[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"child-only\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:child-only":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,49,81,109,135,157,178,201,223,247,275,302,325,344,375,396,414,437,469,494,519,542,570,595,623],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100626833","effects-of-traditional-game-in-school-going-children-100626833",false,"NCT07440771","Effects of Traditional Game in School Going Children","Effects of Traditional Game on Agility and Reaction Time in School Going Children","Inclusion Criteria:\n\n* 8-12 years of school-going children\n* Give informed consent\n* physically healthy and medically fit to participate in physical activity\n* BMI within normal-for-age range to control for physical performance variability.\n\nExclusion Criteria:\n\n* presence of at least one of the following conditions: circulatory, respiratory and musculoskeletal diseases, neuropsychiatric disease, exercise induced anaphylaxis, morbid obesity\n* History of injury or surgery in the past 4 months\n* Currently participating in other structured sports training or agility-specific coaching program, or research procedures\n* Inconsistent attendance in the intervention sessions.",true,"ALL","8 Years","12 Years",{"count":22,"type":23},48,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized controlled trial examines whether regular participation in the traditional game \\*\\*Kho-Kho\\*\\* improves agility and reaction time in school-aged children. Due to limited physical education in schools, many children fail to achieve recommended daily physical activity, leading to physical and mental health issues. The study will involve \\*\\*48 children (8-12 years)\\*\\* from selected schools in Sialkot, divided into an experimental group (Kho-Kho) and a control group (free play). The intervention will be conducted \\*\\*3 times per week for 6 weeks\\*\\*, and outcomes will be measured using the \\*\\*T-Test, Ruler Drop Test, and TOES\\*\\*. Data will be analyzed using \\*\\*SPSS v21\\*\\*, with ethical approval from \\*\\*Riphah International University, Lahore\\*\\*.",[29],"Child, Only",[31,32,33,34,35],"school-aged children","Kho-Kho","agility","traditional game.","Reaction Time","RECRUITING","2026-05-05",{"date":39,"type":40},"2026-05-11","ACTUAL",{"date":42,"type":40},"2026-02-04",{"date":44,"type":23},"2026-07-15",{"name":46,"class":47},"Riphah International University","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":18,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":48},"100497792","pediatric-medication-therapy-management-trial-100497792","NCT05761847","Pediatric Medication Therapy Management Trial","Optimizing the Clinical Management of Polypharmacy for Children With Medical Complexity: The Pediatric Medication Therapy Management (pMTM) Trial","pMTM","Inclusion Criteria:\n\n* 2-18 years old\n* ≥1 complex chronic condition (CCC)\n* ≥5 current medications (including prescription, as needed, and over-the-counter medications)\n* Receives primary care at Children's Hospital Colorado\n\nExclusion Criteria:\n\n* Non-English speaking\n* Sibling or family member already enrolled in this study","2 Years","18 Years",{"count":60,"type":23},371,[26],"The purpose of this study is to evaluate whether an intervention called Pediatric Medication Therapy Management (pMTM) improves the identification and management of medication-related problems among children with medical complexity and polypharmacy.",[29,64,65,66,67],"Disabilities Multiple","Medication Interaction","Medication Compliance","Medication Administered in Error",[69,70,71],"Children with Medical Complexity","Polypharmacy","Medication Safety","2026-04-27",{"date":74,"type":40},"2026-04-28",{"date":76,"type":40},"2023-09-11",{"date":78,"type":23},"2028-01-31",{"name":80,"class":47},"University of Colorado, Denver",{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":12,"sex":18,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":48},"100509075","closed-loop-medtronic-780g-system-in-youth-with-type-1-diabetes-100509075","NCT05908708","Closed-loop Medtronic 780G System in Youth With Type 1 Diabetes","Title: Closed-loop Medtronic 780G System in Youth With Type 1 Diabetes: AWeSoMe Study Group Prospective Trial","Inclusion Criteria:\n\nDiagnosis of type 1 diabetes Diabetes duration ≥ 6 months Routine attendance at clinic visits Initiation of 780G system usage\n\nExclusion Criteria:\n\nChildren under the age of 1 year Children without 780G system","1 Year","21 Years",{"count":91,"type":23},120,"OBSERVATIONAL","The goal of this observational study is to describe data on Israeli children and youth using the 780G system including data regarding glycemic control parameters, various questionnaires, sleep data, bioimpedance measures, and dietary parameters. The main questions it aims to answer are: • whether the 780G system will improve glycemic control • whether the psychosocial aspects will improve. Participants will be followed once connected to 780G, at baseline, one, three, six months, 1 year, and two years after the connection.",[95,29],"Type 1 Diabetes",[97,98],"Technology","Insulin pump","2026-04-03",{"date":101,"type":40},"2026-04-09",{"date":103,"type":40},"2023-06-01",{"date":105,"type":23},"2026-07-01",{"name":107,"class":108},"Sheba Medical Center","OTHER_GOV",{"id":110,"slug":111,"hasResults":12,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":24,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":134},"100517537","urine-and-ultrasound-screening-for-kidney-disease-in-children-100517537","NCT06018831","Urine and Ultrasound Screening for Kidney Disease in Children","Inclusion Criteria:\n\n* All consecutive live newborn infants(regardless of physical condition)\n* Complete at least 3 years of follow-up\n\nExclusion Criteria:\n\n* Declining the screening\n* Missing","6 Years",{"count":117,"type":23},13000,[26],"The aim of this study is to early detect kidney disease in the natural population cohort of children by urine and ultrasound screening, to assist in the precise prevention and treatment of children's kidney disease, and to establish a risk prediction system for children's kidney disease. About 10,000 children called KunQi Cohort are born in Jiangsu Province(8,000 in Kunshan and 2,000 in Qidong) and about 3,000 born in Shanghai. Through the project, child who is found with abnormal urine or ultrasound result will be referred to Children's Hospital of Fudan University to get further examination and treatment.",[121,122,123,124,29],"Kidney Diseases","Diagnostic Techniques","Ultrasound","Urinalysis","2026-03-24",{"date":127,"type":40},"2026-03-27",{"date":129,"type":40},"2022-04-12",{"date":131,"type":23},"2028-02",{"name":133,"class":47},"Children's Hospital of Fudan University",2,{"id":136,"slug":137,"hasResults":12,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":141,"targetDuration":4,"studyType":24,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":48},"100465087","custom-non-invasive-ventilation-masks-in-children-100465087","NCT05336136","Custom Non-invasive Ventilation Masks in Children","Inclusion Criteria:\n\n* Children between 8-12 years of age\n* Followed clinically by the Non-invasive ventilation clinic at the Stollery Children's Hospital\n* Established on non-invasive ventilation as part of their treatment plan.\n\nExclusion Criteria:\n\n* Children with developmental or physical disabilities that would prevent their successful completion of the study protocol (e.g., non-verbal, unable to follow 3-step commands, unalbe to lie still for 20 min).\n* Children whose parent\u002Fguardian are unable to provide consent because of an inability to read the study documents in english.",{"count":142,"type":23},15,[26],"One significant challenge to non-invasive ventilation (NIV) use in children is finding masks to fit a wide range of growing shapes and sizes. While the technology has improved with development of masks specifically for children, the range of options remains limited. Given the smaller size relative to adults, craniofacial abnormalities and craniofacial differences are more likely to compromise mask fit for children. A poor mask fit is uncomfortable, alters delivery of airway pressure, and, in some children, leads to failure of NIV and the need for surgical insertion of an airway in the neck to deliver positive airway pressure through a tracheostomy. This makes expanding the technology to deliver NIV vital and custom NIV masks an exciting solution.In this study, this study will enroll children who are established on long-term NIV with at least some use within 3 months of starting this therapy but who have non-optimal adherence. After consenting to participate and completing demographic and health questionnaire, participants will undergo a facial scan using stereophotogrammetry. This scan will be imported into a computer-aided design software to create a NIV mask customized to the individual face. The steps of mask testing will include: i) Bench testing to compare the leak and comfort parameters of the current commercial mask used by the participant to the custom mask: ii) Efficacy of treatment as measured by polysomonography iii) NIV compliance from machine downloads; iv) Questionnaires to assess the subjective comfort, fit, and adverse events Finally, participants and their parents\u002Fguardian will be asked which mask they prefer and why.",[146,29,147],"Noninvasive Ventilation","Adherence, Patient","2026-03-13",{"date":150,"type":40},"2026-03-16",{"date":152,"type":40},"2023-12-15",{"date":154,"type":23},"2026-06",{"name":156,"class":47},"University of Alberta",{"id":158,"slug":159,"hasResults":12,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":12,"sex":18,"minAge":164,"maxAge":58,"enrollmentInfo":165,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":172,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":48},"100416957","ecmo-treatment-of-children-in-china-in-the-past-10-years-100416957","NCT04709432","ECMO Treatment of Children in China in the Past 10 Years","Extracorporeal Membrane Oxygenation (ECMO) Treatment of Children in Mainland China in the Past 10 Years","Inclusion Criteria:\n\n* age of 1d to 18 years old;\n* children supported by ECMO in mainland China in the past 10 years\n\nExclusion Criteria:\n\n* none","1 Day",{"count":166,"type":23},500,"It is a cross-sectional study to summarize the extracorporeal membrane oxygenation （ECMO）treatment in children in China.",[169,29],"Extracorporeal Membrane Oxygenation",[171],"Extracorporeal membrane oxygenation; children; complication",{"date":150,"type":40},{"date":174,"type":40},"2021-01-11",{"date":176,"type":23},"2026-12-31",{"name":133,"class":47},{"id":179,"slug":180,"hasResults":12,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":185,"minAge":186,"maxAge":187,"enrollmentInfo":188,"targetDuration":4,"studyType":24,"phases":190,"briefSummary":191,"conditions":192,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":48},"100626477","effects-of-posture-and-quality-of-life-in-duchenne-muscular-dystrophy-children-100626477","NCT07436143","Effects of Posture and Quality of Life in Duchenne Muscular Dystrophy Children","Effects of Alexander Technique on Posture Control of Upper Limb and Quality of Life in Children With Duchenne Muscular Dystrophy","Inclusion Criteria:\n\n* Children suffering from duchenne muscular dystrophy,age between 5 to 9\n\nExclusion Criteria:\n\n* Children with metabolic disorder\n* Children with accidental disorder\n* Children with recent of surgery\n* Children with mentally retard","MALE","5 Years","9 Years",{"count":189,"type":23},33,[26],"Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disorder predominantly affecting boys and men, with an estimated incidence of 1 in 3,800 to 1 in 6,200 live male births. This condition leads to progressive muscle weakness due to the absence of the dystrophin protein, which is essential for maintaining muscle cell integrity. Symptoms and functional impairments typically become apparent by the age of two, and individuals with DMD have an average life expectancy of around 28 years. Treatment is generally multifaceted, focusing on enhancing quality of life (QOL) and postural control. The Alexander technique is employed to improve QOL and postural tone, as well as to modify body schema, with reported benefits from these changes. This method leverages spatial attention and executive functions that influence basic motor skills through targeted attention, intention, and haptic communication, thereby enhancing the QOL and postural control of the upper limbs. The aim of the study is to determine the effects of Alexander's technique on postural control of upper limb and quality of life in children with duchenne muscular dystrophy.",[29],"2026-02-23",{"date":195,"type":40},"2026-02-27",{"date":197,"type":40},"2025-10-27",{"date":199,"type":23},"2026-02-28",{"name":46,"class":47},{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":12,"sex":18,"minAge":186,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":24,"phases":211,"briefSummary":212,"conditions":213,"keywords":214,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":222,"locationsCount":48},"100625918","the-effects-of-sits-in-children-with-autism-100625918","NCT07428876","The Effects of SITS in Children With Autism.","Effect of Sensory Integrated Therapy Exercises on Repetitive Behaviour, Communication, Social Interaction and Motor Skills in the Children With Autism Spectrum Disorder","Inclusion Criteria:\n\n\\- Age 5 to 11\n\n* highly functioning autistic children\n* Either gender will be included\n* children reported with sensory processing difficulties ,language and behaviour issues.\n\nExclusion Criteria:\n\n* Any other neurological condition\n\n  * Children with physical disabilities\n  * sedative and hypnotic drug user","11 Years",{"count":210,"type":23},26,[26],"The study will include 30 participants whose pre and post values will be calculated. Inclusion criteria for this study is autism spectrum disorder with the age group of 5\\_11 years ,female and males both are included, those who are physically handi-capped and involved in some other neurological disorder or taking hypnotic and sedative drugs will be excluded. Participants will receive sensory integrated exercises (SIT) . Outcome to be measure and analyze will be repetitive behavior, communication, social interaction and motor skills. Tools used for data collection are REPETITIVE BEHAVIOUR QUESTIONNAIRE (RBQ-2). Gallium autism rating scale (GARS) second edition. Data will be analyzed through the SPSS version 23:00",[29],[215,216],"Autism spectrum disorder (ASD)","Sensory Integrated Therapy (SIT).",{"date":218,"type":40},"2026-02-24",{"date":220,"type":40},"2025-10-22",{"date":193,"type":23},{"name":46,"class":47},{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":12,"sex":18,"minAge":230,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":24,"phases":234,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":134},"100548834","l-citrulline-to-improve-adverse-outcomes-in-admitted-children-echilibrist-clinical-trial-2-inpatients-100548834","NCT06426147","L-citrulline to Improve Adverse Outcomes in Admitted Children (EChiLiBRiST, Clinical Trial 2, Inpatients)","A Randomised, Double-blind, Placebo-controlled Trial of L-Citrulline Oral Supplementation to Improve Short and Long-term Outcomes of Admitted Febrile Paediatric Patients With Biomarker-determined High-risk of Adverse Outcomes","Inclusion Criteria:\n\n* Enrolled in the initial prognostic screening component.\n* Sick children with fever (axillary temperature\\>37.5ºC) or a history of fever (within the preceding 72h) or with suspected severe disease.\n* 1m-\\\u003C60 months of age.\n* With an indication for admission, or having already been admitted to hospital due to their illness.\n* With an sTREM-1 PoC result classifying their disease as of \"moderate-high risk\" (\"yellow\" or \"red\") upon study recruitment and within D3.\n* Residents in the study area or willing to be contacted and traced during the study duration.\n* Willing to sign an informed consent document.\n* Willing to undergo and adhere to study procedures as explained in the IC document.\n\nExclusion Criteria:\n\n* Admission to hospital for social reasons (and not on account of their disease).\n* Children for which informed consent document has not been signed.\n* Known allergy or contraindication to any of the study supplements including lactose intolerance or observing a lactose-free diet.\n* Concurrent participation in any other clinical trial.\n* Patient under NPO or \"nothing by mouth\" prescription .\n* Contraindication for the insertion of a nasogastric tube (NGT) of for the enteral administration of drugs through the NGT in children who cannot tolerate by mouth.\n* Critically sick patient whose prognosis is considered by the clinical researcher as fatal outcome in the following hours after screening.\n* Any other condition determined by the investigators that makes it unlikely that the participant would complete the follow up until day 28 of study.","0 Months","60 Months",{"count":233,"type":23},2200,[26],"In low and middle-income countries, children admitted to hospital are not similarly ill, and do not all have a comparable prognosis. In fact, understanding at first encounter their risk of developing adverse outcomes (including mortality) could allow a more focused management and the tailoring of specific interventions to decrease in hospital mortality, and post discharge adverse longer-term outcomes. This clinical trial, part of the EChiLiBRiST larger project (\"Development and validation of a quantitative point-of-care test for the measurement of severity biomarkers to improve risk stratification of fever syndromes and enhance child survival\") has the two-fold objective of:\n\n1. Assessing whether a POINT-OF-CARE rapid triaging test (PoC RTT) based on the quantitative measurement at the bedside of the \"prognostic\" biomarker sTREM-1 (soluble-triggering receptor expressed on myeloid cells 1) can reliably identify those admitted children with a higher risk of adverse outcomes; and\n2. Assessing whether the therapeutic intervention (the L-arginine precursor, L-Citrulline, key in the nitric oxide biosynthesis), administered orally for 28 days to those children aged 1-\\\u003C60 months identified as \"moderate-to-high risk\" by the prognostic biomarker can improve outcomes as compared to those receiving an indistinguishable placebo.\n\nThis second objective will be assessed in a prospective multi-country, multi-site, individually randomised, two-arm, placebo-controlled, double blind clinical trial involving \\~888 children 1-\\\u003C60m of age admitted to hospital and determined to be at high risk of adverse outcomes by their baseline sTREM-1 levels. The trial will compare the efficacy of a twice-daily dose of L-citrulline syrup vs placebo (200-300mg\u002Fkg\u002Fday depending on weight-band; for 28 days) in reducing adverse outcomes in children with severe disease. The trial will be running independently but in parallel in two high-mortality settings in Mozambique and in Ethiopia.",[237,238,29],"Infectious Disease","Infections","2026-02-19",{"date":193,"type":40},{"date":242,"type":40},"2025-12-08",{"date":244,"type":23},"2027-08-01",{"name":246,"class":47},"Barcelona Institute for Global Health",{"id":248,"slug":249,"hasResults":12,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":12,"sex":18,"minAge":254,"maxAge":231,"enrollmentInfo":255,"targetDuration":4,"studyType":24,"phases":257,"briefSummary":258,"conditions":259,"keywords":261,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":134},"100548541","a-rapid-triage-test-to-improve-risk-stratification-of-febrile-children-echilibrist-clinical-trial-1-outpatients-100548541","NCT06422338","A Rapid Triage Test to Improve Risk-stratification of Febrile Children (EChiLiBRiST, Clinical Trial 1, Outpatients)","A Multi-country, Two-arm, Open-label, Superiority, Randomised Controlled Trial to Study the Performance of a Rapid Triage Test Compared to Standard of Care (IMCI-based) to Guide Admission\u002FDischarge Decisions During the First Clinical Assessment of Children With Fever","Inclusion Criteria:\n\n* Age ≥2 months and \\\u003C60 months\n* Written informed consent from the child's parent or caregiver\n* History of fever for ≤7 days OR hypothermia (i.e., axillary temperature \\\u003C35.5ºC) OR suspected severe infection (e.g., in children with moderate or severe acute malnutrition).\n* Lives within the catchment area of the study facility and must intend to continue to reside there for the duration of the study\n* For the RTI sub-study only: presence of respiratory symptoms compatible with RTI.\n\nExclusion Criteria:\n\n* Weight less than 2.5kg\n* Main reason for consultation is an injury, trauma or acute poisoning\n* Enrolled in another clinical trial testing a new drug\n* Enrolled in a vaccine trial in the last 3 months.\n* Any other condition determined by the investigators that makes it unlikely that the participant would complete the study","2 Months",{"count":256,"type":23},5212,[26],"The overall aim of the study is to provide evidence that introducing novel biomarkers evaluation at triaging (first clinical assessment), in combination with IMCI-based guidelines (SoC), is a viable strategy to enhance rapid and accurate identification of febrile children at increased risk of life-threatening infections compared to IMCI-based strategies alone (SoC), and to demonstrate whether this results in enhanced decisions of admission\u002Freferral vs discharge, and enhanced overall health outcome of children with acute fever in sub-Saharan Africa.",[237,260,29],"Febrile Illness",[262,263,264,265,266],"biomarkers","severity","point-of-care","triage","sub-Saharan Africa","2026-02-12",{"date":269,"type":40},"2026-02-17",{"date":271,"type":40},"2025-07-02",{"date":273,"type":23},"2027-03-01",{"name":246,"class":47},{"id":276,"slug":277,"hasResults":12,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":17,"sex":18,"minAge":282,"maxAge":20,"enrollmentInfo":283,"targetDuration":4,"studyType":24,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":292,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":301},"100543026","the-effect-of-animated-movies-and-storybooks-on-fear-and-anxiety-levels-in-children-with-type-1-diabetes-100543026","NCT06350513","The Effect of Animated Movies and Storybooks on Fear and Anxiety Levels in Children With Type 1 Diabetes","The Effect of Animated Film and Storybook on Fear and Anxiety Levels in Children With Newly Diagnosed Type 1 Diabetes: Randomized Controlled Study","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Parental approval\n* Being between the ages of 7-12,\n* Being diagnosed with T1D for the first time,\n* Being literate and able to communicate in Turkish\n\nExclusion Criteria:\n\n* Having a mental, visual, hearing or communication impairment,\n* Having mental and spiritual health problems,","7 Years",{"count":284,"type":23},64,[26],"This study aims to evaluate the effects of animated films and story books on the fear and anxiety levels of children with newly diagnosed type 1 diabetes.",[288,29,289,290,291],"Diabetes Mellitus, Type 1","Anxiety","Fear","Nurse","2026-02-05",{"date":294,"type":40},"2026-02-09",{"date":296,"type":40},"2024-02-25",{"date":298,"type":23},"2026-07-25",{"name":300,"class":47},"Selverhan Yurttutan",3,{"id":303,"slug":304,"hasResults":12,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":17,"sex":18,"minAge":309,"maxAge":115,"enrollmentInfo":310,"targetDuration":4,"studyType":24,"phases":312,"briefSummary":313,"conditions":314,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":48},"100622082","the-effect-of-therapeutic-play-applied-before-intramuscular-injection-100622082","NCT07378995","The Effect of Therapeutic Play Applied Before Intramuscular Injection","The Effect of Therapeutic Play Applied Before Intramuscular Injection on Fear, Anxiety and Pain in Pre-school Children","Inclusion Criteria:\n\n* Children aged 4-6 years,\n* Those who will receive intramuscular injections,\n* Those who have been prescribed Desefin flk 1x1 IM,\n* Children whose parents have given consent will be included in the study.\n\nExclusion Criteria:\n\n* Those experiencing pain,\n* Those with hearing problems and communication barriers,\n* Those with chronic illnesses,\n* Those with mental and physical disabilities,\n* Those who have taken analgesics within the last 6 hours,\n* Children who have previously been hospitalised will not be included in the study.","4 Years",{"count":311,"type":23},80,[26],"This research aims to evaluate the effectiveness of a therapeutic toy doll developed to reduce the levels of fear, anxiety and pain experienced by children aged 4-6 during intramuscular injection procedures.\n\nChildren, especially at an early age, show great sensitivity towards medical procedures, and these processes can often cause pain, anxiety and fear. This research aims to evaluate the effectiveness of a therapeutic toy doll developed to reduce the levels of fear, anxiety and pain experienced by children aged 4-6 during intramuscular injection procedures. Children, especially at an early age, show great sensitivity to medical procedures, and these processes can often cause pain, anxiety, and fear. This research aims to discover methods of managing and improving children's responses to medical procedures through therapeutic games.\n\nThis study, to be conducted at the Emergency Department of Atatürk University Research Hospital in Erzurum, will be carried out using a randomised controlled design. Participants will be randomly assigned to intervention and control groups. Children in the intervention group will prepare using the therapeutic toy doll, while children in the control group will receive an intramuscular injection at the clinic using routine application methods.\n\nData collection tools will include the Socio-demographic Information Form, the Children's Fear Scale (CFS), the Children's Anxiety Scale-State (CAS-D), and the Wong-Baker Facial Expression Rating Scale.",[29,290,315],"Pain","2026-01-23",{"date":318,"type":40},"2026-01-30",{"date":320,"type":40},"2025-12-30",{"date":322,"type":23},"2027-12-30",{"name":324,"class":47},"Ataturk University",{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":17,"sex":18,"minAge":282,"maxAge":208,"enrollmentInfo":332,"targetDuration":4,"studyType":24,"phases":334,"briefSummary":335,"conditions":336,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":338,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":48},"100622084","mindfulness-based-emotion-regulation-training-for-hospitalized-children-100622084","NCT07379021","Mindfulness-Based Emotion Regulation Training for Hospitalized Children","The Effect of Mindfulness-Based Emotion Regulation Training on Fear and Emotion Regulation in Hospitalized Children","Inclusion Criteria:\n\n* Be aged between 7 and 11 years old,\n* Have a planned hospital stay of at least four days,\n* Be able to speak and understand Turkish,\n* Be able to read and write (to complete questionnaires),\n* The child and parent must be willing to participate in the study.\n\nExclusion Criteria:\n\n* The child has a hearing\u002Fspeech problem that prevents them from communicating,\n* The child has severe pain or acute respiratory distress that prevents them from participating,\n* The child has a known psychiatric diagnosis,\n* The child has previously received similar mindfulness training",{"count":333,"type":23},54,[26],"Hospitalization and medical procedures are a significant source of stress and anxiety for school-age children aged 7-11, who, due to their cognitive development, can perceive events but lack the capacity to cope effectively. The main objective of this project is to examine the effect of Mindfulness-Based Emotion Regulation Training, which will be applied to children aged 7-11 hospitalized in the pediatric clinic, on developing children's emotion regulation skills and reducing their fear levels related to the hospital. The research is a randomized controlled trial to be conducted between April 2026 and April 2027. Data will be collected using the \"Child and Parent Introduction Form,\" the \"Emotion Regulation Scale for Children and Adolescents,\" and the \"Medical Procedure Fear Scale.\" While distraction techniques frequently used in the literature offer a quick and effective solution at the time of the procedure, this project differs in that it aims to provide children with sustainable emotion regulation skills that they can use not only at that moment but also in later stages of the illness and in future life events. As a result of the project, it is expected that the implemented training will increase adaptive emotion regulation strategies in children, significantly reduce medical fear and anxiety, and provide an evidence-based nursing intervention that will facilitate children's compliance with treatment.",[290,29,337],"Hospitalism in Children",{"date":318,"type":40},{"date":340,"type":40},"2025-12-26",{"date":342,"type":23},"2027-12-26",{"name":324,"class":47},{"id":345,"slug":346,"hasResults":12,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":350,"eligibilityCriteria":351,"healthyVolunteers":12,"sex":18,"minAge":186,"maxAge":352,"enrollmentInfo":353,"targetDuration":4,"studyType":24,"phases":354,"briefSummary":355,"conditions":356,"keywords":360,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":48},"100551092","effect-of-apa-on-sleep-quality-in-children-with-cancer-from-5-to-16-years-100551092","NCT06455592","Effect of APA on Sleep Quality in Children With Cancer From 5 to 16 Years","Effect of Practicing Adapted Physical Activity (APA) on Sleep Quality in Children From 5 Years of Age and Adolescents up to 16 Years of Age Undergoing Treatment for a Hematologic Malignancy.","APANYX","Inclusion Criteria:\n\n* Children from 5 to 16 with haematological cancer undergoing treatment\n* Subjects and their parents who were informed about the study and gave informed consent.\n* Enrollment in the Social Security system\n\nExclusion Criteria:\n\n* Children on high-dose corticosteroids\n* Children under anxiolytic treatment\n* Children with sleep disorders (sleep apnea)\n* Children taking melatonin or sleeping pills\n* Contraindication to adapted physical activity\n* Refusal to participate on the part of the participant or his\u002Fher parents\n* Holders of parental authority under curatorship, guardianship, safeguard of justice\n* Pregnant or breast-feeding teenagers","16 Years",{"count":5,"type":23},[26],"Main objective :\n\nEvaluate the effect of adapted physical activity on the sleep of children with cancer from 5 to 16\n\nHypothesis :\n\nPractice daily adapted physical activity improve the sleep of the 5 to 16 children with cancer",[29,357,358,359],"Blood Cancer","Adapted Physical Activity","Sleep",[361,362,363,364,365],"child","blood cancer","adapted physical activity","sleep","hospital and home","2025-12-01",{"date":368,"type":40},"2025-12-05",{"date":370,"type":40},"2025-11-17",{"date":372,"type":23},"2027-11",{"name":374,"class":47},"University Hospital, Clermont-Ferrand",{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":58,"enrollmentInfo":382,"targetDuration":4,"studyType":24,"phases":384,"briefSummary":385,"conditions":386,"keywords":387,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":390,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":395,"locationsCount":48},"100612047","effects-of-bulgarian-exercises-on-lower-limb-function-in-children-100612047","NCT07248501","Effects of Bulgarian Exercises on Lower Limb Function in Children","Effects of Bulgarian Bag Exercise on Lower Limb Function, Posture and Balance Among School Going Children","Inclusion Criteria:\n\n* Ability to perform physical activities\n* Participants must be between 8 to 18 years\n\nExclusion Criteria:\n\n* Children with severe physical disabilities or medical conditions that limit participation in physical activities (e.g., cardiovascular or respiratory conditions).\n* Children unable to comply with study requirements or follow instructions",{"count":383,"type":23},345,[26],"The objective of this study is to investigate the Effect of Bulgarian bag exercises on lower limb function, posture and balance among school going students. In this investigation, our study will include 379 participants girls and boys in our study. Non-Probability Convenient sampling will be used in this research. In this investigation, will collect data from Lahore primary school going girls and boys. The sample that will be included in our study will be 8 to 16 years of age, with both genders, Informed consent, Healthy children without any diagnosed physical or neurological impairments that could affect motor skills or agility. This study use following tools in our study Postural awareness scale PAS-E, Berg balance scale, The lower extremity functional scale.",[29],[388],"Bulgarian exercise, Postural awareness scale PAS-E","2025-11-18",{"date":391,"type":40},"2025-11-25",{"date":393,"type":40},"2025-10-30",{"date":318,"type":23},{"name":46,"class":47},{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":17,"sex":18,"minAge":20,"maxAge":352,"enrollmentInfo":403,"targetDuration":4,"studyType":24,"phases":405,"briefSummary":406,"conditions":407,"keywords":408,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":389,"lastUpdatePostDateStruct":410,"startDateStruct":411,"completionDateStruct":412,"leadSponsor":413,"locationsCount":48},"100612048","effect-of-pillates-on-children-with-backpack-syndrome-100612048","NCT07248514","Effect of Pillates on Children With Backpack Syndrome","Effects of Pilates on Pain and Trunk Muscle Endurance in Children With Backpack Syndrome","Inclusion Criteria:\n\n* Children aged 12-16 years.\n* Being Systemically healthy\n* Being physically active and participating in ordinary assessments(4)\n* Children with musculoskeletal backpain\n* Children with hyper thoracic kyphosis i.e. excessive antero-posterior curvature of the thoracic spine of greater than 40°\n* Children complaining about low back pain\n\nExclusion Criteria:\n\n* Children with a history of severe musculoskeletal conditions (e.g., scoliosis, fractures, or surgery).\n* Any neurological disorders or developmental conditions affecting motor function\n* Children with cardiological, metabolic or rheumatic illness\n* Children with no complaints of low back pain and postural instability.",{"count":404,"type":23},140,[26],"This randomized clinical trial focuses on a sample of 139 of children diagnosed with backpack syndrome, assessing both subjective pain levels and objective measures of trunk muscle endurance before and after a structured Pilates intervention. The Pilates regimen is designed to strengthen core muscles, improve flexibility, and promote better posture, all of which are critical for mitigating the adverse effects associated with heavy backpack use.Data will be collected from North Star School Allama Iqbal town,Lahore,Standard Grammar School, Allama iqbal town ,Kips School, Allama iqbal town,Ali School System, Allama Iqbal Town Using standardized pain assessment scales(VAS) and endurance tests(Modified Biering-Sørensen Test), the effect of pilates on pain and trunk endurance will concluded and the data will analysed with spss 23",[29],[409],"Pilates, Modified Biering-Sørensen Test",{"date":391,"type":40},{"date":197,"type":40},{"date":318,"type":23},{"name":46,"class":47},{"id":415,"slug":416,"hasResults":12,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":12,"sex":18,"minAge":186,"maxAge":19,"enrollmentInfo":421,"targetDuration":4,"studyType":24,"phases":423,"briefSummary":424,"conditions":425,"keywords":426,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":435,"leadSponsor":436,"locationsCount":48},"100611713","effects-of-dynamic-surface-exercise-training-in-children-with-diplegic-cerebral-palsy-100611713","NCT07244159","Effects of Dynamic Surface Exercise Training in Children With Diplegic Cerebral Palsy","Effects of Dynamic Surface Exercise Training on Functional Mobility, Balance and Coordination in Children With Diplegic Cerebral Palsy","Inclusion Criteria:\n\n* Age between 5 and 8 years of both genders\n* Classification as level III and IV on the Gross Motor Function Classification system (GMFCS)\n\nExclusion Criteria:\n\n* • Any orthopedic surgery or botulinum toxin injection in the past 6 months.\n\n  * Refusal by the parents to participate.",{"count":422,"type":23},14,[26],"Data will be collected after the approval of synopsis a total of 14 children with diplegic cerebral palsy of age between 6 and 8 years of both genders with Gross Motor Function Classification System of level III and IV will be recruited to participate in randomized controlled study. The study will be completed within 10 months after the approval of the synopsis. Technique of the study is non-probability convenient sampling technique. Recruited will be randomly divided into two groups, dynamic surface exercise training (DSET) group and standard physiotherapy training group. Both the groups receive active training program lasting for 60 minutes, 4 days\u002Fweek for 6 weeks who have the ability to follow and accept verbal instructions. Gross Motor Function Measure (GMFM)-88 and Pediatric Balance Scale (PBS) and Time up and go test scores will be recorded at baseline, and at the end of 6-week post-intervention.",[29],[427,428,429,430,431],"Diplegic cerebral palsy","Dynamic surface exercise training","Balance","Coordination","Gross Motor Function Measure (GMFM)",{"date":433,"type":40},"2025-11-24",{"date":220,"type":40},{"date":318,"type":23},{"name":46,"class":47},{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":17,"sex":18,"minAge":309,"maxAge":89,"enrollmentInfo":444,"targetDuration":4,"studyType":24,"phases":445,"briefSummary":446,"conditions":447,"keywords":451,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":48},"100393728","metabolic-and-hemodynamic-reserve-in-pediatric-sca-100393728","NCT04406818","Metabolic and Hemodynamic Reserve in Pediatric SCA","The Role of Metabolic and Hemodynamic Reserve in Age-Related Brain Vulnerability in Pediatric Sickle Cell Anemia","Healthy Controls:\n\n* Healthy controls ages 4-21 years of age\n* Able to participate in MRI scan without sedation\n* Not currently pregnant\n* No significant psychiatric history, defined as having a severe psychiatric diagnosis, per PI discretion\n* No history of epilepsy\n* No history of stroke or cerebrovascular disease\n* May have occasional headaches if not taking a daily preventative medication for headaches\n* Not on vasodilatory medication, such as sildenafil or verapamil\n\nSickle Cell Anemia Participants:\n\n* Ages 4-21 years of age\n* Hb SS or SBeta-thal\n* Able to participate in MRI scan without sedation\n* Not currently pregnant\n* Not on vasodilatory medication, such as sildenafil or verapamil\n* No known vasculopathy",{"count":91,"type":23},[26],"The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. SCA participants and healthy controls are age and sex-matched for comparison. Within the SCA cohort, children with infarcts may have thinner cortices than those without, reflecting a greater loss.\n\nThe investigators will examine brain blood flow and metabolism using magnetic resonance imaging (MRI). The brain's blood vessels expand and constrict to regulate blood flow based on the brain's needs. The amount of expanding and contracting the blood vessels may vary by age. The brain's blood flow changes in small ways during everyday activities, such exercise, deep concentration, or normal brain growth. Significant illness or psychological stress may increase the brain's metabolic demand or cause other bigger changes in blood flow. If blood vessels are not able to expand to give more blood flow when metabolic demand is high, the brain may not get all of the oxygen it needs. In extreme circumstances, if the brain is unable to get enough oxygen for a long time, a stroke may occur. Sometimes small strokes occur without other noticeable changes and are only detectable on an MRI. These are sometimes called \"silent strokes.\" In less extreme circumstances, not having a full oxygen supply may cause the brain to grow and develop more slowly than when it has a full supply.\n\nOne way to test the ability of blood vessels to expand is by measuring blood flow while breathing in carbon dioxide. Carbon dioxide causes blood vessels in the brain to dilate without increasing brain metabolism.\n\nDuring this study participants may be asked to undergo a blood draw, MRI, cognitive assessments, and brief questionnaires. The study team will use a special mask to control the amount of carbon dioxide the participants breathe in.",[29,448,449,450],"Brain Diseases","Sickle Cell Disease","Anemia, Sickle Cell",[452,453,454,455,456,457,458,459],"sickle cell anemia","cerebrovascular reactivity","cerebral oxygen metabolism","cortical thickness","gray matter","carbon dioxide","magnetic resonance imaging","brain development","2025-09-03",{"date":462,"type":40},"2025-09-05",{"date":464,"type":40},"2021-06-30",{"date":466,"type":23},"2026-03-31",{"name":468,"class":47},"Washington University School of Medicine",{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":12,"sex":18,"minAge":115,"maxAge":475,"enrollmentInfo":476,"targetDuration":4,"studyType":24,"phases":478,"briefSummary":479,"conditions":480,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":485,"lastUpdatePostDateStruct":486,"startDateStruct":488,"completionDateStruct":490,"leadSponsor":492,"locationsCount":48},"100601608","effect-of-incentive-respiratory-training-on-pulmonary-functions-and-functional-capacity-in-children-with-b-thalassemia-major-100601608","NCT07112703","Effect of Incentive Respiratory Training on Pulmonary Functions and Functional Capacity in Children With B-thalassemia Major","Inclusion Criteria:\n\n1. Diagnosed as thalassemia \\& subjected to blood transfusion\n2. Their age range from 6 to 10 years old\n3. Both sexes, male and female, will participate.\n4. Subjects are able to follow simple verbal commands or instructions included in the procedures.\n\nExclusion Criteria:\n\n1. Children with mental retardation or any other disability .\n2. Children with visual or hearing defects.\n3. Children with cardiovascular, chest pulmonary, and heart diseases.\n4. Children with any postoperative cardiovascular, chest pulmonary, and heart conditions.","10 Years",{"count":477,"type":23},50,[26],"The study was done to:\n\n1. Investigate the effect of respiratory training on functional lung capacity and\n2. To detect the effect of respiratory training on pulmonary functions in children with β-thalassemia major.\n3. To detect the level of oxygen saturation and heart rate during and after blood transfusion in children with β-thalassemia major.",[481,482,483,29,484],"Incentive Spirometer","Pulmonary Function","Functional Capacity","Thalassemia Major","2025-08-02",{"date":487,"type":40},"2025-08-08",{"date":489,"type":40},"2025-04-07",{"date":491,"type":23},"2025-10-08",{"name":493,"class":47},"Rawan Mohammed Khairy Mostafa Elsawy",{"id":495,"slug":496,"hasResults":12,"nctId":497,"briefTitle":498,"officialTitle":498,"acronym":4,"eligibilityCriteria":499,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":20,"enrollmentInfo":500,"targetDuration":4,"studyType":24,"phases":502,"briefSummary":503,"conditions":504,"keywords":508,"overallStatus":510,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":512,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":517,"locationsCount":48},"100595694","effect-of-sevoflurane-on-sweat-threshold-in-children-of-different-ages-100595694","NCT07035782","Effect of Sevoflurane on Sweat Threshold in Children of Different Ages","Inclusion Criteria:\n\n1. Age: 0-12 years old;\n2. American Society of Anesthesiologists physical status I or II;\n3. Weight within the normal range and body-mass index (BMI) for age between the 25th and 85th percentiles;\n4. scheduled elective lower-body surgery under general anesthesia, expected to last at least 1 hour.\n\nExclusion Criteria:\n\n1. The guardian of the child refused to participate in the study;\n2. Operations involving extensive incisions, such as massive debridement or other operations requiring removal of large amounts of tissue;\n3. Contraindications to esophageal temperature probe insertion (e.g., esophageal varices, congenital anomalies);\n4. Thyroid dysfunction or autonomic dysfunction;\n5. Premature infants (≤1 year old).",{"count":501,"type":23},100,[26],"Hypothermia is a common complication in pediatric anesthesia. Hypothermia will prolong the recovery time of anesthesia, and may also lead to increased oxygen consumption, prolonged blood coagulation time, and affect the metabolism of anesthetic drugs and postoperative immune function. Sevoflurane is the most commonly used inhaled anesthetic in children. This study explored the effect of sevoflurane on the sweat threshold of pediatric patients and analyzed the characteristics of body temperature regulation in children of different ages under anesthesia, which will help to understand the mechanism of body temperature regulation in children under anesthesia, and also provide a scientific basis for clinical anesthesia temperature management.",[29,505,506,507],"Temperature Regulation; Disorder","Low Body Temperatures","Sevoflurane",[509,506,507],"Pediatric Anesthesia","NOT_YET_RECRUITING","2025-06-16",{"date":513,"type":40},"2025-06-25",{"date":515,"type":23},"2025-06",{"date":154,"type":23},{"name":518,"class":47},"Second Affiliated Hospital of Wenzhou Medical University",{"id":520,"slug":521,"hasResults":12,"nctId":522,"briefTitle":523,"officialTitle":524,"acronym":4,"eligibilityCriteria":525,"healthyVolunteers":12,"sex":18,"minAge":526,"maxAge":58,"enrollmentInfo":527,"targetDuration":4,"studyType":24,"phases":529,"briefSummary":530,"conditions":531,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":540,"locationsCount":48},"100559825","comparison-of-stent-related-symptoms-between-anti-reflux-stents-and-standard-dj-stents-in-children-with-urolithiasis-100559825","NCT06569173","Comparison of Stent-Related Symptoms Between Anti-Reflux Stents and Standard DJ Stents in Children With Urolithiasis","Comparison of the Drainage\u002FAnti-reflux Effect and Stent-Related Symptoms Between Anti-Reflux Stents and Standard DJ Stents in Children With Urolithiasis","Inclusion Criteria:\n\n1. A definitive diagnosis of urinary tract stones by CT scan, with indications for ureteroscopic lithotripsy (URL), percutaneous nephrolithotomy (PCNL), laparoscopic\u002Fopen stone extraction with or without robotic assistance, or combined endoscopic lithotripsy, and no contraindications;\n2. Age is less than 18 years old;\n3. For preschool children, the informed consent form is signed by the parents; for school-age children, the informed consent form is signed by both the parents and the child themselves.\n\nExclusion Criteria:\n\n1. A history of recurrent bladder irritative symptoms or urinary tract infections;\n2. Severe renal insufficiency, anatomical or functional solitary kidney, and other significant comorbidities that render the child unsuitable for participation in the study;\n3. Stent placement surgery within the past 3 months;\n4. Recent use of medications that may interfere with the study results, such as solifenacin;\n5. Stent removal surgery performed at an external medical facility.","0 Years",{"count":528,"type":23},108,[26],"The aim of this study is to investigate the effectiveness and related complications of anti-reflux stents used in pediatric urolithiasis surgery at the Children's Hospital affiliated with Zhejiang University School of Medicine, by comparing them with conventional stents.",[532,29],"Urolithiasis","2024-11-11",{"date":535,"type":40},"2024-11-12",{"date":537,"type":40},"2024-08-23",{"date":539,"type":23},"2025-08-23",{"name":541,"class":47},"The Children's Hospital of Zhejiang University School of Medicine",{"id":543,"slug":544,"hasResults":12,"nctId":545,"briefTitle":546,"officialTitle":546,"acronym":4,"eligibilityCriteria":547,"healthyVolunteers":12,"sex":18,"minAge":186,"maxAge":475,"enrollmentInfo":548,"targetDuration":4,"studyType":24,"phases":550,"briefSummary":551,"conditions":552,"keywords":556,"overallStatus":510,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":562,"startDateStruct":564,"completionDateStruct":566,"leadSponsor":568,"locationsCount":48},"100566432","the-effect-of-the-educational-movie-shown-to-pediatric-patients-receiving-intrathecal-chemotherapy-treatment-on-pre-procedure-fear-and-post-procedure-pain-in-children-100566432","NCT06655103","The Effect of the Educational Movie Shown to Pediatric Patients Receiving Intrathecal Chemotherapy Treatment on Pre-Procedure Fear and Post-Procedure Pain in Children","Inclusion Criteria:\n\n* 5-10 years old\n* Family's acceptance to participate in the research\n* The child's willingness to participate in the research\n* Absence of a pancytopenic period\n* No sensory loss\n* Developed language skills\u002Fno communication problems\n* Lack of a psychological diagnosis Cognitive abilities are developed in an age-appropriate manner\n* Having not used any anelgesic drug in the last four hours\n\nExclusion Criteria:\n\n* The child has an infection that requires isolation\n* The child wears glasses\n* Child removes virtual reality goggles applied before intrathecal chemotherapy treatment\n* The child does not want to fill in the scales after the application\n* The child or parent wants to leave the study\n* The child has a physical and psychological deficit that prevents him\u002Fher from wearing the glasses that will be worn on his\u002Fher head in order to watch virtual reality",{"count":549,"type":23},99,[26],"In this study, which is planned to be conducted in a randomized controlled experimental design, nonpharmacological methods (educational film shown with virtual reality goggles and cartoon shown with virtual reality goggles) applied to children aged 5-10 years who will receive intrathecal chemotherapy treatment before intrathecal chemotherapy treatment were evaluated. It is aimed to determine the effect on pre-procedure fear and post-procedure pain.\n\nThe study is planned to be conducted between November 2024 and November 2025. The population of the study will consist of children between the ages of 5-10 years who receive inpatient treatment in the Pediatric Hematology Clinic of Izmir Ege University Hospital (Health Practice and Research Center). Random sampling method and stratified randomization method will be used for sample selection. In the calculation of the sample size of the study, using G-Power 3.1.9.7 program; type 1 error (α) 0.05, power (1- β) 99% and Cohen's effect size (δ) 0.5, the sample size to represent the main mass was determined as 90 children for this study. However, when the dropout rate is set as 10% for data loss that may occur in the study, the minimum number to be reached for the study is targeted as 99 (intervention group 1 n=33, intervention group 2 n=33, control group n=33).\n\nResearch data will be collected after project acceptance. In all three groups, children and their parents will be informed before the study and their written and verbal consent will be obtained. Data will be collected by using the \"Introductory Information Form\", \"Intervention Follow-up Form\" and \"Child Fear Scale (CFS)\", \"Wong Baker FACES (WB-FACES) Pain Rating Scale\" and \"Visual Analog Scale (VAS)\" prepared by the researchers with the feedback of nurses, parents and children.\n\nStatistical analyses will be performed using IBM SPSS Statistics 26.0 (IBM SPSS Statistics for Windows) package program. The significance level will be set as 0.05 in all analyzes. In the study, numerical data will be calculated using mean, standard deviation, median, minimum, maximum values and categorical data will be calculated using frequency and ratio values.\n\nWith the nonparametric Brunner-Langer model, the before-after change (group effect, before-after effect and interaction effect) of fear scores in the educational film, cartoon and control groups will be examined using R 3.3.1 software (R software, version 3.3.1, package: nparLD, R Foundation for Statistical Computing, Vienna, Austria; http:\u002F\u002Fr-project.org). In order to visually examine this change, the 'relative effects' graph (since the nonparametric method is used) will be utilized.\n\nWhen the Brunner-Langer model shows that the before-after change in the groups is not similar (interaction \\\u003C 0.05), the before-after comparison in each group will be made separately with the Wilcoxon sign test, and the differences between the groups will be compared with the Kruskal-Wallis test by taking the after-before difference. After Kruskal-Wallis, pairwise comparisons will be made with the Dunn test, and then Bonferroni correction will be used for p values. The agreement between the measurements of Nurses, Parents and Children will be evaluated by Intraclass Correlation (ICC) analysis.",[553,29,554,290,315,555],"Injections, Spinal","Virtual Reality","Chemotherapy",[557,558,559,290,315,560],"Intrathecal","Child","Virtual reality","chemotherapy","2024-10-21",{"date":563,"type":40},"2024-10-23",{"date":565,"type":23},"2024-11-30",{"date":567,"type":23},"2025-11-30",{"name":569,"class":47},"Ege University",{"id":571,"slug":572,"hasResults":12,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":576,"eligibilityCriteria":577,"healthyVolunteers":12,"sex":18,"minAge":88,"maxAge":578,"enrollmentInfo":579,"targetDuration":4,"studyType":24,"phases":580,"briefSummary":582,"conditions":583,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":586,"lastUpdatePostDateStruct":587,"startDateStruct":589,"completionDateStruct":591,"leadSponsor":593,"locationsCount":48},"100481690","phase-4-pharmacokinetic-infliximab-data-in-pediatric-crohns-disease-100481690","NCT05552287","Pharmacokinetic Infliximab Data in Pediatric Crohn's Disease","Prospective Analysis of Pharmacokinetic Infliximab Data in Pediatric CD Patients (ProRAPID)","ProRAPID","Inclusion Criteria:\n\n* Anti-TNF-α naïve children (age 1-15 years) with CD and an indication to start IFX treatment will be eligible for inclusion after a diagnosis of CD is made based on the Porto criteria. Indications of starting IFX treatment as per ECCO-ESPGHAN guidelines include non-response after induction with exclusive enteral nutrition or steroids, non-response to immunomodulators, severe growth delay, extensive disease and\u002For structuring or penetrating disease, with or without perianal disease. Evaluation of the indication to start IFX is performed at the discretion of the attending physician.\n\nExclusion Criteria:\n\n* Established monogenetic IBD\n* Diagnosis with UC or IBD-U, ulcerative colitis like\n* Active fistulizing\u002Fperianal disease at start of IFX treatment (patients with inactive fistulizing\u002Fperianal disease are allowed to participate)\n* Severe comorbidity (not related to IBD)\n* Immediate need for surgery (i.e., symptomatic stenosis or stricture in the bowel)\n* Severe infection such as sepsis or opportunistic infections, positive tuberculin test or a chest radiograph consistent with tuberculosis or malignancy\n* Pregnancy, suspected or definitive\n* Treatment with anti-TNF or other biological drugs in the past\n* Start of corticosteroids or mesalazine less than 2 weeks prior to first IFX infusion\n* Start of Exclusive Enteral Nutrition less than 2 week prior to first IFX infusion","15 Years",{"count":477,"type":23},[581],"PHASE4","Rationale: Crohn's disease (CD) is a chronic, debilitating inflammatory bowel disease (IBD) which is diagnosed during childhood in up to one in ten patients. The use of anti-tumor necrosis factor (TNF)-α agents has significantly ameliorated CD management. Infliximab (IFX) is the first anti-TNF-α agent registered for pediatric CD. The current dosing recommendation of IFX is extrapolated from adult studies, and it is a weight-based dose (5 mg\u002Fkg) delivered during induction (infusion at weeks 0, 2, and 6) and maintenance (every 8 weeks). However, pediatric patients have a 25-40% lower drug exposure compared to adults, particularly children under 10 years of age, resulting in diminished efficacy and an increased risk of developing a complicated disease course. The investigators hypothesize that an intensified IFX induction scheme (instead of the current dosing recommendation) is more effective in the treatment of pediatric CD patients.\n\nObjective: The primary study objective of our study is to assess the efficacy of an IFX intensified induction scheme vs. a standard dosing schedule in improving drug exposure without treatment escalation in pediatric CD patients. Secondary objectives are clinical and biochemical remission without treatment escalation, development of antibodies to IFX (ATI) and adverse reactions.\n\nStudy design: An international, multicenter, prospective, open-label trial. Study population: Anti-TNF-α naïve children (age 1-15 years) with CD and an indication to start IFX treatment.\n\nIntervention: IFX will be given intravenously at 10 mg\u002Fkg at week 0, and 5 mg\u002Fkg at weeks 2, 4, and 8 to all patients (induction). Maintenance will start at week 12, and then ideally continue every 6 weeks till week 24 (end of study). IFX trough levels will be measured at weeks 4, 12, and 24. During the maintenance, the IFX dose and\u002For interval adjustments, the IFX discontinuation or the start of a co-medication (i.e., an immunomodulator) will be possible on indication (i.e., primary nonresponse, secondary loss of response, intolerance to study medication) at the physicians' discretion. Follow-up will continue for the duration of the study (week 24).\n\nMain endpoint: Proportion of patients with IFX TL ≥ 5 µg\u002FmL at week 12 without treatment escalation.",[584,29,585],"Crohn Disease","Biologic; Inadequate","2024-09-12",{"date":588,"type":40},"2024-09-19",{"date":590,"type":40},"2023-08-02",{"date":592,"type":23},"2025-08",{"name":594,"class":47},"Erasmus Medical Center",{"id":596,"slug":597,"hasResults":12,"nctId":598,"briefTitle":599,"officialTitle":600,"acronym":601,"eligibilityCriteria":602,"healthyVolunteers":12,"sex":185,"minAge":115,"maxAge":20,"enrollmentInfo":603,"targetDuration":4,"studyType":24,"phases":605,"briefSummary":606,"conditions":607,"keywords":610,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":614,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":621,"locationsCount":48},"100508025","trial-of-an-exercise-intervention-for-children-with-haemophilia-100508025","NCT05895032","Trial of an Exercise Intervention for Children With Haemophilia","Development Of a haemophiLia PHysiotherapy INtervention for Optimum Musculoskeletal Health in Children (DOLPHIN-II) - a Randomised Controlled Trial","DOLPHIN-II","Inclusion Criteria:\n\n• Children aged 6-12 years, with severe or moderate haemophilia A or B\n\nExclusion Criteria:\n\n* von Willebrand disease\n* past history of fracture or trauma to the lower limb\n* orthopaedic surgery\n* acquired brain injury or any other disturbance of the central nervous system; joint or muscle bleed in the lower limb in the past 6 weeks\n* presence of lower limb pain or unable to fully comply with verbal instructions.",{"count":604,"type":23},132,[26],"\"Being able to participate in games and activities with their friends\" is one of the things that matters most to boys with haemophilia. At present, there is a lack of robust evidence to determine whether muscle strengthening exercise can improve or negatively affect outcomes for young children with haemophilia. With the help of boys with haemophilia, their parents and physiotherapists the investigators have developed an exercise programme designed to increase muscle strength. Using this intervention the investigators will undertake a single-blinded, two-arm pragmatic randomised controlled trial (RCT) of a 12-week intervention verses usual care of boys with haemophilia aged 6-12 years of age.",[608,29,609],"Hemophilia","Musculoskeletal Diseases or Conditions",[611,612,613],"Physical Therapy","Exercise","Muscle strength","2024-08-29",{"date":616,"type":40},"2024-08-30",{"date":618,"type":40},"2021-05-06",{"date":620,"type":23},"2025-06-30",{"name":622,"class":108},"East Kent Hospitals University NHS Foundation Trust",{"id":624,"slug":625,"hasResults":12,"nctId":626,"briefTitle":627,"officialTitle":627,"acronym":628,"eligibilityCriteria":629,"healthyVolunteers":17,"sex":18,"minAge":115,"maxAge":20,"enrollmentInfo":630,"targetDuration":4,"studyType":24,"phases":631,"briefSummary":632,"conditions":633,"keywords":634,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":636,"lastUpdatePostDateStruct":637,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":134},"100560643","effect-of-tubular-bandage-application-on-peripheral-intravenous-catheter-usage-time-and-infiltration-in-children-100560643","NCT06579820","Effect of Tubular Bandage Application on Peripheral Intravenous Catheter Usage Time and Infiltration in Children","chıldren","inclusion criteria\n\nWillingness to participate in the study\n\n* Parent\u002Fchild's proficiency in Turkish\n* Intact skin integrity in the application area\n* First-time application of the peripheral venous catheter to the middle part of the child's forearm\n* Recommendation by a physician for intravenous fluid containing 5% dextrose, 0.45% NaCl, and 75% KCL through a peripheral venous catheter\n* Child's age between 6-12 years\n* Successful placement of the peripheral venous catheter on the first attempt\n\nexclusion criteria\n\nCoagulation abnormalities\n\n* Receiving blood and blood products through the peripheral venous catheter\n* Nutritional issues\n* Hematologic or oncologic diseases\n* Congenital genetic or neurological disorders\n* Problems with skin integrity and movement in the upper extremities\n* Sensitivity to the tubular bandage\n* Fever above 37.5°C\n* Accidental dislodgement of the catheter\n* Early completion of treatment and removal of the catheter",{"count":501,"type":23},[26],"In pediatric patients, placement of peripheral intravenous catheters is the most commonly performed invasive medical procedure. In addition to the administration of medications, parenteral nutrition, intravenous fluids, and blood products, peripheral intravenous catheters are placed prophylactically before procedures and for emergency use in unstable patients.\n\nOne of the most common complications of peripheral intravenous catheters is infiltration. Infiltration is a vascular trauma resulting from a lesion in the vascular layers and subsequent perforation, resulting in the leakage of medications or non-vesicant solutions into the tissues surrounding the site of placement of the peripheral venous catheter.\n\nIn pediatric patients, physical factors (e.g. hyperactivity, sweating), tight fixation (may affect blood circulation and iatrogenic skin injury), loose fixation (may cause peripheral intravenous catheter displacement and infection), poor-quality fixation (may cause unplanned removal and skin injuries due to pressure), etc. causes more peripheral intravenous catheter fixation problems in pediatric patients than in adult patients Additional fixation products may be effective in preventing dislocation and micromotion in an active pediatric patient. However, limited recommendations regarding medical adhesive tapes and additional fixation products are guided only by low-evidence studies. The purpose of this study was to determine the effect of tubular bandage use on the duration of pediatric peripheral intravenous catheter use and the incidence of infiltration.",[29],[635],"child, infiltration,catheter usage time","2024-08-28",{"date":616,"type":40},{"date":639,"type":40},"2024-02-10",{"date":641,"type":23},"2024-12-30",{"name":643,"class":47},"Istanbul University"]