[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-degenerative-disc-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-degenerative-disc-disease":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,38,66,88],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":37},"100545596","post-market-data-collection-to-evaluate-the-performance-of-the-synergy-disc-100545596",false,"NCT06383962","Post-Market Data Collection to Evaluate the Performance of the Synergy Disc®","A Single Site Post-Market Data Collection Protocol to Evaluate the Performance of Synergy Spine Solutions Synergy Disc®","Inclusion Criteria:\n\nAge 21 or above at the time of the surgery. Have had (retrospective cohort) or the decision has been made to have (prospective cohort) the Synergy Disc implanted Skeletally mature patients for reconstruction of the disc from C3-C7 following a single or multiple level discectomy for intractable radiculopathy\n\nIntractable radiculopathy and\u002For myelopathy with at least one of the following producing symptomatic nerve root and\u002For spinal cord compression:\n\nherniated disc and\u002For osteophyte formation Symptomatic nerve root and\u002For spinal cord compression documented by patient history (arm or neck pain and\u002For neurologic deficit) and imaging (CT, MRI, x-rays, etc.) Failed a minimum of 6 weeks conservative treatment Written informed consent given by subject.\n\nExclusion Criteria:\n\nExclusion Criteria: All answers must be NO to be eligible for the study. Moderate to advanced spondylosis Diagnosis of osteoporosis Active systemic infection or infection at the operative site Pregnancy Marked cervical instability on lateral, coronal, or flexion\u002Fextension radiographs Cervical spine condition other than symptomatic cervical disc disease requiring surgical treatment at the involved level Severe pathology of the facet joints of the involved vertebral bodies Previous diagnosis of osteopenia or osteomalacia More than one immobile vertebral level between C1 and T1 from any cause Morbid obesity Vulnerable person (pregnant patients, emergency cases, children, prisoners and people without mental capacity)","ALL","21 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","This is a real world data collection observational study at a single site. There are both prospective and retrospective cohorts. The study will examine the safety and effectiveness of the Synergy cervical disc system in patients with degenerative cervical disc disease.",[24],"Cervical Degenerative Disc Disease","RECRUITING","2026-04-30",{"date":28,"type":29},"2026-05-01","ACTUAL",{"date":31,"type":29},"2025-03-17",{"date":33,"type":20},"2034-12",{"name":35,"class":36},"Synergy Spine Solutions","INDUSTRY",2,{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":4,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":16,"minAge":45,"maxAge":4,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":4},"100626017","screw-integrated-vs-traditional-cervical-cages-in-acdf-for-degenerative-disc-disease-100626017","NCT07430163","Screw-Integrated vs Traditional Cervical Cages in ACDF for Degenerative Disc Disease","Comparative Study Between Cervical Cage With Screws and Traditional Cage in Anterior Cervical Discectomy and Fusion (ACDF) for Treatment of Cervical Degenerative Disc Disease (CDDD)","Inclusion Criteria:\n\n* Patients aged above 18 years old.\n* Clinical diagnosis of cervical degenerative disc disease (CDDD).\n* Single or double level cervical degenerative disc disease (CDDD) confirmed by MRI\n* Failure of conservative treatment for at least 6 weeks.\n* Patients indicated for Anterior Cervical Discectomy and Fusion (ACDF).\n* Availability of complete preoperative and postoperative clinical and radiological data.\n* Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Previous cervical spine surgery.\n* Mutli-level (more than double level) cervical degenerative disc disease (CDDD).\n* Significant cervical instability requiring additional posterior fixation\n* Cervical trauma, fracture, or spinal infection.\n* Cervical tumors or inflammatory spinal disease.\n* Severe cervical deformity (fixed kyphosis)\n* Osteoporosis or metabolic bone disease.\n* Pregnancy\n* Psychiatric illness or substance abuse that would compromise follow-up","19 Years",{"count":47,"type":20},40,"INTERVENTIONAL",[50],"NA","This study is a prospective, comparative clinical trial conducted at Assiut University Hospitals to evaluate the effectiveness of two different interbody fusion devices in patients with Cervical Degenerative Disc Disease (CDDD). The primary objective is to compare cervical cages with integrated screws against traditional stand-alone cervical cages during single or double-level Anterior Cervical Discectomy and Fusion (ACDF). While ACDF is the gold standard for CDDD, traditional cages can sometimes lead to complications like subsidence or incomplete fusion; integrated screw designs aim to provide immediate stability and reduce these risks.\n\nInvestigators will assess 40 patients over a 12-month follow-up period, focusing on primary outcomes of radiological interbody fusion using the Daniel Riew grading system.\n\nSecondary outcomes include the maintenance of cervical alignment (Ishihara Index), change in segmental angles (Cobb's method), disc height restoration, and clinical improvements in pain and function measured by the Visual Analog Scale (VAS) and Neck Disability Index (NDI). The study's rationale is to provide clearer evidence on whether screw-integrated cages offer superior radiological and clinical outcomes to help guide future surgical preferences",[53,24,54],"Cervical Cage With Screw","Anterior Cervical Discectomy and Fusion (ACDF)","NOT_YET_RECRUITING","2026-02-18",{"date":58,"type":29},"2026-02-24",{"date":60,"type":20},"2026-03-15",{"date":62,"type":20},"2027-12-30",{"name":64,"class":65},"Assiut University","OTHER",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":14,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":73,"keywords":74,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},"100545595","real-world-data-collection-on-the-synergy-disc-100545595","NCT06383949","Real World Data Collection on the Synergy Disc","Inclusion Criteria:\n\nAge 21 or above at the time of the surgery. Have had (retrospective cohort) or the decision has been made to have (prospective cohort) the Synergy Disc implanted Skeletally mature patients for reconstruction of the disc from C3-C7 following a single or multiple level discectomy for intractable radiculopathy\n\nIntractable radiculopathy and\u002For myelopathy with at least one of the following producing symptomatic nerve root and\u002For spinal cord compression:\n\nherniated disc and\u002For osteophyte formation Symptomatic nerve root and\u002For spinal cord compression documented by patient history (arm or neck pain and\u002For neurologic deficit) and imaging (CT, MRI, x-rays, etc.) Failed a minimum of 6 weeks conservative treatment Written informed consent given by subject.\n\nExclusion Criteria:\n\nModerate to advanced spondylosis Diagnosis of osteoporosis Active systemic infection or infection at the operative site Pregnancy Marked cervical instability on lateral, coronal, or flexion\u002Fextension radiographs Cervical spine condition other than symptomatic cervical disc disease requiring surgical treatment at the involved level Severe pathology of the facet joints of the involved vertebral bodies Previous diagnosis of osteopenia or osteomalacia More than one immobile vertebral level between C1 and T1 from any cause Morbid obesity Vulnerable person (pregnant patients, emergency cases, children, prisoners and people without mental capacity)-",{"count":19,"type":20},[24],[75,76,77,78],"radiculopathy","myelopathy","disc replacement","motion preservation","2026-01-08",{"date":81,"type":29},"2026-01-09",{"date":83,"type":29},"2024-08-06",{"date":85,"type":20},"2033-02-23",{"name":35,"class":36},1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":95,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":48,"phases":98,"briefSummary":99,"conditions":100,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":87},"100592582","minimally-invasive-posterior-decompression-of-the-cervical-spine-100592582","NCT06995300","Minimally Invasive Posterior Decompression of the Cervical Spine","Minimally Invasive Isolated Decompression From the Posterior Approach for Degenerative Spinal Stenosis of the Cervical Spine","Inclusion Criteria:\n\n1. Over 18 years old;\n2. Degenerative symptomatic cervical stenosis caused by posterior compression (hypertrophied ligament flavum and\u002For hypertrophied facet joints etc.) confirmed by MRI;\n3. Symptoms persisting for at least 3 months prior to surgery;\n4. Planned surgical decompression for one and more cervical level;\n5. Given written Informed Consent;\n6. Able and agree to fully comply with the clinical protocol and willing to adhere to follow-up schedule and requirements.\n\nExclusion Criteria:\n\n1. The need for anterior cervical decompression;\n2. Prior cervical fusion at any level;\n3. Any contraindication or inability to undergo baseline and\u002For follow up MRI or X-ray as required per protocol;\n4. Neck or non-radicular pain of unknown etiology;\n5. History or presence of any other major neurological disease or condition that may interfere with the study assessments;\n6. Previous enrollment in this study, current enrollment or plans to be enrolled in another study (in parallel to this study).","18 Years",{"count":97,"type":20},30,[50],"Degenerative stenosis of the cervical spinal canal may be caused by the compression of the posterior part of the dural sac and spinal cord by the hypertrophied ligamentum flavum and facet joints, by the compression of the anterior part of the dural sac and spinal cord by the posterior longitudinal ligament, vertebral osteophytes and protrusion\u002F herniation.\n\nThe choice of surgical treatment in such cases is challenging. Posterior decompression and fixation is often proposed, but it is associated with a traumatic posterior approach, a large wound, and blood loss, a high risk of surgery site infections, and also instability of the metal fixation is possible. Also important is the increase in the surgical procedure cost due to the use of metal implants. An excellent alternative to standard posterior decompression and fixation is a method with isolated decompression of the cervical canal via posterior approach, which does not require any metal fixation.",[24,101,102],"Cervical Stenosis","Posterior Spine Surgery","2025-06-12",{"date":105,"type":29},"2025-06-17",{"date":107,"type":29},"2025-05-19",{"date":109,"type":20},"2026-08",{"name":111,"class":65},"N.N. Priorov National Medical Research Center of Traumatology and Orthopedics"]