[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"child-development\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:child-development":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,61,0,25,[9,81,123,149,170,198,226,272,303,332,364,398,423,467,505,536,560,583,615,642,675,701,723,742,771],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":57,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100454745","interventions-in-mathematics-and-cognitive-skills-100454745",false,"NCT05201534","Interventions in Mathematics and Cognitive Skills","Interventions in Math Learning Disabilities: Cognitive and Neural Correlates","Inclusion Criteria:\n\n1. Elementary school aged children starting from first grade (6-12 years old)\n2. IQ: Participants with a Full Scale IQ \\> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).\n3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests\n4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests\n5. Normal or corrected-to-normal vision and no hearing impairments\n6. Inclusion in MRI scan session: Right-handed\n\nExclusion Criteria:\n\n1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)\n2. History of trauma involving head injury\n3. Consistent psychiatric medications\n4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)",true,"ALL","6 Years","12 Years",{"count":22,"type":23},180,"ESTIMATED","INTERVENTIONAL",[26],"NA","The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56],"Math Learning Disability","Child Development","Developmental Disability","Learning Disabilities","Learning Disabled","Learning Curve","Mathematics Disorder","Dyscalculia","Dyscalculia, Primary","Dyscalculia, Acquired","Specific Learning Disorder, With Impairment in Mathematics","Individuality","Behavior, Child","Behavior and Behavior Mechanisms","Behavior","Decision Making","Neuronal Plasticity","Cognition","Cognition Disorder","Cognitive Dysfunction","Cognitive Change","Cognitive Impairment, Mild","Cognitive Developmental Delay","Cognitive Orientation","Cognitive Delay, Mild","Cognitive Deficits, Mild","Cognitive Abnormality","Neuroscience",[58,59,60,61,62,63,64,65,66,67],"Numerical skills in children","Low math abilities","Mathematical Learning Disabilities","Mathematical Concepts","Mathematics","Transfer, Psychology","Generalization, Psychology","Early Intervention, Educational","Neural Pathways","Neural Networks, Computer","RECRUITING","2026-06-22",{"date":71,"type":72},"2026-06-25","ACTUAL",{"date":74,"type":72},"2023-05-05",{"date":76,"type":23},"2026-08-31",{"name":78,"class":79},"Stanford University","OTHER",1,{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":17,"sex":18,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":24,"phases":93,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":80},"100644295","sharing-tales-that-teach-shared-picturebook-reading-for-early-childhood-emotional-and-cognitive-development-100644295","NCT07666802","Sharing Tales That Teach: Shared Picturebook Reading for Early Childhood Emotional and Cognitive Development","Sharing Tales That Teach: An RCT of Emotion-Focused Shared Picturebook Reading Versus Standard Dialogic Reading to Support Emotion Regulation and Executive Function in Caregiver-Child Dyads","STTT","Inclusion Criteria:\n\n* Child aged 4 to 5 years at baseline assessment\n* Child enrolled in a participating state primary school\n* At least one primary caregiver willing to participate in shared reading activities and study assessments\n* Caregiver has sufficient proficiency in English to engage with intervention materials and questionnaires\n\nExclusion Criteria:\n\n* Child has an identified sensory impairment, such as uncorrected hearing or vision difficulties, that would impede engagement with study tasks\n* Family is unable to commit to baseline and follow-up assessments","48 Months","59 Months",{"count":92,"type":23},200,[26],"Sharing Tales That Teach is a randomised study of a shared picturebook reading programme for 4- to 5-year-old children and their primary caregivers. The study will test whether a caregiver-delivered, emotion-focused shared reading programme leads to greater improvements in children's emotion regulation than a standard dialogic shared reading programme.\n\nEmotion regulation refers to children's developing ability to understand, express and manage emotions in ways that support learning, relationships and wellbeing. These skills are closely linked with executive function, including children's ability to remember instructions, control impulses and shift flexibly between activities. Shared picturebook reading may provide a natural, low-cost way for caregivers to support these skills through everyday interaction.\n\nFamilies in the randomised part of the study will be allocated to one of two 8-week shared reading programmes. In the emotion-focused group, caregivers will receive training in strategies such as naming emotions, discussing why characters feel as they do, talking about consequences of emotions and modelling ways to manage feelings. In the comparison group, caregivers will receive training in standard dialogic picturebook reading strategies, such as naming, describing, sequencing and asking open questions, without an explicit focus on emotions or emotion regulation. Both groups will use the same picturebooks and will be asked to complete three shared reading sessions per week at home.\n\nThe main hypothesis is that children in the emotion-focused shared reading group will show greater improvement in emotion regulation from baseline to 12-month follow-up than children in the standard dialogic shared reading group. The study will also examine whether the programme affects children's executive function, caregiver wellbeing and caregiver emotion regulation. Additional exploratory analyses will examine caregiver-child interaction processes and whether caregiver or child characteristics are associated with different intervention effects.\n\nThe study will recruit caregiver-child dyads through state primary schools in Greater London. Children will complete age-appropriate tasks and caregivers will complete questionnaires at baseline and follow-up. A laboratory subsample may also complete additional behavioural, observational and neurophysiological assessments. The study is low risk, non-invasive and does not involve medical treatment.",[30,96,97],"Executive Functions (EF)","Emotion Regulation",[97,99,100,101,102,103,104,105,106,107,108,109,110,111,112],"Inhibitory Control","Cognitive Flexibility","Working Memory","Self-Control","Shared Reading","Dialogic Reading","Picturebooks","Early Childhood","Preschool Children","Caregiver-Child Dyads","Randomized Controlled Trial","Randomised Controlled Trial","Behavioural Intervention","Developmental Cognitive Neuroscience","NOT_YET_RECRUITING","2026-06-18",{"date":116,"type":72},"2026-06-24",{"date":118,"type":23},"2026-09",{"date":120,"type":23},"2028-08-01",{"name":122,"class":79},"University of Greenwich",{"id":124,"slug":125,"hasResults":12,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":12,"sex":18,"minAge":129,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":80},"100518163","pregnancy-and-early-neurodevelopmental-outcomes-following-in-utero-lyme-disease-exposure-100518163","NCT06026969","Pregnancy and Early Neurodevelopmental Outcomes Following In Utero Lyme Disease Exposure","Inclusion Criteria:\n\n* English speaker\n* Currently reside in the United States or Canada\n* Meet CDC criteria for: (1) clinical and\u002For laboratory diagnosis of Lyme disease during any stage of current pregnancy, OR (2) clinical diagnosis of PTLDS\u002FChronic Lyme within 3 years of current pregnancy\n* Able to be contacted for follow-up\n\nExclusion Criteria:\n\n* Intellectually unable to comprehend study procedures\n* Health issues or metallic implant that precludes undergoing MRI\n* Incapable of completing study requirements (note: inability to travel to Children's National for in-person follow-up \\[for example, due to bedrest, travel restrictions, or financial inability to travel\\] is NOT an exclusion criterion; any interested and eligible participants requiring \"remote only\" participation will be permitted to join the study and complete all requirements besides in-person follow-up)","18 Years",{"count":131,"type":23},40,"OBSERVATIONAL","The purpose of this pilot study is to assess the feasibility of longitudinal neurodevelopmental evaluation of fetuses and infants exposed to Lyme disease in utero. Participants with Lyme disease or Post-Treatment Lyme Disease Syndrome (PTLDS) will be recruited during pregnancy. Pregnancies will be monitored and infant development will be assessed from birth until age 18 months.",[135,136,137,138,139,30],"Lyme Disease","Post-Treatment Lyme Disease","Chronic Lyme Disease","Tick-Borne Infections","Pregnancy Complications","2026-06-15",{"date":142,"type":72},"2026-06-16",{"date":144,"type":72},"2023-07-01",{"date":146,"type":23},"2026-12",{"name":148,"class":79},"Children's National Research Institute",{"id":150,"slug":151,"hasResults":12,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":12,"sex":18,"minAge":155,"maxAge":156,"enrollmentInfo":157,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":80},"100508830","testing-of-online-version-of-qaps-100508830","NCT05905523","Testing of Online Version of QAPS","Inclusion Criteria:\n\n* Children between 3 to 7 years old\n\nExclusion Criteria:\n\n* Children unable to follow directions to attempt copying shapes.","3 Years","7 Years",{"count":158,"type":23},1000,"Early evaluation of prewriting skills is important, as prewriting skills set the stage for later learning of the fine motor and visual motor skills needed for writing. Evaluation of prewriting skills allows for the identification of those children who struggle with these tasks so that early intervention might address these foundational skills before academic demands become more challenging. However, current prewriting skill assessments are limited to pencil-and-paper assessments that require an evaluator to score the drawn shapes. Manual scoring is time consuming, can be subjective, and limit the ability to capture subtle changes in performance.\n\nWe have developed an assessment on a tablet to assess prewriting skills in children. The preliminary testing of the assessment is published in a paper (https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F35417278\u002F). We are now working on developing an online version of the assessment that will allow offsite data collection and will automate the analysis on the website so that the results can be automatically generated for the clinician or educator who wants to use this with the children they work with.",[30],"2026-06-01",{"date":163,"type":72},"2026-06-03",{"date":165,"type":72},"2023-10-03",{"date":167,"type":23},"2026-12-01",{"name":169,"class":79},"Virginia Commonwealth University",{"id":171,"slug":172,"hasResults":12,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":17,"sex":177,"minAge":129,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":181,"conditions":182,"keywords":184,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":80},"100615707","in-vitro-fertilization-ivf-and-prenatal-effects-independent-of-genetics-100615707","NCT07296107","In Vitro Fertilization (IVF) and Prenatal Effects Independent of Genetics","Leveraging IVF to Identify Prenatal Effects Independent of Shared Maternal-Child Genes","Inclusion Criteria:\n\n1. Individuals at 18-28 gestational weeks with donor and homologous IVF pregnancies, ages 18-50.\n2. Participants must be patients receiving their perinatal health care through Columbia University Irving Medical Center's Department of OB\u002FGYN and delivering at New York-Presbyterian Morgan Stanley Children's Hospital.\n3. Participants must be patients delivering at Columbia University Irving Medical Center's Department of OB\u002FGYN and delivering at New York-Presbyterian Morgan Stanley Children's Hospital.\n4. Participants will include the offspring of patients receiving care and delivering at the above institutions.\n5. Enrollment Location(s): Columbia University Irving Medical Center's Department of OB\u002FGYN, delivering at New York-Presbyterian Morgan Stanley Children's Hospital.\n\nExclusion Criteria:\n\n1. Identified addiction disorder\n2. Severe psychiatric condition (defined as symptoms that significantly impair daily functioning and are untreated or not effectively managed)\n3. Multiple fetal pregnancy\n4. Known chromosomal, genetic, or major fetal malformations (unlikely due to routine preimplantation genetic testing)\n5. Inflammatory conditions including rheumatoid arthritis, lupus, and multiple sclerosis\n6. Not planning to deliver at a CUIMC-affiliated hospital","FEMALE","50 Years",{"count":180,"type":23},360,"This study examines how maternal stress during pregnancy affects infant brain and behavioral development, focusing on whether these effects are due to the prenatal environment or shared genes. By comparing IVF pregnancies using donor eggs\u002Fembryos (no shared genetics) with non-donor IVF pregnancies, the investigators aim to understand how stress influences the baby's development independent of genetic factors.\n\nParticipants will complete questionnaires, provide blood samples, and take part in placenta and cord blood collection, fetal monitoring, and newborn brain activity assessments.\n\nAim 1: The influence of maternal distress on perinatal neurobehavioral development.\n\nHypotheses: Independent of IVF group status, higher maternal AL will be associated with higher 3rd trimester FHR reactivity, lower FHR variability, AND lower FHR-movement coupling\n\nAim 2: Maternal distress affecting placenta gene methylation.\n\nHypotheses: Independent of IVF group status, maternal AL will be associated with placenta differential DNA methylation in glucocorticoid-regulating genes (FKBP5 and HSD11B2),\n\nAim 3: Maternal experiences associated with unique placenta transcriptomic profiles.\n\nHypotheses: Independent of IVF group status, maternal AL and well-being each will be associated with unique placenta gene expression in pro-inflammatory genes",[183,30],"Maternal Distress",[185,186,187,188],"Developmental Origins of Health and Disease (DOHaD)","Maternal Health","Child development","IVF","2026-05-11",{"date":191,"type":72},"2026-05-13",{"date":193,"type":23},"2026-05",{"date":195,"type":23},"2030-07-31",{"name":197,"class":79},"Columbia University",{"id":199,"slug":200,"hasResults":12,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":12,"sex":18,"minAge":205,"maxAge":155,"enrollmentInfo":206,"targetDuration":4,"studyType":24,"phases":208,"briefSummary":209,"conditions":210,"keywords":214,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":221,"leadSponsor":223,"locationsCount":225},"100639102","empowering-families-in-pediatric-cardiovascular-surgery-a-ram-based-approach-100639102","NCT07575451","Empowering Families in Pediatric Cardiovascular Surgery: A RAM-Based Approach","Evaluation of a Nursing Program Based on Roy's Adaptation Model for Empowering Families of Children Aged 1 to 3 Years Post-Cardiac Surgery","Inclusion Criteria:\n\n* Families who agree to participate in the study and sign the informed consent form.\n* Families of children aged 1-3 years in the preoperative period who are scheduled to undergo cardiac surgery due to congenital heart disease.\n* Families who do not speak or read Turkish but will undergo cardiac surgery due to congenital heart disease will also be included in the study with the assistance of an interpreter.\n* Families who are over 18 years of age and have access to a mobile phone or internet at home.\n\nExclusion Criteria:\n\n* Exclusion criteria include the presence of additional congenital malformations, dysmorphic syndromes, chromosomal or endocrine disorders, severe infection, hypothyroidism, or any similar conditions that could lead to growth and developmental delay in the child, alongside congenital heart disease","1 Year",{"count":207,"type":23},80,[26],"The purpose of this clinical trial is to learn about the effects of a nursing support program designed for families of children aged 1 to 3 years who have undergone heart surgery. This program aims to improve parents' caregiving skills and support the healthy growth of their children.\n\nThe primary questions the study aims to answer are:\n\nDoes the nursing program positively affect the physical growth of children, such as their height and weight?\n\nDoes the program improve children's scores on general development tests (Denver II)?\n\nDo parents' attitudes toward child feeding and their confidence in parenting skills increase?\n\nResearchers will divide participants into two groups:\n\nExperimental Group: Families who participate in the nursing education program and receive an informative booklet.\n\nControl Group: Families who only receive an informative booklet and continue with routine hospital follow-ups.\n\nThe researchers will compare these two groups to see if participating in the nursing program leads to better results for the children's development and the families' skills.\n\nParticipants will be asked to:\n\nAttend 5 different education and counseling sessions, starting one week before surgery and continuing until the child reaches 1 year of follow-up.\n\nMeet with the researcher at specific intervals (at 1, 2, 3, 6, 9, and 12 months) for one year to monitor the child's development (height, weight, head circumference) and skills.\n\nComplete surveys regarding child feeding attitudes and parenting skills at the 6th and 12th month follow-ups.",[211,212,30,213],"Congenital Heart Disease","Postoperative Care","Roy Adaptation Model-based Nursing Empowerment Program",[211,215,212,216],"Cardiac Surgery","Nursing Support Program","2026-05-08",{"date":219,"type":72},"2026-05-12",{"date":140,"type":23},{"date":222,"type":23},"2027-06-15",{"name":224,"class":79},"Cukurova University",3,{"id":227,"slug":228,"hasResults":12,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":232,"eligibilityCriteria":233,"healthyVolunteers":12,"sex":177,"minAge":20,"maxAge":4,"enrollmentInfo":234,"targetDuration":4,"studyType":24,"phases":236,"briefSummary":237,"conditions":238,"keywords":255,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":268,"leadSponsor":270,"locationsCount":80},"100636706","improved-child-nutrition-and-development-through-social-transfers-100636706","NCT07569172","Improved Child Nutrition and Development Through Social Transfers","Taabo Enhanced Nutrition and Development Through Economic Rewards","TENDER","Inclusion Criteria:\n\n1. Are enrolled in the Taabo multigenerational birth cohort (MGC)\n2. Completed the postpartum interview of the Taabo MGC\n3. Have a child who is within two weeks of their 12-month birthday,\n4. are breastfeeding at time of recruitment,\n5. live in the Taabo HDSS, Côte d'Ivoire\n6. have no illnesses that contraindicates breastfeeding,\n7. had a healthy singleton infant with a birth weight of at least 2500 grams, and\n8. agree to participate and sign an informed consent; if underage (12-17 years), a legal representative will also have to agree to sign the informed consent\n\nExclusion Criteria:\n\n1. Plans to move permanently outside study area\n2. Has a medical, intellectual or psychological disability\n3. Contraindication for breastfeeding\n4. Children born with \\\u003C 2500 grams",{"count":235,"type":23},1040,[26],"The goal of this clinical trial is to learn if a conditional social transfer works to improve rates of complementary breastfeeding. It will also learn about the impacts of social transfers on maternal and child health and development. The main questions it aims to answer are:\n\n* Does the social transfer increase complementary breastfeeding rates at 24-months postpartum?\n* Does the social transfer increase complementary breastfeeding duration?\n* Does the social transfer impact child health and development?\n* Does the social transfer impact maternal physical and mental health?\n\nResearchers will compare a conditional social transfer to a control group that only receives education about breastfeeding recommendations to see if a conditional social transfers works to increase complementary breastfeeding.\n\nParticipants will:\n\nReceive a pamphlet explaining the current recommendations of breastfeeding Receive instructions that if they meet the recommendation to breastfeed until 24-months postpartum they receive a social transfer or receive no additional information Complete home visits at 12- and 24-months postpartum Complete detailed questionnaire",[239,240,241,242,243,244,245,246,30,247,248,249,250,251,252,253,254],"Breastfeeding","Breastfeeding Education","Breastfeeding Duration","Breastfeeding Continuation","Child Growth","Stress","Infectious Diseases","Anemia","Weight Loss","Blood Pressure","Mental Health","Diarrhea","Coughing","Eczema","Allergies","Antibiotic Use",[256,257,258,259,260,261,262,263],"breastfeeding","cash transfer","child health","maternal health","mental health","child growth","child development","education","2026-04-28",{"date":266,"type":72},"2026-05-06",{"date":161,"type":23},{"date":269,"type":23},"2028-02-28",{"name":271,"class":79},"Swiss Tropical & Public Health Institute",{"id":273,"slug":274,"hasResults":12,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":12,"sex":18,"minAge":280,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":284,"conditions":285,"keywords":288,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":298,"leadSponsor":300,"locationsCount":302},"100578006","prospective-cohort-study-of-protected-children-100578006","NCT06805682","Prospective Cohort Study of Protected Children","PEGASE3, Experimental Program of a Standardized Health Protocol Applied to Children Who Benefited From a Child Protection Measure Before the Age of Five: Effectiveness and Efficiency","ESPER","Inclusion Criteria:\n\n* Child under the supervision of child protective services,\n* Arriving for the first time in a participating center,\n* Less than 42 months old (i.e. 3 and a half years),\n* Non-opposition of the holders of parental authority (in the event of impossibility to obtain the non-opposition of both holders of parental authority, the non-opposition of one of them will be obtained).\n\nExclusion Criteria:\n\n• Children whose child protection measure has not been confirmed by a judicial or administrative decision.","0 Months","42 Months",{"count":283,"type":23},220,"A significant number of children are abused or neglected every year. This exposure is associated with short- and long-term consequences for their mental and somatic health. In France, 308,000 minors are benefiting from at least one child protective service or measure. There are few data on the health status of this population, and how it is evolving. Against this backdrop, interventions are needed to address the many needs of these children early and comprehensively, both in the short and long term.\n\nThe PEGASE program, funded by the French government under Article 51, aims to ensure adequate medical follow-up - both somatic and psychiatric - for children taken into care by child protective services (CPS). An evaluation of the program's effectiveness and efficiency is needed to inform public decision-making on the appropriateness of extending it to all children under CPS's care. This requires the creation of a control cohort of children followed by CPS but not benefiting from the PEGASE program, the ESPER cohort (Prospective cohort study of protected children), which will enable us to carry out a comparative evaluation of the PEGASE program, as well as to provide information on the health of children followed by the CPS at the time of their placement and its evolution over time, data which are rare in France.\n\nThe main objective is to evaluate the effectiveness of the PEGASE program on the evolution of the mental health of children followed by the CPS after 2 years of follow-up.",[286,287,30],"Mental Health Conditions","Physical Health Status",[289,30,290,291,292],"Child Protective Services","Mental health","Cohort study","Comparative study","2026-04-08",{"date":295,"type":72},"2026-04-13",{"date":297,"type":72},"2025-02-18",{"date":299,"type":23},"2029-02-17",{"name":301,"class":79},"Assistance Publique - Hôpitaux de Paris",7,{"id":304,"slug":305,"hasResults":12,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":17,"sex":18,"minAge":155,"maxAge":19,"enrollmentInfo":310,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":312,"conditions":313,"keywords":317,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":80},"100632267","development-sensory-profile-and-sleep-quality-in-preschool-children-across-different-caregiving-models-100632267","NCT07511465","Development, Sensory Profile, and Sleep Quality in Preschool Children Across Different Caregiving Models","Developmental Status, Sensory Processing, and Sleep Quality in Preschool Children Across Different Caregiving Models","Inclusion Criteria:\n\n* Preschool children aged 3 to 6 years\n* Child has been raised within the same primary caregiving model for at least the past 6 months\n* Parent or legal guardian is willing to participate voluntarily and provide informed consent\n* Child and caregiver are able to understand Turkish and follow the study instructions\n\nExclusion Criteria:\n\n* Previously diagnosed neurological, developmental, or psychiatric disorder (e.g., autism spectrum disorder, attention-deficit\u002Fhyperactivity disorder, developmental delay)\n* Currently receiving treatment or therapy for sensory processing problems, sleep problems, or developmental difficulties\n* Parent or legal guardian provides incomplete or incorrect study forms\n* Child is unable to cooperate with or complete the assessment procedures",{"count":311,"type":23},135,"This observational study aims to examine developmental status, sensory processing, and sleep quality in preschool children aged 3 to 6 years across different caregiving models. Children raised primarily by first-degree relatives, second-degree relatives, caregivers, or in daycare settings will be compared. Data will be collected using the Denver II Developmental Screening Test, the Dunn Sensory Profile, and the Tayside Children's Sleep Questionnaire. The study will also evaluate the relationships among developmental status, sensory processing, and sleep quality, and explore whether caregiving model is associated with differences in these outcomes.",[30,314,315,316],"Sensory Processing","Sleep Quality","Caregiving Models",[318,319,320,321,322],"Preschool children","Developmental status","Sensory processing","Sleep quality","Caregiving models","2026-04-05",{"date":325,"type":72},"2026-04-09",{"date":327,"type":72},"2026-01-05",{"date":329,"type":23},"2026-06",{"name":331,"class":79},"Fenerbahce University",{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":336,"acronym":337,"eligibilityCriteria":338,"healthyVolunteers":17,"sex":177,"minAge":129,"maxAge":4,"enrollmentInfo":339,"targetDuration":4,"studyType":24,"phases":341,"briefSummary":342,"conditions":343,"keywords":350,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":363},"100599326","enhancing-preschool-childrens-attention-and-behaviour-parent-focused-program-100599326","NCT07083037","Enhancing Preschool Children's Attention and Behaviour: Parent-Focused Program","BRIDGE-McGill","Inclusion Criteria:\n\nBRIDGE Therapy Group:\n\nParticipants are deemed eligible for the BRIDGE therapy group if they meet the following criteria:\n\n1. Above the age of 18.\n2. Self-identify as a mother of a child between the age of 3-7 years old.\n3. Currently living in Quebec, Ontario, or Manitoba\n4. Fluency in English.\n5. Mothers must have clinically significant symptoms of depression (mild to moderate on the Patient Health Questionnaire and indicate symptoms to \"somewhat cause difficulties\") currently affecting them. Participants also need to report symptoms of depression during pregnancy or shortly after birth.\n6. Their child has attention and\u002For behavior problems (T-score \\> 65 on the Child Behavior Checklist (CBCL) ADHD subscales) or confirmed attention and\u002For behavior problems through clinical interview.\n\nControl Group:\n\nParticipants are deemed eligible for the Control group if they meet the following criteria:\n\n1. Above the age of 18\n2. Self-identify as a mother of a child between the age of 3-7 years old\n3. Currently living in Quebec, Ontario, or Manitoba\n4. Fluency in English or bilingual\n5. Mothers must NOT have clinically significant symptoms of depression (mild to moderate on the Patient Health Questionnaire)\n6. Their child DOES NOT have attention and\u002For behavior problems (T-score \\> 65 on the Child Behavior Checklist (CBCL) ADHD subscales).\n\nExclusion Criteria:\n\nBRIDGE Therapy Group:\n\nParticipants were excluded if they A) did not meet the inclusion criteria listed above or B) were unable to attend the weekly BRIDGE group therapy sessions.\n\nFurthermore, eligible participants were invited to complete a semi-structured intake interview with principal investigator (PI) Dr. Tasmia Hai or a graduate student trainee under Dr. Hai's supervision, during which further questions about their mental health and child behavior were asked to ensure their eligibility. Based on the clinical suitability interview, participants may be excluded if they are deemed to be ineligible based on A) the mother's absence of clinically significant mental health symptoms, and\u002For B) the child's absence of attention and\u002For behavior problems. When relevant, participants may be identified to participate in the control group instead if eligibility is met.\n\nControl Group:\n\nParticipants were excluded if they did not meet the inclusion criteria listed above. Furthermore, eligible participants were invited to complete a semi-structured intake interview with principal investigator (PI) Dr. Tasmia Hai, during which further questions about their mental health and child behavior were asked to ensure their eligibility. Based on the clinical suitability interview, participants may be excluded if they are deemed to be ineligible based on a) the mother's presence of clinically significant mental health symptoms, and\u002For B) the child's presence of attention and\u002For behavior problems. When relevant, participants may be identified to participate in the BRIDGE therapy group instead if eligibility is met.",{"count":340,"type":23},60,[26],"This study aims to evaluate the feasibility and efficacy of the Building Regulation in Dual Generations (BRIDGE) program for caregivers with significant mental health concerns and preschool and young children (3-7 years old) with elevated attention and\u002For behavior problems. The BRIDGE program focuses on supporting parental psychological distress and improving young children's self-regulation (SR), thereby reducing their attention and behavior problems. The long-term goal of this work is to improve family well-being and social-emotional development for young children by implementing an accessible and scalable dual-regulation program. The investigators will achieve this through the following key objectives:\n\n1. Assess the feasibility and accessibility of BRIDGE for preschool and young children (3-7 years old) with significant attention and behavior programs through questionnaires asking about attendance, satisfaction, and unmet needs.\n2. Examine the efficacy of BRIDGE compared to control group at improving maternal mental health and child attention and behavioral difficulties in young children (primary outcomes). The investigators will also examine parenting stress (secondary outcome).\n3. Identify predictors of academic readiness skills in preschool and young children. The investigators hypothesize that an increase in parental and child emotion-regulation skills and reduced attention, as well as behavioral problems, will lead to increased pre-academic skills in children.",[344,345,346,30,347,348,349],"Maternal Depression","Self-Regulation, Emotion","Child Mental Disorder","Attention Problems","Behaviour Problems","Parental Stress",[351,352,353,354],"maternal depression","child attention problems","child behaviour problems","parental stress","2026-04-02",{"date":293,"type":72},{"date":358,"type":72},"2025-02-01",{"date":360,"type":23},"2027-08-31",{"name":362,"class":79},"McGill University",2,{"id":365,"slug":366,"hasResults":12,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":4,"eligibilityCriteria":370,"healthyVolunteers":17,"sex":18,"minAge":371,"maxAge":281,"enrollmentInfo":372,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":374,"conditions":375,"keywords":378,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":80},"100625122","understanding-early-development-of-infants-and-toddlers-100625122","NCT07418528","Understanding Early Development of Infants and Toddlers","Understanding Early Development: A Biopsychosocial Perspective on Infant and Toddler Functioning","Inclusion Criteria:\n\n* Infants and young children aged from 16 days to 42 months at the time of assessment.\n* Participation of a parent or legal guardian able to provide informed consent.\n* Child's ability to participate in a standardized developmental assessment appropriate for age and developmental level.\n* Availability of basic medical and perinatal information provided by parents or caregivers.\n* Assignment to one of the predefined study cohorts based on medical history and developmental status:\n\nchildren from the general population (control group), children with developmental delay, children with confirmed genetic conditions, children born preterm between 33 and 37 weeks of gestation, children born before 33 weeks of gestation, children with a diagnosis of cerebral palsy.\n\nExclusion Criteria:\n\n* Severe acute medical condition at the time of assessment preventing participation in the psychological evaluation.\n* Uncorrected severe sensory impairments (e.g., profound visual or hearing impairment) that preclude valid administration or interpretation of the developmental assessment.\n* Medical instability or conditions requiring immediate intensive medical care.\n* Lack of informed consent from a parent or legal guardian.\n* Inability of the parent or caregiver to provide reliable information required for questionnaire-based assessment.","16 Days",{"count":373,"type":23},1200,"The goal of this observational study is to analyze early development in infants and young children from a biopsychosocial perspective, with a particular focus on cognitive, language, motor, social-emotional, and adaptive functioning during the first years of life.\n\nThe study will include infants and young children from 16 days of age up to 42 months of age, assessed during a single diagnostic session conducted by qualified specialists. The developmental assessment will include standardized diagnostic tasks and direct observation of behavior in the form of play and natural interaction, carried out in the presence of a parent or legal guardian.\n\nIn addition, information regarding the child's everyday functioning will be collected from parents or caregivers using standardized questionnaires, including data on social-emotional competencies, communication, and adaptive skills.\n\nThe main research questions addressed by this study are:\n\nWhat is the developmental profile of infants and young children in the first years of life?\n\nWhat relationships exist between different domains of early development within a biopsychosocial model of child functioning?\n\nCan specific developmental patterns be identified that indicate an increased risk of developmental difficulties in early childhood?\n\nHow does age differentiate the structure and variability of developmental functioning across assessed domains?\n\nThe study is non-invasive and observational in nature. Data will be analyzed exclusively in aggregated form and will contribute to a better understanding of early child development as well as to the development of norms and tools supporting early diagnosis and developmental intervention.",[376,377,30],"Early Childhood Development","Infant Development",[379,380,381,382,383,384,385,386,387],"Early development","Infant development","Toddler development","Neurodevelopment","Cognitive development","Language development","Motor development","Social-emotional development","Adaptive behavior","2026-02-19",{"date":390,"type":72},"2026-02-23",{"date":392,"type":72},"2025-01-02",{"date":394,"type":23},"2027-03",{"name":396,"class":397},"Bartosz M. Radtke","OTHER_GOV",{"id":399,"slug":400,"hasResults":12,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":17,"sex":18,"minAge":155,"maxAge":19,"enrollmentInfo":405,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":407,"conditions":408,"keywords":412,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":80},"100625299","psychological-correlates-of-developmental-delays-in-preschool-children-100625299","NCT07420829","Psychological Correlates of Developmental Delays in Preschool Children","Perinatal, Cognitive, Linguistic, and Social-emotional Correlates of Developmental Delay in Polish Preschool Children From a Biopsychosocial Perspective","Inclusion Criteria:\n\n* Children aged 3 to 6 years at the time of assessment.\n* Attendance at preschool education.\n* Written informed consent provided by a parent or legal guardian.\n* Ability to participate in standardized psychological assessment.\n* Assignment to one of the predefined study cohorts based on developmental history and clinical information.\n\nExclusion Criteria:\n\n* Age below 3 years or above 6 years.\n* Severe acute medical condition preventing participation.\n* Severe uncorrected sensory impairment interfering with valid assessment.\n* Lack of parental informed consent.",{"count":406,"type":23},500,"The goal of this observational study is to investigate perinatal, cognitive, linguistic and social-emotional correlates of developmental delays of preschool children.\n\nThe study group consist of minimal 500 children between 3 and 6 years of age who will be examined by qualified diagnosticians. Participants will be evaluated with tasks related to the studied variables: cognitive functioning, linguistic skills and social-emotional functioning. Furthermore informations regarding social-emotional functioning of children, will be collected from parents.\n\nThe main questions it aims to answer are:\n\n1. Is there a relationship between perinatal factors and risk of occurrence of developmental delay disorder?\n2. Is there a specific pattern of cognitive functioning in preschool children with indicated developmental delay disorder?\n3. Is there a specific pattern of social-emotional functioning in preschool children with indicated developmental delay disorder?\n4. Do gender and age moderates specific patterns of cognitive and socialemotional functioning in the studied groups?\n\nResearchers will compare the following groups of children between 3 and 6 years old:\n\n1. With perinatal risks factors\n2. With developmental delay disorder:\n\n   1. children with early intervention\n   2. children with delayed speech development\n3. Control group",[409,30,410,411],"Development Delay","Social Functioning","Speech Delay",[413,414,415],"early intervention","development","language","2026-02-11",{"date":388,"type":72},{"date":419,"type":72},"2025-09-01",{"date":421,"type":23},"2027-01",{"name":396,"class":397},{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":18,"minAge":430,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":24,"phases":433,"briefSummary":434,"conditions":435,"keywords":449,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":459,"lastUpdatePostDateStruct":460,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":80},"100613028","integrating-systems-and-basic-income-improving-outcomes-for-families-of-young-children-100613028","NCT07261254","Integrating Systems and Basic Income: Improving Outcomes for Families of Young Children","Advancing Health Equity Via Basic Income + Early Childhood Systems Integration: An RCT of the Baby Bonus Program","Inclusion Criteria:\n\nCaregiver Eligibility Criteria\n\n* 18 and Older\n* Family plans to reside in San Mateo County\n* Does not plan to move from the County in the next year\n* Speaks English and\u002For Spanish\n* Cared for in Postpartum Maternity unit\n\nChild Eligibility Criteria\n\n* Baby is being cared for in well newborn nursery\n* Child is enrolled in Medicaid\n* 36 weeks or older\n* To be discharged home in the custody of the caregiver\n\nExclusion Criteria:\n\nCaregiver Exclusion Criteria\n\n* Will not consent to share data via Epic\u002FStudy\n* Caregiver has significant cognitive impairment\n* Caregiver under contact isolation\n\nChild Exclusion Criteria\n\n* Sibling already enrolled in the Baby Bonus Study\n* Child has significant genetic disorder issues at birth\n* Child is a multiple (not a singleton)","0 Days",{"count":432,"type":23},2400,[26],"Early childhood is a critical period, laying the foundation for future growth and deveopment. This foundational period has an outsized effect, impacting health, well-being and achievement across one's lifespan. The U.S. lacks a cohesive early childhood system to support families with young children ages 0-5. The goal of this randomized controlled trial(RCT) is to test if community-based support via community health workers(CHWs) improves social and health services utilization, and child development. Furthermore, the trial will examine if income support enhances the impact of a CHW integrated system. Participants are English and Spanish speaking families with healthy newborns. This RCT was designed based on family priorities, community capacity and needs in a collective impact model. This trial is anchored at a university based children's hospital and involves many partners: families, county health, county leadership, a leading early childhood non-profit organization, the county's Medicaid managed care organization.",[436,437,438,439,440,441,442,443,444,445,446,30,447,448],"Income","Infant, Newborn","Mothers","Poverty","United States","Healthcare Disparities","Child Care","Child Health","Community Health Workers","Hispanic or Latino","Medicaid","Social Services Utilization","Health Services Utilization",[450,444,446,451,452,453,454,455,456,457,458],"Guaranteed Basic Income","Medi-Cal","Community Partners","Coordinated Care","Coordinated Services","randomized trial","surveys","infant, newborn","newborn nursery","2026-02-10",{"date":461,"type":72},"2026-02-12",{"date":463,"type":72},"2025-04-07",{"date":465,"type":23},"2030-03",{"name":78,"class":79},{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":473,"eligibilityCriteria":474,"healthyVolunteers":17,"sex":18,"minAge":475,"maxAge":476,"enrollmentInfo":477,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":479,"conditions":480,"keywords":487,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":80},"100517522","impact-of-diet-and-nutrition-on-growth-and-development-in-young-children-100517522","NCT06018636","Impact of Diet and Nutrition on Growth and Development in Young Children","Dietary Intake\u002FPatterns, Nutritional Status and Their Association With Growth and Development of Children From Remote, Agropastoral Communities of District Swat, Pakistan","DIGEST","Inclusion Criteria:\n\n* Households living in the area from the last two 2 years.\n* Households having infants or young children ≤ years.\n* Households planning to reside in the same area for the next 1 year.\n\nExclusion Criteria:\n\n* Children with any co-existent systemic diseases, confirmed from medical records.\n* Children on continuous medications for any medical issue.\n* Physically or mentally handicapped children","1 Day","24 Months",{"count":478,"type":23},832,"The association between nutrition in early life and its long-term health consequences has long been known. However, there is a scarcity of scientific evidence on how nutritional status affects child growth and development in remote, rural agro-pastoral communities with distinct dietary intake habits, geographical location, socio-economic status, and cultures.",[481,482,483,484,485,486,30],"Nutrition","Growth","Development","Stunting","Wasting","Obesity",[488,489,482,490,491,492,493,494,495],"Nutritional status","Malnutrition","Cognitive Development","Anthropometry","Agropastoral","remote","rural","Urban","2026-01-06",{"date":498,"type":72},"2026-01-08",{"date":500,"type":72},"2023-06-28",{"date":502,"type":23},"2028-09-30",{"name":504,"class":79},"Khyber Medical University Peshawar",{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":511,"eligibilityCriteria":512,"healthyVolunteers":17,"sex":18,"minAge":513,"maxAge":19,"enrollmentInfo":514,"targetDuration":4,"studyType":24,"phases":516,"briefSummary":517,"conditions":518,"keywords":522,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":527,"lastUpdatePostDateStruct":528,"startDateStruct":530,"completionDateStruct":532,"leadSponsor":534,"locationsCount":4},"100616602","motor-focused-exercise-and-brain-development-in-preschool-children-100616602","NCT07307742","Motor-Focused Exercise and Brain Development in Preschool Children","Effects of Motor-Focused Exercise Training on Brain Function and Gross Motor Skills in Preschool Children","MoBraD","Inclusion Criteria:\n\n* Children aged 4 to 6 years enrolled in participating kindergartens in Changsha, China\n* Physically healthy and able to safely participate in structured physical education activities\n* Written informed consent provided by a parent or legal guardian\n\nExclusion Criteria:\n\n* Diagnosed neurological, developmental, or musculoskeletal disorders that may interfere with motor performance or EEG measurement\n* Currently enrolled in specialized sports or motor-training programs outside of the kindergarten curriculum\n* Unable to comply with EEG assessment procedures due to behavioral or sensory intolerance","4 Years",{"count":515,"type":23},110,[26],"This study will test whether a structured motor-focused exercise program can improve both brain function and gross motor skills in preschool children. About 110 children aged 4 to 6 years will be recruited from kindergartens in Changsha, China. Classes will be randomly assigned to receive either (1) motor-focused physical education three times per week for 16 weeks, or (2) ordinary physical education of the same frequency and duration.\n\nThe motor-focused program includes playful, game-based activities designed to strengthen locomotor skills (such as running and hopping) and object-control skills (such as throwing and catching). The main outcome will be changes in children's gross motor skills, measured with a standardized motor test (TGMD-3). Brain activity will also be assessed using portable electroencephalography (EEG) during rest and simple tasks related to attention and memory. Parents and teachers will complete short questionnaires about children's behavior and executive function.\n\nThe results of this study may provide new insights into how physical education influences both movement skills and brain development in early childhood.",[30,519,382,520,521],"Motor Skills","Brain Function","Executive Function (Cognition)",[318,523,524,385,525,526],"Physical education","Gross motor skills","Neurocognitive development","Early childhood education","2025-12-25",{"date":529,"type":72},"2025-12-29",{"date":531,"type":23},"2026-03-01",{"date":533,"type":23},"2026-07-01",{"name":535,"class":79},"Hunan Normal University",{"id":537,"slug":538,"hasResults":12,"nctId":539,"briefTitle":540,"officialTitle":541,"acronym":542,"eligibilityCriteria":543,"healthyVolunteers":12,"sex":18,"minAge":544,"maxAge":545,"enrollmentInfo":546,"targetDuration":4,"studyType":24,"phases":548,"briefSummary":549,"conditions":550,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":552,"lastUpdatePostDateStruct":553,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":558,"locationsCount":80},"100541873","infant-maternal-partnership-and-cognitive-training-study-for-preterm-infants-100541873","NCT06335524","Infant-Maternal Partnership and Cognitive Training Study for Preterm Infants","Infant-Maternal Partnership and Cognitive Training Study for Preterm Infants: A Randomized Clinical Trial","IMPACT","Inclusion Criteria:\n\n* inborn at UAB, delivered at less than 34 weeks' gestation, 32-39 weeks' PMA, off sedatives, and off invasive respiratory support.\n\nExclusion Criteria:\n\n* a major malformation, a known syndrome, enrolled in a competing trial targeting neurodevelopmental outcomes as a primary outcome.","1 Week","17 Weeks",{"count":547,"type":23},188,[26],"This study will test the hypothesis that in preterm infants a caregiver-implemented early developmental intervention (EDI) using finger puppets to develop joint attention and encourage interactive communication with routine EDI care including Bookworm training compared with routine EDI care including Bookworm training alone will increase the Ages and Stages Questionnaire® score at 12 months corrected age.",[30,377,551],"Infant, Premature, Diseases","2025-12-19",{"date":529,"type":72},{"date":555,"type":72},"2024-11-01",{"date":557,"type":23},"2028-12",{"name":559,"class":79},"University of Alabama at Birmingham",{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":566,"eligibilityCriteria":567,"healthyVolunteers":17,"sex":18,"minAge":155,"maxAge":129,"enrollmentInfo":568,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":570,"conditions":571,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":574,"lastUpdatePostDateStruct":575,"startDateStruct":577,"completionDateStruct":579,"leadSponsor":581,"locationsCount":363},"100498469","china-axial-length-study-100498469","NCT05770661","China Axial Length Study","Axial Length Study of Children and Adolescents in Ten Provinces of China","CALS","Inclusion Criteria:\n\n* Aged 3 to 18 years\n* Have been lived in the research areas for at least one year, and will not move to other places in the following two years\n* Parents or guardians sign an informed consent form, and children over 6 years old need oral consent to participate\n\nExclusion Criteria:\n\n* Mental diseases, unable to cooperate to complete the eye assessment\n* Ophthalmic diseases, inability to cooperate to complete the inspection",{"count":569,"type":23},30000,"The primary objective of this multi-center, observational study is to establish the reference ranges of axial length in Chinese children and adolescents.\n\n30,000 children aged 3-18 years were examined with cycloplegia to collect their ocular parameters and were all followed up for three years with annual visits.",[572,573,30],"Axial Length","Myopia","2025-12-11",{"date":576,"type":72},"2025-12-18",{"date":578,"type":72},"2023-03-10",{"date":580,"type":23},"2026-12-31",{"name":582,"class":79},"Shanghai Eye Disease Prevention and Treatment Center",{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":589,"eligibilityCriteria":590,"healthyVolunteers":17,"sex":18,"minAge":155,"maxAge":513,"enrollmentInfo":591,"targetDuration":4,"studyType":24,"phases":592,"briefSummary":593,"conditions":594,"keywords":605,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":609,"startDateStruct":610,"completionDateStruct":612,"leadSponsor":613,"locationsCount":80},"100567397","a-mobile-app-to-improve-24-hour-movement-guideline-adherence-in-preschoolers-100567397","NCT06667661","A Mobile App to Improve 24-Hour Movement Guideline Adherence in Preschoolers","A Home-Based Intervention to Improve Adherence to the 24-Hour Movement Guidelines in Young Children","Shining Star","Inclusion (Child):\n\n* Ages 3-4 years.\n* Parent report that they meet 0 or 1 recommendation for physical activity, sleep, and screen-time as defined by the 24-hour movement guidelines. The physical activity recommendation is defined as greater than or equal to 3 hours\u002Fday of total physical activity, including 1 hour of moderate-to-vigorous physical activity. The sleep recommendation is defined as 10-13 hours\u002Fday. The sedentary behavior recommendation is defined as less than or equal to 1 hour\u002Fday of sedentary screen-time.\n\nInclusion (Parents):\n\n* Parents must agree to use their mobile phone for the duration of the study (\\~12 weeks) and download the mobile app onto their phone.\n* The parent\u002Fcaregiver is fluent in English to participate in testing the mobile app.\n* The parent\u002Fcaregiver must be willing to travel to KUMC to complete study visits.\n\nExclusion (child):\n\n* Mobility limitations as reported by the parent.\n* Meeting two or more recommendations for physical activity, sleep, and screen-time.\n* Sibling or household member is participating or participated in the study.",{"count":207,"type":23},[26],"The goal of this clinical trial is to evaluate whether a home-based mHealth intervention can improve adherence to the 24-Hour Movement Guidelines in preschool-aged children (3-4 years old) who currently meet 0 or 1 of the guidelines for physical activity, sedentary behavior, and sleep. The main questions it aims to answer are:\n\n* Can the intervention increase the proportion of children meeting all three 24-Hour Movement Guidelines (physical activity, screen-time, and sleep)?\n* Is the intervention feasible for parents to implement, as measured by a parent feedback survey?\n\nResearchers will compare an intervention group to a waitlist control group to assess whether the intervention leads to increased guideline adherence.\n\nParents and Participants:\n\n* Children will wear an accelerometer to track physical activity and sleep patterns.\n* Parents will use a mobile app that delivers weekly lessons and behavior-related goals to encourage healthy movement behaviors in their children.\n* Parents will complete questionnaires on their child's movement behaviors and development at baseline, 6 weeks, and 12 weeks.\n* Additionally, children will undergo motor skills assessments, and parents will provide feedback on cognitive development and behavioral changes.",[595,596,597,598,599,600,601,519,46,602,603,604,30],"Healthy","24-Hour Movement Guidelines","Feasibility Studies","Sleep","Physical Activity","Screen Time","Sedentary Behaviors","Parent-Child Relations","Mobile Application","Health Education",[599,606,598,30,519,607,595,596,600,601,46,602,603,604],"Sedentary Behavior","Behavioral problems","2025-12-03",{"date":574,"type":72},{"date":611,"type":72},"2025-01-29",{"date":580,"type":23},{"name":614,"class":79},"University of Kansas Medical Center",{"id":616,"slug":617,"hasResults":12,"nctId":618,"briefTitle":619,"officialTitle":620,"acronym":4,"eligibilityCriteria":621,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":622,"enrollmentInfo":623,"targetDuration":4,"studyType":24,"phases":624,"briefSummary":625,"conditions":626,"keywords":629,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":634,"lastUpdatePostDateStruct":635,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":640,"locationsCount":80},"100334953","centeringparenting-clinical-intervention-on-kindergarten-readiness-in-early-childhood-100334953","NCT03641092","CenteringParenting Clinical Intervention on Kindergarten Readiness in Early Childhood","Evaluation of the Impact of the CenteringParenting Clinical Intervention on Kindergarten Readiness in Early Childhood","Inclusion Criteria:\n\nFor participating practice sites\n\n* Practice provides care to patients who are covered by public insurance and\u002For uninsured (no minimum threshold: all insurance types eligible)\n* Practices have at least 3,000 primary care visits per year\n\nFor parent-child dyad\n\n* Index child age must be 0-3 months\n* Parent must be female\n* Parent must be 18 years of age and older\n* Parent and child must attend one of the 10 study clinical sites\n* Parental consent\n* Parent must be fluent in English or Spanish\n\nExclusion Criteria:\n\nFor participating practice sites\n\n* Does not accept public insurance\n\nFor parent-child dyad\n\n* Child born prior to 34 weeks gestation\n* Child with chronic conditions known to affect neurodevelopment\n* Child with a positive screen on the Children with Special Healthcare Needs screener","3 Months",{"count":373,"type":23},[26],"Disparities in health begin in early childhood. Early life experiences influence brain development and have significant implications on future health and developmental outcomes. Low-income children are at greater risk of developmental delays in large part due to a lack of an enriched environment. Disparities in early childhood development increase risk for stunted academic achievement throughout the life course. Primary care is a universal exposure in early childhood and therefore is also a significant entry point for promoting optimal child development.\n\nThere is a need to provide effective, low-cost, and scalable interventions in primary care to support early childhood development.The CenteringParenting intervention is designed to reduce negative health and developmental outcomes within a model of group routine child health care. To date, there is no evidence of the benefits of the CenteringParenting intervention on school readiness, or improvements in parental behaviors that support optimal developmental milestones and achievement. The intent of this study is to determine the effectiveness of the CenteringParenting intervention on school readiness in early childhood, as measured by language development at 24 months, (in addition to health care utilization, child routine care maintenance, parenting stress, caregiver behaviors and attitudes).",[602,627,30,628],"Parenting","Child Behavior",[630,187,631,632,633],"School readiness","Child behavior","Parenting behavior","CenteringParenting","2025-11-26",{"date":636,"type":72},"2025-12-01",{"date":638,"type":72},"2019-02-19",{"date":118,"type":23},{"name":641,"class":79},"Boston Medical Center",{"id":643,"slug":644,"hasResults":12,"nctId":645,"briefTitle":646,"officialTitle":647,"acronym":648,"eligibilityCriteria":649,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":650,"targetDuration":4,"studyType":24,"phases":652,"briefSummary":653,"conditions":654,"keywords":657,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":666,"lastUpdatePostDateStruct":667,"startDateStruct":669,"completionDateStruct":671,"leadSponsor":673,"locationsCount":225},"100542308","effect-of-sleep-extension-on-body-weight-and-learning-in-children-more2sleep-100542308","NCT06341179","Effect of Sleep Extension on Body Weight and Learning in Children (More2Sleep)","A Randomized Controlled Trial of Sleep Extension to Regulate Body Weight and Improve Learning in School-aged Children","More2Sleep","Inclusion Criteria:\n\n* Age: 6-12 years old (inclusive range).\n* Weight status: having a BMI above average, defined as an age- and sex-specific BMI Z-score above zero using reference standards from the WHO.\n* Sleep duration: sleeping ≤9 h\u002Fnight on the basis of sleep diaries filled in by the children's parents, based on recommendations by the American Academy of Sleep Medicine and the Sleep Health Foundation.\n\nExclusion Criteria:\n\n* Any genetic, neurological, endocrinological or psychiatric condition that affects growth, metabolism, eating behaviors, cognitive function, or body weight (for example: dwarfism, epilepsy, attention deficit hyperactivity disorder, head trauma, β-thalassemia, hypothyroid-ism, hyperthyroidism, type I diabetes).\n* Any sleep-related disorder (for example: obstructive sleep apnea, parasomnias, narcolepsy, restless leg syndrome).\n* Regular use of prescribed or over-the-counter medications that influence study outcomes.\n* Irregular school schedule.\n* If a child's parents live separately, the child is allowed to sleep at both households. How-ever, if one of the parents does not wish to carry out the sleep intervention and follow given instructions, then the child should only sleep at their household Friday, Saturday and\u002For Sunday night.\n* In the circumstance where the child does not speak or understand Danish, the child's parents do not have to speak or understand Danish, as long as both parties can speak and understand English.\n* Participation in other research studies.\n* Metal implants and claustrophobia (only for substudy-II).",{"count":651,"type":23},142,[26],"More2Sleep is a randomized, controlled, parallel trial with two groups (sleep extension vs control) including 142 school-aged children (6-12 years) who have a BMI above average, defined as age- and sex-specific BMI Z-score above zero using WHO reference standards, and habitually sleep for ≤ 9 h\u002Fnight. Data will be collected before and after a 3-month sleep extension intervention, and after a 6-month follow-up (at months 0, 3, and 9). The collection of data is mainly related to the main study. However, some optional examinations will be conducted on a first come, first serve basis, consisting of substudy-I (metabolic mechanisms, n=60) and substudy-II (learning mechanisms, n=142).\n\nThe primary objective is to assess the effects of sleep extension by \\~45 min\u002Fnight, achieved by going to bed 60-90 min earlier, on adiposity and learning ability in school-aged children who have a BMI for age and sex above average, and sleep less than recommended for their age.",[655,656,30,628],"Sleep Duration","Child Obesity",[658,321,659,660,661,662,663,664,665],"Sleep duration","Overweight and Obesity","Energy Intake","Child Development and Behavior","Well-being","Cognitive Function","Learning Ability","Memory","2025-11-19",{"date":668,"type":72},"2025-11-25",{"date":670,"type":72},"2024-08-13",{"date":672,"type":23},"2028-12-31",{"name":674,"class":79},"University of Copenhagen",{"id":676,"slug":677,"hasResults":12,"nctId":678,"briefTitle":679,"officialTitle":680,"acronym":4,"eligibilityCriteria":681,"healthyVolunteers":17,"sex":18,"minAge":129,"maxAge":4,"enrollmentInfo":682,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":684,"conditions":685,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":692,"lastUpdatePostDateStruct":693,"startDateStruct":695,"completionDateStruct":697,"leadSponsor":699,"locationsCount":80},"100534092","peking-university-birth-cohort-in-weifang-pkubc-wf-100534092","NCT06234332","Peking University Birth Cohort in Weifang (PKUBC-WF)","Peking University Birth Cohort in Weifang","Inclusion Criteria:\n\n* Pregnant woman\n\n  1. Pregnant women, 6-13\\^+6 gestational weeks\n  2. Resided in Weifang in the past half years and have no plan to move out after delivery\n  3. Pregnant women who plan to have antenatal care and delivery in Weifang maternal\\&Child Hospital.\n  4. Pregnant women who is willing to participate in this study with informed consent\n* Pregnant woman's husband\n\n  1. His wife was eligible for enrollment\n  2. He is the biological father of the child (his wife's current pregnancy)\n  3. Pregnant women's husband who is willing to participate in this study with informed consent\n* Offspring 4. Children born to pregnant women who met the inclusion criteria after enrolling in this study.\n\n  5\\. Before the age of 8 years, his\u002Fher mother provided written informed consent. 6. After 8 years old, he\u002Fshe agreed to continue this study and signed the informed consent.\n\nExclusion Criteria:\n\n* Participants who cannot communicate normally.",{"count":683,"type":23},2800,"The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces are also collected.",[686,687,688,689,690,486,691,30,246],"Health Problems in Pregnancy","Pregnancy Outcomes","Gestational Diabetes","Gestational Hypertension","Preterm Birth","Mother-Infant Interaction","2025-11-18",{"date":694,"type":72},"2025-11-24",{"date":696,"type":72},"2024-02-01",{"date":698,"type":23},"2043-12-31",{"name":700,"class":79},"Peking University",{"id":702,"slug":703,"hasResults":12,"nctId":704,"briefTitle":705,"officialTitle":706,"acronym":4,"eligibilityCriteria":707,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":708,"targetDuration":4,"studyType":24,"phases":709,"briefSummary":710,"conditions":711,"keywords":712,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":716,"lastUpdatePostDateStruct":717,"startDateStruct":718,"completionDateStruct":720,"leadSponsor":721,"locationsCount":80},"100611705","effects-of-animal-fun-program-in-children-with-dcd-100611705","NCT07244055","Effects of Animal Fun Program in Children With DCD.","Effects Of Animal Fun Program On Motor Skills In Children With Developmental Coordination Disorder","Inclusion Criteria:\n\n* Children with diagnosed with DCD by DCDQ 7 questionnaire\n* Not receiving any intervention within the last 6 months\n* Mentally stable enough to participate in physical activity\n\nExclusion Criteria:\n\n* Medical condition contraindicating active movements\n\n  * Intellectual disability.\n  * Children with any other syndrome and progressive neurodevelopmental diseases",{"count":131,"type":23},[26],"This randomized clinical trial investigates the effects of animal fun program on motor skills in children with developmental coordination disorder. The study involves 40 children from normal school age group 6 to 12 year old, who will be randomly assigned to one of the two groups for a six-week intervention period. Key performance outcomes\n\n-body management truck control, locomotion, balance ,object control,body sequencing social and emotional control will be assessed both before and after the intervention.This study aims to address this gap by evaluating the effects of the Animal Fun Program on both fine and gross motor activity levels in children diagnosed with DCD. By examining objective motor outcomes and child engagement, the study seeks to determine whether this novel, enjoyable intervention can enhance traditional therapy methods, leading to improved motor development and overall quality of life for children with DCD. Data will be analyzed through SPSS version 27.00.",[30],[713,714,715],"Animal Fun program","DCD developmental coordination disoder","BOT 2 (Bruininks-Oseretsky Test of Motor Proficiency )","2025-11-17",{"date":694,"type":72},{"date":719,"type":72},"2025-10-22",{"date":142,"type":23},{"name":722,"class":79},"Riphah International University",{"id":724,"slug":725,"hasResults":12,"nctId":726,"briefTitle":727,"officialTitle":728,"acronym":4,"eligibilityCriteria":729,"healthyVolunteers":17,"sex":18,"minAge":155,"maxAge":19,"enrollmentInfo":730,"targetDuration":4,"studyType":24,"phases":732,"briefSummary":733,"conditions":734,"keywords":735,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":716,"lastUpdatePostDateStruct":737,"startDateStruct":738,"completionDateStruct":740,"leadSponsor":741,"locationsCount":80},"100611710","embodied-writing-versus-conventional-writing-practice-for-handwriting-100611710","NCT07244120","Embodied Writing Versus Conventional Writing Practice for Handwriting","Effects of Embodied Writing Versus Conventional Writing Practice for Handwriting in Preschool Children.","Inclusion Criteria:\n\n* Child has poor handwriting as assessed by the HPSQ (20)\n* Child is of age between 3-6 years.\n* The child attends a regular primary school.\n* Both boys and girls will be included in the study.\n\nExclusion Criteria:\n\n* Developmental delay\n* Physical impairment of upper extremity\n* Hearing deficit (21)\n* Visual problem\n* Any recent trauma to upper limb\n* Gross motor impairment\n* Neurological deficit\n* Receiving any Physiotherapy before",{"count":731,"type":23},148,[26],"This randomized clinical trial will involve 148 preschooler children of age group 3 to 6 years old with handwriting difficulties from Cambridge Foundation School FSD and Behan Je Memorial school FSD, Pakistan. The participants will be divided into two groups: Group A will follow conventional writing practices with parental ergonomics guidance, while Group B will engage in embodied writing practices combined with ergonomic education for parents. Over 8 weeks, handwriting legibility, speed, and motor coordination will be assessed pre- and post-intervention using the Handwriting Proficiency Screening Questionnaire and the Minnesota Handwriting Assessment Scale. The study aims to evaluate each approach's effectiveness in addressing handwriting challenges, providing insights into embodied learning's potential impact on early childhood education. Data analysis will be conducted using SPSS version 23.",[30],[736],"Embodied writing, Conventional writing, HPSQ, MHA.",{"date":694,"type":72},{"date":739,"type":72},"2025-10-27",{"date":459,"type":23},{"name":722,"class":79},{"id":743,"slug":744,"hasResults":12,"nctId":745,"briefTitle":746,"officialTitle":747,"acronym":4,"eligibilityCriteria":748,"healthyVolunteers":12,"sex":18,"minAge":155,"maxAge":749,"enrollmentInfo":750,"targetDuration":4,"studyType":24,"phases":752,"briefSummary":753,"conditions":754,"keywords":759,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":762,"lastUpdatePostDateStruct":763,"startDateStruct":765,"completionDateStruct":767,"leadSponsor":769,"locationsCount":4},"100609324","transform--family-academy-randomized-controlled-trial-in-the-philippines-100609324","NCT07213102","Transform + Family Academy Randomized Controlled Trial in the Philippines","Integration of Household-Based Interventions With Early Childhood Programming: A Randomized Controlled Trial in the Philippines","Inclusion Criteria:\n\n* Households must have a child between 3 to 5 years old who is currently registered in CI's Survival and Early Childhood Program.\n* Households must meet ICM's poverty criteria with a poverty score of 50 and above as determined through asset-based scoring and household income evaluation. Higher scores indicate poorer households.\n* Each participating household must include an adult family member aged 18 to 65 years who serves as a primary caregiver for the target child.\n\nExclusion Criteria:\n\n* Households with previous participation in ICM's Transform program will be excluded from the study.","5 Years",{"count":751,"type":23},700,[26],"This study evaluates the integration of two complementary poverty alleviation programs: Compassion International's (CI) child-focused Survival and Early Childhood Program with International Care Ministries' (ICM) household-level Transform + Family Academy intervention. CI's program provides holistic child development through health support, educational programming, social development, and spiritual formation via local church partners for children aged 3-5 years. ICM's Transform + Family Academy combines a 15-week household intervention targeting health education, livelihood training, and values formation with an 8-week early childhood education component delivered through home visits.\n\nThe primary aim of this research is to assess whether integrating household-level interventions with child-focused programming enhances early numeracy and literacy outcomes among children aged 3-5 living in extreme poverty in Western and Southern Mindanao, Philippines. The study also examines the intervention's impact on children's nutritional status and household financial resilience, including savings behaviors and access to social safety nets.\n\nThe investigators hypothesize that addressing household-level constraints including caregiver capacity, health, and economic challenges will enhance children's academic and nutritional outcomes alongside household financial resilience compared to child-focused programming alone.",[30,755,756,757,758],"Child Nutrition, Child Neurobehavioral Development","Household and Family","Financial Wellbeing","Academic Attainment",[30,760,761],"Child Nutritional Status","Household Financial Resilience","2025-10-01",{"date":764,"type":72},"2025-10-08",{"date":766,"type":23},"2025-11-01",{"date":768,"type":23},"2027-05-30",{"name":770,"class":79},"International Care Ministries, Philippines",{"id":772,"slug":773,"hasResults":12,"nctId":774,"briefTitle":775,"officialTitle":776,"acronym":777,"eligibilityCriteria":778,"healthyVolunteers":17,"sex":18,"minAge":779,"maxAge":155,"enrollmentInfo":780,"targetDuration":4,"studyType":24,"phases":781,"briefSummary":782,"conditions":783,"keywords":784,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":790,"lastUpdatePostDateStruct":791,"startDateStruct":792,"completionDateStruct":794,"leadSponsor":796,"locationsCount":225},"100552340","promoting-mental-health-in-young-children---a-dialogue-based-approach-in-kindergartens-100552340","NCT06471816","Promoting Mental Health in Young Children - a Dialogue Based Approach in Kindergartens","Promoting Mental Health in Young Children - a Dialogue Based Approach in Kindergartens: A Randomized Controlled Trial","PRO-DIALOG","Inclusion Criteria:\n\n* Attendance in kindergarten\n* Inclusion during the first half-year of the third last year in kindergarten\n\nExclusion Criteria:\n\n* Parents don't communicate in Norwegian or English","2 Years",{"count":92,"type":23},[26],"The goal of this clinical trial is to learn if the novel Dialogue Based Early Detection (DBED) method can prevent impaired mental health in kindergarten children. It will also learn about the screening properties of DBED to identify children with impaired mental health, if DBED facilitates early interventions, and if DBED is well accepted and sustainable in an ordinary kindergarten setting.\n\nThe main questions it aims to answer are:\n\n* Do children in kindergartens where DBED is implemented develop better mental health scores than children in kindergarten where DBED is not implemented?\n* How well identifies DBED kindergarten children with impaired mental health compared to a traditional screening instrument (the Strengths and Difficulties Questionnaire)?\n* What is the impact of DBED on activation of interventions for mental health problems?\n* What is the social validity of DBED?\n\nResearchers will compare outcomes in kindergartens where DBED is implemented with outcomes in kindergartens where it's not.\n\n* During the last three years of kindergarten attendance participants (parents of kindergarten children) in the intervention kindergartens will take part in the biannual DBED parent-teacher meetings, while participants in the control kindergartens will take part in traditional parent-teacher meetings.\n* Twice a year all participants will answer questionnaires of the child's mental health and parental stress during the follow-up period (3 years in kindergarten and 2 first years in school).\n* Participants in the intervention kindergartens will answer user satisfaction questionnaires after every parent-teacher meeting.\n* The kindergarten teachers will report on type and time of supportive interventions for each participating child during the follow-up period in kindergarten.",[628,30],[785,786,787,788,789],"Health Promotion","Secondary Prevention","Kindergarten","Child Mental Health","Parent Involvement","2025-09-26",{"date":762,"type":72},{"date":793,"type":72},"2024-01-01",{"date":795,"type":23},"2029-06-30",{"name":797,"class":79},"Haukeland University Hospital"]