60,"type":21},100,"This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program. The program is designed for children with neurodevelopmental disorders, including but not limited to cerebral palsy, autism spectrum disorder, developmental delay, hypoxic ischemic encephalopathy (HIE), and chromosomal or genetic abnormalities.\n\nParticipants receive individualized therapy sessions for approximately 2.5 hours per day over a two week period. The intervention is not standardized but is tailored to each child's specific needs and may include components such as sensory integration, motor planning, reflex integration, oculomotor training, executive functioning activities, communication support, and other brain based therapeutic approaches.\n\nThe purpose of this study is to observe changes in functional abilities, including attention, motor coordination, emotional regulation, communication, and activities of daily living. Outcomes are assessed using clinician observation and parent reported changes before and after the intensive program, with limited follow-up when available.\n\nThis study does not assign participants to a specific treatment as part of a research protocol. Instead, it collects real world data from children already participating in a clinical therapy program to better understand potential benefits of intensive, individualized neurorehabilitation approaches.",[28,63,64,65,66,67,25,68,69,29,70,71,72,73,74,75,76,77,78,79,80,81,82],"Neurodevelopmental Disorders (NDD)","Neurodevelopmental Disorders and Developmental Abnormalities","Developmental Delay (Disorder)","Cerebral Palsy (CP)","Cerebral Palsy Hemiparetic Cerebral Palsy Spasticity Gait Disorders, Neurologic Postural Balance Impairment","Cerebral Palsy Spastic Hemiplegic","Cerebral Palsy, Dyskinetic","Autism Spectrum Disorder (ASD","Hypoxic Ischemic Encephalopathy","Hypoxic Ischemic Encephalopathy (HIE)","Traumatic Brain Injury (TBI)","Sensory Processing Disorder","Chromosomal Abnormalities","Genetic Disorders","Down Syndrome (Trisomy 21)","Fragile X Syndrome (FXS)","RETT Syndrome With Proven MECP2 Mutation","Williams Syndrome","22q11.2 Deletion Syndrome","Sensorimotor Integration",[84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,28,102,103,104,105,106,107],"Photobiomodulation","Low-Level Laser Therapy","Vibration Therapy","Tactile Stimulation","Cognitive Training","Behavioral Therapy","Intensive Therapy","Pediatric Neurorehabilitation","Multimodal Therapy","Neuroplasticity","Sensory Integration","Reflex Integration","Motor Planning","Executive Function","Emotional Regulation","Functional Outcomes","Activities of Daily Living","High Frequency Therapy","Rehabilitation","Child Development Disorders","Occupational Therapy","Physical Therapy Modalities","Early Intervention","Cognitive Therapy","2026-03-19",{"date":110,"type":40},"2026-03-25",{"date":112,"type":40},"2026-03-01",{"date":114,"type":21},"2036-12-30",{"name":116,"class":47},"Healing Hope International",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":129,"phases":130,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":48},"100629043","coaching-learning-empowerment-in-cerebral-palsy---a-6-week-integrated-ptot-caregiver-primer-bootcamp-for-infants-diagnosed-with-or-at-high-risk-for-cerebral-palsy-100629043","NCT07469514","Coaching, Learning, Empowerment in Cerebral Palsy - a 6-Week Integrated PT\u002FOT Caregiver \"Primer\" Bootcamp for Infants Diagnosed With or at High Risk for Cerebral Palsy","CIRCLE-CP Study: Coaching, Learning, Empowerment in Cerebral Palsy - a 6-Week Integrated PT\u002FOT Caregiver \"Primer\" Bootcamp for Infants Diagnosed With or at High Risk for Cerebral Palsy","CIRCLE-CP","Inclusion Criteria:\n\n* Infants 3-15 months corrected age at enrollment\n* Diagnosed with CP or at high possibility of CP\n* Not yet independently walking at baseline\n* Medically stable for therapeutic handling and group play\n* Primary caregiver (\\>=18years) able to attend all weekly group sessions\n* English-speaking only\n\nExclusion Criteria:\n\n* Unstable medical condition (eg, frequent desaturations, emeses, uncontrolled seizures) or acute restrictions incompatible with participation\n* Concurrent enrollment in another intensive motor program\n* Profound sensory impairments that preclude group program participation","3 Months","15 Months",{"count":128,"type":21},32,"INTERVENTIONAL",[131],"NA","This study focuses on the caregiver's knowledge, comfort, and confidence in interacting with and supporting their infant with Cerebral Palsy (CP) or at high risk for Cerebral Palsy. Four caregivers with their infants will be in one cohort to assess the benefits of group intervention. The intervention is delivered in a group, bootcamp-style educational format led by clinical team including pediatric physiatrist, physical therapist and occupational therapist.",[134,66,25,135],"Cerebral Palsy","Infant",[137,138,139,140],"physical therapy","occupational therapy","caregivers","caregiver","NOT_YET_RECRUITING","2026-03-10",{"date":144,"type":40},"2026-03-13",{"date":146,"type":21},"2026-04",{"date":148,"type":21},"2027-04",{"name":150,"class":47},"University of California, San Francisco",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":11,"sex":17,"minAge":159,"maxAge":160,"enrollmentInfo":161,"targetDuration":4,"studyType":129,"phases":163,"briefSummary":164,"conditions":165,"keywords":166,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":177,"leadSponsor":179,"locationsCount":4},"100599974","home-improve-telerrehabilitation-system-100599974","NCT07091461","HOMe-IMprove Telerrehabilitation System","HOMe-IMprove Telerrehabilitation System for CHilDren With Cerebral Palsy","HOMIMTES-CHilD","Inclusion Criteria:\n\n* Confirmed diagnosis of infantile unilateral cerebral palsy\n* Age between 6 and 18 years\n* Stable home Wi-Fi access and space to perform exercises\n* Manual Ability Classification System (MACS) level ≤ 3\n* Informed consent from legal guardian and assent from the child (if \\\u003C12 years)\n\nExclusion Criteria:\n\n* Severe neurological or psychiatric comorbidities\n* Recent orthopedic surgery (\\\u003C12 months) or botulinum toxin treatment (\\\u003C6 months)\n* Concurrent participation in other intervention studies","6 Years","18 Years",{"count":162,"type":21},24,[131],"This pilot study aims to assess the feasibility, adherence, and preliminary efficacy of a home-based telerehabilitation protocol using the HOME Kit Tablet system in children aged 6 to 18 years with cerebral palsy. The study follows a randomized controlled design with parallel groups and single-blind evaluation. The intervention group will use a digitally supervised rehabilitation system, while the control group will follow a traditional home therapy protocol without technological tools.",[25],[167,168,169,170,171,172],"home","children","infantile cerebral palsy","family","upper extremity","balance","2026-02-04",{"date":175,"type":40},"2026-02-05",{"date":112,"type":21},{"date":178,"type":21},"2027-04-01",{"name":180,"class":47},"University of Castilla-La Mancha",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":188,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":190,"conditions":191,"keywords":192,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":48},"100489778","study-of-sagittal-pelvic-statics-in-the-sitting-position-in-children-with-cerebral-palsy-100489778","NCT05657548","Study of Sagittal Pelvic Statics in the Sitting Position in Children With Cerebral Palsy","SPS-PC","Inclusion Criteria:\n\n* Child or adolescent aged 4 to 17 years\n* Child or adolescent with cerebral palsy GMFCS III, IV or V\n* Child or adolescent whose parents, or the child if possible, have given free, informed and written consent\n* Child or adolescent affiliated or beneficiary of a health insurance plan\n\nExclusion Criteria:\n\n* Child or adolescent with history of spinal surgery\n* Child or adolescent with parents unable to give consent\n* Child or adolescent participating in a therapeutic research study (RIPH 1 or drug study)\n* Child or adolescent in an exclusion period determined by another study\n* Child or adolescent under court protection, guardianship or curatorship\n* Pregnant, parturient or breastfeeding patient","17 Years",{"count":60,"type":21},"Cerebral palsy is the leading cause of motor disability in children. Children with little or no walking (GMFCS III, IV and V) represent 43% of children with cerebral palsy, the majority of whom present pelvic and spinal deformities in the frontal and sagittal planes. However, sagittal pelvic spinal statics have been little studied, especially in the sitting position, which is the functional position of these children.\n\nMoreover, there are currently no recommendations on how to perform follow-up radiographs of the spine in children who do not walk much.\n\nA better understanding of pelvic and sagittal spinal statics would help prevent deformities and their complications.\n\nStandardizing the method of performing pelvic-spinal radiographs in the sitting position will make monitoring of spinal statics more reliable.",[25],[193,194,195,196,197,198,199],"Spine","Child","Adolescent","Pelvis","Postural Balance","Posture","Radiography","2025-09-24",{"date":202,"type":40},"2025-09-29",{"date":204,"type":40},"2023-10-30",{"date":206,"type":21},"2027-10",{"name":208,"class":47},"Centre Hospitalier Universitaire de Nīmes",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":11,"sex":17,"minAge":217,"maxAge":160,"enrollmentInfo":218,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":48},"100588936","biofeedback-based-system-to-enhance-robotic-assisted-gait-training-in-children-with-cerebral-palsy-100588936","NCT06947889","Biofeedback Based System to Enhance Robotic Assisted Gait Training in Children With Cerebral Palsy","AID2GAIT: Biofeedback Based System to Enhance Robotic Assisted Gait Training in Children With Cerebral Palsy","AID2GAIT","Inclusion Criteria:\n\nChildren with cerebral palsy aged 3 to 18 years who have a GMFCS level from I to V, with the ability to express discomfort or pain and understanding simple instructions\n\nExclusion Criteria:\n\n* Medical problems that could interfere with training and restrictions on the use of the robotic device;\n* severe lower limb conditions: muscle contractures, instability or subluxation of the hip;\n* recent botulinum toxin A injections to the lower limbs;\n* uncontrolled seizures;\n* open skin disorders and vascular disorders of the lower limbs.\n* Contraindications to gait rehabilitation treatment with Lokomat (e.g. weight \\\u003C10 kg, non-consolidated fractures, cognitive deficits limiting communication).\n* Contractures of fixed joints that limit the range of motion of the orthoses\n* Inability to properly adjust the harness and\u002For orthoses","3 Years",{"count":219,"type":21},11,"The AID2GAIT project aims to develop a biofeedback system with the aim of improving the outcomes of robot-assisted gait training (RAGT) in pediatric patients with cerebral palsy. The physiological signals of children during RAGT therapy sessions, acquired through non-invasive technologies, will be analyzed. These technologies specifically are:\n\n* wearable technology (smartwatch), from which the HRV (Heart Rate Variability) signal will be measured;\n* infrared thermography, from which the temperature in salient facial regions will be obtained;\n* fNIRS (functional near-infrared spectroscopy), from which information on brain activity and its changes over time will be obtained.\n\nInformation on the kinematics of the exoskeleton used during RAGT will be extracted.\n\nThe RAGT will be performed using the Lokomat orthosis (Hocoma), the most widely used exoskeleton in rehabilitation that facilitates a bilaterally symmetrical gait, as the individual actively tries to advance each limb during walking, combined with a patented dynamic body weight support system.",[25,222],"Robotic Assisted Gait Training",[222,224,225,226,227],"Biofeedback","Infant Cerebral Palsy","Human-Robot Interaction","Exoskeleton","2025-04-24",{"date":230,"type":40},"2025-04-27",{"date":232,"type":40},"2024-07-01",{"date":234,"type":21},"2026-02-28",{"name":236,"class":47},"G. d'Annunzio University",{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":17,"minAge":160,"maxAge":4,"enrollmentInfo":244,"targetDuration":246,"studyType":22,"phases":4,"briefSummary":247,"conditions":248,"keywords":250,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":4},"100586207","experiences-outcomes-and-unmet-needs-of-caregivers-of-children-with-cerebral-palsy-100586207","NCT06912373","Experiences, Outcomes and Unmet Needs of Caregivers of Children With Cerebral Palsy","Experiences, Outcomes and Unmet Needs of Caregivers of Children With Cerebral Palsy in Spain: A Mixed-Method Study","Inclusion Criteria:\n\n* \\>18 years old\n* Being a caregiver of a child with Cerebral Palsy\n* Spanish\u002FCatalan speaking\n* Willing to talk about their experiences and be audio\u002Fvideo-recorded.\n* Accept and sign the informed consent form",{"count":245,"type":21},30,"1 Day","Cerebral palsy (CP ) is one of the most prevalent motor disabilities in childhood, significantly impacting both children and their caregivers. This study explores the experiences, psychological well-being, and unmet needs of caregivers of children with CP. Using an explanatory sequential design (QUAN → QUAL), first it will be assessed burden, stress levels, and quality of life of caregivers through standardized questionnaires (PedsQL-FIM , ZBI , PSS-14 ).",[25,249],"Caregiver",[251,134,252,253,254],"Caregivers","Mixed-Method Research","Quality of Life","Parenting Stress","2025-03-30",{"date":257,"type":40},"2025-04-04",{"date":259,"type":21},"2025-04-01",{"date":261,"type":21},"2025-08-01",{"name":263,"class":47},"Universitat de Lleida",{"id":265,"slug":266,"hasResults":11,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":270,"eligibilityCriteria":271,"healthyVolunteers":272,"sex":17,"minAge":273,"maxAge":274,"enrollmentInfo":275,"targetDuration":4,"studyType":129,"phases":277,"briefSummary":278,"conditions":279,"keywords":282,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":4},"100521451","trunk-and-upper-extremities-program-effect-in-decreasing-compensation-patterns-in-unilateral-cerebral-palsy-children-100521451","NCT06069765","Trunk and Upper Extremities Program Effect in Decreasing Compensation Patterns in Unilateral Cerebral Palsy Children","Trunk and Upper Extremities Program Effect in Decreasing Compensation Patterns in Unilateral Cerebral Palsy Children: Randomized Control Trial","TUPEX","Inclusion Criteria:\n\n* Unilateral cerebral palsy diagnostic\n* Level I or II of the Manual Ability Scale Classification\n\nExclusion Criteria:\n\n* Have received any intervention with botulinum toxin or shock waves in the previous six months or have them scheduled during the intervention\n* Are undergoing treatment with intensive therapies.\n* To have known alteration in the hips\n* Have very serious attention or comprehension difficulties that prevent them from following instructions.\n* Suffer uncontrolled epilepsies\n* Suffer from severe visual problems.",true,"8 Years","16 Years",{"count":276,"type":21},40,[131],"The goal of this clinical trial is to test the effectiveness of a trunk and upper extremities exercise program. The main questions it aims to answer are:\n\nWhether the program decreases compensation patterns in unilateral cerebral palsy children Whether the program decreases pain in unilateral cerebral palsy children Whether the program improves bimanual ability in unilateral cerebral palsy children Participants will undertake and 8-week program exercise at home If there is a comparison group: Researchers will compare with the control group to see if this program decreases compensation patterns.",[25,280,281],"Chronic Pain","Upper Extremity Dysfunction",[283,284],"compensation patterns","unilateral cerebral palsy","2025-02-12",{"date":287,"type":40},"2025-02-14",{"date":289,"type":21},"2025-09",{"date":291,"type":21},"2027-07",{"name":293,"class":47},"Fundacio Aspace Catalunya",{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":272,"sex":17,"minAge":217,"maxAge":160,"enrollmentInfo":302,"targetDuration":4,"studyType":129,"phases":303,"briefSummary":304,"conditions":305,"keywords":306,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":314,"leadSponsor":316,"locationsCount":4},"100567787","biochemical-densitometric-technological-and-imaging-tools-to-evaluate-the-bonemuscle-in-children-with-cerebral-palsy-100567787","NCT06672731","BIOchemical, DEnsitometric, TEChnological and Imaging Tools to Evaluate the Bone\u002Fmuscle in Children with Cerebral Palsy","BIODETECT_CP a Novel Combination of BIOchemical, DEnsitometric, TEChnological and Imaging Tools to Evaluate the Bone\u002Fmuscle Unit Health in Children with Cerebral Palsy","BIODETECT_CP","Inclusion Criteria:\n\n* age\n* willing to sign inform content\n\nExclusion Criteria:\n\n* bisphosphonates or bone diseases",{"count":60,"type":21},[131],"Cerebral palsy (CP) is the most common chronic disability in childhood, burden by motor, sensation, cognition, feeding and communication impairment. A serious concern in children with CP is bone\u002Fmuscle health deterioration, which negatively impacts the already reduced quality of life (QoL). Children with CP show low bone density, vitamin D deficiency, sarcopenia and high risk of fragility fractures, with heavy effects on what is already limited home, school and community life. The causes for muscle-bone impairment are low weight-bearing deambulation during skeletal formation with low bone mineralization, poor nutrition and low calcium intake, low sun exposure, use of anticonvulsant medications with a negative profile on bone. Understanding the causes affecting bone quality and setting up interventions to reduce the impact of physical disability are essential in young subjects with CP.\n\nThis project combines complementary expertise and resources in the fields of Endocrinological Biochemistry, Paediatric Neurological Disorders and Neuroimaging, to allow an innovative, technology-assisted workup for bone\u002Fmuscle health evaluation in young subjects with CP, which could drive novel therapeutics, nutritional and rehabilitation programs.\n\nThe first aim of this project is to evaluate bone\u002Fmuscle health in young subjects with CP compared with sex-age matched healthy subjects, providing i) serum biomarkers of mineral metabolism and the metabolome of Vitamin D, assessed with last generation Mass Spectrometry, ii) muscle sarcopenia markers like Irisin and other myokines, depicting the response of the muscle to exercise iii) neuronal damage and inflammatory markers, iv) densitometric data by the low-cost and safe Quantitative ultrasound (QUS) at phalanges of the hand, plus the novel and very promising Radiofrequency Echographic Multi Spectrometry (REMS) served by the software for fragility fractures risk.\n\nWe also aim to correlate the previous mentioned markers of bone\u002Fmuscle health with a combination of demographic, clinical, cognitive and technological parameters, the last obtained by an innovative use of wearable sensors or actigraphs, positioned at the wrists, which depicts movements, physical activity (PA), energy expenditures (EE) and, together with heart-rate monitors, metabolic data during a normal like week in subjects with CP and healthy controls. Finally, a newly validated scoring for brain lesions in subjects with CP and the production of imaging \"biomarkers\" of neuronal damage, will be correlated with their bone\u002Fmuscle health data, PA and EE to understand the impact of brain damage on functional performance and bone metabolism.",[25],[307,308,309],"cerebral palsy","bone health","muscle health","2024-11-01",{"date":312,"type":40},"2024-11-04",{"date":310,"type":21},{"date":315,"type":21},"2025-12-31",{"name":317,"class":47},"IRCCS Fondazione Stella Maris",{"id":319,"slug":320,"hasResults":11,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":11,"sex":17,"minAge":217,"maxAge":58,"enrollmentInfo":325,"targetDuration":4,"studyType":129,"phases":327,"briefSummary":328,"conditions":329,"keywords":330,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":48},"100563472","single-button-mobility-platforms-effect-on-reaction-time-and-keystroke-accuracy-in-children-with-cerebral-palsy-100563472","NCT06616610","Single-Button Mobility Platform's Effect on Reaction Time and Keystroke Accuracy in Children with Cerebral Palsy","Single-Button Mobility Platform's Effect on Reaction Time and Keystroke Accuracy in Children with Cerebral Palsy: a Pilot Study","Inclusion Criteria:\n\n* Diagnosed with cerebral palsy\n* Classified as GMFCS level IV or higher, indicating an inability to walk or operate a powered wheelchair.\n* Under 12 years old.\n* Must be affiliated to a center whose facilities guarantee a proper navigation experience\n\nExclusion Criteria:\n\n\\- Inability to act on an actuator (Start button)",{"count":326,"type":21},4,[131],"The goal of this clinical trial is to determine whether the use of a mobility platform can improve response time in children with cerebral palsy.\n\nThe primary question it seeks to answer is: Can the use of a mobility platform enhance cognitive development in children with severe disabilities?\n\nChildren are randomly assigned to two equal-sized groups: the control group, where participants will continue with their standard therapy, and the intervention group, where participants will use the mobility platform. Researchers will compare outcomes between the two groups.\n\nParticipants in the control group will engage in a traditional cause-and-effect therapy, using a video that frequently pauses, requiring them to press an adapted button to continue watching. Participants in the intervention group will use the mobility platform during their sessions. Movement begins when the participant presses the adapted button, and the platform advances, adjusting its direction using sensors to detect obstacles. Once the preset time limit is reached, the platform stops, and the child must press the button again to resume movement. This stop-start process mirrors the cause-and-effect training in the control group.",[25],[134,331,332,333,334,335,336],"Children","Reaction Time","mobility platform","cognitive development","GMFCS levels IV-V","motor skills","2024-10-10",{"date":339,"type":40},"2024-10-15",{"date":341,"type":40},"2024-01-01",{"date":343,"type":21},"2025-06",{"name":345,"class":47},"University of Seville"]