[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-vascular-accident-cvastroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-vascular-accident-cvastroke":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,73,103],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100641926","evaluation-of-the-safety-and-effectiveness-of-chords-cerebral-protection-system-during-tavr-duet-trial-100641926",false,"NCT07648693","Evaluation of the Safety and Effectiveness of CHORDS® Cerebral Protection System During TAVR: DUET Trial","A Prospective, Multicenter, Randomized Controlled Clinical Trial to Evaluate the Safety and Effectiveness of the Resonova® CHORDS® Cerebral Protection System in Capturing and Removing Embolic Debris During Transcatheter Aortic Valve Replacement","Inclusion Criteria:\n\n* Male or non-pregnant female, ≥18 years\n* Patients with symptomatic severe aortic stenosis who are scheduled to undergo TAVR with commercialized transcatheter aortic valve system.\n* Compatible left common carotid artery (6.5-10 mm) and brachiocephalic artery (9-15mm) diameters without significant stenosis (\\> 70%)\n* Patients who are able to understand the study objectives, voluntarily participate, sign the informed consent form, and are willing to undergo required examinations and clinical follow-up.\n\nExclusion Criteria:\n\nGeneral\n\n* Contraindications to MRI, or planned implantation of an MRI-incompatible device at the index procedure, or planned implantation of an MRI-incompatible pacemaker or defibrillator within 30 days post-procedure.\n* Acute myocardial infarction ≤ 30 days before the intended treatment\n* Pure aortic regurgitation\n* Pre-existing prosthetic aortic valve\n* Echocardiographic evidence of intracardiac or aortic mass, thrombus, or vegetation\n* Contraindication to antiplatelet and\u002For anticoagulant therapy, nitinol , or contrast media, or refusal to receive blood transfusions\n* Vulnerable populations, including those unable to adequately understand the trial, those potentially subject to undue influence or coercion, those unable to complete the informed consent process, and those with severe disabling dementia or cognitive impairment Anatomic\n* Vasculature (ie, right radial\u002Fbrachial artery, carotid artery) precluding the device access\n* Patients whose brachiocephalic or left carotid artery reveals significant stenosis（\\>70%）, ectasia, dissection, or aneurysm at the ostium or within 3 cm of the ostium","ALL","18 Years",{"count":19,"type":20},240,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a prospective, multi-center, randomized controlled study. The goal of the study is to assess the safety and effectiveness of the Resonova® CHORDS® Cerebral Protection System in capturing and removing embolic debris during Transcatheter Aortic Valve Replacement (TAVR). A total of 240 eligible participants will be enrolled and randomized in a 1:1 ratio to undergo TAVR either with the CHORDS® Cerebral Protection System (Test group) or the Sentinel System (Control group).All the participants will be followed up at 30 days and 90 days post-procedure.",[26,27],"Transcatheter Aortic Valve Replacement (TAVR)","Cerebral Vascular Accident (CVA)\u002FStroke",[29,30,31,32],"Cerebral Protection","TAVR","DW-MRI","Stroke","RECRUITING","2026-06-12",{"date":36,"type":37},"2026-06-15","ACTUAL",{"date":39,"type":37},"2025-10-31",{"date":41,"type":20},"2026-12-31",{"name":43,"class":44},"Resonova (Shanghai) Medtech Limited","INDUSTRY",15,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":58,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":72},"100550014","the-natural-history-of-recovery-after-stroke-100550014","NCT06441552","The Natural History of Recovery After Stroke","Learning the Natural History of Recovery After Stroke - Cognitive, Motor and Sensory Function","RESTRO","Inclusion Criteria:\n\n* \\>18 years of age\n* Independent in all activities of daily living before the stroke.\n* In- and out-patients at Adi-Negev Nahalat-Eran rehabilitation center, with first ever stroke, or with a recurrent stroke that did not lead to disability (were independent in ADL before the second stroke).\n* Medically stable\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* The presence of any degenerative neurological condition, neuropathy, myopathy or Polio that are not secondary to stroke, excluding diabetic related changes.\n* Traumatic brain injury and\u002For extra-cerebral hemorrhage.\n* Significant psychiatric condition, including alcoholism and drug abuse.\n* Any severe orthopedic condition (such as amputation or severe pain that limits activity) or chronic pain syndrome.\n* Participation in another interventional study.",true,"85 Years",{"count":57,"type":20},200,"1 Year","OBSERVATIONAL","The goal of this longitudinal observational study is to learn the course of recovery after stroke. Specifically, in this study we will learn and describe the changes in cognitive, motor and sensory function over time in stroke patients.",[27],"2025-09-30",{"date":64,"type":37},"2025-10-03",{"date":66,"type":37},"2024-02-01",{"date":68,"type":20},"2027-01",{"name":70,"class":71},"Adi Negev-Nahalat Eran","OTHER",3,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":72},"100561218","effects-of-different-pressure-garments-on-upper-extremity-sensorimotor-functions-and-quality-of-life-after-stroke-100561218","NCT06587308","Effects of Different Pressure Garments on Upper Extremity Sensorimotor Functions and Quality of Life After Stroke","Effects of Pressure Garments of Varying Designs on Upper Extremity Sensorimotor Functions and Quality of Life After Stroke: A Multicenter, Double-Blind, Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Between 18 and 80 years of age\n* Within 1-12 months of ischemic or hemorrhagic stroke\n* First onset resulting in hemiparesis of a limb with Burnnstrom stage of 3, 4 or 5\n* Modified Ashworth Scale with scores of less than or equal 2 for elbow, wrist, and hand muscle tone in the affected upper extremity\n* Able to understand instruction\n\nExclusion Criteria:\n\n* Serious cardiovascular or respiratory diseases\n* Skin lesions, infections or other skin problems\n* Serious circulatory problems such as deep vein thrombosis\n* Allergies or significant discomfort to pressure garment materials\n* Upper extremity fractures or severe joint problems\n* Severe cognitive impairment with Saint Louis University Mental Status (SLUMs) scores equal to or less than 27 (above high school level of education)\u002F25 (below high school level of education)","80 Years",{"count":82,"type":20},165,[23],"The study aims to compare the effects of dorsal-double-layered 10% circumferential reduction (DD-10), single-layered 10% circumferential reduction (S-10), and single-layered no circumferential reduction (S-0) pressure garments on sensorimotor functions, including motor control, dexterity, muscle tone, pain, self-perceived upper extremity function, and quality of life among stroke patients during the 8 weeks of application (Time 1: Baseline, Time 2: Week 4, Time 3: Week 8).",[27],[87,88,89,90,91,92,93],"Pressure Garment","Quality of Life","Stroke Rehabilitation","Occupational Therapy","Motor Activity","Sensory Feedback","Upper Extremity Paresis","2024-11-24",{"date":96,"type":37},"2024-11-27",{"date":98,"type":37},"2024-10-08",{"date":100,"type":20},"2026-08",{"name":102,"class":71},"National University of Malaysia",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":111,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":72},"100453150","error-enhanced-learning--recovery-in-2--3-dimensions-100453150","NCT05180786","Error-enhanced Learning & Recovery in 2 & 3 Dimensions","Inclusion Criteria:\n\n1. 18 years of age or older\n2. Chronic stroke (8+ months post stroke event) with primary motor cortex involvement\n3. Hemiparesis\n4. Some degree of both shoulder and elbow movement capability\n\nExclusion Criteria:\n\n1. Bilateral paresis\n2. Severe tactile deficits using the Two-Point Discrimination Test (participant must detect\\\u003C11mm)\n3. Severe proprioceptive deficits\n4. Severe spasticity (Modified Ashworth \\>3) preventing movement\n5. Aphasia, cognitive impairment, or affective dysfunction that would influence the ability to perform the experiment\n6. Visual deficits, and hemispatial neglect that would prevent the subjects from seeing the targets.\n7. Inability to provide an informed consent\n8. severe current medical problems\n9. diffuse\u002Fmultiple lesion sites or multiple stroke events\n10. Inability to attain and maintain testing positions\n11. Botox injection to the affected upper extremity within the previous 4 months\n12. Concurrent participation in upper extremity rehabilitation either as part of a research intervention protocol or a prescribed therapy\n13. Participation in previous, similar robotics intervention study\n14. Other neurological issues\n\nNone of the following special populations will be included in this research study:\n\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Pregnant women\n* Prisoners\n* Vulnerable Populations",{"count":110,"type":20},20,[23],"This study is being done to see how errors lead to improvement. Specifically, we are evaluating the errors stroke participants make during an upper extremity exercise program when reaching for a target using their affected arm. Once we understand the participant's reaching errors, we plan to create a customized reaching exercise according to the individual's specific error tendencies which will lead to better performance on movement ability after training.",[32,27],[115,116,117,118,32],"Upper Extremity","Rehabilitation","Arm","Robotics","2024-10-22",{"date":121,"type":37},"2024-10-24",{"date":123,"type":37},"2023-03-01",{"date":125,"type":20},"2025-12-30",{"name":127,"class":71},"Shirley Ryan AbilityLab"]