[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"cheek-wrinkles\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:cheek-wrinkles":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100619267","a-clinical-study-to-assess-histological-changes-from-treatment-of-poly-l-lactic-acid-biostimulator-on-women-at-various-menopausal-stages-100619267",false,"NCT07342400","A Clinical Study to Assess Histological Changes From Treatment of Poly L-lactic Acid Biostimulator on Women at Various Menopausal Stages","A Multi-center, Prospective Clinical Study to Assess Histological Changes From Treatment of Poly L-lactic Acid Biostimulator on Women at Various Menopausal Stages","Inclusion Criteria:\n\n* Subjects diagnosed with symmetrical, moderate-to-severe cheek wrinkles on each side of the face as assessed via the Galderma Cheek Wrinkles Scale.\n* Subject with intent to undergo correction of cheek augmentation or contour deficiencies\n* Subjects willing to have a 3-mm punch biopsy on each preauricular side\n* Subjects willing to maintain the current lifestyle, daily routine (e.g., diet, exercise, sleep, etc.), and a stable Body Mass Index (BMI, ± 5 kg\u002Fm2) throughout the study\n* Ability of giving consent for participation in the study.\n* Agreement to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments.\n\nExclusion Criteria:\n\n* Subjects with asymmetrical severity or unidentical cheek wrinkle score between 2 sides of the cheek.\n* Subjects with a history of allergy or hypersensitivity to any ingredient of the treatment products.\n* Previous tissue-augmenting therapy, contouring, or revitalization treatment in the face, except lips.\n* Previous treatment\u002Fprocedure in the face in the previous 6 months that, in the Investigator's opinion, would interfere with the study injections and\u002For study assessments or exposed the study subject to undue risk by study participation, or planning to undergo any of these procedures affecting the treatment area at any time during the study.\n* Subjects with any medical condition that, in the opinion of the Investigator, would make the subject unsuitable for inclusion.","FEMALE","22 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","To assess protein expression stimulated by poly L-lactic acid (PLLA) via punch biopsy at each follow-up visits compared to Baseline.",[26,27],"Cheek Wrinkles","Menopausal Women","RECRUITING","2026-01-13",{"date":31,"type":32},"2026-01-15","ACTUAL",{"date":34,"type":32},"2025-08-12",{"date":36,"type":20},"2026-11",{"name":38,"class":39},"Galderma R&D","INDUSTRY",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":75},"100587183","quantified-evaluation-of-noninvasive-system-delivering-microwave-energy-for-unwanted-fat-reduction-and-skin-tightening-in-asians-100587183","NCT06925074","Quantified Evaluation of Noninvasive System Delivering Microwave Energy for Unwanted Fat Reduction and Skin Tightening in Asians.","Inclusion Criteria:\n\n* Men and women aged between 20 and 60.\n* Subjects who are capable of understanding and comply with the study procedures, instructions, and visit schedule.\n* Subjects who voluntarily decide to participate in the entire course of the trial and provide written consent in the Informed Consent Form.\n\nExclusion Criteria:\n\n* Subjects with autoimmune diseases\u002Freceived immunotherapy and subjects with diabetes mellitus.\n* Subjects with a history of a hypertrophic scar.\n* Pregnant or breastfeeding women.\n* Subjects with untreated epilepsy or underlying porphyria.\n* When there is an active disease (such as inflammation, infection or tumors) in or near the intended treatment site.\n* Treatment procedure (e.g., bioresorbable fillers, laser\u002Flight therapies, botulinum toxin A injections, facial lift, facial peels, excisional facial surgery, dermal photorejuvenation, oral or maxillofacial surgery, etc.) that may interfere with the treatment area or evaluation within 6 months before screening as determined by the Principal Investigator.\n* The subject who received soft tissue augmentation at the treatment site at any time before screening as determined by the Principal Investigator.\n* Subjects with a scar or skin lesion at the treatment site that may interfere with the judgment of the treatment effect.\n* Subjects who participated in another clinical trial within 60 days before screening or plan to participate in another investigation during this study.\n* Subjects who plan to receive other wrinkle improvement treatments in the face during this trial.\n* Subjects who are otherwise determined by the investigator as ineligible for this study.",true,"ALL","20 Years","60 Years",{"count":51,"type":20},15,"3 Months","OBSERVATIONAL","The goal of this observational study is to evaluate the effectiveness and safety of microwave-assisted heating technology in facial fat reduction and skin tightening in Asians.\n\nThe main questions it aims to answer are:\n\n1. How effective is the microwave-based system in reducing fat and tightening Skin?\n2. What objective methods can be used to measure treatment outcomes?\n3. What are the optimal treatment parameters for maximum efficacy?\n4. What are the safety and side effects associated with the treatment?\n5. How long-lasting are the results?\n\nParticipants will go through three treatment sessions using the \"DEKA\" ONDA Microwave treatment system, with each session lasting 12 minutes.",[56,57,26],"Facial Aging","Skin Laxity",[59,60,61,62,63],"3D imaging","Skin laxity","Microwaves","Fat reduction","Facial aging","NOT_YET_RECRUITING","2025-04-06",{"date":67,"type":32},"2025-04-13",{"date":69,"type":20},"2025-05",{"date":71,"type":20},"2026-04",{"name":73,"class":74},"Chang Chang Cheng","OTHER",1]