[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebral-vasospasm\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebral-vasospasm":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,70,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100584763","registry-on-neva-vs-for-cerebral-vasospasm-management-in-post-sah-patients-100584763",false,"NCT06893588","Registry on NeVa VS for CerebraL VAsospasm ManagemenT in Post SAH PatiEnts","Prospective, Open-Label, Multi-Center ProceDural Data CollectIon Case Registry on NeVa VS for CerebraL VAsospasm ManagemenT in Post SAH PatiEnts (The DILATE Registry)","DILATE","Inclusion Criteria:\n\n1. Age ≥22\n2. Symptomatic cerebral vasospasm secondary to aneurysmal subarachnoid hemorrhage (aSAH) in the internal carotid artery (ICA), middle cerebral artery (MCA), anterior cerebral artery (ACA), posterior cerebral artery (PCA), or basilar artery (BA)\n3. Vessel dilation procedure was performed with the NeVa VS\n4. Subject or legal representative is able and willing to give informed consent within 3 days (72 hours) post-index procedure\n\nExclusion Criteria:\n\n* None","ALL","22 Years",{"count":20,"type":21},200,"ESTIMATED","30 Days","OBSERVATIONAL","A multi-center, observational registry study intended to assess the HDE-approved NeVa VS cerebral artery dilation device in patients with symptomatic cerebral vasospasm caused by aneurysmal subarachnoid hemorrhage (aSAH)",[26,27],"Cerebral Vasospasm","Aneurysmal Subarachnoid Hemorrhage (aSAH)",[29],"vasospasm","RECRUITING","2026-05-23",{"date":33,"type":34},"2026-05-27","ACTUAL",{"date":36,"type":34},"2025-04-14",{"date":38,"type":21},"2027-03-15",{"name":40,"class":41},"Vesalio","INDUSTRY",16,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100637311","nitric-oxide-consumption-as-a-predictor-of-vasospasm-in-subarachnoid-hemorrhage-100637311","NCT07614906","Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage","Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage (SAH): a Prospective Observational Study","Inclusion Criteria:\n\n* Adult\n* patient with SAH and with an external ventricular drainage (EVD) placed within 24 hours after the onset of the hemorrhage\n\nExclusion Criteria:\n\n* pregnancy\n* pre-existing neurological comorbidities\n* coagulation disorders\n* anemia\n* absence of a good cranial window to perform Transcranial Doppler (TDC)\n* presence of \\>50% stenosis of carotid arteries confirmed by doppler ultrasound\n* Technical problems on EVD that prevent CSF withdrawals\n\nFor the control group, we will invite to participate patients without neurological comorbidities undergoing spinal anesthesia in the operating room or with a spinal drain for major vascular surgery.",true,"18 Years",{"count":53,"type":21},40,"The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH). To reach this goal, the investigators will compare NO consumption levels in SAH and non-SAH patients. NO consumption levels will be analyzed from samples of participants' cerebral spinal fluid (CSF).",[56,26],"Aneurysmal Subarachnoid Hemorrhage",[58],"Nitric Oxide Consumption","2026-05-22",{"date":61,"type":34},"2026-05-29",{"date":63,"type":34},"2024-03-03",{"date":65,"type":21},"2027-06",{"name":67,"class":68},"Massachusetts General Hospital","OTHER",2,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":115},"100638580","noninvasive-ca-monitoring-validation-and-autonomic-modulation-in-aneurysmal-subarachnoid-hemorrhage-100638580","NCT07577739","Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage","Non-Invasive Cerebral Autoregulation Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage: A Two-Component Prospective Study of EVD Clamping Validation, CA Natural History, and the Effects of Cervical Sympathetic Block and Transcutaneous Auricular Vagal Nerve Stimulation on Cerebral Autoregulation Parameters","Inclusion Criteria (Component 1 - All Enrolled Participants):\n\n* Age 18 years or older\n* Primary diagnosis of aneurysmal subarachnoid hemorrhage (aSAH), confirmed by imaging\n* Admitted to the NSICU at Clements University Hospital, UT Southwestern Medical Center\n* Informed consent obtained from subject or legally authorized representative (as defined under Texas Health and Safety Code Section 166.039)\n* Brain4Care extensometry sensor placeable at an appropriate cranial site not occluded by surgical dressings or EVD hardware\n* Open EVD with active continuous ICP monitoring (required for EVD clamping sub-protocol only; not required for Aims 2 or 3)\n\nExclusion Criteria (Component 1):\n\n* Age younger than 18 years\n* Prisoner status\n* Primary NSICU admission diagnosis other than aSAH\n* Active declination by subject or legally authorized representative\n* Brain4Care sensor not placeable at any accessible cranial site\n* Active clinical deterioration making research monitoring impractical at time of approach\n* Physician-of-record declining research enrollment for clinical reasons\n* Inability to provide informed consent in English\n* Known pregnancy at time of enrollment\n\nAdditional Inclusion Criteria for Component 2 (Aim 3 - CSB and taVNS):\n\n* At least one successful EVD clamping session completed\n* PI documentation of Component 2 operational readiness, co-signed by qualified co-investigator or Department Director\n* INR 1.5 or less and platelet count 50,000\u002FuL or greater within 24 hours prior to each CSB procedure\n* No active infection or cellulitis at right anterolateral neck\n* No known allergy to ropivacaine or amide local anesthetics\n* No contralateral phrenic nerve palsy or severe pre-existing respiratory compromise\n* No cardiac pacemaker or implanted cardiac device contraindicating taVNS\n* No allergy to electrode adhesive materials\n* Continuous cardiac telemetry active and interpretable\n* Resting HR 60 bpm or greater on two readings within 24 hours prior to session\n* No current use of Class I or III antiarrhythmic medications\n* No clinically significant AV conduction abnormality\n\nAdditional Exclusion Criteria for Component 2:\n\n* Prior ipsilateral right-sided cervical surgery, radiation, or known anatomical distortion precluding safe C6 approach\n* Hemodynamic instability with active vasopressor escalation at time of planned CSB\n* Active uncontrolled tachyarrhythmia or bradyarrhythmia at time of taVNS session\n* Physician-of-record declining autonomic modulation procedures for any clinical reason\n* Known or suspected pregnancy",{"count":78,"type":21},300,"INTERVENTIONAL",[81],"NA","This is a two-component prospective study of adult aneurysmal subarachnoid hemorrhage (aSAH) patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center. Component 1 (active upon IRB approval) validates Brain4Care (B4C) extensometry-derived noninvasive cerebral autoregulation (CA) indices against invasive ICP-derived equivalents in aSAH patients with open external ventricular drains (EVDs), and characterizes the prospective natural history of multi-modal CA parameter evolution through the delayed cerebral ischemia (DCI) window (admission through Day 14). Component 2 (activated upon PI readiness declaration) assesses the within-subject effect of cervical sympathetic block (CSB) and transcutaneous auricular vagal nerve stimulation (taVNS) on CA parameters in enrolled aSAH patients.",[84,85,26,86],"Subarachnoid Hemorrhage, Aneurysmal","Delayed Cerebral Ischemia","Autonomic Nervous System Diseases",[88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104],"aneurysmal subarachnoid hemorrhage","delayed cerebral ischemia","cerebral autoregulation","CPPopt","MAPopt","pressure reactivity index","Brain4Care","cervical sympathetic block","stellate ganglion block","transcutaneous auricular vagal nerve stimulation","taVNS","autonomic modulation","EVD clamping","external ventricular drain","near-infrared spectroscopy","noninvasive ICP monitoring","neurocritical care","NOT_YET_RECRUITING","2026-05-04",{"date":108,"type":34},"2026-05-11",{"date":110,"type":21},"2026-07",{"date":112,"type":21},"2030-06",{"name":114,"class":68},"University of Texas Southwestern Medical Center",1,{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":79,"phases":125,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":115},"100559149","incidence-characteristics-and-evolution-of-cerebral-vasospasm-with-clinical-impact-in-moderate-to-severe-traumatic-brain-injury-complicated-by-subarachnoid-hemorrhage-at-martinique-university-hospital-100559149","NCT06560372","Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital","VASO-TC","Inclusion Criteria:\n\n* Adult patient aged 18 or over,\n* Hospitalized at the Martinique University Hospital for the treatment or monitoring of a moderate or severe TBI (Glasgow Score less than or equal to 13 at initial treatment) presenting with SAH on the cerebral CT scan,\n* Patient if capable, or representative of the patient in case of incapacity, having been informed of the research, and having given free, informed and written consent,\n* After an emergency inclusion procedure if the patient's representative is initially unreachable and written agreement, informed within the first 48 hours of inclusion by the representative or the patient if his neurological condition allows it,\n* Be affiliated to a social security system.\n\nExclusion Criteria:\n\n* Pregnant woman,\n* Presence of an aneurysmal pathology known or diagnosed at initial treatment,\n* History of chronic kidney failure stage 4 (creatinine clearance measured less than 30ml\u002Fmin),\n* Imminent death of the patient,\n* Patient presenting criteria for non-admission to critical care (death expected within 48 hours, progressive fatal pathology with vital prognosis in less than 30 days, patient in palliative situation),\n* Known allergy to iodized contrast products,\n* Be placed under legal protection, guardianship or curatorship,\n* Patient or representative who refused to allow the patient to participate in the study.\n\nAdditional Exclusion Criteria after patient's inclusion:\n\n* Death of the patient expected within the first 48 hours,\n* Minor,\n* Release from hospitalization against medical advice,\n* Transfer to another establishment before the 13th day of treatment (outside the Martinique University Hospital),\n* Change of opinion of the patient's representative (after neurological recovery) regarding the patient's participation in research,\n* Withdrawal of consent to participate in the study being supported with refusal to use the data collected until withdrawal of participation,",{"count":124,"type":21},154,[81],"Context :\n\nModerate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for 30% of deaths by trauma. It is complicated in 30-60% of cases by subarachnoid hemorrhage (SAH), which makes it the leading cause of SAH. SAH and its complications are well described when the origin is aneurysmal, notably cerebral vasospasm (CV) because it promotes delayed cerebral ischemia with a major prognostic impact. This is why the screening and prevention of this vasospasm are well established in the literature and in practice, in the nosological context of aneurysmal SAH.\n\nResearch problem :\n\nHowever, when it comes to post-traumatic SAH, CV is a more maligned entity, with a much less detailed description. However, when we know the prognostic interest that it could have for patients, it seems legitimate to seek to define its physiopathological and epidemiological contours. On a prospective cohort of 290 subjects, Oertel et al. (2005) demonstrated, in head trauma patients, an incidence of approximately 40% of compatible signs with the recognized criteria of CV.\n\nTo date, the literature remains sparse on this subject.\n\nProposed study :\n\nIn view of the incomplete scientific literature, the study team wish to carry out a prospective epidemiological study in moderate to severe head trauma patients complicated by SAH and hospitalized at the Martinique University Hospital, with the aim of better characterizing the incidence of the occurrence, and evolution of CV with clinical impact in these patients.\n\nOne of the original aspects of the proposed study is the use of CT scan with perfusion sequence, which has shown its superiority to Transcranial Doppler. The other particularity is its prospective aspect and triggered by an alteration in the clinical state of the patient presenting a traumatic SAH, then directly linking the pathophysiology (cerebral ischemia) and the clinical impact. Thus, the diagnosis of traumatic CV will be made on a cerebral CT scan by the association of the 50% reduction in the caliber of one or more cerebral arteries and a perfusion defect in the perfusion sequence in a context of alteration of neurological clinical examination or deterioration of neurological monitoring parameters. Finally, few studies have monitored the evolution of these patients at 1 and 6 months after the initial event.\n\nHypothesis :\n\nThe research hypothesis is that in the population of moderate to severe head trauma patients hospitalized at the Martinique University Hospital, when a new neurological symptomatology or a deterioration in the state of consciousness occurs, it could be a post-truamatic CV in 15 to 20% of cases.\n\nIndeed, the rare studies find frequencies of radiologically confirmed CV in head trauma patients of around 30-45%, with low numbers of subjects, retrospective studies, or not correlated with the clinic and with the clinical and paraclinical data necessary for the positive diagnosis of this entity. The reported frequency of traumatic CV with clinical impact ranges between 15-20%.\n\nThe study team therefore expect an incidence of 15 to 20% of CV with clinical impact in patients with traumatic SAH in Martinique. CV could be responsible for sudden deterioration of the neurological state in patients suffering from traumatic SAH between the 3rd and 12th day inclusive of treatment (according to retrospective studies already carried out) and responsible for its specific morbidity linked to cerebral ischemia localized in the spasmed area manifested by a worsening of the neurological prognosis on the modified Rankin scale.",[128,26,129,130],"SAH (Subarachnoid Hemorrhage)","Moderate Traumatic Brain Injury","Severe Traumatic Brain Injury",[128,26,132,133,134],"Moderate and severe Traumatic Brain Injury","CT scan","Cerebral perfusion","2025-03-26",{"date":137,"type":34},"2025-03-31",{"date":139,"type":34},"2024-11-06",{"date":141,"type":21},"2028-12-06",{"name":143,"class":68},"University Hospital Center of Martinique"]