[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-spondylosis-with-myelopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-spondylosis-with-myelopathy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,57],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100493123","comparison-of-artificial-disc-implants-in-cervical-disc-arthroplasty-100493123",false,"NCT05701059","Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty","Comparison of Unconstrained and Semi-constrained Artificial Disc Implants Used in Cervical Disc Arthroplasty","Inclusion Criteria:\n\n* Patient is skeletally mature and between 18 to 60 years of age\n* Experiences cervical spondylotic myelopathy and\u002For radiculopathy typically caused by disc herniation or degenerative disc disease at a single level between C3 to C7\n* Is unresponsive to at least six weeks of non-surgical conservative care\n* Has the intention of undergoing cervical arthroplasty for their chief complaint\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Patient has had prior cervical spine surgery\n* Has more than two diseased levels requiring surgery\n* Has a known allergy to a metal alloy or polyethylene\n* Is morbidly obese\n* Has active local or system infection\n* Has any circumstances or conditions such that their ability to provide informed consent comply with follow-up requirements, or provide self-assessments is compromised (eg: psychiatric disorders, chronic alcohol or substance abuse, etc.)","ALL","18 Years","60 Years",{"count":20,"type":21},20,"ESTIMATED","OBSERVATIONAL","This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and\u002For radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nuvasive Simplify implementing a three-piece design with two endplates and a semi-constrained mobile core while the Biomet Zimmer Mobi-C implements an unconstrained three piece design. Subjects will be age-matched and randomly assigned to either implant with informed consent. All subjects will undergo a variety of assessments that evaluate neck disability, quality of life, pain, physiological outcome (radiographic assessments), and neck range-of motion before and after their procedure. One baseline testing will be conducted along with three post-operation visits (three months, six months, and one year) in accordance to standard follow-up procedure. Thus, the duration of participation in the study will be approximately one and a half years.",[25,26,27,28],"Cervical Spondylosis With Myelopathy","Cervical Radiculopathy","Cervical Disc Herniation","Degenerative Disc Disease",[30,31,32,33,34,35,36,37,38,39,40,41,42,43],"cervical","spondylosis","myelopathy","radiculopathy","disc","cervical disc","artificial disc","artificial disc implantation","cervical arthroplasty","disc herniation","degenerative disc disease","ACDF","Biomet Zimmer Mobi-C","Nuvasive Simplify","RECRUITING","2026-02-10",{"date":47,"type":48},"2026-02-13","ACTUAL",{"date":50,"type":48},"2023-05-01",{"date":52,"type":21},"2026-12-01",{"name":54,"class":55},"University of California, Los Angeles","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":66,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":56},"100616770","gait-and-paraspinal-semg-in-degenerative-spinal-diseases-100616770","NCT07309926","Gait and Paraspinal sEMG in Degenerative Spinal Diseases","Comparative Analysis of Spatiotemporal Gait Parameters and Paraspinal Surface Electromyography Parameters in Degenerative Spinal Diseases: A Cross-Sectional Study Using Motion Capture and Electromyographic Ensemble Averaging","TDGKSEPDSD","Inclusion Criteria:\n\n1. Patients with the following single disease: degenerative scoliosis, coronal imbalance, lumbar spinal stenosis, lumbar disc herniation, spinal cord-type cervical spondylosis;\n2. Age ≥ 60 years, regardless of gender;\n3. Planned to undergo elective open spinal fusion surgery;\n4. Voluntarily participate in the study, understand and agree to the study content, and sign the informed consent form.\n\nExclusion Criteria:\n\n1. History of previous spinal surgery;\n2. Combined with other neuromuscular diseases (such as Parkinson's disease), inflammatory diseases (such as ankylosing spondylitis), infectious diseases (such as spinal tuberculosis), sepsis, tumors, or lower limb joint diseases that may cause low back and lower limb pain, affecting physical activity;\n3. Suffering from severe cardiovascular, cerebral, liver, or kidney disease;\n4. Suffering from mental illness, dementia, or unable to cooperate to complete clinical research.\n\n   * Skin rupture in the waist;",true,{"count":67,"type":21},120,"This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal conditions-including lumbar disc herniation (LDH), lumbar spinal stenosis (LSS), lumbar sagittal imbalance (LSI), degenerative lumbar scoliosis (DLS), and cervical spondylotic myelopathy (CSM)-alongside a healthy control group. The analysis focuses on spatiotemporal gait characteristics (step length, stride length, cadence), lower limb kinematics and kinetics (hip\u002Fknee\u002Fankle joint angles, moments, and powers during stance and swing phases), and surface EMG amplitudes (thoracic erector spinae, multifidus, gluteus maximus, and rectus abdominis muscles) during standardized walking tasks. Additionally, radiological parameters (e.g., pelvic incidence-lumbar lordosis mismatch, C2-C7 sagittal vertical axis, coronal Cobb angle) will be correlated with gait and muscle activation deviations. The study employs motion capture systems, force plates, and high-density EMG to objectively differentiate disease-specific movement impairments. Findings from this study may establish biomechanical and neuromuscular signatures for each degenerative condition, providing a framework for personalized rehabilitation strategies, gait retraining, and surgical outcome assessment in spinal disorders. Comparative analysis with healthy controls will further elucidate pathological alterations in gait and muscle recruitment patterns caused by degenerative spinal diseases.",[70,71,72,73,74,75,76,25],"Adult Spinal Deformity","Degenerative Scoliosis","Sagittal Deformity","Sagittal Imbalance","Coronal Vertical Axis","Lumbar Spinal Stenosis","Lumbar Disc Herniation","NOT_YET_RECRUITING","2025-12-15",{"date":80,"type":48},"2025-12-30",{"date":82,"type":21},"2025-12-10",{"date":84,"type":21},"2029-12-01",{"name":86,"class":55},"Xuanwu Hospital, Beijing"]