[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cervical-spondylotic-myelopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cervical-spondylotic-myelopathy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100588457","efficacy-of-two-approaches-in-cervical-single-door-laminoplasty-for-spinal-canal-enlargement-100588457",false,"NCT06941649","Efficacy of Two Approaches in Cervical Single-door Laminoplasty for Spinal Canal Enlargement","Comparison of the Clinical Efficacy of Cervical Single-door Laminoplasty Via the Intermuscular Space Approach and the Conventional Approach: A Multicenter, Prospective Controlled Study","Inclusion Criteria:\n\n1. Age \\>18\n2. Patients with cervical spondylotic myelopathy meeting surgery indications.\n3. Sign informed consent\n\nExclusion Criteria:\n\n1. Poor general condition, can not tolerate surgery\n2. Patients with long course of disease, degenerative spinal cord, atrophy of limb muscles, and severe joint dysfunction\n3. The cervical spine has obvious segmental instability, especially in the case of injury or lesion of the anterior structure, which has not been healed\n4. History of cervical spine surgery\n5. Combined with obvious cervical kyphosis\n6. Combined with cervical fracture, dislocation, etc\n7. Combined with cervical spinal infection, arthritis and other pathological changes\n8. Combined with tumors of cervical spine or spinal cord.\n9. Mental retardation or other causes of limited behavioral ability","ALL","18 Years",{"count":19,"type":20},376,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn if cervical single-door laminoplasty via the intermuscular space approach can better prevent axial symptom while reaching equal neurological outcome than the conventional approach in adults patients with cervical spondylotic myelopathy. The main questions it aims to answer are:\n\n* Can cervical single-door laminoplasty via the intermuscular space approach better prevent axial symptom than the conventional approach?\n* Can cervical single-door laminoplasty via the intermuscular space approach reach the neurological outcome not second to the conventional approach? If there is a comparison group: Researchers will compare the intermuscular space approach and the conventional approach of cervical single-door laminoplasty to see if the intermuscular space approach better prevent axial symptom.\n\nParticipants will:\n\n* Received cervical single-door laminoplasty via the intermuscular space approach or the conventional approach once meet the indication.\n* Visit the clinic 1 month, 3 months, 6 months, 1 year and 2 years after the surgery.\n* Keep a diary of their symptoms and other unexpected conditions.",[26],"Cervical Spondylotic Myelopathy","NOT_YET_RECRUITING","2025-04-22",{"date":30,"type":31},"2025-04-24","ACTUAL",{"date":33,"type":20},"2025-04-15",{"date":35,"type":20},"2035-12-31",{"name":37,"class":38},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":49,"briefSummary":50,"conditions":51,"keywords":52,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100434357","fusion-or-no-fusion-after-decompression-of-the-spinal-cord-in-patients-with-degenerative-cervical-myelopathy-100434357","NCT04936074","Fusion or no Fusion After Decompression of the Spinal Cord in Patients With Degenerative Cervical Myelopathy","Comparison of Posterior Muscle-preserving Selective Laminectomy and Laminectomy With Fusion for Treating Degenerative Cervical Myelopathy: Myelopathy Randomized Controlled Trial (MyRanC)","MyRanC","Inclusion Criteria:\n\n* Age \\>18 years\n* 1-4 levels of cervical degenerative myelopathy in the subaxial spine, C3-C7, without or with deformity not exceeding exclusion criteria, see below.\n* Eligible for both treatments\n* Ability to understand and read Swedish language\n* Symptomatic myelopathy with at least one clinical sign of myelopathy\n* No previous spine surgery\n* Psychosocially, mentally, and physically able to fully comply with this protocol, including adhering to scheduled visits, treatment plan, completing forms, and other study procedures\n* Personally, signed and dated informed consent document prior to any study-related procedures, indicating that the patient has been informed of all pertinent aspects of the trial\n\n  * Definition of kyphosis - cSVA \\> 40 mm and\u002For C2-C7 Cobb \\> 10° kyphosis. Definition of spondylolisthesis - anterior slippage of \\> 2 mm on cervical radiographs taken in the neutral position.\n\nExclusion Criteria:\n\n* Local kyphosis; a modified K-line minimum interval distance (INT) of \\\u003C4 mm\n* Spondylolisthesis \\>4 mm and simultaneous translation \\>2 mm on lateral flexion\u002Fextension radiographs\n* Soft disc herniations only (no signs of osteophyte formation and hypertrophy of the ligamentum flavum)\n* Active infection\n* Neoplasm\n* Trauma\n* Inflammatory disease (i.e., rheumatoid arthritis or ankylosing spondylitis or DISH)\n* Systemic disease including HIV\n* Lumbar or thoracic spinal disease to the extent that surgical consideration is probable or anticipated within 6 months after the cervical surgical treatment (significant lumbar stenosis as defined by Schizas C or worse).\n* OPLL\n* Parkinson´s disease\n* Drug abuse, dementia, or other reason to suspect poor adherence to follow-up\n* Previous cervical spine surgery",{"count":48,"type":20},300,[23],"Background:\n\nDegenerative cervical myelopathy (DCM) is characterized by neck pain, neck stiffness, weakness, paresthesia, sphincter disturbance and balance disorder. The mean age for symptoms is 64 years and more men than women, 2.7:1, are affected. The most common level is C5-C6. DCM is the predominant cause of spinal cord dysfunction in the elderly worldwide. Surgical options include stand-alone laminectomy, laminectomy and fusion and laminoplasty. The preferable surgical approach is though, a matter of controversy. The objective of this study is to compare stand-alone laminectomy to laminectomy and fusion.\n\nMethods\u002FDesign:\n\nThis is a multicenter randomized, controlled, parallel group non-inferiority trial. A total of 300 adult participants are allocated in a ratio of 1:1. The primary endpoint is reoperation for any reason within 5 years of follow-up. Sample size and power calculations were performed by estimating the reoperation rate after laminectomy to 3.4% and after laminectomy with fusion to 7.9% based on data from the Swedish spine registry (Swespine) on patients with DCM.\n\nSecondary outcomes are the patient derived modified Japanese orthopaedic association (P-mJOA) score, Neck disability index (NDI), European quality of life five dimensions (EQ-5D), Numeric rating scale (NRS) for neck and arm pain, Hospital anxiety and depression scale (HADS), development of kyphosis measured as the cervical sagittal vertical axis (cSVA) and, death. Clinical and radiological follow-up is performed at 3, 12, 24 and 60 months after surgery. The main inclusion criteria is 1-4 levels of DCM in the subaxial spine, C3-C7, with or without deformity. The REDcap will be used for safe data management. Data will be analyzed in the per protocol (PP) population, defined as randomized patients who are still alive without having emigrated or left the study after five years.\n\nDiscussion:\n\nThis will be the first randomized controlled trial comparing two of the most common surgical treatments for DCM; the posterior muscle-preserving selective laminectomy and posterior laminectomy with instrumented fusion. The results of the MyRanC study will provide surgical treatment recommendations for DCM. This may result in improvements in surgical treatment and clinical practice regarding DCM.",[26],[53,54,55,56,57],"Cervical fusion","Cervical spine","Laminectomy","Spinal surgery","Randomized controlled trial","RECRUITING","2025-04-04",{"date":61,"type":31},"2025-04-08",{"date":63,"type":31},"2022-02-21",{"date":65,"type":20},"2033-02-01",{"name":67,"class":38},"Uppsala University Hospital",1]