[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"chemotherapy-induced-cardiotoxicity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:chemotherapy-induced-cardiotoxicity":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100625213","grape-polyphenols-for-prevention-of-chemotherapy-induced-cardiotoxicity-100625213",false,"NCT07419711","Grape Polyphenols for Prevention of Chemotherapy-Induced Cardiotoxicity","Cardioprotective Effects of Grape Polyphenols to Reduce Chemotherapy-Induced Cardiotoxicity in Breast Cancer Patients: A Randomized Pilot Study","Inclusion Criteria:\n\n* Female patients aged 30 to 75 years.\n* Histologically confirmed breast cancer.\n* Planned treatment with anthracycline- and\u002For trastuzumab-based chemotherapy.\n* High or very high risk of chemotherapy-induced cardiotoxicity (≥20%), based on clinical assessment.\n* Eastern Cooperative Oncology Group (ECOG) performance status 0-3.\n* Ability to take oral study products.\n* Willingness to comply with study procedures and follow-up visits.\n* Written informed consent provided prior to any study procedures.\n\nExclusion Criteria:\n\n* ECOG performance status of 4.\n* Pre-existing severe cardiovascular disease that would interfere with study participation.\n* Permanent atrial fibrillation or other clinically significant arrhythmias.\n* Severe hepatic or renal impairment.\n* Active central nervous system tumors or metastases.\n* Uncontrolled arterial hypertension.\n* Acute gastrointestinal diseases that may impair absorption.\n* Known allergy or intolerance to grape products or study components.\n* Participation in another interventional clinical trial that may interfere with the outcomes of this study.","FEMALE","30 Years","75 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","This pilot randomized clinical study aims to evaluate the cardioprotective effects of a grape polyphenol concentrate in patients receiving anthracycline- and\u002For trastuzumab-based chemotherapy. Adult patients at high or very high risk of chemotherapy-induced cardiotoxicity will be randomized to receive either a grape polyphenol concentrate or placebo for three months, starting with chemotherapy. Cardiac function and cardiotoxicity will be assessed using echocardiographic parameters and circulating biomarkers at baseline, 3 months, and 6 months.",[27,28],"Chemotherapy-induced Cardiotoxicity","Breast Cancer","NOT_YET_RECRUITING","2026-02-16",{"date":32,"type":33},"2026-02-19","ACTUAL",{"date":35,"type":21},"2026-02-09",{"date":37,"type":21},"2027-11-01",{"name":39,"class":40},"Nazarbayev University","OTHER","Chemotherapy Induced Cardiotoxicity"]