[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebrospinal-fluid-leakage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebrospinal-fluid-leakage":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100508258","role-of-novel-rada16-hydrogel-in-endoscopic-skull-base-surgery-100508258",false,"NCT05898074","Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery","Novel Application of RADA16 Hydrogel in Reducing Sinonasal Morbidity After Endoscopic Skull Base Surgery","Inclusion Criteria:\n\n* Patient is 18 years of age or older\n* Patient is undergoing endoscopic endonasal approach for the management of a skull base tumor or cerebrospinal fluid leak. Nasoseptal Flap must be harvested.\n* Patient is undergoing surgery via bi-nostril approach requiring bilateral surgical dissection of the nasal cavity in approach to the skull base\n\nExclusion Criteria:\n\n* Patient has evidence of radiographic baseline sinus disease consistent with acute or chronic rhinosinusitis (including nasal polyposis, prior septal perforation) on pre-operative CT sinus\n* Patient has had prior sinonasal surgery or has undergone sinonasal radiation treatment\n* Patient has a known coagulation disorder or immune deficiency.",true,"ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to specifically evaluate the effectiveness of PuraGel, a RADA16 polypeptide hydrogel, in expediting post-operative healing and re-mucosalization of the nasoseptal flap harvest site during endoscopic skull base surgery and the impact on patient and sinonasal morbidity.",[27,28,29],"Skull Base Neoplasms","Cerebrospinal Fluid Leakage","Nasal; Hypertrophy, Mucous Membrane (Septum)",[31,32,33,34],"Nasoseptal Flap Harvest","Sinonasal Morbidity","Extracellular Matrix","Endoscopic Skull Base Surgery","RECRUITING","2026-04-06",{"date":38,"type":39},"2026-04-09","ACTUAL",{"date":41,"type":39},"2023-10-09",{"date":43,"type":21},"2026-06-09",{"name":45,"class":46},"Indiana University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":47},"100552393","using-polyglycolic-acid-mesh-prevents-cerebrospinal-fluid-leakage-100552393","NCT06472505","Using Polyglycolic Acid Mesh Prevents Cerebrospinal Fluid Leakage","Using Polyglycolic Acid Mesh Prevents Cerebrospinal Fluid Leakage: Clinical Application to Endoscopic Endonasal Transsphenoidal Surgery","A. Inclusion criteria\n\n1\\. Patients with primary or recurrent pituitary tumors require endoscopic nasal surgery.\n\nB. Exclusion criteria\n\n1. Patients with pituitary gland tumors who do not receive surgical treatment.\n2. Patients with other brain tumors.\n3. Patients allergic to polyglycolic acid (PGA).\n4. Patients who have had previous radiation therapy or chemotherapy.","20 Years",{"count":20,"type":21},[24],"The papers propose a new method to prevent postoperative cerebrospinal fluid leakage. Doctors use the absorbable polyglycolic acid (PGA) and fibrin glue to repair in surgery, prevent cerebrospinal fluid leakage and reduce the necessity of postoperative lumbar drainage after surgery. This study will analyze the changes in cerebrospinal fluid leakage in patients with pituitary tumors and skull base tumors after surgery, and further understand the effectiveness of Neoveil , as the basis for the development of new treatments.",[60,28],"Pituitary Tumor",[62,63,64],"Pituitary tumor","Endoscopic transnasal transsphenoidal","CSF leakage","2024-06-24",{"date":67,"type":39},"2024-06-25",{"date":69,"type":39},"2023-12-01",{"date":71,"type":21},"2025-12-31",{"name":73,"class":46},"National Taiwan University Hospital"]