[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-spinal-cord-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-spinal-cord-injury":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,46,82,110,146,172,210,231,252,281,308,333,354,376,412,438,458,480,509,536,561,586],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100555426","feasibility-of-the-braingate2-neural-interface-system-in-persons-with-tetraplegia-bg-tablet-01-100555426",false,"NCT06511934","Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)","Intuitive, Complete Neural Control of Tablet Computers for Communication","BG-Tablet-01","Inclusion Criteria:\n\n* Clinical diagnosis of spinal cord injury, brainstem stroke, muscular dystrophy, amyotrophic lateral sclerosis or other motor neuron disorders\n* Complete or incomplete tetraplegia (quadriplegia)\n* Must live within a three-hour drive of the Study site\n* Prior enrollment in BrainGate2 clinical trial (NCT00912041)\n\nExclusion Criteria:\n\n* Visual impairment such that extended viewing of a computer monitor would be difficult even with ordinary corrective lenses\n* Chronic oral or intravenous steroids or immunosuppressive therapy\n* Other serious disease or disorder that could seriously affect ability to participate in the study\n\n(There are additional exclusion criteria)","ALL","18 Years","80 Years",{"count":21,"type":22},6,"ESTIMATED","INTERVENTIONAL",[25],"NA","People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert. In this project, the investigators seek to further translate knowledge about interpreting brain signals related to movement, and to further develop an intracortical brain-computer interface (iBCI) that could restore rapid and intuitive use of communication apps on tablet computers by people with paralysis.",[28,29,30,31,32],"Brainstem Stroke","ALS","Tetraplegia","Spinal Cord Injuries","Cervical Spinal Cord Injury","RECRUITING","2026-06-22",{"date":36,"type":37},"2026-06-25","ACTUAL",{"date":39,"type":37},"2024-07-22",{"date":41,"type":22},"2027-07-30",{"name":43,"class":44},"Leigh R. Hochberg, MD, PhD.","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100451833","early-phase-1-spinal-cord-associative-plasticity-study-100451833","NCT05163639","Spinal Cord Associative Plasticity Study","SCAP","NON-INVASIVE\n\nInclusion Criteria:\n\n(All participants)\n\n* Age between 18-80 years.\n* Must have stable prescription medication for 30 days prior to screening\n* Must be able to: abstain from alcohol, smoking and caffeine consumption on the day of each experiment; abstain from recreational drugs for the entirety of the study; commit to study requirements (i.e., 7 visits); provide informed consent.\n\n(Able-bodied participants)\n\n* No known central or peripheral neurological disease or injury.\n\n(SCI participants - including patients scheduled for intraoperative procedures)\n\n* Score of 1-4 (out of 5) on manual muscle testing of finger extension, finger flexion, or finger abduction in left or right hand.\n\nExclusion criteria:\n\n(All participants)\n\n* Personal or extensive family history of seizures;\n* Ventilator dependence or patent tracheostomy site;\n* Use of medications that significantly lower seizure threshold, such as amphetamines, neuroleptics, dalfampridine, and bupropion;\n* History of stroke, brain tumor, brain abscess, or multiple sclerosis;\n* History of moderate or severe head trauma (loss of consciousness for greater than one hour or evidence of brain contusion or hemorrhage or depressed skull fracture on prior imaging);\n* History of implanted brain\u002Fspine\u002Fnerve stimulators, aneurysm clips, ferromagnetic metallic implants in the head (except for inside mouth); cochlear implants; cardiac pacemaker\u002Fdefibrillator; intracardiac lines; currently increased intracranial pressure; or other contraindications to brain or spine stimulation;\n* Significant coronary artery or cardiac conduction disease; recent history of myocardial infarction and heart failure with an ejection fraction of less than 30% or with a New York Heart Association Functional Classification of Class III or IV;\n* Recent history (within past 6 months) of recurrent autonomic dysreflexia, defined as a syndrome of sudden rise in systolic pressure greater than 20 mm Hg or diastolic pressure greater than 10 mm Hg, without rise in heart rate, accompanied by symptoms such as headache, facial flushing, sweating, nasal congestion, and blurry vision (this will be closely monitored during all screening and testing procedures);\n* History of significant hearing problems;\n* History of bipolar disorder;\n* History of suicide attempt;\n* Active psychosis;\n* Recent history (\\>1 year) of chemical substance dependency or significant psychosocial disturbance;\n* Heavy alcohol consumption (greater than equivalent of 5oz of liquor) within previous 48 hours;\n* Open skin lesions over the face, neck, shoulders, or arms;\n* Pregnancy; and\n* Unsuitable for study participation as determined by study physician.\n\nINTRA-OPERATIVE\n\nInclusion Criteria:\n\n* Clinical indication for cervical spine surgery.\n\nExclusion criteria:\n\n(For experiments involving cortical stimulation)\n\n* Epilepsy;\n* A history of skull surgery with metal implants;\n* Cochlear implants;\n* Patients with aneurysm stents in neck or brain blood vessels;\n* Evidence of skull shrapnel; (For experiments involving spinal cord stimulation)\n* Stimulation devices in the neck or chest (e.g., vagal nerve stimulation, cardiac patients with pacemakers)",true,{"count":55,"type":22},92,[57],"EARLY_PHASE1","Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury.\n\nThe proposed study will advance understanding of SCAP, which is critical to its effective translation to human therapy. The purpose of the study is to:\n\n1. Determine whether signaling through the spinal cord to the muscles can be strengthened by electrical stimulation.\n2. Improve our understanding of the spinal cord and how it produces movement.\n3. Determine whether spinal surgery to relieve pressure on the spinal cord can improve its function.\n\nAim 1 is designed to advance mechanistic understanding of spinal cord associative plasticity (SCAP).\n\nAim 2 will determine whether SCAP increases spinal cord excitability after the period of repetitive pairing. In rats, SCAP augments muscle activation for hours after just 5 minutes of paired stimuli.\n\nWhereas Aims 1 and 2 focused on the effects of paired stimulation in the context of uninjured spinal cord, Aim 3 assesses whether paired stimulation can be effective across injured cord segments. Aim 3 will incorporate the experiments from Aim 1 and 2 but in people with SCI, either traumatic or pre-operative patients with myelopathy in non-invasive experiments, or targeting myelopathic segments in intraoperative segments.",[32,60,61],"Tetraplegia\u002FTetraparesis","Cervical Myelopathy",[63,64,65,66,67,68,69,70,71],"spinal cord injury","paired brain and spinal cord stimulation","convergent stimulation","spinal cord associative plasticity","transcutaneous spinal cord stimulation","intraoperative monitoring","upper-limb muscle activation","motor cortex","cervical spinal cord","2026-06-16",{"date":74,"type":37},"2026-06-18",{"date":76,"type":37},"2021-09-10",{"date":78,"type":22},"2027-12-30",{"name":80,"class":44},"Columbia University",3,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":45},"100642898","low-volume-nose-resistance-breathing-exercise-with-incentive-spirometer-in-patient-with-cervical-spinal-cord-injuries-100642898","NCT07645027","Low Volume Nose Resistance Breathing Exercise With Incentive Spirometer in Patient With Cervical Spinal Cord Injuries","Effect of Low Volume Nose Resistance Breathing Exercise With Incentive Spirometer on Pulmonary Function Test, Dyspnea, Cough and Sputum in Patient With Cervical Spinal Cord Injuries","Inclusion Criteria:\n\n* Diagonosed cervical spine injury C4-C7\n* Age 18-38 years\n* Undergoing in-patient rehabilitation\n* No previous history of severe pulmonary disease\n* Disease duration \\\u003C1 year\n* Ability to give informed consent\n* Road Accident\n\nExclusion Criteria:\n\n* Uncontrolled hypertension\n* Other Neuromuscular disease\n* Stage 3-4 pressure wound\n* Clinical instability\n* Traumatic Brain injury","38 Years",{"count":91,"type":22},42,[25],"This randomized clinical trial aims to evaluate the effectiveness of combining Low Volume Nose Resistance Breathing Exercises (LVNRBE) with Incentive Spirometry (IS) on respiratory outcomes in patients with cervical spinal cord injury (SCI). Respiratory complications are a major concern in cervical SCI due to impaired respiratory muscle function, leading to reduced lung volumes, dyspnea, ineffective cough, and sputum retention. The study will recruit 42 inpatients aged 18-38 years with cervical SCI (C4-C7), randomly divided into two groups: Data Analysis: Statistical tests (paired and independent t-tests) will determine intra- and intergroup differences using SPSS v25, with significance set at p \\\u003C 0.05.\n\n* Group A (Intervention): Receives LVNRBE using an Acapella device plus IS for 20 minutes, three times daily, five days a week for four weeks.\n* Group B (Control): Receives conventional respiratory physiotherapy with the same frequency and duration.\n\nOutcomes will be assessed pre- and post-intervention using:\n\n* Pulmonary Function Tests (FVC, FEV1),\n* Modified Borg Dyspnea Scale,\n* Cough Frequency Scale,\n* Sputum Grading Scale.",[32,95],"Cervical Cord Injuries Spinal",[97,98,99,100],"Cervical cord injury","Dyspnea","Incentive spirometer","Low volume nose resistance breathing exercise","2026-06-08",{"date":103,"type":37},"2026-06-12",{"date":105,"type":37},"2026-05-01",{"date":107,"type":22},"2026-08-01",{"name":109,"class":44},"Riphah International University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":116,"enrollmentInfo":117,"targetDuration":119,"studyType":120,"phases":4,"briefSummary":121,"conditions":122,"keywords":129,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":145},"100488290","nerve-transfer-surgery-to-restore-upper-limb-function-after-cervical-spinal-cord-injury-100488290","NCT05638191","Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury","Inclusion Criteria:\n\n* Traumatic, motor-complete cervical SCI (AIS A or B)\n* Male or female, ages 18-70\n* Consent and plan to undergo nerve transfer to restore grasp function in at least one limb\n* Motor grade 4-5 at C5\n* Motor grade 0-1 at C8\u002FT1\n* Injury duration within 6 months at the time of surgery\n* English-speaking and cognitively intact\n* Able to provide informed written consent\n* Able to attend and comply with the testing protocols\n\nExclusion Criteria:\n\n* Inability or unwillingness to participate in post-operative rehabilitation (in person or virtual)\n* Secondary complication of SCI (e.g., intractable neuropathic pain, edema, contracture) or major medical comorbidity (e.g., traumatic brain injury) that would independently influence response to surgery or ability to participate in rehabilitation","70 Years",{"count":118,"type":22},40,"2 Years","OBSERVATIONAL","The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function. The main questions it aims to answer are:\n\n* Does nerve transfer improve hand function in individuals with cervical spinal cord injury?\n* What factors are associated with functional improvement following nerve transfer? Researchers will compare functional outcomes at 24 months post-surgery to 1) baseline outcomes and 2) individuals with cervical spinal cord injury who did not undergo nerve transfer.\n\nParticipants who have received nerve transfer surgery as part of their regular medical care will complete functional hand tests, electrodiagnostic assessments, and questionnaires on independence and mood every 3 months for 24 months after surgery.",[123,124,125,126,127,30,128,32],"Spinal Cord Injury","Spinal Cord Injury at C5-C7 Level","SCI - Spinal Cord Injury","Upper Extremity Paralysis","Upper Extremity Dysfunction","Upper Extremity Paresis",[63,130,131,132,133,134,135],"upper extremity nerve transfer","nerve transfer","SCI","nerve reconstruction","quadriplegia","paresis","2026-05-27",{"date":138,"type":37},"2026-05-29",{"date":140,"type":37},"2021-06-03",{"date":142,"type":22},"2028-01",{"name":144,"class":44},"University of British Columbia",4,{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":23,"phases":156,"briefSummary":157,"conditions":158,"keywords":159,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":45},"100490428","brain-controlled-spinal-cord-stimulation-in-participants-with-cervical-spinal-cord-injury-for-upper-limb-rehabilitation-100490428","NCT05665998","Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation","Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation (UP2)","UP2","* Must provide Informed Consent as documented by signature (Appendix Informed Consent Form),\n* Must be at least 18 years old and no older than 75 years old at the time of enrolment,\n* Must be suffering from non-progressive traumatic cervical spinal cord injury,\n* Must be graded A, B, C, or D in the American Spinal Injury Association (ASIA) Impairment Scale (AIS) classification,\n* Must have completed primary standard of care rehabilitation,\n* Must be severely impaired in his upper limb function as determined by the investigator,\n* Must have sustained the injury at least 6 months before signing the consent form,\n* Must be able to understand and interact with the study team in French or English,\n* Must agree to comply in good faith with all conditions of the study and to attend all scheduled appointments,\n* Must use safe contraception for women of childbearing capacity,\n* Must not be pregnant nor breast feeding,\n* Must not have history of severe autonomic dysreflexia,\n* Must not have brain damage,\n* Must not have history of epilepsy,\n* Must not have spinal stenosis,\n* Must not have gastrointestinal ulcers in the last five years,\n* Must not have any psychological disorder,\n* Must not have the intention to become pregnant during the course of the study,\n* Must not be known or suspected of drug or alcohol abuse,\n* Must not have participated in another clinical study using drugs or medical devices within the 30 days preceding and during the present study,\n* Must not have previously been injected with stem cells in the spinal cord,\n* Must not be the investigator himself, his\u002Fher family members, employees or other dependent persons,\n* Must not have any unstable or significant medical condition that is likely to interfere with study procedures or likely to confound study endpoint evaluations as determined by the Investigator,\n* Must not have any hematological disorders with increased risk for surgical intervention,\n* Must not require ventilator support,\n* Must not suffer from spinal cord injury from other etiology than traumatic (ischemic, tumoral, autoimmune, etc),\n* Must not be subject to spasms that limit the ability of the subject to participate in the study training as determined by the investigator,\n* Must not display spinal stenosis or post traumatic damage at location of implantation,\n* Must not require the use of an intrathecal baclofen pump,\n* Must not be implanted with a device such as pacemakers or defibrillators,\n* Must not have any indication that would require an MRI,\n* Must not suffer from congenital nor acquired upper limb abnormalities (affection of joints or bones).","75 Years",{"count":81,"type":22},[25],"Cervical spinal cord stimulation can elicit arm and hand movements through recruitment of proprioceptive neurons in the dorsal roots. In participants with cervical spinal cord injury, the spare roots bellow the lesion can be used to reactivate motor function. Decoding of motor intentions can be achieved through implantable electrocorticography (ECoG) devices.\n\nIn this study, the investigators will use an investigational system using ECoG signal recording over the motor cortex to drive muscle specific electrical epidural spinal cord stimulation (EES). The investigators will assess the safety and preliminary efficacy of this system in 3 participants.",[32,30],[160,161,162],"Spinal cord stimulation","Brain computer interface","Brain spine interface","2026-04-20",{"date":165,"type":37},"2026-04-23",{"date":167,"type":37},"2023-05-22",{"date":169,"type":22},"2026-12-31",{"name":171,"class":44},"Ecole Polytechnique Fédérale de Lausanne",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":17,"minAge":180,"maxAge":154,"enrollmentInfo":181,"targetDuration":4,"studyType":23,"phases":183,"briefSummary":184,"conditions":185,"keywords":190,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":81},"100620423","connect-one-early-feasibility-study-of-connexus-brain-computer-interface-bci-100620423","NCT07357428","Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)","Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI) to Provide Human Connection Through Communication","CONNECT-ONE","Inclusion Criteria:\n\n* Clinical diagnosis of a progressive neuromuscular disease or a neurological injury.\n* Clinical diagnosis of anarthria or severe dysarthria.\n* Wheelchair dependent with severely impaired upper limb function.\n* Has a reliable method of communication and the ability to read and understand the English language.\n* Has a study care partner (e.g. caregiver or multiple caregivers) for the duration of the study.\n* Lives within a 4-hour radius of a study site.\n\nExclusion Criteria:\n\n* Cognitive impairment or psychiatric illness that could impact the ability to comply with study requirements, as determined by the Study Investigator.\n* Co-morbidities or an ongoing chronic medical condition that would impair the ability to comply with study requirements.\n* The presence of another implanted device, like a pacemaker, deep brain stimulator, or implantable pulse generator.\n* Requires, or is expected to require regular MRI scans for on-going medical conditions.\n* In the opinion of the Study Investigator, the patient is not an appropriate candidate for the study, for reasons that could place the patient at undue risk or otherwise result in non-compliance with the study requirements.","22 Years",{"count":182,"type":22},2,[25],"The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI). The Connexus BCI is intended to be used as: (1) an assistive communication device to decode imagined language correlates and speech for patients with impaired communication as a result of severe loss of voluntary motor control; and (2) to provide control of computer devices for individuals with severe loss of voluntary motor control of the upper extremity.",[186,187,188,60,32,189],"Amyotrophic Lateral Sclerosis","Neuromuscular Disease","Stroke","Dysarthria",[191,29,192,193,194,195,196,197,198,199,200],"BCI","Paradromics","speech","dysarthria","neural injury","progressive neuromuscular disease","stroke","assistive technology","communication device","brain computer interface","2026-04-09",{"date":203,"type":37},"2026-04-14",{"date":205,"type":37},"2026-03-31",{"date":207,"type":22},"2032-01",{"name":192,"class":209},"INDUSTRY",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":53,"sex":17,"minAge":180,"maxAge":216,"enrollmentInfo":217,"targetDuration":4,"studyType":23,"phases":219,"briefSummary":220,"conditions":221,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":45},"100533394","augmenting-rehabilitation-outcomes-and-functional-neuroplasticity-using-epidural-stimulation-of-cervical-spinal-cord-100533394","NCT06225245","Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord","Inclusion Criteria:\n\n* All participants must provide a signed and dated informed consent form.\n* Stated willingness to comply with all study procedures and availability for the duration of the study.\n* Male or female aged 22 - 65 years old.\n* Must provide documentation from personal primary treating physician that reports stable medical condition.\n* Able to passively range bilateral upper extremities within normal mobility parameters including:\n\n  * greater than 90 degrees of shoulder flexion and 20 degrees of shoulder extension;\n  * greater than 120 degrees of elbow flexion and reach elbow extension of approximately 150 degrees;\n  * neutral wrist position reaching a minimum of 70 degrees of movement (between flexion and extension;\n  * ability to passively flex and extend fingers.\n* Maintain current oral anti-spasticity regimen\u002Fdosage as approved by study physician with no change in regular use that may affect study outcomes.\n* Six (6) months to 20 years post spinal cord injury.\n* Non-progressive spinal cord injury.\n* Chronic SCI with neurologic level of injury as defined by ISNCSCI AIS A, B, or C.\n* Neurological level of injury above T2.\n* Eligible for fMRI per safety questionnaire.\n* Women of childbearing potential must agree to the use of an effective means of avoiding pregnancy for the duration of the study.\n\nExclusion Criteria:\n\n* Currently involved in another rehabilitation training study.\n* Lower motor neuron injury revealed in the upper limbs.\n* Stabilization hardware in the cervical spine, preventing implantation of ESS system.\n* Active pressure sores, wounds, unhealed bone fractures, peripheral neuropathies, or painful musculoskeletal dysfunction (including contractures in the upper and lower extremities).\n* Any ongoing medical condition which would preclude participant from regular physical activity (including but not limited to: ventilator dependence, cardiopulmonary disease, uncontrollable autonomic dysreflexia or orthostatic hypotension, active urinary tract infections, pregnant or nursing).\n* Intrathecal baclofen pump therapy for spasticity.\n* Must not have received Botox injections to primary lower extremity and trunk musculature within the past 3 months which would result in absence of muscle tone and thus preclude response to electrical stimulation therapy.\n* Current or history of neuromuscular conditions (including but not limited to: unhealed ligament of muscular tears in the upper or lower extremities, pain in weight bearing positions for upper and lower extremities).\n* Clinically significant depression, psychiatric disorders, or ongoing drug abuse.\n* Any reason the PI or treating physician may deem as harmful to the participant or inappropriate for the participant to enroll or continue in the study.\n* Body Mass Index (BMI) over 30.\n* Pregnancy.","65 Years",{"count":218,"type":22},12,[25],"The goal of this study is to investigate the effects of cervical epidural spinal stimulation with upper extremity training.\n\nThis is an investigational study. The device used for epidural spinal stimulation (ESS) to deliver spinal stimulation is called the CoverEdgeX 32 Surgical Lead system. This device is approved by the Food and Drug Administration (FDA) for the treatment of severe pain and to manage chronic pain when other treatments have not been effective. In this study, the device is considered an investigational device because it is not approved for use in the treatment of spinal cord injury",[31,32],"2026-04-07",{"date":224,"type":37},"2026-04-08",{"date":226,"type":37},"2024-08-06",{"date":228,"type":22},"2027-01-01",{"name":230,"class":44},"The Methodist Hospital Research Institute",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":239,"targetDuration":4,"studyType":23,"phases":241,"briefSummary":242,"conditions":243,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":45},"100573232","spinal-stimulation-for-upper-extremity-recovery-in-the-home-100573232","NCT06743607","Spinal Stimulation for Upper Extremity Recovery in the Home","Spinal Stimulation to Improve Upper Extremity Recovery in the Home (SSTIM UE Recover [SURe])","SURe","Inclusion Criteria:\n\n* Age 18 or older\n* History of traumatic SCI\n* Less than 12 months post SCI\n* SCI injury level C1-C8\n* SCI categorized as AIS B-D\n* Have passive range of motion (ROM) within functional limits at wrists, shoulders, and elbows\n* Have caregiver support to attend three in-person sessions and ongoing training at home\n* Have a caregiver who, in the judgment of the research team, is qualified to assist the participant in the safe use of TSS\n* Able to complete in-person training sessions and return to Craig Hospital for assessments\n* Experience no complicating physical or cognitive conditions as determined by their physician that would preclude the safe use of electrical stimulation\n* If using prescribed anti-spasticity medications, must be at a stable dose for at least four weeks prior to starting study procedures\n* Agrees to comply with investigational devices instructions for use, protocol visits, and return of the device\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Experience unstable chronic cardiac or respiratory complaints\n* Have a recent history of fracture, contractures, or skin pressure injuries that might interfere with the intervention\n* Received Botox injections to the UEs, neck, or hands within the last three months\n* Pregnant, planning to become pregnant, or currently breastfeeding\n* Have breakdown in skin area that will come into contact with electrodes\n* Prior nerve or tendon transfer procedure for the UEs\n* Concurrently are participating in another drug or device trial that may interfere with this study\n* Have an implanted pacemaker, spinal cord stimulator, ventriculoperitoneal shunt, deep brain stimulator, or intrathecal pump\n* In the opinion of the investigators, the study is not safe or appropriate for the participant",{"count":240,"type":22},46,[25],"The purpose of this research is to evaluate the safety, feasibility, and tolerability of non-invasive spinal stimulation used in the home and\u002For community in combination with a functional home exercise program for the upper extremities (arm\u002Fhand function) as well as their combined impacts on changes in upper extremity function. The expected duration of participation in this study is about 31-33 hours over a 13-25-week period. Enrollees in this study will be randomly assigned to one of two groups: 1) upper extremity functional task-specific training combined with non-invasive transcutaneous spinal stimulation, or 2) waitlist control, which involves the same intervention, but with a 12-week delayed start. Participants complete initial testing (one time if in group one and three times \\[at weeks 0, 8, and 12\\] if in group two), 24 1-hour training sessions (2x\u002Fweek in home with caregiver\u002Fcompanion support and 1x\u002Fweek with research team in person or via video conference for 8 weeks), a post-treatment evaluation, and a final evaluation (4 weeks after post-treatment).",[32],"2026-03-26",{"date":205,"type":37},{"date":247,"type":37},"2025-05-28",{"date":249,"type":22},"2027-08",{"name":251,"class":44},"Craig Hospital",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":259,"targetDuration":4,"studyType":120,"phases":4,"briefSummary":261,"conditions":262,"keywords":263,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":280},"100538279","nerve-transfer-to-improve-function-in-high-level-tetraplegia-100538279","NCT06288763","Nerve Transfer to Improve Function in High Level Tetraplegia","Nerve Transfer to Restore Upper Limb Function and Quality of Life in High Tetraplegia","Inclusion Criteria:\n\n* 18-80 years of age\n* High cervical SCI (motor level C1-C4)\n* Motor complete SCI AIS grade A-B\n* Plateaued spontaneous recovery for at least 6 months of non-operative therapy\n* SCI greater than 6 months and fewer than 60 months since injury\n* At least MRC 4\u002F5 donor strength\n* Mentally and physically willing and able to comply with evaluations\n\nExclusion Criteria:\n\n* Active infection at the operative site or systemic infection\n* Any return or ongoing recovery of distal motor function\n* Significant joint contractures and\u002For limitations in passive range of motion in the arm\n* Mentally or physically compromised making it impossible to complete study activities\n* Immunologically suppressed\n* Currently undergoing long-term steroid therapy\n* Active malignancy\n* Pregnancy",{"count":260,"type":22},30,"The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.\n\nParticipants will:\n\n* undergo standard of care pre- and post-op testing and study exams\n* complete pre- and post-questionnaires\n* undergo standard of care nerve transfer surgeries\n* follow-up with surgeon at 6\u002F12\u002F18\u002F24\u002F36 and potentially at 48 months\n* attend therapy at local therapist for up to 2 years postop.",[32,30],[123,264,265,266,267,30,268,269,270],"Cervical spinal cord injury","Nerve Transfer Surgery","High Cervical Spinal Cord Injury","Cervical SCI","Quadriplegia","Nerve transfer","Spinal Accessory Nerve","2026-03-10",{"date":273,"type":37},"2026-03-11",{"date":275,"type":37},"2024-02-05",{"date":277,"type":22},"2028-12-31",{"name":279,"class":44},"Washington University School of Medicine",10,{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":11,"sex":17,"minAge":180,"maxAge":154,"enrollmentInfo":289,"targetDuration":4,"studyType":23,"phases":291,"briefSummary":292,"conditions":293,"keywords":296,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":182},"100549109","precise-robotically-implanted-brain-computer-interface-100549109","NCT06429735","Precise Robotically IMplanted Brain-Computer InterfacE","PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","PRIME","Inclusion Criteria:\n\n* Severe quadriplegia (tetraplegia) due to spinal cord injury or amyotrophic lateral sclerosis (ALS) for at least 1 year without improvement, where quadriplegia is defined as having very limited or no hand, wrist, and arm movement and all levels below\n* Life expectancy ≥ 12 months.\n* Ability to communicate in English\n* Presence of a stable caregiver\n\nExclusion Criteria\n\n* Moderate to high risk for serious perioperative adverse events\n* Active implanted devices\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Use of smoking tobacco or other tobacco products\n* Psychiatric or psychological disorder\n* Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy.\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure",{"count":290,"type":22},15,[25],"The PRIME Study is a first-in-human early feasibility study to evaluate the initial clinical safety and device functionality of the Neuralink N1 Implant and R1 Robot device designs in participants with tetraparesis or tetraplegia. The N1 Implant is a skull-mounted, wireless, rechargeable implant connected to electrode threads that are implanted in the brain by the R1 Robot, a robotic electrode thread inserter.",[60,268,32,186,294,295],"Quadriplegia\u002FTetraplegia","Tetraplegic; Paralysis",[63,132,191,200,29,134,297,298],"tetraplegic","paralysis","2026-01-07",{"date":301,"type":37},"2026-01-09",{"date":303,"type":37},"2024-01-09",{"date":305,"type":22},"2031-01",{"name":307,"class":209},"Neuralink Corp",{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":216,"enrollmentInfo":315,"targetDuration":4,"studyType":23,"phases":317,"briefSummary":318,"conditions":319,"keywords":320,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":45},"100615986","early-phase-1-feasibility-and-safety-of-a-combined-augmented-reality-and-functional-electrical-stimulation-system-100615986","NCT07299734","Feasibility and Safety of a Combined Augmented Reality and Functional Electrical Stimulation System","Assessing the Feasibility and Safety of a Combined Closed Loop Functional Electrical Stimulation and Augmented Reality System for Individuals With Cervical Spinal Cord Injury","Inclusion Criteria:\n\n* Chronic cervical SCI\n* Any level or severity of cervical SCI, traumatic or non-traumatic\n* Can carry out object manipulations but with visible impairment (i.e., 5-25 on the GRASSP Prehension Performance sub-score).\n\nExclusion Criteria:\n\n* Any disease or injury other than the SCI that may be affecting grasping performance.\n* Individuals with any self-reported FES contraindications (pacemakers, implantable defibrillator, implanted neurostimulation device, metallic implants in the stimulated areas, cardiac conditions, epilepsy, uncontrolled seizures, wounds or fractures on the target limb)\n* Inability to understand the study procedures\n* Muscles do not respond to FES to produce grasping movements\n* Currently participating in another upper limb rehabilitation intervention study (regular physical and occupational therapy is permitted).",{"count":316,"type":22},7,[57],"Cervical spinal cord injury (cSCI) can result in substantial loss of upper-limb function, with associated socio-economic impact on affected individuals and the healthcare system. Evidence suggests that non-invasive neuromodulation such as functional electrical stimulation (FES) therapy can contribute to regaining upper-limb function, which is a top priority for this population. This pilot study will involve individuals with cSCI using a device that combines augmented reality (AR) and functional electrical stimulation (FES) for 20, one-hour sessions over a 10-week period. The sessions will include upper-limb rehabilitation where individuals will interact with different objects with the aid of the AR +FES system. The primary objective is to assess safety and feasibility, measured by the absence of serious adverse events and participants' ability to independently set up and use the system. Secondary objectives include adherence to the intervention and user feedback through structured interviews. Exploratory outcomes will examine preliminary efficacy using clinical measures such as the Spinal Cord Independence Measure (SCIM) and the Graded Redefined Assessment of Strength, Sensation and Prehension (GRASSP).",[32],[264,321,322,323],"Augmented reality","Functional electrical stimulation","Neuromodulation","2025-12-09",{"date":326,"type":37},"2025-12-23",{"date":328,"type":22},"2026-01",{"date":330,"type":22},"2026-10",{"name":332,"class":44},"University Health Network, Toronto",{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":339,"targetDuration":4,"studyType":23,"phases":341,"briefSummary":342,"conditions":343,"keywords":344,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":182},"100569990","targeting-cervical-epidural-spinal-cord-stimulation-for-functional-recovery-100569990","NCT06701422","Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery","Inclusion Criteria:\n\n•Clinical indication for cervical spine surgery.\n\nExclusion criteria:\n\n•Stimulation devices in the neck or chest (e.g., vagal nerve stimulation, cardiac patients with pacemakers)",{"count":340,"type":22},36,[25],"The proposed study seeks to understand how the cervical spinal cord should be stimulated after injury through short-term physiology experiments that will inform a preclinical efficacy trial. The purpose of this study is to determine which cervical levels epidural electrical stimulation (EES) should target to recruit arm and hand muscles effectively and selectively in spinal cord injury (SCI).",[32,60,61],[63,69,71,345],"myelopathy","2025-11-20",{"date":348,"type":37},"2025-11-24",{"date":350,"type":37},"2024-12-06",{"date":352,"type":22},"2026-06-30",{"name":80,"class":44},{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":11,"sex":17,"minAge":180,"maxAge":154,"enrollmentInfo":360,"targetDuration":4,"studyType":23,"phases":361,"briefSummary":362,"conditions":363,"keywords":364,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":368,"lastUpdatePostDateStruct":369,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":45},"100610182","voice-an-early-feasibility-study-of-a-precise-robotically-implanted-brain-computer-interface-for-communication-restoration-100610182","NCT07224256","VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration","Inclusion Criteria:\n\nAdults with diagnosis of ALS, PLS, stroke, or Spinal Cord Injury who have severe speech impairment and impaired upper limb function.\n\n* Life expectancy ≥ 12 months.\n* Ability to communicate in English\n* Presence of a stable caregiver\n\nExclusion Criteria\n\n* Moderate to high risk for serious perioperative adverse events\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Psychiatric or psychological disorder\n* Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy.\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure",{"count":21,"type":22},[25],"The VOICE Study is an early feasibility study to evaluate the initial clinical safety and efficacy of the N1 and R1 Systems device design concept in providing an ability to communicate. The Neuralink N1 Implant is intended to provide the ability to communicate to individuals with severe and irreversible speech production impairment. It is indicated for adults with neurological conditions of the central speech pathways who have impaired upper limb function. The N1 Implant is a skull-mounted, wireless, rechargeable implant connected to electrode threads that are implanted in the brain by the R1 Robot, a robotic electrode thread inserter.",[60,268,32,186,294,295,188],[197,63,132,29,200,191,365,366,193,194,367],"PLS","voice","neuralink","2025-10-31",{"date":370,"type":37},"2025-11-04",{"date":372,"type":37},"2025-10-03",{"date":374,"type":22},"2031-10",{"name":307,"class":209},{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":380,"acronym":381,"eligibilityCriteria":382,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":383,"targetDuration":4,"studyType":23,"phases":384,"briefSummary":385,"conditions":386,"keywords":391,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":182},"100602719","gb-prime-an-early-feasibility-study-of-a-precise-robotically-implanted-brain-computer-interface-for-the-control-of-external-devices-100602719","NCT07127172","GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","GB-PRIME","Inclusion Criteria:\n\n* (a) A diagnosis of a spinal cord injury, brain stem stroke, or other neurological condition causing the participant to be non-ambulant and with bilateral upper limb motor impairment with no expectation of recovery that significantly or completely impairs the participant's ability to manually control a computer, smartphone or tablet with their hands.\n\nOR (b) A diagnosis of Amyotrophic Lateral Sclerosis (ALS) or other progressive neurological condition where the natural history of the disease is well understood and where there is tetraparesis and the expectation in the view of the participants treating neurologist that the disease will progress such that the participant will meet 1a within 1 year of recruitment.\n\n* Life expectancy ≥ 12 months.\n* Ability to communicate in English\n* Presence of a stable caregiver\n\nExclusion Criteria:\n\n* Moderate to high risk for serious perioperative adverse events\n* Active implanted devices\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Use of smoking tobacco or other tobacco products\n* Psychiatric or psychological disorder\n* Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy.\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure",{"count":316,"type":22},[25],"The GB-PRIME Study is an early feasibility study designed to assess the clinical safety and functionality of the Neuralink N1 Implant and R1 Robot. This study involves participants who have tetraparesis, tetraplegia, or a diagnosis that may lead to these conditions.\n\nThe N1 Implant is a wireless, rechargeable device mounted on the skull, connected to electrode threads that are inserted into the brain by the R1 Robot, which is a robotic device specifically designed for this procedure.",[60,268,294,32,387,388,123,389,390],"Amyotrophic Lateral Sclerosis (ALS)","Spinal Cord Injury (Quadraplegia)","Motor Neuron Disease","Brain Stem Stroke",[200,392,393,394,395,396,134,29,63,397,398,399,400,401,402,132,298,403],"Neuralink N1 Implant","Neuralink","Robot","tetraparesis","tetraplegia","Amyotrophic lateral sclerosis","chip","brain chip","External device control","Wireless implant","Neuroprosthetics","motor neuron disease","2025-08-11",{"date":406,"type":37},"2025-08-17",{"date":408,"type":37},"2025-07-31",{"date":410,"type":22},"2031-02",{"name":307,"class":209},{"id":413,"slug":414,"hasResults":11,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":4,"eligibilityCriteria":418,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":419,"targetDuration":4,"studyType":23,"phases":421,"briefSummary":422,"conditions":423,"keywords":424,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":45},"100465623","efficacy-of-a-brain-computer-interface-controlled-functional-electrical-stimulation-therapy-for-spinal-cord-injury-neurorehabilitation-100465623","NCT05343130","Efficacy of a Brain-Computer Interface Controlled Functional Electrical Stimulation Therapy for Spinal Cord Injury Neurorehabilitation","Efficacy of a Therapy With Brain-Computer Interface Controlled Functional Electrical Stimulation for Neurorehabilitation of Patients With Spinal Cord Injury (Eficacia de Una Terapia Con estimulación eléctrica Funcional Controlada Con Interfaz Cerebro-computadora Para neurorrehabilitación de Pacientes Con lesión Medular)","Inclusion Criteria:\n\n* Spinal Cord Injury at neurological levels C6 or C7\n* American Spinal Injury Association (ASIA) classification A, B, C or D\n* Upper limb spasticity of less or equal to +1 measured with the Modified Ashworth Scale\n* Time since disease onset of more than 6 months and less than 60 months\n* Normal or corrected to normal vision\n\nExclusion Criteria:\n\n* Severe attention deficits\n* Previous diagnosis of traumatic brain injury\n* Previous diagnosis of peripheral nerve injury\n* Previous stroke diagnosis\n* Previous diagnosis of neurodegenerative diseases\n* History of fractures in upper extremities\n* Skin lesions\n* Contractures in upper extremities that hamper mobility\n* Excessive muscle spasms",{"count":420,"type":22},32,[25],"The study's main goal is to determine the efficacy of a therapy with brain-computer interface controlled functional electrical stimulation for neurorehabilitation of spinal cord injury patients' upper limbs. For this purpose, a randomized controlled trial will be performed to compare the clinical and physiological effects of the brain-computer interface therapy with those of a sham intervention comprised by the application of functional electrical stimulation independently of brain-computer interface control.",[32],[425,426,427,396],"brain-computer interface","functional electrical stimulation","motor rehabilitation","2025-06-20",{"date":430,"type":37},"2025-06-25",{"date":432,"type":37},"2022-08-01",{"date":434,"type":22},"2027-12",{"name":436,"class":437},"Instituto Nacional de Rehabilitacion","OTHER_GOV",{"id":439,"slug":440,"hasResults":11,"nctId":441,"briefTitle":442,"officialTitle":442,"acronym":443,"eligibilityCriteria":444,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":445,"targetDuration":4,"studyType":23,"phases":446,"briefSummary":447,"conditions":448,"keywords":449,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":45},"100592374","uae-prime-a-feasibility-study-of-a-precise-robotically-implanted-brain-computer-interface-for-the-control-of-external-devices-100592374","NCT06992596","UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","UAE-PRIME","Inclusion Criteria:\n\n* (a) A diagnosis of a spinal cord injury (\\>12 months), stroke (\\>12 months), or other neurological condition causing the participant to experience bilateral upper limb motor impairment, with no expectation of recovery.\n\nOR (b) A diagnosis of Amyotrophic Lateral Sclerosis (ALS) or other progressive neurological condition where the natural history of the disease is well understood and where there is tetraparesis and the expectation, in the view of the participant's treating neurologist, that the disease will progress such that the participant will meet criteria 1a within 1 year of recruitment.\n\n* Life expectancy ≥ 12 months.\n* Ability to communicate verbally or with the use of a computer or communication aid, and working proficiency in English.\n* Presence of a stable caregiver\n\nExclusion Criteria:\n\n* Moderate to high risk for serious perioperative adverse events\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Smoking tobacco or use of other tobacco products \\> once per month within the last year.\n* Psychiatric or psychological disorder\n* Pre-existing damage to the cortical region of interest (as determined by MRI)\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure",{"count":280,"type":22},[25],"The UAE-PRIME Study is a feasibility study designed to assess the initial clinical safety and functionality of the Neuralink N1 Implant and R1 Robot. This study involves participants who have tetraparesis, tetraplegia, or a diagnosis that may lead to these conditions.\n\nThe N1 Implant is a wireless, rechargeable device mounted on the skull, connected to electrode threads that are inserted into the brain by the R1 Robot, which is a robotic device specifically designed for this procedure.",[60,268,294,32,387,388,123,389,390],[200,392,393,394,395,396,134,29,63,397,398,399,400,401,402,132,298,403],"2025-06-03",{"date":452,"type":37},"2025-06-05",{"date":454,"type":37},"2025-05-09",{"date":456,"type":22},"2027-11",{"name":307,"class":209},{"id":459,"slug":460,"hasResults":11,"nctId":461,"briefTitle":462,"officialTitle":463,"acronym":464,"eligibilityCriteria":465,"healthyVolunteers":11,"sex":17,"minAge":466,"maxAge":4,"enrollmentInfo":467,"targetDuration":4,"studyType":23,"phases":468,"briefSummary":469,"conditions":470,"keywords":471,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":479,"locationsCount":45},"100569904","can-prime-precise-robotically-implanted-brain-computer-interface-for-the-control-of-external-devices-100569904","NCT06700304","CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","CAN-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","CAN-PRIME","Inclusion Criteria:\n\n* Severe quadriplegia (tetraplegia) due to spinal cord injury or amyotrophic lateral sclerosis (ALS) for at least 1 year without improvement, where quadriplegia is defined as having very limited or no hand, wrist, and arm movement and all levels below\n* Life expectancy ≥ 12 months.\n* Ability to communicate in English\n* Presence of a stable caregiver\n\nExclusion Criteria:\n\n* Moderate to high risk for serious perioperative adverse events\n* Active implanted devices\n* Morbid obesity (Body Mass Index \\> 40)\n* History of poorly controlled seizures or epilepsy\n* History of poorly controlled diabetes\n* Requires magnetic resonance imaging (MRI) for any ongoing medical conditions\n* Acquired or hereditary immunosuppression\n* Use of smoking tobacco or other tobacco products\n* Psychiatric or psychological disorder\n* Brain MRI demonstrating hemorrhage, tumor, distorted or adverse anatomy.\n* Any condition which, in the opinion of the Investigator, would compromise your ability to safely participate in the study or undergo the implantation procedure","19 Years",{"count":21,"type":22},[25],"The CAN-PRIME Study is to test the safety and functionality of Neuralink's N1 Implant and R1 Robot in people who have difficulty moving their arms and legs (tetraparesis or tetraplegia). The N1 Implant is a small, wireless device placed in the skull. It connects to tiny threads inserted into the brain by the R1 Robot, which is a machine designed to carefully place these threads. This study will help researchers learn how well the implant and robot work and if they are safe for use.",[60,268,294,32,387,388,123],[200,392,393,394,395,396,134,29,63,397,398,399,400,401,402,132,298],"2025-05-27",{"date":474,"type":37},"2025-05-31",{"date":476,"type":37},"2024-11-20",{"date":478,"type":22},"2030-11-30",{"name":307,"class":209},{"id":481,"slug":482,"hasResults":11,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":4,"eligibilityCriteria":486,"healthyVolunteers":11,"sex":17,"minAge":487,"maxAge":488,"enrollmentInfo":489,"targetDuration":4,"studyType":23,"phases":491,"briefSummary":492,"conditions":493,"keywords":497,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":45},"100499673","study-of-individualized-precise-and-standardized-cervical-open-door-surgery-for-cervical-spinal-stenosis-100499673","NCT05786313","Study of Individualized, Precise and Standardized Cervical Open-door Surgery for Cervical Spinal Stenosis","Prospective Controlled Clinical Study of Individualized, Precise and Standardized Posterior Cervical Open-door Surgery for Cervical Spinal Stenosis","Inclusion Criteria:\n\n* The age of 28-85 years old; Through systematic clinical and imaging examination, patients diagnosed with C3-7 multilevel cervical spondylitis myelopathy or cervical spinal stenosis who need to undergo posterior cervical open-door surgery.\n* No contraindications in preoperative routine tests and examinations.\n* Informed consent of patients.\n\nExclusion Criteria:\n\n* Cervical radiculopathy\n* Cervical kyphosis or instability\n* Cervical spondylosis caused by trauma, tumor, tuberculosis and metabolic diseases\n* Revision surgery or combined anterior-posterior surgery is required\n* Serious neurological diseases affect the postoperative effect evaluation\n* Mental illness cannot cooperate with follow-up\n* Contraindications for MRI examination\n* Patients themselves or their families do not agree to participate in the study\n* Other situations that are not suitable for study participation.","28 Years","85 Years",{"count":490,"type":22},500,[25],"To evaluate the safety and effectiveness of individualized, precise and standardized open-door posterior cervical surgery through a single-center, exploratory clinical study, so as to provide a more reliable basis for the treatment of cervical spinal stenosis.",[494,32,495,496],"Cervical Spinal Stenosis","Individuation","Standardization",[498,499],"cervical spinal stenosis","open angle","2025-04-06",{"date":502,"type":37},"2025-04-09",{"date":504,"type":37},"2023-03-01",{"date":506,"type":22},"2025-12-31",{"name":508,"class":44},"Xijing Hospital",{"id":510,"slug":511,"hasResults":11,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":488,"enrollmentInfo":516,"targetDuration":4,"studyType":23,"phases":517,"briefSummary":518,"conditions":519,"keywords":521,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":528,"lastUpdatePostDateStruct":529,"startDateStruct":531,"completionDateStruct":533,"leadSponsor":534,"locationsCount":45},"100497411","neurostimulation-for-respiratory-function-after-spinal-cord-injury-100497411","NCT05756894","Neurostimulation for Respiratory Function After Spinal Cord Injury","Pilot Study: Spike-timing-dependent Plasticity for Respiratory Function After Spinal Cord Injury","Inclusion Criteria:\n\n1. Male and females between ages 18-85 years\n2. SCI at least 6 months post-injury\n3. Spinal Cord injury at C1-C5\n4. Demonstrate respiratory deficit following spinal cord injury as following: (1) Individuals using mechanical ventilation, and (2) individuals with pulmonary function testing (PFT) deficits corresponding to having a vital capacity (VC) \\\u003C 80% (predicted)\n5. Must have a family member or caregiver who is trained and willing to operate the mechanical ventilator during study visits.\n\nExclusion Criteria:\n\n1. Any illness or condition that based on the research team's assessment, will compromise with the participant's ability to comply with the protocol, patient safety, or the validity of the data collected during this study.\n2. Any debilitating disease prior to the SCI that caused exercise intolerance.\n3. Individuals entirely dependent on the support of a diaphragmatic pacer (24 hours per day).\n4. Premorbid, ongoing major depression or psychosis, altered cognitive status.\n5. History of head injury or stroke\n6. Vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without a history of seizure, and without anticonvulsant medication\n7. History of seizures or epilepsy\n8. Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold\n9. Pregnant females\n10. If a woman of childbearing age is unsure of the pregnancy, and does not want to take the pregnancy test\n11. Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, MS, or herniated disk\n12. Metal plate in skull\n13. Individuals with scalp shrapnel, cochlear implants, or aneurysm clips\n14. Individuals taking Bupropion, Dolutegravir, Lacosamide, Trilaciclib, or PR Interval prolonging drugs",{"count":280,"type":22},[25],"The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is:\n\nChanges in respiratory function and recovery using stimulation and respiratory exercise training in spinal cord-injured individuals.\n\nParticipants will complete a maximum of 55 study visits. They will be asked to complete about 40 treatment sessions which include multiple stimulation sessions over the scalp and neck, followed by about 60 minutes of respiratory training. Assessment sessions will be completed prior at baseline, after 20 sessions and after 40 sessions of study treatment.",[31,32,520],"Respiratory Function Impaired",[522,523,524,525,526,527],"Neural plasticity","Spinal cord injury","Diaphragm","Respiratory training","Spike-timing-dependent plasticity","Neurostimulation","2025-04-01",{"date":530,"type":37},"2025-04-04",{"date":532,"type":37},"2023-02-28",{"date":169,"type":22},{"name":535,"class":44},"Shirley Ryan AbilityLab",{"id":537,"slug":538,"hasResults":11,"nctId":539,"briefTitle":540,"officialTitle":541,"acronym":542,"eligibilityCriteria":543,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":544,"targetDuration":4,"studyType":23,"phases":545,"briefSummary":546,"conditions":547,"keywords":548,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":552,"lastUpdatePostDateStruct":553,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":558,"locationsCount":45},"100575718","robot-assisted-vs-conventional-occupational-therapy-of-the-upper-limb-in-individuals-with-cervical-spinal-cord-injury-100575718","NCT06775925","Robot-assisted Vs. Conventional Occupational Therapy of the Upper Limb in Individuals with Cervical Spinal Cord Injury","Robot-assisted Vs. Conventional Occupational Therapy of the Upper Limb in Individuals with Cervical Spinal Cord Injury: the Armeo X-over Trial","Armeo X-over","Inclusion Criteria:\n\n* Informed Consent signed by the subject\n* Intermediate (\\>16 days and ≤81 days post-injury) traumatic or non-traumatic cSCI during primary rehabilitation at the Swiss Paraplegic Centre (SPC)\n* Neurological level of injury: C1-T1\n* American Spinal Injury Association Impairment Scale (AIS): A-D\n* Impairment of upper limb function (GRASSP-QtG score unilateral \\\u003C 25 at baseline t0)\n* Ability to sit for 60 minutes and perform training with ArmeoSpring\n* Stratification parameters available\n\nExclusion Criteria:\n\n* Inability to follow the procedures of the investigation\n* Severe concomitant neurological disease\n* Concomitant neurodegenerative or progressive diseases\n* Impairment of upper limb function due to peripheral nerve lesions\n* Severe concurrent medical disease or any other issue that in the opinion of the investigator would confound the results\n* Orthopedic limitations of the upper limb\n* Device specific contraindications\n* Participation in other interventional trials",{"count":118,"type":22},[25],"The goal of this clinical trial is to learn the effects of robot-assisted therapy using the ArmeoSpring on upper limb function compared to conventional occupational therpay in individuals with cervical spinal cord injury (cSCI). The main questions it aims to answer are:\n\n\\- Which of the two forms of therapy, robot-assisted therapy or conventional occupational therapy, is more effective in terms of improving arm and hand function?\n\nThe study is designed as a cross-over trial, which means that each participant will receive both therapy forms consecutively, whereas the order is assigned randomly (either robot-assisted therapy first and then occupational therapy, or vice versa).\n\nIn addition to their clinical routine therapy , participants will:\n\n* complete a baseline assessment\n* practice one therapy form (either robot-assisted or occupational therapy) with one arm for 6 weeks (3 x 30 min per week)\n* complete a intermediate assessment\n* practice the other therapy form (either occupational or robot-assisted therapy) with one arm for 6 weeks (3 x 30 min per week)\n* complete a post assessment\n* complete a follow-up assessment (if the post assessment was completed prior to 150 days post-injury)",[32],[549,550,551],"upper limb function","robot-assisted therapy","occupational therapy","2025-03-05",{"date":554,"type":37},"2025-03-10",{"date":556,"type":37},"2025-02-01",{"date":434,"type":22},{"name":559,"class":560},"Swiss Paraplegic Research, Nottwil","NETWORK",{"id":562,"slug":563,"hasResults":11,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":216,"enrollmentInfo":568,"targetDuration":4,"studyType":120,"phases":4,"briefSummary":569,"conditions":570,"keywords":573,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":45},"100557663","nerve-transfers-plus-electrical-stimulation-to-improve-hand-function-in-cervical-spinal-cord-injury-100557663","NCT06541041","Nerve Transfers Plus Electrical Stimulation to Improve Hand Function in Cervical Spinal Cord Injury","Evaluation of Electrical Stimulation During Nerve Transfer Surgery for Cervical Spinal Cord Injury","Inclusion Criteria:\n\n1. Cervical spinal cord injury, ASIA A or ASIA B\n2. International Standards for Neurological Classification of Spinal Cord Injury neurological level of injury C6 or C7\n3. Agreed upon surgical plan includes at least 1 nerve transfer targeting finger flexion with the anterior interosseous nerve as the recipient and at least 1 nerve transfer targeting finger extension with the posterior interosseous nerve as the recipient\n4. Age 18-65 years\n5. Mentally and physically able to comply with evaluations and assessments\n6. Upper motor neuron pattern of injury in the recipient nerve with planned surgery 36 months or less from the time of injury OR lower motor neuron pattern of injury in the recipient nerve with planned surgery 9 months or less from the time of injury\n7. Muscle grade at least 4+\u002F5 on the Medical Research Council (MRC) scale in the territory of the donor nerve(s)\n8. Stable function for at least 3 months (i.e., no ongoing recovery)\n9. Non-operative rehabilitation for at least 3 months\n10. Able to read and write in English at a level necessary to complete the questionnaires\n\nExclusion Criteria:\n\n1. Contraindication to electrical stimulation, including any implanted electronic device such as a pacemaker or intrathecal drug delivery pump\n2. Active infection at the operative site or systemic infection\n3. Active malignancy\n4. Pregnancy\n5. Joint contractures or limited passive range of motion that would limit recovery of function\n6. Lack of appropriate social support and\u002For infrastructure to commit to scheduled follow-up visits\n7. Previous tendon transfer or other surgery for restoration of function following cervical spinal cord injury\n8. Planned tendon transfer surgery or other surgery for restoration of function following cervical spinal cord injury",{"count":280,"type":22},"The goal of this prospective observational study is to determine whether brief intraoperative electrical stimulation and temporary postoperative electrical stimulation improve motor and\u002For pain outcomes for patients with cervical spinal cord injury undergoing standard of care nerve transfer surgery to improve hand function.\n\nThe main hypotheses include:\n\nHypothesis #1: Brief intraoperative electrical stimulation of the donor nerves will result in improved motor outcomes (hand function) compared to standard nerve transfer surgery in patients with cervical spinal cord injuries.\n\nHypothesis #2: Placement of a temporary peripheral nerve stimulator for 60 days of postoperative electrical stimulation will result in improved pain outcomes compared to standard nerve transfer surgery in patients with cervical spinal cord injuries.\n\nResearchers will prospectively enroll patients with cervical spinal cord injury and no hand function who will undergo standard of care nerve transfer surgery combined with standard of care brief intraoperative electrical stimulation and temporary postoperative electrical stimulation. Motor and pain outcomes will be compared to a retrospective group of patients who underwent nerve transfer surgery without intraoperative or postoperative electrical stimulation.\n\nParticipants will receive standard medical care (nothing experimental) as part of this study. Participants will:\n\n* Have a preoperative assessment including physical examination, electrodiagnostic studies, functional electrical stimulation, and will complete questionnaires assessing function and quality of life\n* Agree upon a surgical plan, including the specific nerve transfers to be performed and whether to include brief intraoperative electrical stimulation and\u002For temporary postoperative electrical stimulation before being considered for enrollment in the study\n* Will undergo standard of care nerve transfer surgery, with at least one nerve transfer targeting improvement in hand function and will receive brief intraoperative electrical stimulation of the donor nerves and placement of a temporary peripheral nerve stimulator\n* Will follow-up with the surgeon 3, 6, 12, 24, and 36 months after the surgery\n* Will have a physical examination and will complete questionnaires at the postoperative visits\n* Will participate in hand therapy following the operation\n* Will be eligible for placement of a permanent peripheral nerve stimulator, depending on response to the temporary peripheral nerve stimulator.",[32,571,30,60,572],"Cervical Spinal Cord Paralysis","Tetraplegic Spinal Paralysis",[32,574,575,576,30],"Nerve Transfer","Brief Intraoperative Electrical Stimulation","Peripheral Nerve Stimulation","2025-02-16",{"date":579,"type":37},"2025-02-19",{"date":581,"type":37},"2025-02-10",{"date":583,"type":22},"2028-09",{"name":585,"class":44},"Stanford University",{"id":587,"slug":588,"hasResults":11,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":4,"eligibilityCriteria":592,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":593,"targetDuration":4,"studyType":23,"phases":595,"briefSummary":596,"conditions":597,"keywords":599,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":612,"locationsCount":45},"100428192","dysphagia-after-anterior-cervical-spine-surgery-100428192","NCT04855838","Dysphagia After Anterior Cervical Spine Surgery","Impaired Swallowing Function After Anterior Cervical Spine Surgery- Incidence, Long-term Effect on Nutrition and Effect of Oral Neuromuscular Training","Inclusion Criteria:\n\n* All patients enrolled at the University Hospital of Umeå who have undergone ACSS between C2 and Th1 level due to trauma are eligible participants in the first part of the study.\n* Eligibility criteria to participate in part 2 is swallowing dysfunction on FEES at 4±1-week post-operation\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* known dysphagia prior to the trauma\u002Finjury\n* affected brainstem that is shown on a CT or MRI\n* severe brain damage.",{"count":594,"type":22},60,[25],"The purpose of this research project is to investigate the incidence of impaired swallowing (dysphagia) after anterior cervical spine surgery (ACSS) and to study the long-term effect of dysphagia on nutritional status 12 ± 3 months later. Furthermore, to investigate the effect of a new rehabilitation method for dysphagia among individuals with swallowing dysfunction after ACSS.",[598,32],"Dysphagia",[600,601,602,603,604],"Swallowing disorder","Anterior cervical spine surgery","Intervention","Incidens","Nutritional status","2024-12-05",{"date":607,"type":37},"2024-12-11",{"date":609,"type":37},"2020-12-17",{"date":611,"type":22},"2024-12-31",{"name":613,"class":44},"Umeå University"]