[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"childhood-apraxia-of-speech\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:childhood-apraxia-of-speech":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100633404","motor-based-intervention-for-childhood-apraxia-of-speech-dttc-connect-100633404",false,"NCT07526246","Motor-based Intervention for Childhood Apraxia of Speech: DTTC-Connect","A Randomized Control Trial of Motor-based Intervention for Childhood Apraxia of Speech: Dynamic Temporal and Tactile Cueing-Connect (DTTC-Connect)","Inclusion Criteria:\n\n1. Diagnosis of childhood apraxia of speech (CAS). The diagnosis will be made by two speech language pathologists (SLPs) who have extensive experience in the differential diagnosis of CAS.\n2. Age between 3;6 and 12;11 years.\n3. Normal structure of the oral-peripheral mechanism as determined by a motor speech examination using established lab protocol.\n4. Participants must pass a hearing screening conducted at 20 dB SPL at 500, 1000, 2000 and 4000 Hz.\n5. Not receiving speech treatment elsewhere over the course of this study, although language, augmentative and alternative communication (AAC) treatment, or similar non-speech treatment, would be permitted.\n6. Language Testing: Receptive Language Index standard score greater than or equal to 70 on the Clinical Evaluation of Language Fundamentals - Preschool 3rd edition (CELF-P3) for children 3;6-5;11 years of age, or the Clinical Evaluation of Language Fundamentals - 5th edition (CELF-5) for children 6;0-12;11 years of age.\n7. Nonverbal Cognition Testing: Standard score greater than or equal to 70 on the Developmental Assessment of Young Children-2nd edition (DAYC-2) for children 3;6- 5;11 years of age, or the Reynolds Intellectual Assessment Scales- 2nd edition, Remote (RIAS) for children 6;0-12;11 years old.\n8. Evidence of multi-word spontaneous speech up to five syllables in length.\n9. English as the primary language.\n\nExclusion Criteria:\n\n1. Primary dysarthria diagnosis, even if CAS is a secondary diagnosis.\n2. Abnormal structure of the oral peripheral mechanism.\n3. Fluency disorder, even if the child meets criteria for CAS.\n4. Conductive or sensorineural hearing loss, even if the child meets criteria for CAS.\n5. English is not the primary language.","ALL","3 Years","12 Years",{"count":20,"type":21},68,"ESTIMATED","INTERVENTIONAL",[24],"NA","Childhood apraxia of speech (CAS) is a complex motor speech disorder that significantly limits a child's ability to communicate in daily activities, with difficulties often persisting into adolescence and adulthood. There is solid evidence that motor-based interventions, such as Dynamic Temporal and Tactile Cueing (DTTC), improve word production in children with CAS. Building on this strong foundation, the next critical step is to extend this work to support functional communication in connected speech, where children with CAS often continue to struggle. There is a critical need for a systematic bridge within the context of treatment from word-level practice to connected speech, as robust word-level gains often fail to generalize to other speaking contexts. This work addresses this gap by transitioning children from word- to phrase-level practice using Dynamic Temporal and Tactile Cueing-Connect (DTTC-Connect), a novel, structured adaptation of DTTC that targets connected speech production. Our approach builds on established DTTC principles while incorporating progression to more complex utterances, offering a developmentally appropriate, research-informed pathway to functional communication.\n\nThis study is a Phase II randomized controlled trial (RCT) designed to examine the efficacy of DTTC-Connect, a motor-based treatment that includes phrase-level practice to refine connected speech and support communicative participation for children with CAS. The overall objectives of this work are to test the efficacy of DTTC-Connect and document changes in speech motor control at the connected speech level in 68 children with CAS (3;6 - 12;11 years of age) who receive treatment twice a week for 8 weeks (16 sessions). The central hypothesis is that DTTC-Connect will lead to lasting improvements in phrase accuracy, speech intelligibility and speech motor control, ultimately enhancing a child's communicative participation.",[27],"Childhood Apraxia of Speech",[29,30,31],"Pediatric Motor Speech Disorder","Speech Motor Control","Communicative Participation","NOT_YET_RECRUITING","2026-06-24",{"date":35,"type":36},"2026-06-29","ACTUAL",{"date":38,"type":21},"2026-09-15",{"date":40,"type":21},"2031-03-31",{"name":42,"class":43},"New York University","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100609547","phase-2-role-of-omega-dek-in-childhood-apraxia-of-speech-100609547","NCT07216001","Role of Omega-DEK in Childhood Apraxia of Speech","Inclusion Criteria:\n\n1. Confirmed diagnosis of childhood apraxia of speech\u002Fverbal apraxia by a qualified professional (SLP) based on established guidelines\n2. Male and female, age 36 months - 6 years (inclusive)\n3. Ability to comprehend and use Standard American English\n\nExclusion Criteria:\n\n1. Children unable to tolerate oral supplementation\n2. Known allergy to fish oil, palm kernel oil or other ingredients in investigational drug\n3. Medical or genetic condition that in the opinion of the PI\u002FCo-Is may affect participation and compromise results (including significant receptive language delay, moderate-severe cognitive delay, complex medical history, hearing loss, cerebral palsy, history of traumatic brain injury or severe anoxic event, Down's syndrome)\n4. Known seizure disorder or history of febrile seizures\n5. History of cardiac dysrhythmia or abnormal ECG at baseline\n6. A prothrombin time test with an international normalised ratio (PT\u002FINR) \\>1.2\n7. Use of blood thinners, including chronic aspirin, chronic NSAIDS, warfarin etc.\n8. A history of PUFA or vit E supplementation use within 3 months prior to enrollment in the study\n9. On an elimination diet for \\\u003C 3 months (gluten, casein, yeast free etc.) prior to enrollment, or planning to initiate a special diet during the study\n10. Recent reintroduction of food items from elimination diet \\\u003C 3 months\n11. On any additional nutritional interventions\u002Fsupplements \\\u003C 3 months (i.e. high dose vitamins\u002Fminerals that exceed what would be found in a children's multivitamin supplement etc., probiotics)\n12. Any new chronic medication \\\u003C 3 months prior to enrollment (stable doses \\> 3 months allowed; medications for acute illness allowed including antipyretics, antibiotics, asthma medication)\n13. Anticipated initiation of new chronic medication during study timeline including new attention-deficit\u002Fhyperactivity disorder (ADHD) medications, other behavior medications\n14. Plans to try additional complementary interventions or diets during the study period\n15. Planned surgery during or within 4 weeks after conclusion of trial\n\nInclusion Criteria for Expanded Cohort:\n\n1. Working Diagnosis of CAS, or intestinal lymphangiectasia, or fat malabsorption syndrome (in isolation or associated with other medical conditions such as cystic fibrosis, celiac disease, etc.)\n2. Male and female, aged ≥2 years\n3. Ability to comprehend and use Standard American English\n\nExclusion Criteria for Expanded Cohort:\n\n1. Subjects unable to tolerate oral supplementation\n2. Known allergy to fish oil, palm kernel oil or other ingredients in investigational drug\n3. History of cardiac dysrhythmia or abnormal ECG at baseline\n4. PT-INR \\>1.2. A clinical lab performed within a month of enrollment will be accepted to meet this exclusion criteria\n5. Use of blood thinners, including chronic aspirin, chronic NSAIDS, warfarin etc. (Symptomatic use of NSAIDS for acute fever or pain permitted)","2 Years","6 Years",{"count":53,"type":21},34,[55],"PHASE2","This is a 20-week study for children between 3 and 6 years old with confirmed childhood apraxia of speech (CAS). The study includes a 12-week open-label pilot feasibility study of an investigational drug (Omega-DEK) plus L-carnitine (Carnitor®), which is followed by an 8-week randomized, placebo-controlled discontinuation period among the same study participants.",[27,58,59],"Verbal Apraxia","Autism","2026-02-24",{"date":62,"type":36},"2026-02-27",{"date":64,"type":21},"2026-05",{"date":66,"type":21},"2027-12",{"name":68,"class":43},"Claudia R. Morris",2,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100599650","efficacy-of-ultrasound-biofeedback-in-brazilian-childhood-apraxia-of-speech-100599650","NCT07087249","Efficacy of Ultrasound Biofeedback in Brazilian Childhood Apraxia of Speech","Efficacy of Ultrasound Biofeedback in Brazilian Childhood Apraxia of Speech: A Randomized Clinical Trial","Inclusion Criteria:\n\nClinical diagnosis of Childhood Apraxia of Speech (CAS) confirmed by at least two certified speech-language pathologists; Aged between 5 and 16 years; Monolingual Brazilian Portuguese speakers; Normal hearing, cognitive, and receptive language skills; Normal results on oral-facial and non-verbal intelligence screenings.\n\nExclusion Criteria:\n\nHearing impairment or auditory processing disorders Neurological, intellectual, or anatomical conditions affecting speech (e.g., cleft palate, cerebral palsy, dysarthria) Diagnosis of global motor developmental disorders Bilingual speakers or those exposed to other languages at home","FEMALE","5 Years","16 Years",{"count":81,"type":21},20,[24],"This study is a single-blind, randomized controlled trial evaluating the efficacy of ultrasound visual biofeedback (UVB) in the treatment of Childhood Apraxia of Speech (CAS) among Brazilian children. Approximately half of the participants are randomly assigned to an Experimental group receiving the ultrasound biofeedback intervention, and the other half to a Control group receiving conventional motor-based therapy without ultrasound. Randomization is performed using a computer-generated sequence (allocation ratio 1:1), with allocation concealment (e.g. sealed opaque envelopes) to prevent selection bias. Blinding is maintained for outcome assessment: an independent speech-language pathologist who is masked to group assignment will evaluate pre- and post-therapy speech samples for all children. Neither the therapists nor the participants are blinded (due to the nature of the intervention), but the use of blinded outcome evaluators helps ensure objective assessment.",[27,85],"Speech Sound Disorders",[87,88,27,89,90],"Speech Therapy","Motor Speech Disorder","Verbal Dyspraxia","Ultrasound Biofeedback","2025-07-23",{"date":93,"type":36},"2025-07-25",{"date":95,"type":21},"2025-08-06",{"date":97,"type":21},"2026-01-15",{"name":99,"class":43},"Aline Mara de Oliveira",1]