[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cerebrospinal-fluid\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cerebrospinal-fluid":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100629955","molecular-insights-into-post-cardiac-arrest-brain-injury-via-csf-multi-omics-100629955",false,"NCT07481396","Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics","Identification of Novel Molecular Pathophysiological Mechanisms of Secondary Brain Injury in Post-cardiac Arrest Syndrome Patients Using Cerebrospinal Fluid Multi-omics Analysis","PCABI-OMICS","Inclusion Criteria:\n\n* Patients receiving post-resuscitation care after out-of-hospital cardiac arrest for secondary brain injury treatment.\n* Patients without contraindications for lumbar puncture catheter insertion for cerebrospinal fluid (CSF) collection. This includes the absence of:\n* Uncontrolled diabetes.Coagulation disorders.\n* Thrombocytopenia (platelet count $\\\u003C 100,000).\n* A history of cirrhosis diagnosis.\n* Current receipt of low molecular weight heparin.\n* Current use of platelet inhibitors.\n* A history of posterior spinal fusion that may interfere with catheter insertion.\n* Local skin infection or rash at the puncture site.\n* Signs of systemic infection or sepsis.\n* A history of lumbar puncture within the past 6 hours.\n\nExclusion Criteria:\n\n* Cerebral Edema: Patients with evidence of cerebral edema on a brain computed tomography (CT) scan performed immediately after spontaneous circulation recovery.\n* Patients who underwent extracorporeal membrane oxygenation (ECMO).\n* Patients who could not maintain integrated therapy for more than 24 hours after cardiac arrest.\n* Patients with a history of acute or chronic brain disease.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","3 Months","OBSERVATIONAL","The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques.\n\nThe main question this study aims to answer is:\n\nWhich genome-, transcriptome-, proteome-, and metabolome-level changes in CSF are associated with secondary brain injury after cardiac arrest?\n\nTo address this question, CSF samples collected from post-cardiac arrest patients will undergo multi-omics analyses. Identified molecular pathways will be used to screen existing drug databases and generate new therapeutic candidates through computational modeling and compound synthesis. These findings will provide the scientific foundation needed to design and implement future preclinical experiments using cardiac arrest animal models.",[26,27,28,29],"Cardiac Arrest (CA)","Cerebrospinal Fluid","Multiomics","Hypoxic-Ischemic Brain Injury","RECRUITING","2026-03-16",{"date":33,"type":34},"2026-03-18","ACTUAL",{"date":36,"type":34},"2025-12-01",{"date":38,"type":21},"2028-02-28",{"name":40,"class":41},"Chungnam National University Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":42},"100443167","stenting-versus-neurosurgical-treatment-of-idiopathic-intracranial-hypertension-100443167","NCT05050864","Stenting Versus Neurosurgical Treatment of Idiopathic Intracranial Hypertension.","Randomized Controlled Trial Evaluating the Efficacy of Venous Sinus Stenting Versus Neurosurgical Internal Ventricular Shunt on Papillary Edema in the Management of Idiopathic Intracranial Hypertension","HYDROPTIC","Inclusion Criteria:\n\n* Patient aged 18 or over\n* HTICi proven greater than 25cm of water\n* Presence of papillary edema (grade\\> 0 on the Frisen scale)\n* Stenosis of at least one transverse sinus on MRI\n* Failure of medical treatment and surgical \u002F interventional indication defined by the medical team taking care of the patient\n* Consent to participate in the study\n\nExclusion Criteria:\n\n* Fulminant HTICi\n* Contraindication to antiplatelet aggregation\n* Contraindication to one or the other of the interventions under study\n* Pregnant or breastfeeding woman",{"count":52,"type":21},276,"INTERVENTIONAL",[55],"NA","Idiopathic intracranial hypertension (HTICi) is a pathology, affecting young adults with a predominance of women, due to an increase in intracranial pressure, which may be associated with stenosis of the cerebral venous sinuses and whose origin remains unknown.\n\nThis hypertension can lead to papillary edema (OP) which can lead to a narrowing of the visual field and progress to blindness. Along with weight reduction, acetazolamide, which reduces the production of cerebrospinal fluid (CSF), is prescribed as a first-line treatment. Its efficacy is inconsistent in resolving papillary edema and there are many side effects.\n\nIn the event of ineffectiveness or dependence on acetazolamide associated with hygiene and dietetic rules, a second line of therapy is then considered: neurosurgical (internal shunt of the LCS) or endovascular (venous stenting) treatment.\n\nThese invasive techniques have each proven their effectiveness in the rapid and permanent resorption of OP, allowing improvement or preservation of visual function. In terms of induced morbidity, the superiority of one technique over the other, if it exists, has not been established.\n\nOur objective is to compare the efficacy, safety, and safety of LCS bypass surgery versus venous sinus stenting in HTICi with moderate to severe visual impairment after failure of medical treatment defined by the absence of resorption of the OP after several months",[58,27,59],"Pseudotumor Cerebri","Transverse Sinuses",[61,62,63,64],"Endovacascular","ventricular shunt","papillary edema","visual field","2025-12-30",{"date":67,"type":34},"2026-01-05",{"date":69,"type":34},"2022-03-02",{"date":71,"type":21},"2026-12-07",{"name":73,"class":74},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":42},"100458802","comparison-of-different-csf-sampling-sites-on-external-ventricular-drains-100458802","NCT05254353","Comparison of Different CSF Sampling Sites on External Ventricular Drains","CSF3S","Inclusion Criteria:\n\n* Patients with an EVD in place regardless of the underlying pathology.\n* Written informed consent to participate in the study must be obtained from the subject. If the subject is not capable of self-consent, all efforts will be made to locate a legally acceptable representative to act on behalf of the subject.\n\nWhen the patient is considered capable to consent but physically unable to sign an informed consent form and a representative is not available an impartial witness can attend the informed consent process.\n\n\\- Males and females of all ages, including children and pregnant females\n\nExclusion Criteria:\n\n* Patients in whom the removal of the drain is planned within 48 hours, before routine sampling, will be excluded.",{"count":83,"type":21},55,"The aim of the current study is to evaluate the difference between proximal and distal CSF sampling. If the characteristics of distally and proximally sampled CSF are similar or correlate well, it may be possible to only sample CSF distally in the future, thereby avoiding the risks mentioned above.",[27],[87,88,89],"neurosurgery","CSF","EVD","2024-06-28",{"date":92,"type":34},"2024-07-01",{"date":94,"type":34},"2022-01-31",{"date":96,"type":21},"2025-01",{"name":98,"class":41},"Universitaire Ziekenhuizen KU Leuven"]