[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-cerclage\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-cerclage":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100630761","use-of-nitrous-oxide-for-pain-and-anxiety-management-during-cervical-cerclage-removal-100630761",false,"NCT07491874","Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal","Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal- A Multicenter Randomized Controlled Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Women at ≥34 weeks of gestation\n* Singleton or twin pregnancy\n* Ability to understand, sign informed consent, and complete questionnaires\n\nExclusion Criteria:\n\n* Triplet or higher-order pregnancy\n* Contraindications to nitrous oxide use\n* Fetal monitoring category 2 or higher\n* Maternal body temperature \\>38°C\n* Significant vaginal bleeding\n* Severe preeclampsia\n* Cerclage removal under general anesthesia\n* Language or cognitive barrier\n* Baseline pain \\>3 on VAS scale, prior to the procedure","FEMALE","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to determine whether inhaled nitrous oxide can reduce pain and anxiety during cervical cerclage removal compared with standard care. Cervical cerclage removal is commonly performed in the outpatient setting during the third trimester of pregnancy and may be associated with discomfort and anxiety despite being a brief procedure.\n\nThe study will include pregnant women aged 18 years or older undergoing elective cervical cerclage removal at 36 weeks of gestation or later.\n\nThe main questions the study aims to answer are:\n\n* Does inhaled nitrous oxide reduce pain during cervical cerclage removal?\n* Does inhaled nitrous oxide reduce anxiety during the procedure?\n* Does the use of nitrous oxide improve overall patient satisfaction during cerclage removal?\n\nResearchers will compare women receiving inhaled nitrous oxide to those receiving standard care without analgesia, as routinely practiced in the participating institutions, in order to determine whether nitrous oxide improves pain control and patient experience during the procedure.\n\nParticipants will:\n\n* Be randomly assigned to receive either inhaled nitrous oxide (50% nitrous oxide \u002F 50% oxygen) or standard care without analgesic treatment during cervical cerclage removal.\n* Undergo the procedure according to routine clinical practice in the participating centers.\n* Complete questionnaires assessing pain and anxiety, including a visual analog scale (VAS) for pain and the State-Trait Anxiety Inventory (STAI).\n* Have routine clinical data recorded from their medical records, including maternal vital signs and any procedure-related side effects.",[26,27,28],"Preterm Delivery","Cervical Cerclage","Cervical Insufficiency","NOT_YET_RECRUITING","2026-04-02",{"date":32,"type":33},"2026-04-08","ACTUAL",{"date":35,"type":20},"2026-05-01",{"date":37,"type":20},"2028-05-01",{"name":39,"class":40},"Kaplan Medical Center","OTHER",4]