[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-palsy-spastic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-palsy-spastic":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,47,76,118,143,170,199,225,247,271,291],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100612459","effects-of-hand-and-arm-bimanual-intensive-therapy-including-lower-extremity-in-spastic-cerebral-palsy-100612459",false,"NCT07253857","Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy","Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity on Motor Function and Cognition in Children With Spastic Cerebral Palsy","HABIT-ILE","Inclusion Criteria:\n\n* Diagnosed with diplegic cerebral palsy\n* CP children with manual ability level 1-3 on manual ability classification system\n* Participants with gross motor function classification system level ranging from 1-3 will be included in the study.\n* With an ability to grasp light objects and lift the more affected arm 15 cm above a table surface.\n* Base line cognition level should be 20 or above assessed through mini mental state exam for children (MMC).\n\nExclusion Criteria:\n\n* Uncontrolled seizures\n* Recent or planned botulinum toxin injections within 6 months\n* Any recent orthopedic interventions that may affect motor function\n* Visual impairments impeding with treatment protocol","ALL","6 Years","12 Years",{"count":21,"type":22},42,"ESTIMATED","INTERVENTIONAL",[25],"NA","Cerebral palsy (CP), particularly the spastic diplegic subtype, is characterized by motor impairments such as spasticity and mobility limitations. In addition to motor dysfunction, children with CP often experience cognitive impairments affecting decision-making, problem-solving, working memory, selective attention, and inhibitory control. These non-motor challenges contribute to reduced social interaction and quality of life.\n\nHand-Arm Bimanual Intensive Therapy Including Lower Extremity (HABIT-ILE) has demonstrated improvements in gross motor function among children with spastic CP. However, evidence regarding its impact on cognitive outcomes remains limited. This randomized controlled trial (RCT) aims to evaluate the effects of HABIT-ILE compared with conventional therapy on both motor and cognitive functions in children with spastic diplegic CP. By addressing both upper and lower limb the research seeks to provide a comprehensive therapeutic approach that may yield more significant developmental benefits. Ultimately, the findings could inform the interventions for improving outcomes in pediatric populations affected by diplegic cerebral palsy.\n\nParticipants will receive 90 hours of intervention, with assessments conducted at baseline, mid-intervention, and post-intervention. The study will investigate outcomes across motor domains and cognitive functions such as inhibitory control and working memory. Findings are expected to inform comprehensive therapeutic approaches to improve developmental outcomes and quality of life in pediatric populations affected by spastic diplegic CP.",[28,29],"Cerebral Palsy","Cerebral Palsy, Spastic",[15,31,28,32,33],"Intensive motor therapy","diplegic cerebral palsy with spasticity","Spastic cerebral palsy","RECRUITING","2026-06-17",{"date":37,"type":38},"2026-06-18","ACTUAL",{"date":40,"type":38},"2025-12-20",{"date":42,"type":22},"2026-06",{"name":44,"class":45},"Lahore University of Biological and Applied Sciences","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100541519","muscle-tendon-pathology-and-metabolic-dysregulation-in-cp-100541519","NCT06330922","Muscle-tendon Pathology and Metabolic Dysregulation in CP","Muscle-tendon Pathology, Metabolic Dysregulation and Chronic Inflammation in Adolescents and Young Adults With Moderate to Severe Spastic Cerebral Palsy","Inclusion Criteria:\n\n* spastic cerebral palsy\n* mildly, moderately or severly affected (Gross Motor Function Classification System level I-IV)\n* age range 14 - 30 years\n* ability to accept and follow verbal instructions\n* strong communication skills\n* sufficient vision (visual function that enables safe movement with reference to people and obstacles)\n* less than 15 hours of experience with the Frame Runners; healthy peers in the same age range\n\nExclusion Criteria:\n\n* other forms of cerebral palsy\n* orthopaedic surgery in the last 12 months\n* Botulinum toxin application in the last 6 months",true,"14 Years","30 Years",{"count":58,"type":22},50,"OBSERVATIONAL","The main aim of this project is to gain knowledge about the muscle-tendon pathology of moderately to severely affected young people with cerebral palsy and their risk for cardiometabolic diseases and chronic inflammation. Furthermore, it will be investigated whether there are associations between the existing pathophysiology as well as inactivity and muscle function, cardiometabolic risk factors and inflammation. Moreover, the potential of the target group for adaptation of its muscular, cardiorespiratory, and endocrine system will be investigated.\n\nThe study parameters will be determined in adolescents and young adults aged 14 to 30 years with moderate to severe spastic cerebral palsy and compared with those of their less severely affected and healthy peers (cross-sectional study). In addition, the more affected individuals will participate in a 12-week training intervention (longitudinal study) performed with special tricycles (i.e., Frame Runners).\n\nTo measure the study parameters, ultrasound, strength tests, near-infrared spectroscopy, blood analyses, and spiroergometry will be used. The fitness training will be performed two times a week for 12 weeks with the Frame Runners.",[29],[28,63,64,65,66],"Spasticity","Cardiorespiratory Fitness","Frame Running","Muscle","2026-04-28",{"date":69,"type":38},"2026-04-29",{"date":71,"type":38},"2024-03-08",{"date":73,"type":22},"2027-03-31",{"name":75,"class":45},"University of Graz",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":46},"100602032","ultrasonographic-assessment-of-muscle-morphology-function-and-clinical-findings-in-spastic-cerebral-palsy-100602032","NCT07118228","Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy","Evaluation of the Relationship Between Ultrasonographic Muscle Morphology, Functional Properties, and Clinical Parameters in Children With Spastic Cerebral Palsy","US-sCP","Inclusion Criteria:\n\n* Diagnosis of spastic cerebral palsy (SCP) according to the criteria defined by Rosenbaum et al. (2007)\n* Age between 4 and 18 years\n* Gross Motor Function Classification System (GMFCS) Level I, II, or III\n* Manual Ability Classification System (MACS) Level I, II, III, or IV\n\nExclusion Criteria:\n\n* Non-spastic types of cerebral palsy (e.g., dyskinetic, ataxic)\n* Diagnosis of neuromuscular disorders other than cerebral palsy (e.g., hereditary neuropathy, myopathy)\n* Presence of muscle contractures or fixed deformities in the limbs selected for ultrasound and clinical assessment\n* Cognitive or behavioral impairments that prevent cooperation during ultrasound or clinical evaluation\n* Botulinum toxin-A (BoNT-A) injection applied to the target muscles within the last 6 months\n* Current treatment with oral or intrathecal antispastic medications\n* History of orthopedic surgery or selective dorsal rhizotomy involving the target muscles\n* Acute infection, febrile illness, or severe systemic disease (e.g., advanced heart failure, respiratory insufficiency) that may compromise the safety of assessments","4 Years","18 Years",{"count":87,"type":22},36,"This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities. It is designed as a prospective, cross-sectional, observational study. Planned ultrasound-based assessments include parameters such as muscle thickness, pennation angle, fascicle length, echo intensity, tissue stiffness (via shear wave elastography), and microvascular flow (via superb microvascular imaging). These measurements are intended to be compared with standard clinical evaluations, including the GMFCS, GMFM-66, MAS, MACS, and Tardieu Scale. The study seeks to contribute to a better understanding of the relationship between muscle architecture and functional outcomes, with the goal of generating insights that may inform individualized rehabilitation planning.",[90,91,29],"Muscle Spasticity","Gait Disorders, Neurologic",[93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108],"Spastic Cerebral Palsy","Muscle Morphology","Shear Wave Elastography","Muscle Architecture","Superb Microvascular Imaging","Muscle Stiffness","Pennation Angle","Fascicle Length","Intramuscular Vascularity","Echo Intensity","GMFM-66","Gross Motor Function","Muscle Morphology and Function","Ultrasound Imaging","Ultrasound Imaging of Spastic Muscle","Functional Assessment","2026-01-30",{"date":111,"type":38},"2026-02-03",{"date":113,"type":38},"2025-12-15",{"date":115,"type":22},"2026-06-30",{"name":117,"class":45},"Kocaeli University",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":19,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":131,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":142},"100565339","power2walk-the-impact-of-functional-power-training-on-participation-and-activity-in-children-with-cerebral-palsy-100565339","NCT06640894","Power2Walk: The Impact of Functional Power Training on Participation and Activity in Children With Cerebral Palsy.","Power2Walk: The Impact of Functional Power Training on Participation and Activity in Children With Cerebral Palsy - A Randomized Controlled Trial","Power2Walk","Inclusion Criteria:\n\n* Children with cerebral palsy or a related non-progressive disorder between the ages of 4 to 12.\n* Gross Motor Function Classification System (GMFCS) level I - III.\n* Parents and\u002For children have a treatment question related to participation of the child.\n\nExclusion Criteria:\n\n* Participants that suffer from a progressive neurological disorder.\n* Treatment with botulinum toxin and\u002For serial casting in lower extremities planned during the study period.\n* Treatment with botulinum toxin in the twelve weeks prior to participation in the study.\n* Treatment with serial casting in the three weeks prior to participation in the study.\n* Children that underwent a selective dorsal rhizotomy twelve months prior to participation in the study.\n* Children that underwent orthopedic surgery on their lower extremities in the 12 months before participation in the study.\n* Children that have received MegaPower training in the last 4 months before participation in the study.\n* Children for whom walking is not their preferred method of locomotion (yet).",{"count":127,"type":22},66,[25],"Rationale: Children with cerebral palsy (CP) experience limitations in walking ability due to functional motor impairments caused by neurodevelopmental damage during fetal or early child development. Due to these motor impairments, children with CP struggle to keep up with typically developing peers when participating in physical and\u002For social activities. Consequently, the development of these children may be hampered. Recently, functional power training (FPT) emerged as a potentially successful supplementary treatment method to improve participation in children with CP. It is understood that FPT is more effective than progressive resistance training in improving walking ability and endurance, and thereby better supports participation in ambulatory children with CP. Nevertheless, high-level scientific evidence underpinning the efficacy of FPT on these parameters in ambulant children with CP is still lacking. The investigators hypothesize that FPT effectively helps accomplish patient-tailored participation and activity goals in ambulant children with CP.\n\nObjective: This study aims to investigate whether twelve weeks of FPT (MegaPower training) effectively accomplish patient-tailored participation and activity goals in ambulant children with CP, when compared to their usual care. Additionally, the goal is to investigate i) whether MegaPower training improves walking ability, aerobic endurance, and anaerobic capacity; ii) what factors best identify which ambulant children with CP benefit most from twelve weeks of MegaPower training; iii) to what extend the MegaPower training was implemented as intended in the participating study centers?, and iv) whether the effects of the MegaPower training are maintained after 12 and 24 weeks of follow-up.\n\nStudy design: A single-blind randomized controlled parallel trial with a 24 week follow-up. During the follow-up, the control group will also receive MegaPower training.\n\nStudy population: Ambulant children with cerebral palsy or a related non-progressive disorder between the ages of 4 - 12.\n\nIntervention: One group will receive twelve weeks of FPT (MegaPower training), whilst the other group will receive twelve weeks of usual care (control group).\n\nMain study parameters\u002Fendpoints: Accomplishment of patient-tailored participation and activity goals, measured through Goal Attainment Scaling.",[29],[132],"Cerebral palsy","2025-12-19",{"date":135,"type":38},"2025-12-29",{"date":137,"type":38},"2024-07-19",{"date":139,"type":22},"2027-08-31",{"name":141,"class":45},"Amsterdam UMC, location VUmc",10,{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":23,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":160,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":46},"100612152","effect-of-robotic-assisted-therapy-on-hand-functions-grip-strength-and-proprioception-in-children-with-hemiplegia-100612152","NCT07249866","Effect of Robotic Assisted Therapy on Hand Functions, Grip Strength and Proprioception in Children With Hemiplegia","Inclusion Criteria:\n\n* Their ages range from 6-9 years\n* They have mild to moderate spasticity (grade 1- 2) according to Modified Ashworth Scale\n* Their motor function will be at level I and II according to Gross Motor Function Classification System GMFCS\n* Their manual abilities will be at level II and Level III according to Manual Ability classification system\n* They will be able to understand and follow instructions\n\nExclusion Criteria:\n\n* Fixed deformity in any joints of the upper limb.\n* Previous history of surgical intervention in the upper limb.\n* Auditory, visual and cognitive problems.\n* Botulinum Toxin injection in last 6 months.","9 Years",{"count":151,"type":22},32,[25],"Statement of the problem:\n\nDoes robotic assisted therapy have an effect on hand functions, grip strength and proprioception in children with hemiplegic cerebral palsy?\n\nSignificance of the study:\n\nNew technologies allow and promote active involvement, leading directly to functional changes that are far beyond those obtained with conventional therapy. Many features of robotic therapy may contribute to enhanced recovery of upper limb motor function. These include task-specific practice, intensity of repetition, robotic assistance, enhanced sensory feedback, continual motivation (because every trial yields a degree of success, even if robot assistance is required).\n\nThe implementation of robotics with hemiplegic cerebral palsy focuses on functional motor performance by providing intensive repetitive training, sensorimotor integration and cognitive engagement through goal-directed tasks to address the underlying symptoms. Robotic technologies offer numerous potential advantages over conventional therapies, chief among these being the ability to provide high-intensity repetitive training. Robotic treatment is a novel approach that has demonstrated promise in enhancing motor function, enhancing the quality of life, and lessening the burden on caregivers.",[29],[156,157,158,159],"robotic therapy","hand functions","hemiplegia","cerebral palsy","NOT_YET_RECRUITING","2025-11-18",{"date":163,"type":38},"2025-11-25",{"date":165,"type":22},"2025-11",{"date":167,"type":22},"2026-02",{"name":169,"class":45},"Cairo University",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":23,"phases":178,"briefSummary":179,"conditions":180,"keywords":181,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":46},"100484886","late-presenting-hip-dislocation-in-non-ambulatory-children-with-cerebral-palsy-a-comparison-of-three-procedures-100484886","NCT05593887","Late-presenting Hip Dislocation in Non-ambulatory Children With Cerebral Palsy: A Comparison of Three Procedures","Inclusion Criteria:\n\n* Lesion: neglected deformed dislocated hip (Deformed head Group B, C, and D according to Rutz classification modified from MCPHCS )\n* Non-ambulatory: as defined by GMFCS level IV and V\n\nExclusion Criteria:\n\n* Ambulatory patients\n* patients underwent any previous hip bony procedures.\n* Non-deformed Femoral head Group A according to Rutz classification\n* Neuromuscular hip dislocation other than cp.",{"count":177,"type":22},51,[25],"Cerebral palsy (CP) is characterized by a fixed lesion that affects the neurological system during development. Pathologic hip conditions, such as subluxation or dislocation, are of great concern in non-ambulatory CP patients. Complete hip dislocations are commonly encountered in non-ambulatory CP patients and this can be quite problematic if pain is experienced or when sitting, balance, posture, or hygiene become affected.\n\nThe management of this patient population includes both reconstructive surgery, which aimed to center the dislocated femoral head into the acetabulum, and salvage surgeries, which are performed to reduce associated pain and\u002For functional deficits (e.g., sitting problems).\n\nThere are many options for salvage management of dislocated hips in CP patients, including proximal femoral resection (PFR) either with or without cartilage capping, proximal femoral valgus osteotomy, hip arthrodesis, and prosthetic hip arthroplasty.\n\nTo date, there is no conclusive evidence to determine which option is superior compared to the others in terms of efficacy and postoperative complications in CP patients due to the lack of a comparison group and the small number of included patients. Furthermore, the decision to take reconstructive vs. salvage procedures is still a matter of debate in the literature.\n\nTherefore, this study is being conducted to compare outcomes between PFR, reconstructive hip surgery, and proximal femur valgus osteotomy in terms of clinical improvement (Including pain) and complications",[29],[132,182,183,184,185,186,187,188,189],"McHale","dislocated hip","GMFCS IV","GMFCS V","Hip reconstruction surgery","HRS","Proximal femoral resection","valgus osteotomy","2025-08-07",{"date":192,"type":38},"2025-08-11",{"date":194,"type":38},"2022-10-18",{"date":196,"type":22},"2025-10-26",{"name":198,"class":45},"Muhammad Ayoub",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":17,"minAge":206,"maxAge":85,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":212,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":46},"100554094","effects-of-botulinum-toxin-injection-combined-with-reswt-in-lower-extremity-spasticity-in-children-with-cerebral-palsy-100554094","NCT06494618","Effects of Botulinum Toxin Injection Combined with RESWT in Lower Extremity Spasticity in Children with Cerebral Palsy","The Effects of Botulinum Toxin Type a Injection Combined with RESWT in Lower Extremity Spasticity in Children with Cerebral Palsy","Inclusion Criteria:\n\n* Diagnosed with cerebral palsy.\n* Spasticity in at least one of the lower extremity muscle groups.\n* No contraindications to shockwave therapy.\n* Applied Botulinum Toxin Type A injection for at least one spastic muscle of lower extremity.\n* Agreed to participate to study (patient\u002Fprimary caregiver)\n\nExclusion Criteria:\n\n* Surgery history within the last year of the muscle to be injected and treated\n* Having uncontrolled epilepsy.\n* Having infection\n* Coagulopathy","2 Years",{"count":208,"type":22},20,[25],"This study aimed to check and compare the effects of botulinum toxin injection combined with shock wave therapy versus botulinum toxin injection only for lower extremity spasticity in children with cerebral palsy",[29],[159,213,214,215],"spasticity","botulinum toxin injection","extracorporeal shockwave therapy","2025-03-08",{"date":218,"type":38},"2025-03-11",{"date":220,"type":22},"2025-03",{"date":222,"type":22},"2025-06",{"name":224,"class":45},"Istanbul Medeniyet University",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":17,"minAge":232,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":23,"phases":235,"briefSummary":236,"conditions":237,"keywords":4,"overallStatus":160,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":46},"100549455","effect-of-pully-system-on-hemiplegic-children-100549455","NCT06434246","Effect of Pully System on Hemiplegic Children","Effect of Pully System Exercise on Upper Limb Function in Hemiplegic Cerebral Palsy Children: a Randomized Clinical Trials","Inclusion Criteria\n\n* Children aged between 3 and 7 years.\n* Diagnosed with hemiplegic cerebral palsy, confirmed by a pediatric neurologist.\n* Ability to follow simple instructions and participate in exercise sessions.\n* Presence of upper limb motor function deficits attributable to hemiplegic cerebral palsy.\n\nExclusion Criteria\n\n1. Children with additional neurological disorders or severe cognitive impairments that might interfere with the ability to participate in exercise regimens.\n2. Recent surgery (within the last 6 months) on the upper limbs.\n3. Children who have been involved in similar rehabilitation programs in the past 3 months.\n4. Severe uncontrolled medical conditions such as cardiac or respiratory diseases. Presence of any contraindication to physical activity as advised by a medical professional.","3 Years","7 Years",{"count":151,"type":22},[25],"Introduction Cerebral palsy (CP) is a group of sensory, motor, and postural disorders caused by non-progressive brain injury in early development. It can manifest in various forms, including hemiplegia, which affects about 21% to 40% of CP cases. Upper extremity (UE) impairments in CP individuals are significant, impacting daily activities and quality of life.\n\nObjective This study aims to investigate the effects of pulley system exercises on improving upper limb function in children with hemiplegic CP.\n\nMethods Design: Randomized controlled double-blinded trial. Participants: 32 children aged 3-7 years with hemiplegic CP, divided into intervention and control groups.\n\nIntervention: The intervention group receives pulley system exercises plus standard care, while the control group receives standard physical therapy.\n\nDuration: Conducted between June 2024 and August 2024. Inclusion Criteria: Diagnosed with hemiplegic CP, aged 3-7 years, able to follow instructions, and with upper limb motor deficits.\n\nExclusion Criteria: Additional neurological disorders, recent upper limb surgery, previous rehabilitation programs, severe medical conditions, or contraindications to physical activity.\n\nAssessment Tools: Assisting Hand Assessment (AHA), Bruininks-Oseretsky Test of Motor Proficiency (BOT-2), Quality Upper Extremity Skills Test (QUEST), and Lafayette Manual Muscle Tester.\n\nTiming: Baseline and after 3 months of intervention. Treatment Intervention Group: 45-60 minute sessions, three times a week, involving warm-up, pulley system exercises, and cool-down.\n\nControl Group: Standard care physical therapy, twice a week, 45-60 minute sessions.\n\nStatistical Analysis Methods: Descriptive statistics and Analysis of Covariance (ANCOVA) to analyze improvements in upper limb function.\n\nSignificance Level: p \\\u003C 0.05. Analysis: Intention-to-treat to handle missing data. This study aims to provide evidence on the effectiveness of pulley system exercises in enhancing upper limb function in children with hemiplegic CP, potentially improving their independence and quality of life.",[29],"2025-01-19",{"date":240,"type":38},"2025-01-22",{"date":242,"type":22},"2025-02-20",{"date":244,"type":22},"2025-11-20",{"name":246,"class":45},"Kafrelsheikh University",{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":253,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":255,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":257,"conditions":258,"keywords":259,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":46},"100489193","effect-of-functional-power-training-on-calf-muscle-length-and-strength-in-children-with-spastic-paresis-100489193","NCT05649930","Effect of Functional Power Training on Calf Muscle Length and Strength in Children With Spastic Paresis","Effect of Functional Power Training on Muscle Morphology and Strength of the Medial Gastrocnemius in Children With Spastic Paresis","MegaMuscle","Inclusion Criteria:\n\n* Gross Motor Function Classification System I-III\n* Children should be able to lie on their stomach for min. one minute\n* Children should be able to follow instructions.\n\nExclusion Criteria:\n\n* Received (one of) the following interventions within six months:\n* Casting\n* Botulinum toxin type-A injections\n* Orthopedic surgery.",{"count":256,"type":22},23,"Spastic paresis (SP) is a common motor condition in children and is often caused by cerebral palsy. Skeletal muscles develop differently in children with SP due to brain damage in early development; muscle strength and muscle length are reduced compared to typically developing (TD) children. Especially, the calf muscles are affected, which particularly affects their ability to walk and to run, hindering participation in society. There are several treatments aimed to increase the range of motion of the joint by lengthening the muscle, for example botulinum toxin injections. However, these treatments can have a weakening effect on the muscle due to deconditioning from immobilization and due to paralysis.\n\nIn rehabilitation centers in the Netherlands functional power training (MegaPower) is offered to children with SP who want to walk and run better. It has been shown that this training improves calf muscle strength and performance during functional walking tests. However, the effect of MegaPower training on muscle morphology (i.a. muscle volume and length) is still unknown. Therefore, the aim of this study is to assess the effect of MegaPower training on the muscle morphology of the medial gastrocnemius in children with SP using 3D ultrasonography. It is expected that MegaPower training results in an increase of muscle volume as well as elongation of the muscle belly. Muscle volume could increase due to hypertrophy of the muscle fibers induced by the training, which could elongate the muscle belly length due to the pennate structure of the medial gastrocnemius. A double-baseline design will be applied for this study with three different measurement times (T0-T1-T2) to compare the training period (12 weeks) with a period (12 weeks) of usual care.",[29],[260,261,262],"Medial gastrocnemius morphology","3D ultrasonography","Functional power training","2025-01-06",{"date":265,"type":38},"2025-01-08",{"date":267,"type":38},"2022-06-20",{"date":269,"type":22},"2025-09-30",{"name":141,"class":45},{"id":272,"slug":273,"hasResults":11,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":278,"targetDuration":4,"studyType":23,"phases":280,"briefSummary":281,"conditions":282,"keywords":4,"overallStatus":160,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":289,"locationsCount":46},"100454544","the-effectiveness-of-repetitive-transcranial-magnetic-stimulation-for-spastic-diplegia-cerebral-palsy-100454544","NCT05198921","The Effectiveness of Repetitive Transcranial Magnetic Stimulation for Spastic Diplegia Cerebral Palsy","The Effectiveness of Repetitive Transcranial Magnetic Stimulation for the Treatment of Spastic Diplegia Cerebral Palsy Based on the Gross Motor Function in School-aged Children: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Primary school children with diagnose of Spastic Diplegia CP\n* \\> 1 on Mas in hip flexors, adductors and tibialis anterior of both lower extremities.\n* Parents\u002Flegal guardians signed the Informed consent\n\nExclusion Criteria:\n\n* Severe mental retardation\n* Present epilepsy\n* Present any remedial surgery\u002Fmedication\n* Less than 1 year post orthopaedic surgery\n* Less than 6 months post botulinum toxin type A injection\n* Present metallic implants\n* Present any comorbidity unfit for the study\n* Congenital disorders such as Down's syndrome, fragile-x syndrome or congenital anomalies",{"count":279,"type":22},30,[25],"Cerebral palsy describes a group of permanent disorders of the development of movement and posture, causing activity limitation that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain.\n\nNowadays, CP is not fully curable, and physiotherapy should be used in conjunction with other interventions such as oral drugs, botulinum toxin type A, continuous pump-administered intrathecal baclofen, orthopaedic surgery and selective dorsal rhizotomy. However, several systematic reviews conclude that there is low evidence that these invasive therapies are more effective than placebo.\n\nRepetitive transcranial magnetic stimulation (rTMS) is a type of neuromodulatory technique through magnetic impulses. The effect of rTMS depends on the frequency of the emitted electromagnetic field; low frequencies (≤1 Hz) lead to an inhibition of neuronal electrical activity at the stimulation site, while high frequencies (≥3 Hz) cause neuronal depolarization.\n\nThe objective of the project is to evaluate the effectiveness of a repetitive Transcranial Magnetic Stimulation (rTMS) protocol, as an adjunct treatment to neurorehabilitation to improve gross motor function and quality of life in school-age children with spastic diplegia-type infantile cerebral palsy.",[29],"2024-09-13",{"date":285,"type":38},"2024-09-19",{"date":287,"type":22},"2025-01",{"date":222,"type":22},{"name":290,"class":45},"Universitat de Lleida",{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":297,"eligibilityCriteria":298,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":299,"targetDuration":4,"studyType":23,"phases":301,"briefSummary":302,"conditions":303,"keywords":304,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":46},"100560037","effect-of-task-specific-training-in-an-augmented-reality-context-on-upper-limb-function-and-activities-in-children-with-spastic-cerebral-palsy-100560037","NCT06571929","Effect of Task-Specific Training in an Augmented Reality Context on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy","Effect of Task-Specific Training in Augmented Reality Context (INTERACT Protocol) on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy: A Randomized Controlled Trial","INTERACT","Inclusion Criteria:\n\n* In the experimental and control groups, children who have been medically diagnosed with cerebral palsy, either unilateral or bilateral, with spasticity classification, will be included.\n* Participants must be classified at GMFCS levels I and II, meaning they are capable of walking independently.\n* The MACS (Manual Ability Classification System) should be between levels I (manipulates objects easily), II (manipulates most objects with reduced quality and speed), and III (manipulates objects with difficulty).\n* The modified Ashworth score should be between 0 and 2.\n* Ability to understand verbal commands and good comprehension of the proposed games.\n\nExclusion Criteria:\n\n* Children with dystonic tone classification (identified by the Hypertonia Assessment Tool (HAT)), athetoid, or ataxic.\n* GMFCS levels III, IV, and V.\n* MACS levels IV and V.\n* Modified Ashworth score of 3 to 4.\n* Undergoing orthopedic surgical procedures within the past year.\n* Receiving chemical blocks within the last 6 months.\n* Deformities (muscle shortening and\u002For loss of joint mobility in the upper limbs) that prevent or compromise the ability to reach the midline.\n* Presence of visual and\u002For auditory sensory deficits not corrected with devices.\n* Use of medications that may alter muscle strength or tone.\n* Cardiovascular limitations of any intensity, such as excessive fatigue, low exercise tolerance.\n* Children who have undergone other intensive therapies within the past 6 months.\n* Children with cognitive impairment indicated by caregivers or perceived by researchers due to difficulties in understanding verbal commands and virtual reality games.\n* Children who do not accept playing augmented reality games.",{"count":300,"type":22},34,[25],"Children with Cerebral Palsy (CP), a condition that affects movement and coordination, face difficulties in daily activities such as dressing, reaching for objects in high places, and getting up from seats. These challenges can negatively impact the quality of life for these children. Therefore, it is essential to seek effective treatments that help improve these skills.\n\nThe use of technology in treatments, especially with games that utilize augmented reality (AR), has proven to be a good strategy. This technique aids motor learning, improving the skills that children struggle with while also increasing motivation, allowing them to engage in activities they enjoy. However, the application of AR in children with CP is still limited.\n\nIn this context, it is crucial to provide appropriate treatments for these children, harnessing the benefits of AR technology. This study aims to investigate the effects of a protocol called \"INTERACT protocol,\" which consists of training activities that interest children, such as reaching for objects and getting up from a bench. These activities are linked to AR games and will be conducted with accessible equipment for children with CP, aiming to improve their quality of life.\n\nThe children selected for the research will be divided into two groups: the experimental group (INTERACT) and the control group. This division will be done by random draw. The children in the control group will continue receiving the physiotherapy they are already undergoing for the same duration as the children in the INTERACT group. All children will participate in the treatment for 4 weeks, three times a week, with sessions lasting 1 hour and 20 minutes each.\n\nOur hypothesis is that the children participating in the INTERACT protocol will show improvements in activities involving reaching for objects and in the transition from sitting to standing.",[29],[28,305,306,307],"Children","Games","Augmented reality","2024-08-22",{"date":310,"type":38},"2024-08-26",{"date":312,"type":38},"2024-05-21",{"date":314,"type":22},"2026-11",{"name":316,"class":45},"Universidade Federal de Sao Carlos"]