[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-palsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-palsy":26},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,167,0,25,[9,44,75,104,132,156,177,199,230,255,283,309,338,362,390,413,432,456,477,510,537,564,593,632,657],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100053535","influence-of-hawthorne-effect-and-dual-tasks-on-gait-in-cp-100053535",false,"NCT05417399","Influence of Hawthorne Effect and Dual-tasks on Gait in CP","Ecological Validity of Clinical Gait Analysis in Children With Cerebral Palsy: Influence of the Hawthorne Effect and Dual-tasks. A Pilot Study","Inclusion Criteria:\n\n* Cerebral palsy, bilateral spastic, GMFCS classification I-III\n* Age \\\u003C16 years\n* Use of bilateral AFO's (rigid or ground reaction AFO's) to improve knee extension in stance\n\nExclusion Criteria:\n\n* Behavioural issues or poor instructability which might affect participation in the protocol\n* Significant visual disorders\n* Other diagnoses influencing gait\n* Not willing to sign informed consent before inclusion","ALL","4 Years","16 Years",{"count":21,"type":22},15,"ESTIMATED","OBSERVATIONAL","It is the clinical experience of the authors that some children with cerebral palsy who walk in crouch gait show sufficient knee extension during the clinical gait analysis, but walk in considerable knee flexion when they leave the gait laboratory. Possible differences between walking in a gait lab and walking in daily life may be caused by the effect of observational awareness in the lab (also known as the Hawthorne effect), and the lack of dual-tasks (DT) during the analysis (which are common during daily life walking). Since so far there is no technique to reliably measure gait kinematics in children with CP outside of the laboratory, the researchers aim to objectify the influence of both the Hawthorne effect and dual-tasks by introducing different conditions during a standard clinical 3D gait analysis.",[26,27,28,29,30],"Cerebral Palsy","Gait Disorders, Neurologic","Hawthorne Effect","Dual-tasks","Kinematics","RECRUITING","2026-07-10",{"date":34,"type":35},"2026-07-13","ACTUAL",{"date":37,"type":35},"2022-09-01",{"date":39,"type":22},"2028-12-01",{"name":41,"class":42},"Roessingh Research and Development","OTHER",1,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":43},"100054132","effects-of-proprioceptive-neuromuscular-facilitation-and-task-oriented-training-on-upper-extremity-function-in-children-with-spastic-diplegic-cerebral-palsy-100054132","NCT07694804","Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy","Isolated Versus Combined Effects of Proprioceptive Neuromuscular Facilitation and Task-Oriented Training on Upper Extremity Function in Children With Spastic Diplegic Cerebral Palsy","PNF-TOT-CP","Inclusion Criteria:\n\n* Children aged 6 to 12 years.\n* Clinical diagnosis of spastic diplegic cerebral palsy.\n* Gross Motor Function Classification System (GMFCS) Levels I-III.\n* Ability to understand and follow simple verbal instructions.\n* Medically stable and able to participate in physiotherapy sessions.\n* Parent or legal guardian willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Orthopedic surgery involving the upper or lower extremities within the previous 6 months.\n* Botulinum toxin injections administered within the previous 6 months.\n* Severe visual, hearing, or cognitive impairments that would interfere with assessment or treatment.\n* Uncontrolled epilepsy or other unstable neurological or medical conditions.\n* Fixed upper extremity contractures or musculoskeletal deformities preventing participation in the intervention.\n* Participation in another structured upper extremity rehabilitation program during the study period.\n* Failure to obtain informed consent from a parent or legal guardian.","6 Years","12 Years",{"count":55,"type":22},63,"INTERVENTIONAL",[58],"NA","Children with spastic diplegic cerebral palsy often experience upper extremity impairments, including reduced coordination, muscle control, and functional hand use, which limit independence in daily activities. Proprioceptive Neuromuscular Facilitation (PNF) and Task-Oriented Training (TOT) are commonly used rehabilitation approaches to improve motor function; however, evidence comparing their individual and combined effects on upper extremity function remains limited.\n\nThis randomized controlled trial aims to compare the effects of PNF alone, TOT alone, and a combined PNF plus TOT intervention on upper extremity function in children with spastic diplegic cerebral palsy. Sixty-three children aged 6 to 12 years with Gross Motor Function Classification System (GMFCS) levels I to III will be randomly assigned to one of three intervention groups. Each group will receive supervised 45-minute treatment sessions, three times per week for six weeks.\n\nUpper extremity function, functional independence, and joint range of motion will be assessed at baseline, mid-intervention (3 weeks), and post-intervention (6 weeks) using the Melbourne Assessment of Unilateral Upper Limb Function (MA2), Pediatric Evaluation of Disability Inventory-Functional Skills Scale (PEDI-FSS), and goniometric measurements. The findings of this study are expected to provide evidence regarding the most effective rehabilitation approach for improving upper extremity function in children with spastic diplegic cerebral palsy.",[26,61],"Spastic Diplegia",[63,64,65,66,67],"Spastic diplegic cerebral palsy","Proprioceptive neuromuscular facilitation","Task-oriented training","Motor function","Functional independence",{"date":34,"type":35},{"date":70,"type":35},"2026-02-17",{"date":72,"type":22},"2026-07-08",{"name":74,"class":42},"Ibadat International University, Islamabad",{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":56,"phases":86,"briefSummary":87,"conditions":88,"keywords":89,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":100,"leadSponsor":102,"locationsCount":43},"100645260","a-gamified-breathing-and-postural-awareness-education-model-for-children-with-cerebral-palsy-100645260","NCT07681947","A Gamified Breathing and Postural Awareness Education Model for Children With Cerebral Palsy","N.E.F.E.S.-CP (Qualified Education for Awareness, Accessible Breathing: Cerebral Palsy) A Gamified Breathing and Postural Awareness Education Model","NEFES-CP","Inclusion Criteria:\n\n* Diagnosed with cerebral palsy.\n* Classified as Level I-III according to the Gross Motor Function Classification System (GMFCS).\n* Aged between 6 and 18 years.\n* Having a cognitive level sufficient to understand and follow simple instructions (for active participation in gamified training).\n\nExclusion Criteria:\n\n* Presence of uncontrolled medical conditions or systemic limitations.\n* Use of medications affecting respiratory function.\n* Presence of musculoskeletal problems (other than CP diagnosis) that may affect walking ability, and\u002For the presence of cognitive and mental impairment that may affect participation and\u002For motivation.\n* Visual or hearing loss that severely restricts participation in digital game and video-based applications (if appropriate adaptation cannot be provided).","18 Years",{"count":85,"type":22},40,[58],"This project aims to develop an accessible, learning-oriented model based on gamified breathing and posture training that emphasizes active participation for children with cerebral palsy (CP), their families, and educators. Since current practices are largely clinic-centered, there is a growing need for game-based, motivational and widely discernible programs. In this context, the project aims to provide an inclusive model that enhances breathing and postural awareness through digital technology, thereby increasing motivation and adherence.",[26],[90,91,92,93,94],"awareness","cerebral palsy","gamification","posture","respiration","NOT_YET_RECRUITING","2026-07-01",{"date":98,"type":35},"2026-07-02",{"date":32,"type":22},{"date":101,"type":22},"2026-11-30",{"name":103,"class":42},"Yeditepe University",{"id":105,"slug":106,"hasResults":12,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":4,"leadSponsor":129,"locationsCount":43},"100196174","cerebral-palsy-and-the-study-of-brain-activity-during-motor-tasks-100196174","NCT01829724","Cerebral Palsy and the Study of Brain Activity During Motor Tasks","Near-infrared Spectroscopy and Electroencephalography to Assess and Train Cortical Activation During Motor Tasks","* INCLUSION CRITERIA\n* Age 5 years and older\n* Surgery free for six months in either the upper or lower extremities.\n* Free from botulinum toxin injections within four months in either the upper or lower extremities.\n* Either a healthy volunteer or have a diagnosis of a childhood-onset (before 13 years of age) brain injury resulting in motor impairment of one arm and one leg on the same side of the body or motor impairment of both legs or have a diagnosis of childhood-onset (before 13 years of age) peripheral injury resulting in sensory or motor impairment of any limb or multiple limbs.\n* Able to understand and follow simple directions that include how to perform a repetitive task and when to start and stop doing the task, based on parent report if the subject is a child and physician observation during history and physical examination.\n* Able to walk at least 20 feet without stopping with or without a walking aid\n* Able to provide informed consent (Guardian or parent of child participants) or verbal\u002Fwritten assent as appropriate (for child participant).\n* Agreement to not drink caffeine or alcohol for 24 hours before each assessment session because both agents can modify brain activity and may confound outcome measures. This restriction does not apply to the training sessions in Objective 3.\n\nEXCLUSION CRITERIA:\n\n* Any neurological, musculoskeletal or cardiorespiratory injury, health condition, or diagnosis other than childhood-onset brain or peripheral injury that would affect the ability to mentally concentrate or move a body part repetitively for short periods of time. Examples of this include, but are not limited to, congestive heart failure, end stage cardiac disease, or fractures that have not completely healed.\n* Uncontrolled seizures.\n* Concurrent use of medicines for muscle tone (e.g., baclofen, trihexyphenedyl, dantrolene sodium, tizanidine, or carbidopa\u002Flevodopa). If patients are taking these medications daily, the treating physician will be contacted by the MAI to determine if it is acceptable for the subject to temporarily discontinue the medication(s) for 24 hours prior to participating in testing for this study for each of the first 2 objectives. If that is not deemed to be safe, the subject will be excluded. Subjects who are on these medications will not be allowed to participate in Objective 3.\n* Pregnancy: Childbearing potential will be determined during the history and physical exam and urine pregnancy test may be required\n* Adult who can t consent for themselves.\n\nTo participate in Objective 1, it is preferable that all subjects be willing and able to have, or have previously had, a structural MRI to aid in the interpretation of results. Inability or refusal to complete an MRI, or to provide access to a previous structural MRI scan, will not constitute an exclusion criterion for this study.\n\nAdditional exclusion criteria for MRI\n\n* Inability to lie flat on the back for up to 45 minutes without sedation.\n* Discomfort being in small spaces for up to 45 minutes.\n* Cardiac pacemakers, implanted medication pumps, intracardiac lines, or acute, unstable cardiac disease, with intracranial implants (e.g. aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth that cannot be safely removed.\n\nAdditional exclusion criteria for EEG\n\n-History of allergic reaction to water-based electrode gel",true,"5 Years","100 Years",{"count":115,"type":22},320,"Background:\n\n\\- Two ways to study the brain while people are moving are near-infrared spectroscopy (NIRS) and electroencephalography (EEG). NIRS uses light to look at blood flow in the brain when it is active. EEG records electrical activity in the brain. Both have been used safely for many years, even in very young children. NIRS or EEG can be used while a person is moving to show which parts of the brain are the most active. Researchers want to use NIRS and EEG to study brain activity during movement in people with cerebral palsy and healthy volunteers. Learning more about how people with and without cerebral palsy use their brain to control their muscles may lead to new ways of training people with cerebral palsy to move better.\n\nObjectives:\n\n\\- To study how the brain controls body movement in people with and without cerebral palsy.\n\nEligibility:\n\n* Individuals at least 5 years of age who have cerebral palsy.\n* Healthy volunteers at least 5 years of age.\n\nDesign:\n\n* This study has three parts. People with cerebral palsy will be selected for all three. Healthy volunteers will be asked to do only two of them. Everyone who participates will have NIRS and\u002For EEG exams during movement. People with cerebral palsy may also have biofeedback sessions to train coordination of movement and brain activity.\n* Participants will be screened with a physical exam and medical history. Urine samples may be collected.\n* All participants will have at least one session of NIRS and\u002For EEG imaging studies. Sessions may also include the following tests:\n* Magnetic resonance imaging to look at the brain\n* Electromyography to measure electrical activity of the muscles\n* Motion analysis of specific body parts\n* Ultrasound to measure activity of the muscles\n* Motorized, robotic, and electrical stimulation of the muscles\n* Other clinical tests of muscle movement as needed.\n* Participants with cerebral palsy will have biofeedback sessions. These sessions will help them learn to coordinate muscle movement and brain activity.",[26,118],"Children",[120,26,121,122,123],"Functional Brain Imaging","Motion Analysis","Macro-EMG","Natural History","2026-06-27",{"date":126,"type":35},"2026-06-30",{"date":128,"type":35},"2013-08-22",{"name":130,"class":131},"National Institutes of Health Clinical Center (CC)","NIH",{"id":133,"slug":134,"hasResults":12,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":56,"phases":142,"briefSummary":143,"conditions":144,"keywords":145,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":151,"completionDateStruct":152,"leadSponsor":154,"locationsCount":4},"100644847","functional-progressive-resistive-training-and-cerebral-palsy-100644847","NCT07675343","Functional Progressive Resistive Training and Cerebral Palsy","Effect of Functional Progressive Resistance Training on Bone Mineral Density and Balance in Children With Cerebral Palsy","Inclusion Criteria:\n\n1. A diagnosis of spastic diplegic CP\n2. Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)\n3. The age of the selected children will range from 6 to 10 years old.\n4. Children are levels II and III according to GMFCS\n\nExclusion Criteria:\n\n1 - Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).","10 Years",{"count":141,"type":22},60,[58],"Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance. It involves performing task-oriented exercises, such as sit-to-stand, stair climbing, and walking-related activities, while gradually increasing the load to enhance muscle strength, endurance, and functional performance. FPRE is widely used in rehabilitation programs to improve mobility and the ability to perform activities of daily living in various populations, including children with neurological and musculoskeletal disorders.",[26],[91,146,147,148],"functional progressive resistive exercise","bone mineral density","balance","2026-06-26",{"date":126,"type":35},{"date":96,"type":22},{"date":153,"type":22},"2026-11-09",{"name":155,"class":42},"Cairo University",{"id":157,"slug":158,"hasResults":12,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":111,"sex":17,"minAge":162,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":176},"100454469","anatomical-and-functional-imaging-correlates-of-chronic-pain-in-cerebral-palsy-100454469","NCT05197946","Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy","Participants with CP (Survey-only):\n\nInclusion Criteria:\n\n* Individual 8+ years of age\n* Diagnosis of cerebral palsy\n\nExclusion Criteria:\n\n-None\n\nNeurotypical participants: (Survey-only):\n\nInclusion Criteria:\n\n* Individual 8+ years of age\n* Adult subject able to indicate understanding and affirmative consent OR Adult\u002Fchild subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents\n\nExclusion Criteria:\n\n-Clinically-significant neurologic or developmental diagnosis\n\nParticipants with CP (Survey and MRI):\n\nInclusion Criteria:\n\n* Individual 8+ years of age\n* Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents\n* Diagnosis of cerebral palsy\n* Clinical imaging demonstrating isolated periventricular white matter injury\n* Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury\n* Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI\n\nExclusion Criteria:\n\n-None\n\nNeurotypical participants (Survey and MRI):\n\nInclusion Criteria:\n\n* Individual 8+ years of age\n* Adult subject able to indicate understanding and affirmative consent\n* Able to lie still in scanner for 1.5 hours and be able to have MRI\n\nExclusion Criteria:\n\n-Clinically-significant neurologic or developmental diagnosis","8 Years",{"count":164,"type":22},300,"The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.",[26,167],"Chronic Pain",{"date":169,"type":35},"2026-06-29",{"date":171,"type":35},"2018-12-04",{"date":173,"type":22},"2028-12",{"name":175,"class":42},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.",4,{"id":178,"slug":179,"hasResults":12,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":17,"minAge":162,"maxAge":184,"enrollmentInfo":185,"targetDuration":4,"studyType":56,"phases":187,"briefSummary":188,"conditions":189,"keywords":190,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":197,"locationsCount":43},"100644666","comparative-effect-of-cimt-and-pnftechnique-on-hands-dexterity-in-cerebral-palsy-100644666","NCT07673289","Comparative Effect of CIMT and PNFTechnique on Hands Dexterity in Cerebral Palsy","Comparative Effect of Constraint Induced Movement Therapy and Proprioceptive Neuromuscular Facilitation Technique on Hands Dexterity in Cerebral Palsy","Inclusion Criteria:\n\n* 8 to 13 years of age\n* Both male and female\n* Children with moderate level of mental retardation who are able to follow commands\n\nExclusion Criteria:\n\n* Children with other musculoskeletal and neurological issues.\n* Children who have complications such as epilepsy, congenital heart condition","13 Years",{"count":186,"type":22},26,[58],"Cerebral Palsy (CP) is a group of permanent disorders of the development of movement and posture, causing activity limitations that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The primary motor impairments in CP often include issues with muscle tone, reflexes, and coordination. Among the various motor disorders associated with CP, impairment of the upper extremities is particularly common and functionally debilitating. Specifically, reduced hand dexterity the ability to perform coordinated, fine motor tasks significantly impacts a child's independence in daily activities such as feeding, dressing, and school-related tasks like writing. Therefore, improving hand function is a critical goal in physiotherapy for this population The objective of this study was to compare the effectiveness of a constraint induced movement therapy ( CIMT ) and Proprioceptive neuromuscular facilitation technique on dexterous movement of hands in cerebral palsy .The study design will be Randomized Controlled Trail. The study setting will be Pediatric Rehabilitation Center or Physiotherapy Department. The duration of study will be 10 months after approval of synopsis. The sample size will be 20 which is calculated by epitools. The sampling technique will be Non-probability convenient sampling . Children who are diagnosed with cerebral palsy will be included. Children with other musculoskeletal and neurological issues will be excluded. Data Collection Tools will be Box and Block test and Pediatric Evaluation of Disability Inventory.. The data will be analyzed using SPSS 23.\n\nKeyword Cerebral Palsy, Constraint induced movement therapy (CIMT), dexterous movement, Proprioceptive neuromuscular facilitation",[26],[26,191],"Constraint induced movement therapy","2026-06-23",{"date":169,"type":35},{"date":195,"type":35},"2026-01-11",{"date":96,"type":22},{"name":198,"class":42},"Riphah International University",{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":207,"targetDuration":4,"studyType":56,"phases":209,"briefSummary":211,"conditions":212,"keywords":218,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":223,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":43},"100644540","phase-3-tranexamic-acid-to-reduce-blood-loss-after-varus-derotation-osteotomy-100644540","NCT07672158","Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy","Postoperative Continuous Intravenous Tranexamic Acid Infusion to Reduce Blood Loss in Non-Ambulatory Children With Cerebral Palsy Following Bilateral Bony Hip Reconstructive Surgery: A Phase III Parallel-Group Randomised Placebo-Controlled Trial","TABLO","Inclusion Criteria:\n\n* Children (aged 4 to 16 years)\n* Diagnosis of cerebral palsy (CP). CP is an umbrella term under which many specific diagnoses are captured, and the clinical team at the study institution operates a comprehensive referral network to ensure patients with any relevant diagnoses are included.\n* Gross Motor Function Classification System (GMFCS) levels IV and V, with substantial hip displacement (\\>40% migration percentage per Australian Hip Surveillance Guidelines (Wynter M, Gibson N, Kentish M, Love S, Thomason P, Willoughby K, et al. Australian hip surveillance guidelines for children with cerebral palsy 2014. Australian Academy of Cerebral Palsy and Developmental Medicine. 2014.)), who are on the waitlist for bilateral proximal femoral varus derotational osteotomy (VDRO) +\u002F- unilateral or bilateral pelvic osteotomy.\n\nExclusion Criteria:\n\n* Haematological disorder (defined as an active genetic or acquired bleeding disorder)\n* Known hypersensitivity to tranexamic acid (TXA)\n* Children with promyelocytic leukaemia being treated with oral tretinoin will be excluded from the trial because combination with TXA has resulted in fatal thrombotic complications\n* Known coagulation defect\n* Known renal disorder (moderate to severe as per study institution guidelines)",{"count":208,"type":22},52,[210],"PHASE3","TABLO (Tranexamic Acid to reduce Blood Loss after varus derotation Osteotomy) is a clinical trial of postoperative tranexamic acid vs placebo in non-ambulatory children with cerebral palsy (CP) undergoing reconstructive hip surgery.\n\nImproving surgical outcomes is a high priority in this patient population given the high risk of bleeding and the diminished capacity for these children to withstand substantial blood loss. Preliminary data from the study institution indicates that approximately one third of these patients receive transfusion of blood products in the postoperative period. There is growing evidence that hidden blood loss occurring in the postoperative period is substantial and can potentially be attenuated with the administration of Tranexamic Acid (TXA). However, trials on postoperative TXA have been carried out exclusively in adult surgical populations.",[26,213,214,215,216,217],"Hip Surgery Corrective","Tranexamic Acid Use","Blood Loss, Surgical","Paediatrics","Orthopedics",[26,219,220,221,222],"Hip surgery","Tranexamic Acid","Blood Loss","Orthopaedics",{"date":149,"type":35},{"date":225,"type":22},"2026-07",{"date":227,"type":22},"2029-04",{"name":229,"class":42},"Murdoch Childrens Research Institute",{"id":231,"slug":232,"hasResults":12,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":111,"sex":17,"minAge":112,"maxAge":237,"enrollmentInfo":238,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":240,"conditions":241,"keywords":242,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":43},"100554400","investigating-new-methods-to-study-movement-in-children-and-young-adults-with-movement-disorders-100554400","NCT06498596","Investigating New Methods to Study Movement in Children and Young Adults With Movement Disorders.","A Natural History Study Evaluating the Use of Multimodal Signal Acquisition Techniques to Characterize Movement in Children and Young Adults With Movement Disorders","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet criteria 1-4 and 5a as given below. If they also meet 5b, 5c or 6, they will perform the tasks related to the respective joint(s) for which criteria are met, and\u002For walking.:\n\n1. Provision of signed and dated separate informed consent and assent forms for screening purposes. Upon inclusion in the protocol, provision of signed and dated informed consent and assent forms to begin participation in the study will be necessary.\n2. Stated willingness to comply with all study procedures and availability for the duration of the study, or alternatively, ability to do so based on parent report and physician observation during history and physical examination.\n3. Age 5 to 25 years old.\n4. Group A: Have a gait pathology arising from a diagnosis of cerebral palsy.\n\n   Group B: Healthy volunteers who are age and sex matched to individuals recruited in Group A.\n5. Sufficient range of motion to perform the target acquisition task, specifically:\n\n   1. Knee joint range of motion of at least 50 degrees in the sagittal plane (knee extension\u002Fflexion) assessed with hip extended in supine position. Limited hamstring flexibility as assessed by straight leg raising test does not limit ability to participate in the study.\n   2. Ankle joint range of motion of at least 40 degrees in the sagittal plane (dorsiplantar- flexion) with the foot in neutral alignment.\n   3. Wrist joint range of motion of at least 50 degrees in the frontal plane (wrist extension\u002Fflexion) assessed with hip extended in standing position.\n6. Able to walk at least 1 minute on a treadmill without stopping with or without holding onto side or front support rails. This assessment will be completed by the physician during the medical history and physical exam.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Any neurological, musculoskeletal or cardiorespiratory injury, health condition, or diagnosis other than cerebral palsy that would affect the ability to move the required joints through the necessary range of motion or walk as directed on a treadmill.\n2. A history of multiple seizures that have occurred in the past year that are not controlled by medication.\n3. Pregnancy.","25 Years",{"count":239,"type":22},30,"Background:\n\nCerebral palsy (CP) is the most common motor disorder that affects children. People with CP have weak muscles; they may have trouble controlling the movements of their arms and legs. Researchers have been developing braces called robotic exoskeletons for people with CP. These devices can adapt to the person s movements and help them move better. This natural history study will explore new technologies that may tell us more about how people with CP move and improve how these exoskeletons work.\n\nObjective:\n\nTo test new technologies to measure people s movements and brain function while they move with and without a robotic exoskeleton.\n\nEligibility:\n\nPeople aged 5 to 25 years with CP. Healthy volunteers are also needed.\n\nDesign:\n\nParticipants will have 3 to 5 clinic visits in 2 months.\n\nParticipants will be fitted with an exoskeleton that will be worn on one of their legs.\n\nAt each visit, participants will be asked to move their wrist, ankle, and knee while the following measurements are taken:\n\nUltrasound. A bar will be placed against the skin. It will send soundwaves into the body to take pictures of the muscles.\n\nElectroencephalography (EEG). Participants will wear a cap with sensors. Their brain waves will be recorded.\n\nElectromyography (EMG). Small metal discs will be taped to the skin. They will measure electrical activity of muscle.\n\nParticipants will flex and extend each joint (wrist, ankle, or knee) on one side of their body. These movements will be done on their own and while assisted by two devices:\n\nFunctional electrical stimulation (FES). Small adhesive pads will be placed on the skin and electric. Pulses will stimulate muscles to help move the limb. This will be done for the wrist, ankle and knee.\n\nRobotic Exoskeleton. A leg brace will be placed on one limb with a motor that will help move the knee. The exoskeleton can be used with or without FES.\n\nParticipants will also walk on a treadmill at their own pace.\n\nPhotographs and videos will record how they move.",[26],[26,243,244,245,246,247],"Ultrasound","EEG","Exoskeleton","Functional Electrical Stimulation","Walking","2026-06-19",{"date":192,"type":35},{"date":251,"type":35},"2025-02-20",{"date":253,"type":22},"2027-12-31",{"name":130,"class":131},{"id":256,"slug":257,"hasResults":12,"nctId":258,"briefTitle":259,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":12,"sex":17,"minAge":262,"maxAge":263,"enrollmentInfo":264,"targetDuration":4,"studyType":56,"phases":266,"briefSummary":267,"conditions":268,"keywords":269,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":4},"100641296","pilot-study-on-the-validity-tolerability-and-impact-of-a-walking-rehabilitation-intervention-using-cruro-malleolar-cast-in-children-with-cerebral-palsy-100641296","NCT07650370","Pilot Study on the Validity, Tolerability, and Impact of a Walking Rehabilitation Intervention Using Cruro-Malleolar Cast in Children With Cerebral Palsy","RCMs","INCLUSION CRITERIA\n\n* Children aged 7 to 14 years\n* Pubertal development at Tanner stage 1 or 2\n* Bilateral cerebral palsy (diplegia or quadriplegia)\n* Ambulatory with or without assistive device (GMFCS levels I, II, or III)\n* Clinical indication for walking training\n* Ability to use an adapted visual analogue scale to rate perceived pain\n* No botulinum toxin injection in the 4 months preceding study entry\n* Affiliated to or beneficiary of a French social security scheme\n* Not currently enrolled in another biomedical research study (not in an exclusion period from the national registry)\n\nEXCLUSION CRITERIA\n\n* Pubertal development at Tanner stage greater than 2\n* Refusal to wear cruro-malleolar casts (CMCs)\n* Inability to walk on a treadmill\n* Refusal to participate in the repeated assessment sessions required by the study protocol\n* Refusal to delay the next scheduled botulinum toxin injection series until after completion of study participation","7 Years","14 Years",{"count":265,"type":22},6,[58],"This pilot study investigates whether walking training using cruro-malleolar casts (CMCs) - rigid leg splints extending from the thigh to the ankle - can safely improve gait quality in children with bilateral cerebral palsy (CP). CMCs are already used in routine clinical care at our center, but their biomechanical effects and therapeutic value have never been formally studied.Children aged 7 to 14 with bilateral spastic CP (diplegia or quadriplegia, GMFCS levels I-III) will participate in a 4-week treadmill walking program wearing CMCs, preceded by a 1-month observation baseline and followed by a 6-month follow-up. The investigators will use motion capture technology and surface electromyography to measure how the CMCs immediately change the way children walk - particularly at the hip and pelvis - and whether the training program leads to lasting improvements in walking speed, quality, and endurance.The study also carefully monitors pain and effort perceived by children during each training session, so that tolerance of the intervention can be rigorously assessed. Six participants will be enrolled. The study uses a Single-Case Experimental Design (SCED), which allows rigorous conclusions to be drawn from a small number of patients through repeated measurements over time.",[26],[26,270,271,272,273],"Gait rehabilitation","Knee-extension orthosis","Treadmill training","Single-case experimental design","2026-06-18",{"date":276,"type":35},"2026-06-22",{"date":278,"type":22},"2026-09-01",{"date":280,"type":22},"2028-09",{"name":282,"class":42},"Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française",{"id":284,"slug":285,"hasResults":12,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":291,"targetDuration":4,"studyType":56,"phases":293,"briefSummary":294,"conditions":295,"keywords":297,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":43},"100612459","effects-of-hand-and-arm-bimanual-intensive-therapy-including-lower-extremity-in-spastic-cerebral-palsy-100612459","NCT07253857","Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity in Spastic Cerebral Palsy","Effects of Hand and Arm Bimanual Intensive Therapy Including Lower Extremity on Motor Function and Cognition in Children With Spastic Cerebral Palsy","HABIT-ILE","Inclusion Criteria:\n\n* Diagnosed with diplegic cerebral palsy\n* CP children with manual ability level 1-3 on manual ability classification system\n* Participants with gross motor function classification system level ranging from 1-3 will be included in the study.\n* With an ability to grasp light objects and lift the more affected arm 15 cm above a table surface.\n* Base line cognition level should be 20 or above assessed through mini mental state exam for children (MMC).\n\nExclusion Criteria:\n\n* Uncontrolled seizures\n* Recent or planned botulinum toxin injections within 6 months\n* Any recent orthopedic interventions that may affect motor function\n* Visual impairments impeding with treatment protocol",{"count":292,"type":22},42,[58],"Cerebral palsy (CP), particularly the spastic diplegic subtype, is characterized by motor impairments such as spasticity and mobility limitations. In addition to motor dysfunction, children with CP often experience cognitive impairments affecting decision-making, problem-solving, working memory, selective attention, and inhibitory control. These non-motor challenges contribute to reduced social interaction and quality of life.\n\nHand-Arm Bimanual Intensive Therapy Including Lower Extremity (HABIT-ILE) has demonstrated improvements in gross motor function among children with spastic CP. However, evidence regarding its impact on cognitive outcomes remains limited. This randomized controlled trial (RCT) aims to evaluate the effects of HABIT-ILE compared with conventional therapy on both motor and cognitive functions in children with spastic diplegic CP. By addressing both upper and lower limb the research seeks to provide a comprehensive therapeutic approach that may yield more significant developmental benefits. Ultimately, the findings could inform the interventions for improving outcomes in pediatric populations affected by diplegic cerebral palsy.\n\nParticipants will receive 90 hours of intervention, with assessments conducted at baseline, mid-intervention, and post-intervention. The study will investigate outcomes across motor domains and cognitive functions such as inhibitory control and working memory. Findings are expected to inform comprehensive therapeutic approaches to improve developmental outcomes and quality of life in pediatric populations affected by spastic diplegic CP.",[26,296],"Cerebral Palsy, Spastic",[289,298,26,299,300],"Intensive motor therapy","diplegic cerebral palsy with spasticity","Spastic cerebral palsy","2026-06-17",{"date":274,"type":35},{"date":304,"type":35},"2025-12-20",{"date":306,"type":22},"2026-06",{"name":308,"class":42},"Lahore University of Biological and Applied Sciences",{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":12,"sex":17,"minAge":162,"maxAge":83,"enrollmentInfo":317,"targetDuration":4,"studyType":56,"phases":319,"briefSummary":320,"conditions":321,"keywords":322,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":337},"100557118","gait-training-program-with-blood-flow-restriction-in-children-with-cerebral-palsy---embrin-pilot-study-100557118","NCT06533956","Gait Training Program With Blood Flow Restriction in Children With Cerebral Palsy - EMBRIN: Pilot Study","Programme d'Entrainement à la Marche Avec Blood Flow RestrIctioN Chez l'Enfant Avec Paralysie cérébrale - EMBRIN: Etude Pilote","EMBRIN","Inclusion Criteria:\n\n* Patients aged 8 to 18 with bilateral spastic cerebral palsy\n* Patient with functional level II or III according to the Gross Motor Function Classification System (GMFCS)\n* Patient able to assess pain with NRS-11\n* Patient able to walk on a treadmill without body weight support, with or without technical aids\n* Patient able to perform the 10-meter walk test\n* No skin pathology at the pressure cuff application site (eczema, inflammatory scarring, etc.)\n* Patient affiliated to or benefiting from a social security scheme\n* Informed consent, dated and signed by parents or guardians (if a minor) or by the patient (if of age), to participate in the study;\n\nExclusion Criteria:\n\n* Patients who have undergone surgical treatment or intramuscular injections of botulinum toxin in the lower limbs within the last 3 months\n* Patients with a history of arterial hypertension, thrombo-embolic events, thrombophilia or cancer.\n* Patient with insufficient understanding of the French language;\n* Opposition of the patient (child or adolescent);\n* Pregnant, breast-feeding or parturient women;\n* Persons deprived of their liberty by judicial or administrative decision;\n* Persons under compulsory psychiatric care;\n* Persons under legal protection",{"count":318,"type":22},13,[58],"This is a single-center prospective experimental pilot study to assess the feasibility, tolerability and effect of a 10-week gait training program combined with simultaneous blood flow restriction (BFR) on the walking speed of children, aged 8 to 18, with bilateral spastic cerebral palsy.\n\nThe children will receive a 10-week intervention (1 week of habituation without BFR + 9 weeks with BFR) comprising 3 30-minute treadmill sessions per week. At each session, the first 5 minutes will enable a gradual increase in speed, and then the maximum tolerated walking speed will be sought. Maximum speed corresponds to the walking speed maintained by the child for an effort of between 5 and 7 on Borg's 10-point VAS. The rehabilitator will encourage the child to maintain this speed and provide feedback on performance. The BFR setting will maintain an occlusion, at the root level of both lower limbs, of 60% of the total occlusal pressure.\n\nChildren receiving the 10-week EMBRIN program are expected to improve their walking ability and muscular strength, two targets recognized as priorities for individuals with CP by the HAS. In this population, a major limitation of implementing rehabilitation programs is the large amount of practice required to bring about significant changes. This large amount of practice requires a major investment on the part of the individual, as well as significant rehabilitation resources. Muscle-strengthening programs are also particularly repetitive and therefore not very motivating for children. The EMBRIN program could reduce the training load and duration required to impact functional performance in children with CP. It could also help reduce the cost of rehabilitation interventions and reduce physical therapy time for individuals with CP in favor of their social participation.",[26],[323,324,325,326],"Cerebral palsy","Blood Flow Restriction","Walking training","Pediatric rehabilitation","2026-06-12",{"date":329,"type":35},"2026-06-16",{"date":331,"type":35},"2024-10-31",{"date":333,"type":22},"2026-10-01",{"name":335,"class":336},"University Hospital, Angers","OTHER_GOV",2,{"id":339,"slug":340,"hasResults":12,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":111,"sex":17,"minAge":262,"maxAge":83,"enrollmentInfo":345,"targetDuration":4,"studyType":56,"phases":347,"briefSummary":348,"conditions":349,"keywords":350,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":358,"leadSponsor":360,"locationsCount":43},"100508341","gait-adaptation-and-biofeedback-for-cerebral-palsy-100508341","NCT05899153","Gait Adaptation and Biofeedback for Cerebral Palsy","Quantifying Patient-specific Changes in Neuromuscular Control in Cerebral Palsy: Adaptation and Biofeedback During Gait","Inclusion Criteria:\n\n* Diagnosis of bilateral cerebral palsy that impacts both legs\n* Gross Motor Functional Classification System Level II\n* No surgery or lower-extremity injuries 12 months prior to enrollment\n* No botulinum toxin injections in prior 3 months\n* No prior selective dorsal rhizotomy surgery\n* No history of seizures or cardiac conditions that would preclude walking on a treadmill for 20 minutes\n* No current pain that hinders walking",{"count":346,"type":22},36,[58],"This research aims to evaluate walking function in children with cerebral palsy (CP). The researchers want to understand how children with CP adapt and learn new ways of moving. They have previously found that measuring how a person controls their muscles is important for assessing walking ability and response to interventions. In these studies, they will adjust the treadmill belt speeds and\u002For provide real-time feedback to evaluate how a child can alter their movement. The feedback will include a wearable exoskeleton that provides resistance to the ankle and audio and visual cues based on sensors that record muscle activity. This research will investigate three goals: first, to measure how children with CP adapt their walking; second, to see if either repeated training or orthopedic surgery can improve adaptation rates; and third, to determine if individual differences in adaptation relate to improvements in walking function after treatment. This research will help develop better treatments to enhance walking capacity and performance for children with CP.",[26],[351,352],"Gait","Rehabilitation","2026-06-04",{"date":355,"type":35},"2026-06-08",{"date":357,"type":35},"2023-11-28",{"date":359,"type":22},"2029-01-01",{"name":361,"class":42},"University of Washington",{"id":363,"slug":364,"hasResults":12,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":4,"eligibilityCriteria":368,"healthyVolunteers":12,"sex":17,"minAge":112,"maxAge":369,"enrollmentInfo":370,"targetDuration":4,"studyType":56,"phases":372,"briefSummary":373,"conditions":374,"keywords":378,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":387,"leadSponsor":388,"locationsCount":4},"100639537","theratogs-effects-on-balance-and-mobility-in-cerebral-palsy-100639537","NCT07618962","TheraTogs Effects on Balance and Mobility in Cerebral Palsy","The Effect of the Dynamic Orthotic Garment TheraTogs on Balance and Functional Mobility of Children and Adolescent With Cerebral Palsy: A Cross-Sectional Clinical Study","Inclusion Criteria\n\n* Diagnosis of unilateral or bilateral spastic Cerebral Palsy\n* GMFCS level I or II\n* MAS level lower than +1\n* Ability to understand and follow instructions\n* Ability to walk without assistive devices\n\nExclusion Criteria\n\n* Use of medications affecting balance\n* Hearing or visual impairments\n* Intellectual disability\n* Botulinum toxin (Botox) injection in the lower limbs within the previous 6 months\n* Severe musculoskeletal deformities\n* Surgery within the previous 6 months\n* Uncontrolled seizures during the previous 6 months","15 Years",{"count":371,"type":22},12,[58],"Cerebral Palsy (CP) is the most common cause of childhood disability, with an estimated prevalence of 17 million individuals worldwide. Children and adolescents with CP present impaired postural control and balance, negatively affecting their mobility and functional performance. The use of dynamic orthotic garments may contribute to the improvement of postural control, balance, and functional mobility in children and adolescents with CP.\n\nThe aim of the present study is to investigate the immediate effect of the dynamic orthotic garment TheraTogs on balance and functional mobility in children and adolescents with CP.\n\nIn this cross-sectional pilot study, children and adolescents with CP classified as levels I and II according to the Gross Motor Function Classification System (GMFCS), and with spasticity levels lower than +1 according to the Modified Ashworth Scale, will participate. Balance will be assessed using the Pediatric Balance Scale (PBS), while functional mobility will be evaluated with the Timed Up and Go (TUG) test and the 10 Meter Walk Test (10MWT). Each assessment will be performed twice by each participant, with and without the TheraTogs dynamic orthotic garment, in random order. Statistical analysis will be conducted using SPSS Statistics V29 software, with the level of significance set at p \\\u003C 0.05.",[26,375,376,377],"THERATOGS","BALANCE","FUCTIONAL MOBILITY",[26,379,380,148,381,382],"children","adolescents","functional mobility","TheraTogs","2026-05-30",{"date":385,"type":35},"2026-06-02",{"date":306,"type":22},{"date":306,"type":22},{"name":389,"class":42},"University of West Attica",{"id":391,"slug":392,"hasResults":12,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":12,"sex":17,"minAge":162,"maxAge":397,"enrollmentInfo":398,"targetDuration":4,"studyType":56,"phases":399,"briefSummary":401,"conditions":402,"keywords":403,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":406,"startDateStruct":408,"completionDateStruct":409,"leadSponsor":411,"locationsCount":43},"100626350","phase-2-smart-afo-and-5-azacitidine-to-enhance-mobility-in-children-with-cerebral-palsy-100626350","NCT07434492","Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy","Smart Ankle-Foot Orthosis and 5-Azacitidine to Enhance Gait and Community Mobility for Children With Cerebral Palsy","Inclusion Criteria:\n\n* Diagnosis of cerebral palsy classified as Gross Motor Function Classification System (GMFCS) levels I to III\n* Between 8 and 17 years and 8 months of age at the time of enrollment\u002Fconsent. Participants that will turn 18 during the course of the study will not be included as pausing the at-home protocol until re-consenting is possible could interfere with intervention results.\n* Stable medical condition as determined by the investigator.\n* Adequate caregiver support to be able to participate in training and assessment sessions for the duration of the study, at the discretion of the PI.\n* Height\u002Fweight\u002FBMI between the 5th - 95th percentile of children with cerebral palsy\n* Able to walk for at least 6 minutes (assisted or unassisted)\n* Able to understand and follow simple directions\n* Able to safely fit into a device configuration and tolerate assistance without knee hyperextension while walking\n* At least 20 degrees of passive ankle plantar flexion range of motion\n* Physician approval for participation\n\nExclusion Criteria:\n\n* Knee extension or ankle dorsiflexion contractures greater than 15 degrees\n* Immunodeficiency or hematologic condition\n* Allergy to AZA or mannitol\n* Plans to receive a vaccine within 30 days of the planned AZA or placebo injection to take place at week 5\n* Pregnancy\n* Orthopedic surgery on the lower limbs completed in the prior 12 months\n* New implanted device (e.g., baclofen pump) and\u002For active intrathecal medication titration that may affect muscle spasticity\n* Botulinum toxin treatment within 3 months preceding enrollment unless given approval by the study physician\n* Severe osteoporosis unless given approval by the study physician\n* Current enrollment in a conflicting research study\n* Any other health condition or diagnosis not listed above that may put the participant at risk as determined by the PI or study physician","17 Years",{"count":141,"type":22},[400],"PHASE2","This is an intervention study to investigate the impact of a smart ankle-foot orthosis (AFO) on mobility outcomes in children with Cerebral Palsy. Participants will complete a three phase protocol including 6-weeks of at home training with the smart AFO. Participants will also have the option to participate in a randomized control trial to investigate the impact of 5-Azacitidine combined with the smart AFO to further effect mobility outcomes.",[26],[404],"Pediatric","2026-05-28",{"date":407,"type":35},"2026-06-01",{"date":405,"type":35},{"date":410,"type":22},"2030-08-31",{"name":412,"class":42},"Shirley Ryan AbilityLab",{"id":414,"slug":415,"hasResults":12,"nctId":416,"briefTitle":417,"officialTitle":418,"acronym":4,"eligibilityCriteria":419,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":397,"enrollmentInfo":420,"targetDuration":4,"studyType":56,"phases":422,"briefSummary":423,"conditions":424,"keywords":425,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":405,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":430,"leadSponsor":431,"locationsCount":43},"100626237","phase-2-tscs-and-5-azacitidine-for-enhanced-motor-outcomes-in-cerebral-palsy-100626237","NCT07433023","tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy","Advancing Neurorehabilitation: Evaluating Transcutaneous Spinal Stimulation and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy","Inclusion Criteria:\n\n* Diagnosis of cerebral palsy (CP) classified as Gross Motor Function Classification System (GMFCS) Levels I-V.\n* Between 4 and 17 years old at the time of enrollment\u002Fconsent.\n* Diagnosis of spastic CP hemiplegia, diplegia, or quadriplegia.\n* Stable medical condition as determined by the investigator.\n* Adequate caregiver support to be able to participate in training and assessment sessions for the duration of the study, at the discretion of the Investigator.\n* Capable of performing simple cued motor tasks and can follow 2-3 step commands.\n* Capable of communicating an accurate yes or no answer to questions according to parent or guardian.\n* Able to localize pain\u002F discomfort.\n* Physician approval for participation.\n* Parent\u002F guardian permission.\n\nExclusion Criteria:\n\n* Concurrent neurological disease affecting the central nervous system.\n* Cardiovascular or musculoskeletal disease or injury that would prevent full participation in physical therapy intervention\n* Orthopedic dysfunction, injury, or surgery that would impact an individual's ability to use the upper and\u002For lower extremity\n* Unhealed fracture or other musculoskeletal impairment that might interfere with upper or lower extremity rehabilitation or testing activities\n* Implanted stimulator (e.g., epidural stimulator, vagus nerve stimulator, pacemaker, cochlear implant) or drug delivery device (e.g., baclofen pump)\n* Dependence on an electro-magnetic medical implant (e.g., cardiac pacemaker, implanted drug pump), ventilation support, or another external device.\n* History of uncontrolled seizures\n* Unexplained presence of persistent complaints of pain of any kind\n* Unable to localize pain\u002Fdiscomfort\n* Severe cortico-visual impairment\n* Active pressure sores\n* Active urinary tract infection\n* Active cancer or cancer in remission less than 5 years\n* Clinically significant depression, psychiatric disorders, or ongoing drug abuse\n* Immunodeficiency or hematologic condition\n* Allergy to AZA or mannitol\n* Plans to receive a vaccine within 30 days of the planned AZA or placebo injection to take place at week 10\n* Pregnancy\n* Orthopedic surgery completed in the prior 12 months\n* Intrathecal medication titration that may affect muscle spasticity\n* Botulinum toxin treatment within 3 months preceding enrollment unless given approval by the treating physician\n* Current enrollment in a conflicting research study\n* Any other health condition or diagnosis not listed above that may put the participant at risk as determined by the investigator or treating physician",{"count":421,"type":22},80,[400],"This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy. Participants will complete a 16-week training program with weekly sessions of spinal stimulation and walking or activity-based training. Participants will also have the option to participate in a randomized control trial to investigate the impact of 5-Azacitidine combined with the spinal stimulation to further affect mobility outcomes.",[26],[404,426],"Transcutaneous Spinal Stimulation",{"date":428,"type":35},"2026-05-29",{"date":405,"type":35},{"date":359,"type":22},{"name":412,"class":42},{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":437,"acronym":4,"eligibilityCriteria":438,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":19,"enrollmentInfo":439,"targetDuration":4,"studyType":56,"phases":441,"briefSummary":442,"conditions":443,"keywords":444,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":452,"leadSponsor":454,"locationsCount":4},"100639635","soft-tissue-release-for-elbow-pronation-in-cerebral-palsy-100639635","NCT07601165","Soft Tissue Release for Elbow Pronation in Cerebral Palsy","Distal Soft Tissue Release for Elbow Pronation Deformity in Cerebral Palsy: Functional Outcomes","Inclusion Criteria:\n\n* Being between 6 and 16 years of age,\n* Having a diagnosis of spastic-type cerebral palsy,\n* presenting with an elbow pronation deformity requiring surgical intervention,\n* obtaining consent from the parent\u002Fguardian\n\nExclusion Criteria:\n\n* History of previous upper-extremity surgery\n* History of progressive neurological disease\n* Cognitive or physical capacity insufficient to complete the assessment tools",{"count":440,"type":22},28,[58],"Upper extremity deformities are highly common in individuals with cerebral palsy (CP) as a result of motor control impairment and muscle imbalance. Among these deformities, elbow pronation deformities are frequently observed, particularly in spastic-type CP (Koman et al., 2004). The imbalance between the pronator muscle group (pronator teres, pronator quadratus) and the supinator muscle group (supinator, biceps brachii) leads to the forearm remaining in a persistent pronated position (Sahoo et al., 2017). This deformity is not only aesthetically concerning but also results in significant functional limitations. Both fine and gross motor skills-such as washing the face, handshaking, and clapping-are adversely affected (Soutar \\& McComas, 1990). Additionally, children may experience difficulty using assistive devices such as walkers, which in turn can negatively impact ambulation (Flett, 2003).\n\nAn elbow fixed in pronation forces children to compensate for limited range of motion by using shoulder and trunk movements, which over time predisposes them to abnormal postural development (Gracies, 2005). In advanced cases, structural alterations such as posterolateral radial head dislocations may also occur (Van Heest \\& House, 2000). Both conservative (orthoses, botulinum toxin injections, physical therapy) and surgical interventions are employed in the treatment of pronation deformities. Surgical options include tenotomy of the pronator teres and pronator quadratus, muscle transfers, or combined procedures (Zancolli, 1975). However, there is no consensus in the literature regarding which surgical method should be applied to which patient group and at what stage (House et al., 1981).\n\nThe aim of this study is to evaluate the effects of distal soft-tissue release surgery for the treatment of elbow pronation deformity on upper extremity function in children with cerebral palsy.",[26],[91,445,446,447],"upper extremity","function","release surgery","2026-05-20",{"date":450,"type":35},"2026-05-22",{"date":126,"type":22},{"date":453,"type":22},"2028-01-30",{"name":455,"class":42},"Istanbul University - Cerrahpasa",{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":4,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":263,"enrollmentInfo":463,"targetDuration":4,"studyType":56,"phases":464,"briefSummary":465,"conditions":466,"keywords":467,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":472,"completionDateStruct":473,"leadSponsor":475,"locationsCount":4},"100637905","early-mobilization-and-equinus-correction-in-spastic-cerebral-palsy-100637905","NCT07598604","Early Mobilization and Equinus Correction in Spastic Cerebral Palsy","Impact of Early Postoperative Mobilization on Equinus Correction in Spastic Cerebral Palsy","Inclusion Criteria\n\n1. Diagnosis: Children diagnosed with spastic-type Cerebral Palsy (CP).\n2. Age Range: Participants aged between 4 and 14 years.\n3. Functional Level: Children with Gross Motor Function Classification System (GMFCS) levels I-II (able to walk independently or with minimal assistance).\n4. Surgical Indication: Scheduled for orthopedic surgery (gastrotenotomy) due to equinus deformity.\n5. Cognitive Status: Sufficient cognitive capacity to understand verbal instructions.\n6. Parental Consent: Written informed consent obtained from parents or legal guardians.\n\nExclusion Criteria\n\n1. Other CP Types: Children diagnosed with dyskinetic, ataxic, or mixed-type CP.\n2. Functional Level: Participants with GMFCS levels III, IV, or V (unable to walk independently or dependent on a wheelchair).\n3. Concomitant Orthopedic Problems: Presence of hip dysplasia, scoliosis, or severe lower extremity contractures that may affect gait patterns.\n4. Neuromuscular or Other Diseases: Presence of non-CP neuromuscular disorders (e.g., muscular dystrophy, peripheral neuropathy).\n5. Previous Surgery: History of tendon lengthening or muscle release surgery in the same lower extremity.\n6. Postoperative Complications: Development of surgical site infection, excessive pain, or conditions requiring reoperation.\n7. Noncompliance with Rehabilitation: Inability to attend prescribed physical therapy and rehabilitation sessions regularly or poor adherence to the treatment program.",{"count":292,"type":22},[58],"The aim of this study is to investigate the effect of early postoperative mobilization on the correction of equinus deformity and the improvement of motor functions following gastrotenotomy in children with spastic-type Cerebral Palsy (CP).\n\nH1: Early postoperative mobilization combined with AFO use after gastrotenotomy in children with spastic CP has a significant effect on equinus correction and motor function improvement.\n\nH0: Early postoperative mobilization combined with AFO use after gastrotenotomy in children with spastic CP has no significant effect on equinus correction or motor function improvement.\n\nThe study is designed as a prospective, comparative clinical investigation. Children aged 4-14 years with spastic-type CP and Gross Motor Function Classification System (GMFCS) levels I-II will be included. Participants will be randomly assigned into two groups:\n\nGroup 1: A cast will be applied for 3 weeks postoperatively, followed by 24-hour AFO use for 3 weeks, and thereafter night-time use only. A rehabilitation program will be initiated for 12 weeks postoperatively, twice per week.\n\nGroup 2: AFO will be used 24 hours a day for 6 weeks postoperatively, followed by night-time use only. Early postoperative rehabilitation will be provided twice per week for 12 weeks.\n\nAssessments will be conducted preoperatively and at postoperative months 3, 6, and 12. The Gross Motor Function Measure-88 (GMFM-88) and the Edinburgh Visual Gait Score will be used as measurement tools.\n\nGastrotenotomy is a commonly preferred surgical technique in children with spastic CP; however, there is no consensus regarding the optimal duration of postoperative immobilization or the appropriate timing of mobilization. Early mobilization has been reported to have beneficial effects on muscle-tendon flexibility, joint range of motion, and gait pattern.\n\nThe findings of this study are expected to contribute to the evidence-based standardization of rehabilitation protocols following gastrotenotomy, and to provide scientific insight into the safety and effectiveness of early mobilization. The results may support clinicians in developing more functional and time-efficient postoperative rehabilitation programs.",[26],[91,468,469],"gastrotenotomy","eqinus","2026-05-14",{"date":448,"type":35},{"date":126,"type":22},{"date":474,"type":22},"2027-01-30",{"name":476,"class":42},"Elcin Akyurek",{"id":478,"slug":479,"hasResults":12,"nctId":480,"briefTitle":481,"officialTitle":481,"acronym":482,"eligibilityCriteria":483,"healthyVolunteers":12,"sex":17,"minAge":369,"maxAge":4,"enrollmentInfo":484,"targetDuration":4,"studyType":56,"phases":486,"briefSummary":487,"conditions":488,"keywords":489,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":506,"completionDateStruct":507,"leadSponsor":508,"locationsCount":43},"100639091","comparative-study-of-augmented-reality-and-virtual-reality-in-music-therapy-interventions-for-individuals-with-cerebral-palsy-100639091","NCT07596550","Comparative Study of Augmented Reality and Virtual Reality in Music Therapy Interventions for Individuals With Cerebral Palsy","HARMONY-CP","Inclusion Criteria:\n\n* Individuals with a confirmed diagnosis of Cerebral Palsy\n* Aged between 15 and 35 years\n* Participants of any sex\n* Cognitive ability compatible with participation in the study, determined by a minimum Intelligence Quotient (IQ) score established through the Wechsler Intelligence Scale for Children (WISC) or Wechsler Adult Intelligence Scale (WAIS)\n* Ability to participate in immersive music therapy activities using hand-tracking interaction with the Meta Quest 3 headset\n\nExclusion Criteria:\n\n* Failure to attend the second experimental session\n* Withdrawal or interruption of participation in the study for any reason before completion of all study procedures\n* Insufficient corrected visual acuity to adequately interact with the immersive system, verified through a simple visual screening assessment\n* Failure to achieve the minimum Intelligence Quotient (IQ) score required for understanding the proposed tasks, as determined by the Wechsler Intelligence Scale for Children (WISC) or Wechsler Adult Intelligence Scale (WAIS) assessments",{"count":485,"type":22},10,[58],"The goal of this clinical trial is to compare the user experience of Augmented Reality (AR) and Virtual Reality (VR) applications during music therapy interventions in individuals with Cerebral Palsy aged 15 to 35 years with Gross Motor Function Classification System (GMFCS) level I-V.\n\nThe main questions it aims to answer are:\n\nDoes AR or VR result in lower levels of cybersickness as measured by the Simulator Sickness Questionnaire (SSQ)? Does AR or VR provide better usability, preference, and perceived ease of interaction?\n\nResearchers will compare AR and VR conditions to determine which technology results in lower cybersickness levels, higher usability scores, and greater user preference.\n\nParticipants will:\n\ncomplete a pre-intervention SSQ assessment; engage in AR and VR sessions in a counterbalanced order using the Meta Quest 3 headset; explore each virtual environment for 5 minutes; perform motor tasks involving reaching and interacting with virtual musical objects (musical cubes representing musical notes: C-D-E-F-G-A-B); perform cognitive tasks involving identification and reproduction of musical note sequences guided by a therapist; perform percussion activities by following rhythmic patterns played by a therapist using virtual instruments; complete post-condition assessments after each session, including SSQ, System Usability Scale (SUS), preference, and reported difficulties.",[26],[26,490,491,492,493,494,495,496,497,498,499,500,501,502],"Augmented Reality","Virtual Reality","Mixed Reality","Music Therapy","User Experience","Usability","Cybersickness","System Usability Scale","Meta Quest 3","Motor Rehabilitation","Assistive Technology","Accessibility","Human-Computer Interaction","2026-05-12",{"date":505,"type":35},"2026-05-19",{"date":306,"type":22},{"date":306,"type":22},{"name":509,"class":42},"Mackenzie Presbiterian University",{"id":511,"slug":512,"hasResults":12,"nctId":513,"briefTitle":514,"officialTitle":515,"acronym":4,"eligibilityCriteria":516,"healthyVolunteers":111,"sex":17,"minAge":52,"maxAge":517,"enrollmentInfo":518,"targetDuration":4,"studyType":56,"phases":519,"briefSummary":520,"conditions":521,"keywords":523,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":530,"startDateStruct":531,"completionDateStruct":533,"leadSponsor":535,"locationsCount":43},"100636543","repetitive-transcranial-magnetic-stimulation-on-motor-function-and-meta-plasticity-in-cerebral-palsy-tms-eeg-study-100636543","NCT07567053","Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study","6-Hz Primed Low and High-Frequency Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Children With Cerebral Palsy: TMS-EEG Study","Inclusion Criteria (CP):\n\n* Aged 6 - 20 years,\n* A confirmed diagnosis of CP by a specialized professional (pediatric neurologist, PM\\&R physician, neonatal developmental specialist, or neonatologist) is a prerequisite for participation,\n* Classified as high functioning (Level I, II, or III) according to the Gross Motor Function Classification System (GMFCS),\n* Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,\n* Preserved vision and hearing (with or without correction).\n\nInclusion Criteria (TD):\n\n* Aged 6 - 20 years\n* Age-appropriate ability to understand and comply with study procedure throughout the entire duration of the study,\n* Preserved vision and hearing (with or without correction).\n\nExclusion Criteria (CP):\n\n* Syndromic or genetic brain-related associations,\n* History of major trauma or brain surgery,\n* Inability to remain still,\n* History of Epilepsy,\n* Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,\n* Modified Ashworth Scale: Shoulder, elbow, and wrist scores more than 3,\n* Limb contractures caused by any other injury except CP,\n* Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,\n* Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.\n\nExclusion Criteria (TD):\n\n* Syndromic or genetic brain-related associations,\n* History of major trauma or brain surgery,\n* Inability to remain still,\n* History of Epilepsy,\n* Severe coexisting sickness or illness unrelated to CP or unstable medical conditions such as pneumonia,\n* Limb contractures caused by injury,\n* Severe movement disorders that prevent intentional limb movements, such as choreoathetosis, or ballismus,\n* Contraindications for rTMS include non-removable metallic objects close to a coil and implanted electronic devices, such as cochlear implants and pacemakers.","20 Years",{"count":141,"type":22},[58],"This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP). By applying 6-Hz primed low and high-frequency rTMS and measuring brain responses through TMS-EEG, the study aims to enhance neural plasticity and motor recovery. The goal is to promote faster rehabilitation and reduce long-term healthcare needs.",[26,522],"Typically Developing Children",[26,524,525,526,527,528,529],"CP","TMS","repetitive Transcranial Magnetic Stimulation","Transcranial Magnetic Stimulation","rTMS","TMS-EEG",{"date":470,"type":35},{"date":532,"type":22},"2026-05-01",{"date":534,"type":22},"2030-06-01",{"name":536,"class":42},"Cook Children's Health Care System",{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":111,"sex":17,"minAge":83,"maxAge":544,"enrollmentInfo":545,"targetDuration":546,"studyType":23,"phases":4,"briefSummary":547,"conditions":548,"keywords":551,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":562,"locationsCount":43},"100626285","evaluation-of-brain-mri-changes-in-cerebral-palsy-patients-100626285","NCT07433647","Evaluation of Brain MRI Changes in Cerebral Palsy Patients","Evaluation of Brain Changes in Cerebral Palsy Patients","Inclusion Criteria:\n\n* Have multiple MRI scans of brain and\u002For spinal cord spaced at least 24 months apart\n* Between 18-80 years of age with at least one MRI scan after the age of 18\n* No known central or peripheral neurological disease or injury other than cerebral palsy causing brain degeneration\n* Inclusion in CPRN registry\n* diagnosis of Cerebral Palsy\n* \\>18 years of age\n* Have received at least one past brain MRI scan as part of standard care (patients who have two or more brain MRI scans can be included in the retrospective arm only)\n\nExclusion Criteria:\n\n* History of more than one seizure in lifetime\n* History of known degenerative genetic disorder\n* History of brain tumor, abscess, or multiple sclerosis\n* History of moderate or severe head trauma\n* History of metal implants in head","80 Years",{"count":239,"type":22},"2 Years","Cerebral palsy (CP) is a neurodevelopmental syndrome characterized by sensorimotor impairment that arises during early childhood defined as a static insult to the developing brain. A key part of the definition for CP is a non-progressive brain injury; however, as individuals with CP age, a functional decline greater than neurotypical individuals is often present. The investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.\n\nThis will be a single-center study that will compare retrospective clinical and imaging data with similar prospective data. The objective is to find out if people with Cerebral Palsy (CP) experience changes in the structures of their brain over time. A key part of the CP definition is that it is a non-progressive brain injury. However, as people with CP age, their function often deteriorates. This study seeks to determine whether changes in the brain structure may result in function changes, as they do in other types of brain injuries.\n\nThe investigators are doing this research study to improve understanding of whether there is brain and spinal cord atrophy over time that could indicate neurodegeneration. To do this, the investigators will partner with the Cerebral Palsy Research Network to obtain brain and spinal cord MRIs from people with CP across the United States, as well as locally. The investigators will perform analyses on multiple longitudinal MR images of the brain and spinal cord obtained from adults with CP. Putative changes will be related with changes in function across time.",[26,61,549,550],"Spastic Quadriplegia","Spastic Hemiplegia",[552,553,554],"brain volume","cortical thickness","aging","2026-05-11",{"date":557,"type":35},"2026-05-13",{"date":559,"type":35},"2023-06-20",{"date":561,"type":22},"2029-07-01",{"name":563,"class":42},"Columbia University",{"id":565,"slug":566,"hasResults":12,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":570,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":17,"minAge":572,"maxAge":83,"enrollmentInfo":573,"targetDuration":4,"studyType":56,"phases":575,"briefSummary":576,"conditions":577,"keywords":581,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":587,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":591,"locationsCount":43},"100600265","pediatric-outcomes-and-recovery-with-peri-operative-iron-supplement-evaluation-100600265","NCT07095244","Pediatric Outcomes and Recovery With Peri-Operative Iron Supplement Evaluation","Pediatric Outcomes and Recovery With Peri-Operative Iron Supplement Evaluation (PORPOISE)","PORPOISE","Inclusion Criteria:\n\n* All patients scheduled for VDRO and\u002For pelvic osteotomy surgery (prospective cohort)\n* All patients who had VDRO and\u002For pelvic osteotomy surgery between February 2022 and December 2024 (historical cohort)\n* Ages 0-18 years old\n\nNote that the investigators will include patients who do or do not have a diagnosis of a neuromotor condition. The investigators may not include patients who are enrolled in other conflicting research studies.\n\nExclusion Criteria:\n\n* Patients who have undergone a major surgical intervention in the last 3 months\n* Patients who have received a nutritional intervention that includes iron testing and treatment within the last 3 months\n* Patients in whom oral\u002Fenteral iron supplementation is contraindicated\n* Patients who have a bleeding disorder\n* Patients taking erythropoietin\n* Patients who cannot read and understand English\\*\n\n  * Patients and their families who cannot read and understand English will be excluded from the study because the surveys and interviews are conducted in English. These patients will still have access to the same nutrition management and interventions as study participants.","0 Years",{"count":574,"type":22},180,[58],"Varus-derotation osteotomy (VDRO) is a surgery to prevent or address hip displacement in children. Many children having this surgery have cerebral palsy or other neuromotor disorders, who have a higher rate of malnutrition, including low iron or anemia. This can affect their surgical outcomes, such as increasing their need for blood transfusions. This project aims to develop a preoperative nutritional program for VDRO patients, to improve their surgical outcomes and decrease their need for transfusions. This may include taking iron supplementation for patient with low iron or anemia. Participants will undergo a nutrition program before their surgery.",[578,579,580,26],"Varus-Derotation Osteotomy Surgery","Iron-deficiency Anemia","Pelvic Osteotomy Surgery",[582,583,584,585,586],"Varus-derotation osteotomy","Anemia","Iron deficiency","Nutrition","Perioperative blood management",{"date":470,"type":35},{"date":589,"type":35},"2025-09-01",{"date":253,"type":22},{"name":592,"class":42},"University of British Columbia",{"id":594,"slug":595,"hasResults":12,"nctId":596,"briefTitle":597,"officialTitle":598,"acronym":599,"eligibilityCriteria":600,"healthyVolunteers":111,"sex":17,"minAge":601,"maxAge":602,"enrollmentInfo":603,"targetDuration":605,"studyType":23,"phases":4,"briefSummary":606,"conditions":607,"keywords":617,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":626,"completionDateStruct":628,"leadSponsor":630,"locationsCount":176},"100581994","assessing-intellectual-and-motor-outcomes-in-high-risk-infants-100581994","NCT06857539","Assessing Intellectual and Motor Outcomes in High-risk Infants","The ELEVATE Program for Prediction, Early Detection & Intervention in Cerebral Palsy","AIM-High","Inclusion Criteria (High Risk Group) :\n\n* Legal guardians must be able and willing to give written informed consent and to comply with the requirements of this study protocol.\n* All infants considered high risk for a diagnosis of cerebral palsy and neuro-developmental impairment will be eligible, specifically including:\n\n  * All preterm infants born ≤32 weeks Post Menstrual Age or ≤1500 gm birth weight\n  * All encephalopathic infants\n  * Neurological risk factors (e.g., cerebral birth defect, injury\u002Fmalformation on neuroimaging, persistently abnormal neurological exam)\n\n(Control Group)\n\n-A control arm will also be recruited.\n\nExclusion Criteria:\n\n* Death prior to discharge from the neonatal unit (High-Risk Infants only)\n* No parental consent (High-Risk and Control Infants)","0 Days","4 Months",{"count":604,"type":22},600,"30 Months","Cerebral palsy (CP) is a condition when a baby has a brain injury that affects their movement and muscle tone. Some people with CP can have other developmental issues, like learning impairments, but many do not and have isolated issues with their motor skills. Some newborns are at higher risk of developing CP, including babies born prematurely, those who have an injury to their brain, and those who have an abnormal neurological examination. However, most babies with a higher risk of CP do not develop CP. The problem is that doctors can't tell early on who will and who will not develop CP, they can only say who has a risk of it. Therefore, these babies are followed up in out-patient clinics to see how they are progressing, usually by a neonatologist (baby doctor), often a physiotherapist, and some may also be referred to services in the community like the Early Intervention Team. If there is a significant concern, doctors will often perform a scan of the baby's brain to provide more information. Even with all this follow-up, it still usually takes at least 12 months, and can be up to 2 years, to diagnose a child as having CP.\n\nIn this study the aim is to try and reduce the age of diagnosis of CP by assessing children in high-risk out-patient clinics using novel and specific examinations. We would also like to improve our ability to predict who will need help with learning, language or other non-motor outcomes. This study is being conducted at several hospitals in Ireland, including Cork University Maternity Hospital (CUMH), The Rotunda Hospital and the Coombe Women and Infants Hospital. It is being coordinated by the In4kids network and will be conducted in the INFANT Centre\u002F University College Cork (UCC). The study has been funded by Research Ireland and the Cerebral Palsy Foundation, USA.",[26,608,609,610,611,612,613,614,615,616],"Cerebral Palsy (CP)","Cerebral Palsy Children","High-risk Infants","Intellectual and Developmental Disabilities","Motor Impairment","Cognitive Development","HIE - Hypoxic - Ischemic Encephalopathy","Preterm","Prematurity; Extreme",[26,618,619,620,621,622,623],"High-Risk Infant Follow-up","Motor Difficulty","Intellectual Delay","Cognitive Impairment","Hypoxic--Ischaemic Encephalopathy","Prematurity","2026-05-08",{"date":557,"type":35},{"date":627,"type":35},"2025-03-21",{"date":629,"type":22},"2030-07-31",{"name":631,"class":42},"University College Cork",{"id":633,"slug":634,"hasResults":12,"nctId":635,"briefTitle":636,"officialTitle":636,"acronym":4,"eligibilityCriteria":637,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":83,"enrollmentInfo":638,"targetDuration":4,"studyType":56,"phases":640,"briefSummary":641,"conditions":642,"keywords":643,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":651,"lastUpdatePostDateStruct":652,"startDateStruct":653,"completionDateStruct":654,"leadSponsor":656,"locationsCount":4},"100640933","effects-of-multimodal-neuro-rehabilitation-on-cortical-activity-and-muscle-syenergy-in-spastic-cerebral-palsy-100640933","NCT07574996","Effects of Multimodal Neuro Rehabilitation on Cortical Activity and Muscle Syenergy in Spastic Cerebral Palsy","Inclusion Criteria:\n\n* Children aged 6-18 years.\n* Neurologist-confirmed spastic cerebral palsy.\n* GMFCS Levels I-III (mild to moderate motor impairment).\n* Ability to understand and follow simple instructions.\n* Medically stable (no planned major surgery; no recent adjustment of medications affecting cortical excitability).\n* Parental\u002Fguardian written informed consent and child assent.\n\nExclusion Criteria:\n\n* Active uncontrolled epilepsy or history of seizure in the last year.\n* Metal implants in the head or implanted medical\u002Felectrical devices (e.g., cochlear implants, ventriculoperitoneal shunts, pacemakers).\n* Significant visual or auditory impairments that would interfere with task performance.\n* Severe behavioral or cognitive difficulties that would prevent safe application of tDCS or training tasks.\n* Currently taking medications known to significantly alter cortical excitability (e.g., benzodiazepines, antiepileptics) if dosage is unstable.\n* Participation in other experimental neurorehabilitation or brain stimulation interventions within the last 6 months.",{"count":639,"type":22},150,[58],"* To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy.\n* To determine the retention effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy, one-month follow-up across the five groups.",[26],[644,645,646,65,647,648,649,650],"Spastic Cerebral Palsy","Pediatric Neurorehabilitation","Transcranial direct current stimulation","Virtual reality","Conventional Physiotherapy","Cortical Activity","Muscle synergy","2026-05-04",{"date":624,"type":35},{"date":407,"type":22},{"date":655,"type":22},"2028-01-14",{"name":198,"class":42},{"id":658,"slug":659,"hasResults":12,"nctId":660,"briefTitle":661,"officialTitle":662,"acronym":4,"eligibilityCriteria":663,"healthyVolunteers":12,"sex":17,"minAge":664,"maxAge":665,"enrollmentInfo":666,"targetDuration":4,"studyType":56,"phases":668,"briefSummary":669,"conditions":670,"keywords":672,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":651,"lastUpdatePostDateStruct":683,"startDateStruct":684,"completionDateStruct":685,"leadSponsor":687,"locationsCount":4},"100639401","early-intervention-in-cerebral-palsy-perception-action-vs-neurodevelopmental-therapy-100639401","NCT07575659","Early Intervention in Cerebral Palsy: Perception-Action vs Neurodevelopmental Therapy","Efficacy of the Perception-Action Approach Versus Neurodevelopmental Therapy in Early Intervention for Children With Cerebral Palsy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of Cerebral Palsy\n* Being at high risk for Cerebral Palsy (based on MRI or cranial ultrasound findings and neurological examination)\n* Age between 0-36 months (using corrected age for preterm infants)\n* Parental agreement to participate in the study and attend all assessment and therapy sessions; signed informed consent form from the parent(s) or legal guardian(s)\n\nExclusion Criteria:\n\n* Presence of severe visual or hearing impairment that would prevent full participation in therapy sessions\n* Uncontrolled seizures\n* Receipt of botulinum toxin injection or orthopedic surgery within the last 6 months\n* Diagnosis of an additional neurometabolic, genetic, or other neurological disorder","6 Months","36 Months",{"count":667,"type":22},24,[58],"The goal of this clinical trial is to compare two different physiotherapy approaches used in early intervention for children with cerebral palsy. These approaches are the Perception-Action Approach and Neurodevelopmental Therapy (Bobath). The study aims to understand which approach is more effective in supporting neurodevelopmental outcomes in early childhood in Cerebral Palsy.\n\nThe main questions this study aims to answer are:\n\nHow does the Perception-Action Approach affect motor function in young children with cerebral palsy? How does Neurodevelopmental Therapy (Bobath) affect motor function in young children with cerebral palsy? Are there differences in outcomes between these two approaches?\n\nResearchers will compare these two approaches to see which one better supports motor development.\n\nParticipants will:\n\nBe children aged 0 to 36 months with cerebral palsy or at high risk Be assigned to one of the two therapy groups Receive one therapy session per week for 12 weeks Be assessed before and after the intervention using standardized tests\n\nThe results of this study may help therapists and families choose the most effective early intervention approach for children with cerebral palsy.",[26,671],"Cerebral Palsy Early Intervention",[26,673,674,675,676,677,678,679,680,681,682],"Early Intervention","Pediatric Physiotherapy","Neurodevelopmental Therapy","Bobath Concept","Perception-Action Approach","Neuro-Developmental Treatment (NDT)","GMFM-66","Infant Motor Profile","Bayley III","Pediatric Evaluation of Disability Inventory",{"date":624,"type":35},{"date":306,"type":22},{"date":686,"type":22},"2027-04",{"name":688,"class":42},"Tuba Derya Doğan"]