[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-spinal-stenosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-spinal-stenosis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100588786","phase-2-the-effect-of-oxytocin-nasal-spray-on-preventing-postoperative-delirium-in-elderly-patients-undergoing-orthopedic-surgery-100588786",false,"NCT06945926","The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery","The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery：Two-Stage Designs for Phase II Clinical Trials","Elderly patients undergoing orthopedic surgery under general anesthesia\n\nInclusion criteria:\n\n1. Age ≥ 65 years;\n2. Patients who were to undergo elective orthopedic surgery under general anesthesia with tracheal intubation;\n3. ASA class I-III;\n4. Estimated duration of surgery ≥ 1 hour; (5) The patient himself\u002Fherself or his\u002Fher legal representative;\n5. Informed consent from the patient or legal representative;\n6. Proficiency in the use of Chinese language for communication.\n\nExclusion criteria:\n\n1. Nasal cavity occupation, patients with fillers in the nose\n2. Oxytocin allergy;\n3. Patients with previous psychiatric and neurological disorders, such as depression, severe central nervous system depression, Parkinson's disease, basal ganglia disease.\n\n   Goldson's disease, basal ganglia lesions, schizophrenia, epilepsy, Alzheimer's disease, myasthenia gravis, and so on;\n4. Pregnant and lactating women\n5. Patients with severe hepatic insufficiency (Child-Pugh class C);\n6. patients with severe renal insufficiency (dialysis is required before surgery)\n7. Severe heart failure (METS\\\u003C4);\n8. Preoperative inability to communicate (coma or dementia);\n9. Severe preoperative blindness, deafness, or inability to understand Mandarin to complete preoperative delirium screening;\n10. Preoperative cognitive impairment as determined by a MoCA evaluation prior to surgery;\n11. Patients who are scheduled for 2 surgeries within 7 days of surgery;\n12. Patients with bone malignancy\n13. Currently participating in other clinical trials.","ALL","65 Years",{"count":19,"type":20},220,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","Postoperative delirium is a delirium that occurs within 7 days after surgery or before hospital discharge. It has been shown that combined POD can increase the incidence of postoperative pulmonary infections, deep vein thrombosis and decubitus ulcers, and increase the incidence of disability and mortality. The incidence of postoperative delirium in geriatric orthopedics is high.\n\nInvestigators conduct a prospective clinical study on geriatric orthopedic surgery patients to investigate the effect of oxytocin nasal spray on the prevention of postoperative delirium in geriatric orthopedic surgery. Cases were included according to the inclusion and exclusion criteria, and induction, maintenance and resuscitation were performed according to the standard protocol for general anesthesia. Before the end of surgery, the Investigators administered oxytocin nasal spray (Oxytocin) that was 3 sprays in each nostril (4 IU each) for a total of 24 IU. Beginning 1 day postoperatively, administer 24 IU of oxytocin nasal spray 2 times\u002Fday in the morning and in the evening. Until 7 days after surgery or discharge. The sample size are 77 cases in phase I and 143 cases in phase 2, total 220 cases.",[26,27,28,29,30,31,32],"Cervical Spinal Stenosis","Thoracic Spinal Stenosis","Lumbar Spinal Stenosis","Rotator Cuff Injury","Femoral Head Necrosis","Spinal Trauma","Knee Joint Injury",[34,35,36],"Postoperative delirium","elderly orthopedics","oxytocin nasal spray","NOT_YET_RECRUITING","2025-05-23",{"date":40,"type":41},"2025-05-25","ACTUAL",{"date":43,"type":20},"2025-06-01",{"date":45,"type":20},"2026-06-30",{"name":47,"class":48},"Zhejiang University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":49},"100499673","study-of-individualized-precise-and-standardized-cervical-open-door-surgery-for-cervical-spinal-stenosis-100499673","NCT05786313","Study of Individualized, Precise and Standardized Cervical Open-door Surgery for Cervical Spinal Stenosis","Prospective Controlled Clinical Study of Individualized, Precise and Standardized Posterior Cervical Open-door Surgery for Cervical Spinal Stenosis","Inclusion Criteria:\n\n* The age of 28-85 years old; Through systematic clinical and imaging examination, patients diagnosed with C3-7 multilevel cervical spondylitis myelopathy or cervical spinal stenosis who need to undergo posterior cervical open-door surgery.\n* No contraindications in preoperative routine tests and examinations.\n* Informed consent of patients.\n\nExclusion Criteria:\n\n* Cervical radiculopathy\n* Cervical kyphosis or instability\n* Cervical spondylosis caused by trauma, tumor, tuberculosis and metabolic diseases\n* Revision surgery or combined anterior-posterior surgery is required\n* Serious neurological diseases affect the postoperative effect evaluation\n* Mental illness cannot cooperate with follow-up\n* Contraindications for MRI examination\n* Patients themselves or their families do not agree to participate in the study\n* Other situations that are not suitable for study participation.","28 Years","85 Years",{"count":60,"type":20},500,[62],"NA","To evaluate the safety and effectiveness of individualized, precise and standardized open-door posterior cervical surgery through a single-center, exploratory clinical study, so as to provide a more reliable basis for the treatment of cervical spinal stenosis.",[26,65,66,67],"Cervical Spinal Cord Injury","Individuation","Standardization",[69,70],"cervical spinal stenosis","open angle","RECRUITING","2025-04-06",{"date":74,"type":41},"2025-04-09",{"date":76,"type":41},"2023-03-01",{"date":78,"type":20},"2025-12-31",{"name":80,"class":48},"Xijing Hospital",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":101,"locationsCount":49},"100498200","correlation-between-parameters-and-prognosis-of-cervical-single-open-door-surgery-100498200","NCT05767164","Correlation Between Parameters and Prognosis of Cervical Single Open-door Surgery","Correlation Between Parameters and Prognosis of Cervical Single Open-door Surgery: a Multicenter Retrospective Clinical Study","Inclusion Criteria:\n\n* Symptoms and signs of the patients were typical. MRI showed single or multiple central herniation of C3-C7 intervertebral discs or spinal stenosis at corresponding levels, which confirmed cervical myeloid cervical spondylosis or cervical spinal stenosis.\n* Conservative treatment for more than 3 months before surgery was ineffective.\n* The patients underwent cervical single open-door surgery.\n* Informed consent was obtained from the patient and his family, informed consent was signed, and a complete follow-up was completed after surgery\n\nExclusion Criteria:\n\n* Cervical spondylotic radiculopathy.\n* Cervical kyphosis or instability.\n* Cervical spondylosis caused by trauma, tumor, tuberculosis and metabolic diseases.\n* Revision surgery or combined anterior-posterior surgery is required.\n* The patients had severe neurological diseases affecting the evaluation of postoperative results.\n* Psychopath.\n* MRI or CT for contraindications.","18 Years","86 Years",{"count":60,"type":20},[62],"The aim of study was evaluated the relationship between the relevant evaluation indexes of cervical spine open-door surgery, prognosis and complication rate, and provided theoretical basis for personalized surgical program through multi-center retrospective clinical study",[26],[95,26,96],"Cervical single open-door surgery","Open angle",{"date":74,"type":41},{"date":99,"type":41},"2023-01-01",{"date":78,"type":20},{"name":80,"class":48}]