[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-conization\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-conization":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100570931","predicting-treatment-failure-in-hsil-patients-with-positive-margins-after-conization-via-detection-of-pax1-methylation-100570931",false,"NCT06713655","Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 Methylation","Multicenter Study on PAX1 Methylation for Predicting Lesion Persistence\u002FRecurrence in HSIL Patients with Positive Margins After Cervical Conization","Inclusion Criteria:\n\n* Age greater than 25 years and less than 55 years;\n* First-time cervical conization (cold knife conization or loop electrosurgical excision procedure);\n* Postoperative pathology showing HSIL (CIN2 or CIN3);\n* Positive margins for HSIL (CIN2 or CIN3) in conization specimen.\n\nExclusion Criteria:\n\n* The presence of other malignant tumors or precancerous lesions;\n* Lack of willingness for follow-up;\n* Pregnant or breastfeeding women;\n* Unable or unwilling to complete follow-up examinations;\n* History of prior cervical disease treatment (surgical or physical therapy);\n* Presence of immune system disorders.","FEMALE","26 Years","54 Years",{"count":20,"type":21},800,"ESTIMATED","OBSERVATIONAL","The goal of this multicenter, observational study is to evaluate whether methylation testing of paired box gene 1 (PAX1) can better predict and diagnose recurrence or persistent disease in patients with positive margins after cervical conization for high-grade squamous intraepithelial lesion (HSIL). The main question it aims to answer is:\n\nCan PAX1 gene methylation testing provide a more accurate and effective prediction and diagnosis of cervical disease recurrence\u002Fpersistence in addition to existing methods? Participants will be managed according to the latest clinical guidelines, and during follow-up, a non-invasive test, PAX1 gene methylation testing, will be added.",[25,26],"High-grade Squamous Intraepithelial Lesions (HSIL)","Cervical Conization",[28,29,30,31,32,33],"cervical intraepithelial neoplasia","conization","positive margins","cervical cancer","treatment failure","residual\u002Frecurrent disease","NOT_YET_RECRUITING","2024-12-03",{"date":37,"type":38},"2024-12-06","ACTUAL",{"date":40,"type":21},"2024-12",{"date":42,"type":21},"2028-07",{"name":44,"class":45},"Women's Hospital School Of Medicine Zhejiang University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100478504","diagnostic-cervical-conization-for-persistent-infection-or-integration-of-hpv-100478504","NCT05510830","Diagnostic Cervical Conization for Persistent Infection or Integration of HPV","A Study of the Value of Diagnostic Cervical Conization for Persistent Infection or Integration of Human Papillomavirus","Inclusion Criteria:\n\n1. The patients are referred to colposcopy and biopsy examinations due to abnormal cervical screening results with no precancerous lesions discovered by pathology.\n2. The cervical precancerous lesions are highly suspected by clinicians with one or more following risk factors:\n\n   * The course of HPV type 16\u002F18 persistent infection is more than two years.\n   * The integration reads of HPV is more than 15.\n   * The impression of colposcopy indicates precancerous lesions.\n   * The cervical TCT indicates ASC-H\u002FHSIL\u002FSCC\u002FAGC-FN\u002FAIS\u002FAC.\n\nExclusion Criteria:\n\n1. Pregnant women.\n2. Vaginal intraepithelial neoplasia is highly suspected by colposcopy and pathological examinations.\n3. The patients are suffering malignant tumors of other system and have not been cured.\n4. There is acute inflammation of the lower genital or anal tract.\n5. The patients' health will be severely harmed by the colposcopy and cervical conization due to some circumstances such as severe insufficiency of liver and kidney function, blood diseases and acute inflammation of other systems.","25 Years","70 Years",{"count":57,"type":21},250,"INTERVENTIONAL",[60],"NA","For the patients with cervical persistent infection or integration of HPV, we has designed a program to perform cervical conization for certain patients to earlier and better diagnose and cure the diseases of HPV infection and related cervical intraepithelial neoplasia\u002Fcancer.",[63,64,65,66,26],"Human Papilloma Virus Infection","Human Papilloma Virus Integration","Cervical Intraepithelial Neoplasia","Cervical Cancer",[68,69,70],"HPV persistent infection","HPV integration","diagnostic cervical conization","2022-09-07",{"date":73,"type":38},"2022-09-08",{"date":75,"type":21},"2022-10",{"date":77,"type":21},"2030-01",{"name":79,"class":45},"Tongji Hospital"]