[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-disc-herniation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-disc-herniation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,51,89,129,149,169,195],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100617479","assessment-of-upper-extremity-proprioception-in-patients-with-cervical-radiculopathy-100617479",false,"NCT07319156","Assessment of Upper Extremity Proprioception in Patients With Cervical Radiculopathy","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Presence of radicular pain diagnosed through clinical examination and cervical -MRI imaging Patients with cervical MRI findings demonstrating cervical disc herniation at least at one level consistent with their symptoms\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* History of cervical physical therapy within the past year\n* Symptoms or diagnosis of upper-extremity entrapment neuropathy\n* Patients with documented vitamin B12 or vitamin D deficiency within the last 2 years in available medical records\n* History of cervical surgery or cervical trauma\n* History of upper-extremity surgery or trauma\n* Individuals with intellectual disability\n* Presence of major psychiatric comorbidity\n* Diagnosis of polyneuropathy\n* Diagnosis of Diabetes Mellitus\n* Diagnosis of fibromyalgia\n* Use of medications that may impair proprioception\n* Pregnancy\n* Refusal to provide informed consent",true,"ALL","18 Years","65 Years",{"count":20,"type":21},58,"ESTIMATED","OBSERVATIONAL","There is no study in the current literature that systematically investigates the extent of upper-extremity proprioceptive impairment in patients with radicular neuropathic symptoms secondary to cervical disc herniation, nor its association with clinical findings. Although existing reviews emphasize proprioceptive deficits in populations with neck pain or cervical spondylosis, no studies specifically address the subgroup of cervical disc-related radiculopathy. This gap in knowledge hinders the integration of proprioceptive assessments with upper-extremity functional outcome measures in diagnostic and rehabilitative processes, suggesting a need for more specific data to guide sensory-motor training approaches. The primary aim of the present study is to assess upper-extremity proprioception in patients with cervical radiculopathy by comparing them with a healthy control group. The secondary aim is to examine the relationship between upper-extremity proprioception and clinical outcomes, including parameters such as pain and functional status.",[25,26,27,28,29,30],"Cervical Radiculopathy","Proprioception","Cervical Disc Herniation","Proprioception Reaching Test","Pro-reach","Upper Extremity",[32,33,34,35,36,37],"cervical radiculopathy","proprioception","cervical disc herniation","proprioception reaching test","pro-reach","upper extremity","RECRUITING","2026-06-02",{"date":41,"type":42},"2026-06-04","ACTUAL",{"date":44,"type":42},"2025-12-20",{"date":46,"type":21},"2026-12-20",{"name":48,"class":49},"Marmara University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":50},"100493123","comparison-of-artificial-disc-implants-in-cervical-disc-arthroplasty-100493123","NCT05701059","Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty","Comparison of Unconstrained and Semi-constrained Artificial Disc Implants Used in Cervical Disc Arthroplasty","Inclusion Criteria:\n\n* Patient is skeletally mature and between 18 to 60 years of age\n* Experiences cervical spondylotic myelopathy and\u002For radiculopathy typically caused by disc herniation or degenerative disc disease at a single level between C3 to C7\n* Is unresponsive to at least six weeks of non-surgical conservative care\n* Has the intention of undergoing cervical arthroplasty for their chief complaint\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Patient has had prior cervical spine surgery\n* Has more than two diseased levels requiring surgery\n* Has a known allergy to a metal alloy or polyethylene\n* Is morbidly obese\n* Has active local or system infection\n* Has any circumstances or conditions such that their ability to provide informed consent comply with follow-up requirements, or provide self-assessments is compromised (eg: psychiatric disorders, chronic alcohol or substance abuse, etc.)","60 Years",{"count":60,"type":21},20,"This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and\u002For radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nuvasive Simplify implementing a three-piece design with two endplates and a semi-constrained mobile core while the Biomet Zimmer Mobi-C implements an unconstrained three piece design. Subjects will be age-matched and randomly assigned to either implant with informed consent. All subjects will undergo a variety of assessments that evaluate neck disability, quality of life, pain, physiological outcome (radiographic assessments), and neck range-of motion before and after their procedure. One baseline testing will be conducted along with three post-operation visits (three months, six months, and one year) in accordance to standard follow-up procedure. Thus, the duration of participation in the study will be approximately one and a half years.",[63,25,27,64],"Cervical Spondylosis With Myelopathy","Degenerative Disc Disease",[66,67,68,69,70,71,72,73,74,75,76,77,78,79],"cervical","spondylosis","myelopathy","radiculopathy","disc","cervical disc","artificial disc","artificial disc implantation","cervical arthroplasty","disc herniation","degenerative disc disease","ACDF","Biomet Zimmer Mobi-C","Nuvasive Simplify","2026-02-10",{"date":82,"type":42},"2026-02-13",{"date":84,"type":42},"2023-05-01",{"date":86,"type":21},"2026-12-01",{"name":88,"class":49},"University of California, Los Angeles",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":96,"maxAge":4,"enrollmentInfo":97,"targetDuration":99,"studyType":22,"phases":4,"briefSummary":100,"conditions":101,"keywords":111,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":50},"100617738","smartwatch-accuracy-for-measuring-vitals-and-anxiety-before-disc-surgery-100617738","NCT07322523","Smartwatch Accuracy for Measuring Vitals and Anxiety Before Disc Surgery","Validation of Smartwatch Technology for Preoperative Monitoring of Sleep Quality, Anxiety, and Vital Signs in Patients Undergoing Disc Herniation Surgery","Inclusion Criteria:\n\n* 22 years and older\n* Currently receiving preoperative care\u002Fassessment for disc herniation surgery.\n* No history of any cardiovascular disease other than controlled hypertension.\n* Willingness to wear the smartwatch for a minimum of 8 consecutive hours during the night before surgery.\n* Ability to follow all instructions related to the smartwatch operation and data collection independently.\n* No known allergy to nickel.\n\nExclusion Criteria:\n\n* Patients who are currently receiving prescribed medication specifically for sleep in the clinical setting.\n* Refusal or unwillingness to participate in the study.\n* The participant fails to wear the smartwatch correctly or appropriately as per study instructions, leading to incomplete or unreliable data collection.","22 Years",{"count":98,"type":21},60,"3 Months","This study aims to verify the accuracy of blood pressure, heart rate, blood oxygen saturation, anxiety level, and sleep cycle data measurements obtained from Samsung smartwatches compared to the currently accepted method used in patients with disc herniation undergoing the preoperative period.",[102,103,27,104,105,106,107,108,109,110],"Disc Herniations","Disc Herniation, Lumbar","Preoperative Anxiety Score","Sleep Quality","Preoperative Care","Vital Signs Monitoring","Smart Watch","Wearable Devices","Surgical Nursing",[112,113,114,115,116,117,118,119],"Disc herniations","wearable devices","smart watch","vital signs monitoring","sleep quality","anxiety","surgical nursing,","preoperative","2025-12-22",{"date":122,"type":42},"2026-01-07",{"date":124,"type":42},"2025-11-01",{"date":126,"type":21},"2026-03-30",{"name":128,"class":49},"Halil Kalaycı",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":136,"minAge":17,"maxAge":18,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":50},"100614663","sensory-and-functional-impairments-in-cervical-disc-herniation-100614663","NCT07282522","Sensory and Functional Impairments in Cervical Disc Herniation","Investigation of Somatosensory Perception, Pain, Kinesiophobia, and Upper Extremity Functional Skills in Cervical Disc Herniation: A Case-Control Study","Inclusion criteria for volunteers in the study: Neck pain lasting at least 3 months, Being between the ages of 18-65 with a diagnosis of cervical disc herniation, Being able to cooperate with the applied parameters, Having good cognitive function, Being literate, Agreeing to participate in the study.\n\nFor the control group, having no complaints of neck pain and not having any neck-related diagnosis.\n\nExclusion criteria for volunteers in the study: Neck pain intensity during activity according to the Visual Analog Scale (VAS) below 3, Individuals who have undergone any surgery related to neck problems, Individuals who have undergone surgery related to upper extremity problems, Individuals with cervical radiculopathy, Having a systemic malignant disease anywhere in the body, Having any disease related to connective tissue or inflammatory rheumatic diseases, Having a psychiatric diagnosis and receiving treatment, Being illiterate, Not having sufficient cognitive function, Having received any neck-related physical therapy in the last 6 months for the CBA group.","FEMALE",{"count":138,"type":21},64,"The aim of the study was to evaluate the levels of somatosensory perception, pain threshold and kinesiophobia in individuals with SDH, to examine their relationship with upper extremity functional skills and to compare them with healthy individuals.",[27],"2025-12-15",{"date":120,"type":42},{"date":144,"type":42},"2025-10-24",{"date":146,"type":21},"2026-03-12",{"name":148,"class":49},"Inonu University",{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":17,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":159,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":4},"100582002","functional-outcome-after-surgery-for-cervical-disc-prolapse-100582002","NCT06857643","Functional Outcome After Surgery for Cervical Disc Prolapse","Inclusion Criteria:\n\n* Patients with degenerative cervical disc prolapse.\n\nExclusion Criteria:\n\n* Traumatic Cervical disc prolapse\n* Patients with ossification of the posterior longitudinal ligament (OPLL)",{"count":156,"type":21},30,"Cervical disc herniation (CDH) is the result of the displacement of the nucleus pulposus of the intervertebral disc, which may result in impingement of the traversing nerves as they exit the neural foramen or directly compressing the spinal cord contained within the spinal canal.\\[1\\] Eventually symptoms may arise because of a CDH with compression of the rootlet or spinal cord.\\[2\\] When conservative treatment for CDH fails, surgical treatment may be considered.\\[3\\] The main goals of surgical treatment are to remove pressure from the nerves, restore the alignment of the vertebrae, to stabilize the spine \\[3\\] and to prevent progression of neurological deficit in case of myelopathy.\\[4\\] Anterior cervical discectomy and fusion (ACDF) has proven to be an effective surgical intervention for both cervical radiculopathy and myelopathy and has become standard treatment for both of these disease states over the last half century.\\[5\\] Certain reports have indicated that various complications are associated with ACDF namely, incomplete decompression, recurrence of myelopathy due to adjacent segment degeneration.\\[6\\] In cases where the stenosis is extensive, or attributed in part to congenital stenosis, the posterior approach may be advantageous to achieve more extensive decompression that would otherwise not be possible through an anterior approach.\\[7\\] Given that most stenosis occurs from anterior pathology, a posterior decompression works to indirectly relieve pressure on the spinal cord.\\[8\\] Misalignment and large anterior compression of the spinal cord can be risk factors for insufficient functional recovery in patients treated with posterior decompression alone.\\[9\\] In this study we will perform ACDF for patients with CDH occupying less than 50% of cervical canal and combined posterior laminectomy and ACDF for patients with CDH occupying 50% or more of the cervical canal with canal stenosis.Cervical disc herniation (CDH) is the result of the displacement of the nucleus pulposus of the intervertebral disc, which may result in impingement of the traversing nerves as they exit the neural foramen or directly compressing the spinal cord contained within the spinal canal.\\[1\\] Eventually symptoms may arise because of a CDH with compression of the rootlet or spinal cord.\\[2\\] When conservative treatment for CDH fails, surgical treatment may be considered.\\[3\\] The main goals of surgical treatment are to remove pressure from the nerves, restore the alignment of the vertebrae, to stabilize the spine \\[3\\] and to prevent progression of neurological deficit in case of myelopathy.\\[4\\] Anterior cervical discectomy and fusion (ACDF) has proven to be an effective surgical intervention for both cervical radiculopathy and myelopathy and has become standard treatment for both of these disease states over the last half century.\\[5\\] Certain reports have indicated that various complications are associated with ACDF namely, incomplete decompression, recurrence of myelopathy due to adjacent segment degeneration.\\[6\\] In cases where the stenosis is extensive, or attributed in part to congenital stenosis, the posterior approach may be advantageous to achieve more extensive decompression that would otherwise not be possible through an anterior approach.\\[7\\] Given that most stenosis occurs from anterior pathology, a posterior decompression works to indirectly relieve pressure on the spinal cord.\\[8\\] Misalignment and large anterior compression of the spinal cord can be risk factors for insufficient functional recovery in patients treated with posterior decompression alone.\\[9\\] In this study we will perform ACDF for patients with CDH occupying less than 50% of cervical canal and combined posterior laminectomy and ACDF for patients with CDH occupying 50% or more of the cervical canal with canal stenosis.\n\nthe aim of the study to Assessment of the functional outcome after surgery for cervical disc prolapse",[27],"NOT_YET_RECRUITING","2025-02-27",{"date":162,"type":42},"2025-03-04",{"date":164,"type":21},"2025-03-01",{"date":166,"type":21},"2026-05-01",{"name":168,"class":49},"Assiut University",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":176,"targetDuration":4,"studyType":178,"phases":179,"briefSummary":181,"conditions":182,"keywords":183,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":50},"100556532","the-effect-of-tendon-release-techniques-in-patients-with-cervical-disc-herniation-100556532","NCT06526325","The Effect of Tendon Release Techniques in Patients With Cervical Disc Herniation","The Effect of Improved Golgi Tendon Organ Stimulation From Tendon Relaxation Techniques on Pain, Range of Motion, Functionality, Endurance and Quality of Life in Patients With Cervical Disc Herniation","Inclusion Criteria:\n\n* Being diagnosed with cervical disc herniation\n* Volunteering for the research\n\nExclusion Criteria:\n\n* Chronic bone disease\n* Have had surgery for a cervical disc herniation\n* Have a structural abnormality",{"count":177,"type":21},51,"INTERVENTIONAL",[180],"NA","The goal of this clinical trial is to investigate the effect of using enhanced golgi tendon organ stimulation on symptoms in patients with cervical disc herniation. The main question\\[s\\] it aims to answer are:\n\n* Enhanced Golgi tendon organ stimulation is effective in reducing symptoms in patients with cervical disc herniation.\n* Enhanced golgi tendon organ stimulation is not effective in reducing symptoms in patients with cervical disc herniation.\n\nParticipants will receive enhanced golgi tendon organ stimulation to the Sternocleidomastoideus, platysma, longus colli, longus capitis, scalene, rhomboid major \\& minor, levator scapulae and trapezius muscles for 3 weeks, 2 sessions per week for 45 minutes.",[27],[75,184,185,66],"enhanced golgi tendon organ stimulation","pain","2024-07-29",{"date":188,"type":42},"2024-07-31",{"date":190,"type":42},"2024-02-19",{"date":192,"type":21},"2024-08-19",{"name":194,"class":49},"Istanbul Arel University",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":178,"phases":205,"briefSummary":206,"conditions":207,"keywords":226,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":50},"100410368","cervical-arthroplasty-cost-effectiveness-study-caces-100410368","NCT04623593","Cervical Arthroplasty Cost Effectiveness Study (CACES)","Economic Evaluation of Anterior Cervical Discectomy With Arthroplasty Versus Anterior Cervical Discectomy With Fusion in the Surgical Treatment of Cervical Degenerative Disc Disease, a Randomized Controlled Trial","CACES","Inclusion Criteria:\n\n* Indication for anterior cervical decompression surgery.\n* Single- or multilevel CDDD between C3 and C7.\n* Symptoms of myelopathy, radiculopathy, or myeloradiculopathy.\n* In case of pure radiculopathy: refractory to at least 6 weeks of conservative therapy.\n* In case of myelopathy: symptomatic myelopathy.\n* Patients ≥ 18 years of age.\n\nExclusion criteria\n\n* Indication for (additional) posterior surgical approach.\n* Indication for additional stabilization of the pathological segment by a plate.\n* Previous ventral surgery of the cervical spine.\n* Traumatic origin of the compression.\n* Previous radiotherapy of the cervical spine.\n* Metabolic bone disease.\n* Inflammatory spinal disease: e.g., Bechterew's disease, Forestier's disease.\n* Infection of the cervical spine.",{"count":204,"type":21},198,[180],"To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD). The most commonly used surgical treatment for patients with single- or multilevel symptomatic CDDD is anterior cervical discectomy with fusion (ACDF). However, new complaints of radiculopathy and\u002For myelopathy commonly develop at adjacent levels, also known as clinical adjacent segment pathology (CASP). It remains unknown to what extent kinematics, surgery-induced fusion and natural history of disease play a role in its development. Anterior cervical discectomy with arthroplasty (ACDA) is thought to reduce the incidence of CASP by preserving motion in the operated segment. ACDA is often discouraged as the implant costs are higher whilst the clinical outcomes are similar to ACDF. However, preventing CASP might be a reason for ACDA to be a more cost-effective technique in the long-term.\n\nIn this randomized controlled trial patients will be randomized to receive ACDF or ACDA in a 1:1 ratio. Adult patients with single- or multi-level CDDD and symptoms of radiculopathy and\u002For myelopathy will be included. The primary outcome is cost-effectiveness and cost-utility of both techniques from a societal perspective. Secondary objectives are the differences in clinical and radiological outcomes between the two techniques, as well as the qualitative process surrounding anterior decompression surgery. All outcomes will be measured at baseline and every 6 months till 4 years postoperatively.\n\nHigh quality evidence regarding the cost-effectiveness of both ACDA and ACDF is lacking, to date no prospective trials from a societal perspective exist. Considering the ageing of the population and the rising healthcare costs, the need for a solid clinical cost-effectiveness trial addressing this question is high.",[208,209,210,211,212,213,214,215,216,27,217,218,219,220,221,222,223,224,225],"Radiculopathy, Cervical","Myelopathy Cervical","Myelopathy, Compressive","Radiculopathy, Cervical Region","Radiculopathy; in Spondylosis","Radiculopathy; in Intervertebral Disc Disorder","Myelopathy Neurological","Myelopathy Due to Spondylosis","Cervical Disc Disease","Cervical Disc Degeneration","Cervical Disc Disorder With Myelopathy","Cervical Disc Prolapse With Myelopathy","Cervical Spondylosis","Cervical Fusion","Cervical Disc Disorder With Radiculopathy","Cervical Disc Prolapse With Radiculopathy","Fusion of Spine","Disc Prolapse Cervical",[227,228,229,230,231,232,77,233,234,235,236,237,238,239],"Cost-effectivity","Economic evaluation","Health Utility","Randomised controlled trial","RCT","ACDA","Anterior cervical discectomy and fusion","Anterior cervical discectomy with arthroplasty","Degenerative cervical myelopathy","Degenerative cervical radiculopathy","ASD","Adjacent Segment Disease","Adjacent Level Disease","2024-01-24",{"date":242,"type":42},"2024-01-25",{"date":244,"type":42},"2022-01-17",{"date":246,"type":21},"2028-06-01",{"name":248,"class":49},"Valérie Schuermans"]