[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cesarean-birth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cesarean-birth":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,60,83,113,142,172],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100644265","hyperangulated-vs-macintosh-style-blades-for-intubation-in-obstetric-patients-100644265",false,"NCT07667010","Hyperangulated vs. Macintosh Style Blades for Intubation in Obstetric Patients","HyperANGulated Versus Macintosh styLE blaDes for INtubation in OBstetric Patients: a Cluster Randomized Feasibility Study","ANGLED","Inclusion Criteria:\n\n1\\. Pregnant patients undergoing emergency or urgent cesarean delivery under general anesthesia requiring tracheal intubation.\n\nExclusion Criteria:\n\n1. No tracheal intubation performed and (ii) patient refusal of consent.\n2. Patients not receiving general anesthesia.\n3. Patients that previously participated in the study.","FEMALE",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","Cesarean section under general anesthesia requires intubation (insertion of a tube through the mouth into the breathing pipe to support breathing during the surgery). A device called a video laryngoscope is used, which has a smooth, curved, or less curved component called 'a blade' that helps the doctor gently see the voice box and guide the breathing tube safely into place during anesthesia; it is not a sharp tool blade.\n\nThere are two types of video laryngoscopes blades: a Macintosh- style blade with a gentle curve, approximately 90 degrees) and a hyperangulated blade (with a more pronounced curve).\n\nAlthough video laryngoscopes are safe and both types have been used for around 20 years, it is not known whether one type works better that the other in patients undergoing cesarean delivery under general anesthesia. Because general anesthesia is used in only a small proportion (about 5%) of all cesarean deliveries, research in this area is limited.\n\nThe main purpose of the study is to assess if a study comparing these two types of blades in the obstetric population is feasible. This is also known as a feasibility study, which aims to test the study plan and determine whether enough participants will join a larger study and accept the study procedures. The results will be used as a guide for a larger study.",[26,27,28,29,30,31,32,33,34],"Obstetric","Cesarean Birth","Airway Anesthesia","Intubation","General Anesthesia; Tracheal Intubation","Video Laryngoscopy","Obstetric Anesthesia","Obstetric Anesthesia Problems","General Anesthesia",[36,37,38,39,40,41,42,43,44,45,46],"obstetric","obstetric anesthesia","intubation","airway safety in OB patients","video laryngoscopy","cesarean delivery","general anesthesia in cesarean delivery","macintosh blade","hyperangulated blade","intubation in OB patients","general anesthesia","NOT_YET_RECRUITING","2026-06-19",{"date":50,"type":51},"2026-06-24","ACTUAL",{"date":53,"type":20},"2026-06-15",{"date":55,"type":20},"2028-06-30",{"name":57,"class":58},"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":11,"sex":17,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100634454","the-role-of-preoperative-internal-jugular-vein-collapsibility-and-perfusion-index-in-predicting-hypotension-after-spinal-anesthesia-in-elective-cesarean-sections-a-prospective-observational-study-100634454","NCT07539896","The Role of Preoperative Internal Jugular Vein Collapsibility and Perfusion Index in Predicting Hypotension After Spinal Anesthesia in Elective Cesarean Sections: A Prospective Observational Study","Inclusion Criteria:\n\nAge 18-45 years Singleton pregnancy Scheduled for elective cesarean section Planned spinal anesthesia ASA physical status II\n\nExclusion Criteria:\n\nHypertensive disorders of pregnancy (e.g., preeclampsia, HELLP syndrome) Known significant cardiac disease or pulmonary hypertension Chronic kidney disease Hemoglobinopathies Multiple pregnancy Emergency cesarean section Conversion to general anesthesia Anatomical or pathological conditions preventing IJV ultrasound assessment -","18 Years","45 Years",{"count":69,"type":20},110,"OBSERVATIONAL","Spinal anesthesia is widely preferred for elective cesarean delivery due to its favorable safety profile and superior postoperative analgesia. However, post-spinal hypotension (PSH) remains a common complication, with reported incidence rates ranging from 40% to 70%, potentially compromising maternal hemodynamic stability and uteroplacental perfusion. Early identification of patients at high risk for PSH is therefore of critical clinical importance.\n\nThis prospective observational study aims to evaluate the predictive performance of preoperative internal jugular vein collapsibility index (IJV-CI), assessed by ultrasonography, and baseline perfusion index (PI), obtained via pulse oximetry, for the development of PSH in patients undergoing elective cesarean section under spinal anesthesia. While IJV-CI reflects intravascular volume status and preload, PI represents peripheral vascular tone; thus, their combined use may improve predictive accuracy.\n\nStudy Design This is a single-center, prospective observational study conducted in patients scheduled for elective cesarean delivery under spinal anesthesia. No additional intervention will be applied, and all anesthetic management will follow standard clinical practice.\n\nObjectives\n\nPrimary Objective:\n\nTo assess the ability of preoperative IJV collapsibility index (IJV-CI) and baseline perfusion index (PI) to predict post-spinal hypotension.\n\nSecondary Objectives:\n\nTo evaluate the relationship between IJV-CI and PI with:\n\nDuration and number of hypotensive episodes Minimum systolic and mean arterial pressure Total vasopressor requirement Incidence of intraoperative nausea and vomiting Pregnant women aged 18-45 years, ASA II, with singleton pregnancies scheduled for elective cesarean section under spinal anesthesia.\n\nInclusion Criteria Age 18-45 years Elective cesarean section Planned spinal anesthesia ASA physical status II Singleton pregnancy Exclusion Criteria Hypertensive disorders of pregnancy (e.g., preeclampsia, HELLP) Significant cardiac or pulmonary disease Chronic kidney disease Multiple pregnancy Emergency cesarean delivery Conversion to general anesthesia\n\nConditions preventing IJV ultrasonographic assessmentBaseline PI will be recorded preoperatively using standard pulse oximetry. IJV diameters will be measured via ultrasound, and the collapsibility index will be calculated as:\n\nIJVI: (Dmax-Dmin\u002FDmax)X100 Hemodynamic parameters will be recorded at 3-minute intervals from spinal anesthesia administration until delivery. Statistical analysis will include ROC curve analysis, correlation analysis, and logistic regression to evaluate predictive performance.",[73,27],"Postspinal Hypotension","2026-04-14",{"date":76,"type":51},"2026-04-20",{"date":78,"type":20},"2026-04-25",{"date":80,"type":20},"2026-06-25",{"name":82,"class":58},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":66,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":59},"100631557","phase-3-the-effect-of-lactoferrin-on-pain-management-following-cesarean-section-100631557","NCT07502235","The Effect of Lactoferrin on Pain Management Following Cesarean Section","Inclusion Criteria:\n\n* Referred to elective (non-emergency) cesarean section\n* Undergoing spinal anesthesia) with American Society of Anesthesiologists (ASA) classification I and II\n* Term gestational age\n\nExclusion Criteria:\n\n* History of seizures\n* Pre-eclampsia or eclampsia\n* Hypertension\n* Use of narcotic painkillers for 24 h before the intervention\n* Medications inducing neuropathy including Amiodarone, Metronidazole, Phenytoin \\& Colchicine.\n* Prolongation of cesarean section (more than 1.5 h)\n* Increase in the size of the incision\n* Occurrence of any unusual complication during surgery,\n* Failure of spinal anesthesia and its conversion to general anesthesia\n* Contraindications to spinal anesthesia\n* Use of interacting medication: fluoroquinolones, loratadine, fexofenadine, alvimopan, armodafinil","70 Years",{"count":91,"type":20},90,[93],"PHASE3","This study evaluates whether lactoferrin, a naturally occurring protein with anti-inflammatory and antioxidant properties, can improve pain control after cesarean section. Effective management of postoperative pain is essential to support maternal recovery, mobility, and the ability to care for the newborn, while minimizing reliance on opioid medications and their associated side effects.\n\nIn this randomized, double-blind, placebo-controlled trial, women undergoing elective cesarean section will receive either oral lactoferrin or a matching placebo in addition to standard postoperative analgesia. Lactoferrin will be administered starting before surgery and continued for 48 hours after delivery.\n\nThe study will assess whether lactoferrin reduces postoperative pain intensity and opioid consumption, and improves recovery outcomes such as time to mobilization, patient satisfaction, and incidence of common postoperative symptoms. Safety and tolerability will also be evaluated.",[27,96],"Post Operative Analgesia",[98,99,100,101,102,103],"post operative pain","lactoferrin","analgesia","pain management","obstetric surgery","post operative analgesia","2026-03-25",{"date":106,"type":51},"2026-03-30",{"date":108,"type":20},"2026-03-26",{"date":110,"type":20},"2026-09-26",{"name":112,"class":58},"Ain Shams University",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":120,"sex":17,"minAge":121,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":21,"phases":125,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":59},"100625245","phase-4-comparison-of-two-different-doses-of-phenylephrine-on-oxytocin-hemodynamic-effect-100625245","NCT07420127","Comparison of Two Different Doses of Phenylephrine on Oxytocin Hemodynamic Effect","Effects of Two Different Doses of Phenylephrine co Administration on Oxytocin- Induced Hemodynamic Effects","Inclusion Criteria:\n\n\\- Females having a singleton pregnancy Patients planned for elective cesarean section under spinal anesthesia\n\nExclusion Criteria:\n\n* Patients having a placental abnormality\n\n  * Patients taking beta-blocker and vasodilator therapy\n  * Patients with hypertensive disorder",true,"20 Years","40 Years",{"count":124,"type":20},112,[126],"PHASE4","Cesarean section is one of the commonly performed surgical procedures in the world. Once baby is delivered during the surgical procedure anesthesiologist administer Oxytocin drug through IV cannula which helps the Uterus to contract so that excessive blood loss doesnt occur. But this is associated with fall in blood pressure frequently requiring administration of medications to treat low blood pressure. The most frequently used drug is phenylephrine which can administered along with oxytocin to prevent fall in blood pressure. This study will compare to different doses of Phenylephrine to prevent fall in blood pressure.",[129,27],"Phenylephrine",[129,131],"Oxytocin induced hypotension","RECRUITING","2026-02-21",{"date":135,"type":51},"2026-02-24",{"date":137,"type":51},"2026-02-13",{"date":139,"type":20},"2026-07-13",{"name":141,"class":58},"Rawalpindi Medical College",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":120,"sex":150,"minAge":4,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":21,"phases":153,"briefSummary":154,"conditions":155,"keywords":159,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":59},"100624524","effect-of-combined-skin-to-skin-contact-and-kangaroo-care-on-breastfeeding-and-bonding-in-cesarean-born-newborns-100624524","NCT07410754","Effect of Combined Skin-to-Skin Contact and Kangaroo Care on Breastfeeding and Bonding in Cesarean-Born Newborns","The Effect of Consecutive Skin-to-Skin Contact Applied by the Mother and Father on Breastfeeding Parameters and Bonding in Babies Born by Cesarean Section","SSC-CS","Inclusion criteria:\n\n* Mothers who delivered by cesarean section\n* Mothers and fathers willing to participate and provide written informed consent\n* Newborns who are stable after birth\n* No health conditions in mothers or fathers that would prevent participation in skin-to-skin contact\n\nExclusion criteria:\n\n* Serious maternal or neonatal illness\n* Newborns requiring NICU admission\n* Mothers or fathers unwilling to participate\n* Any maternal or paternal condition preventing the implementation of skin-to-skin contact\n\nAdditional note:\n\n-Eligibility is based on biological sex (female for mothers, male for fathers, newborns of any sex), not on gender identity.","ALL",{"count":152,"type":20},60,[23],"This randomized controlled study aims to evaluate the effect of consecutive skin-to-skin contact applied by the mother and father on breastfeeding parameters and parent-infant bonding in babies born by cesarean section. The study includes two groups: an intervention group receiving consecutive skin-to-skin contact by the father followed by the mother, and a control group receiving routine postnatal care. Breastfeeding success and parental bonding will be assessed using validated measurement tools during the early postnatal period and follow-up.",[156,157,27,158],"Breastfeeding","Skin to Skin Contact","Kangaroo Care",[160,27,161,162,163],"Skin-to-Skin Contact","Breastfeeding Outcomes","Maternal Attachment","Paternal Attachment","2026-02-08",{"date":137,"type":51},{"date":167,"type":20},"2026-03",{"date":169,"type":20},"2026-07",{"name":171,"class":58},"Istanbul University - Cerrahpasa",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":120,"sex":17,"minAge":66,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":21,"phases":181,"briefSummary":182,"conditions":183,"keywords":187,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":4},"100621266","qr-code-based-preoperative-education-for-cesarean-birth-anxiety-pain-and-comfort-100621266","NCT07368387","QR Code-Based Preoperative Education for Cesarean Birth: Anxiety, Pain, and Comfort","The Effect of QR Code-Based Preoperative Education on Anxiety, Postpartum Pain, and Comfort in Women Undergoing Cesarean Birth","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older\n* Scheduled for elective (planned) cesarean birth\n* Able to read and understand Turkish and complete study questionnaires\n* Able to provide written informed consent\n* Has access to a smartphone and is able to use a QR code to view the educational materials (intervention arm)\n\nExclusion Criteria:\n\n* Emergency cesarean birth or unplanned change to emergency surgery\n* Presence of high-risk pregnancy or serious obstetric\u002Fmedical complications requiring intensive management (e.g., severe preeclampsia\u002Feclampsia, major hemorrhage risk, unstable systemic disease)\n* Known psychiatric disorder or current use of medications that may substantially affect anxiety assessment (as judged by the clinical team)\n* Communication barriers that prevent participation (e.g., severe visual\u002Fhearing impairment, cognitive impairment) or inability to complete questionnaires\n* No smartphone access or inability\u002Funwillingness to use QR code materials (for intervention delivery)\n* Refusal to participate or withdrawal of consent at any time",{"count":180,"type":20},88,[23],"This study aims to evaluate the effect of QR code-based preoperative education on anxiety, postpartum pain, and comfort levels in women undergoing cesarean birth. Cesarean delivery is a common surgical procedure, and insufficient preoperative information may increase anxiety and negatively affect postoperative recovery and comfort.\n\nIn this randomized controlled study, eligible pregnant women scheduled for elective cesarean birth will be assigned to either an intervention group or a control group. Women in the intervention group will receive preoperative education delivered through QR code-based digital materials, including information about the cesarean procedure, postoperative pain management, and comfort-enhancing strategies. The control group will receive routine care provided by the hospital.\n\nAnxiety levels will be assessed preoperatively, while postpartum pain and comfort levels will be evaluated after delivery using validated measurement tools. The findings of this study are expected to contribute to the development of accessible and effective educational interventions to improve maternal well-being and postoperative outcomes in cesarean birth.",[184,185,186,27],"Preoperative Anxiety","Postpartum Pain","Maternal Comfort",[27,188,189,190,185,186,191,192,193],"Preoperative Education","QR Code-Based Education","Maternal Anxiety","Digital Health Education","Randomized Controlled Trial","Prenatal Education","2026-01-18",{"date":196,"type":51},"2026-01-26",{"date":198,"type":20},"2026-02-02",{"date":200,"type":20},"2026-06-20",{"name":202,"class":58},"Karabuk University"]