[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"childhood-obesity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:childhood-obesity":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,44,0,25,[9,48,81,108,134,156,182,210,235,273,300,330,361,392,412,440,467,492,517,539,564,587,610,634,667],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644305","the-bottle-optimization-testing-tiny-little-eaters-study-100644305",false,"NCT07665983","The Bottle Optimization Testing Tiny Little Eaters Study","Managing Excess Infant Energy Intake by Increasing Satiation Responsiveness in Dyadic Feeding Interactions","BOTTLE","Inclusion Criteria:\n\n1. Mother-infant dyad: The biological mother is the legal guardian of the infant and has custody for ≥5 days per week (in cases of joint custody).\n2. Maternal age: Mother is ≥18 years old.\n3. Language: Mother understands spoken and written English sufficiently to provide informed consent, answer questionnaires and follow study instructions.\n4. Gestational age: Infant was born at 37.0-42.0 weeks gestation.\n5. Birthweight: Infant's birthweight was appropriate for gestational age.\n6. Bottle feeding: Infant currently receives at least one bottle feeding of ≥2 ounces at least once per week.\n7. Residence: Family lives within approximately one hours driving distance of Ann Arbor, Michigan to participate in an at- home appointment or is willing to drive to the U-M North Campus research site.\n8. Infant age: Infant is 4.0-6.0 months old at enrollment.\n\nExclusion Criteria:\n\n1. Current maternal depression or anxiety, as assessed by screening questionnaires, or any cognitive impairment that would limit ability to follow study instructions.\n2. Infant developmental delay, genetic condition, or medical problems or diagnosis affecting current or future eating, growth, or development.\n3. History of significant sucking or feeding difficulties or breastfeeding difficulties requiring significant medical intervention or support.\n4. Current weight-for-age below the 10th percentile or significant history of poor weight gain.\n5. Infant already typically uses a slower-flow nipple (flow rate \\\u003C 5 mL\u002Fmin).",true,"ALL","4 Months",{"count":22,"type":23},440,"ESTIMATED","INTERVENTIONAL",[26],"NA","The researchers will study how babies respond to bottle nipples with different flow rates over a few days, and how this may affect how much milk they drink, their feeding patterns, and their sleep.",[29],"Childhood Obesity",[31,32,33,34],"Infant growth","Responsive feeding","Satiation cues","Milk intake","RECRUITING","2026-06-29",{"date":38,"type":39},"2026-07-01","ACTUAL",{"date":41,"type":39},"2026-06-26",{"date":43,"type":23},"2028-08",{"name":45,"class":46},"University of Michigan","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":19,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100614649","phase-2-phentermines-impact-on-treatment-in-teens-100614649","NCT07282340","Phentermine's Impact on Treatment in Teens","Phentermine's Impact on Treatment in Teens (PhITT): A Randomized Placebo-Controlled Trial of Phentermine for Adolescents With Obesity","PhITT","Inclusion criteria\\* include, but are not limited to:\n\n* Age ≥ 12 years and \\\u003C 18 years at time of consent;\n* Tanner Staging ≥ 2 at the time of screening;\n* Obesity (BMI ≥ 95th age- and sex-specific CDC percentile or BMI ≥ 30 kg\u002Fm2);\n* Biological females must agree to use adequate contraception, defined as double barrier methods, stable hormonal contraception plus single barrier method, tubal ligation, or abstinence.\n\nExclusion criteria\\* include, but are not limited to:\n\n* Contraindications to phentermine in adults such as:\n\n  * A history of cardiovascular disease (e.g., coronary artery disease, stroke, clinically significant congenital heart disease, clinically significant cardiac arrhythmias, and congestive heart failure);\n  * History of glaucoma;\n  * Current or recent (within 14 days of screening) use of a monoamine oxidase (MAO) inhibitor;\n  * Any previous history of drug dependency or current use of an illicit substance (positive urine drug screen);\n  * Current pregnancy or breastfeeding;\n  * Plans to become pregnant within the study duration;\n  * Known hypersensitivity to sympathomimetic amines;\n* Current nicotine use or nicotine cessation within 3 months of screening;\n* Stage 2 hypertension (or greater) or taking any medication to treat hypertension;\n* Current type 1 or type 2 diabetes mellitus or taking any medication to treat diabetes or prediabetes;\n* Current or recent (within 3 months of screening) use of prescribed weight loss medication(s)\u002Fmedically prescribed diets (e.g., low calorie, meal replacement\u002Fherbal agents\u002Fdietary supplements or weight loss program);\n* Current or recent (within 3 months of screening) use of other sympathomimetic amines such as stimulants to treat attention- deficit\u002Fhyperactive disorder;\n* Use of chronic systemic glucocorticoid therapy (consecutive use of 3 months or more) or other steroid hormone therapy other than oral contraceptives;\n* Use of tricyclic antidepressants, lithium, levodopa, or dopamine receptor agonists;\n* History of bariatric surgery;\n* History or current diagnosis of schizophrenia, psychosis, bipolar disorder, or mental illness requiring hospitalization within 12 months of screening;\n* History of suicide attempt within 2 years or self-harm within 3 months of screening;\n* Current Patient Health Questionnaire-9 (PHQ-9) score of ≥ 10;\n* Current suicidal ideation type 4 or 5 on Columbia Suicide Severity Rating Scale (C-SSRS);\n* Current Eating Attitudes Test-26 (EAT-26) score ≥ 20 or any history of anorexia or bulimia.\n* Current condition or disease interfering with metabolism, such as untreated hypo- or hyperthyroidism, Cushing's syndrome;\n* Current clinically significant hepatic aspartate transaminase (AST) or alanine transaminase (ALT) \\> 3x upper limit of age- and sex-specific normal range or renal disease (creatinine clearance \\\u003C 60 mL\u002Fminute); hypertriglyceridemia (triglyceride ≥ 400 mg\u002FdL) or syndromic or monogenic obesity;\n* Any clinically significant abnormalities on a standard 12-lead electrocardiogram at baseline;\n* Heart rate \\> 100 bpm at screening;\n* Current or recent use of any investigational medication or device or participation in an interventional clinical trial within 30 days of screening;\n* Any clinically significant medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation, investigational product administration, or interpretation of trial results.","12 Years","17 Years",{"count":59,"type":23},240,[61],"PHASE2","PhITT is a Phase IIb, multicenter, randomized, double-blind, placebo-controlled clinical trial evaluating the efficacy and safety of phentermine (16 mg daily) in adolescents aged 12 to \\\u003C18 years with obesity. Conducted across approximately 10 sites within the IDeA States Pediatric Clinical Trials Network (ISPCTN), the study aims to enroll up to 240 participants and then randomize up to 198 who meet eligibility criteria, randomized in a 2:1 ratio to phentermine or placebo over a 52-week treatment period, followed by a 2-week withdrawal assessment.",[29],[65,66,67,68,69],"Adolescent Obesity","Pediatric Obesity","Weight Loss","BMI Reduction","Phentermine","2026-06-12",{"date":72,"type":39},"2026-06-16",{"date":74,"type":39},"2026-06-03",{"date":76,"type":23},"2028-01",{"name":78,"class":79},"Russell McCulloh, MD","NETWORK",2,{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":18,"sex":19,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":24,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":80},"100441426","ebt-fruit-and-vegetable-prescription-100441426","NCT05028205","EBT Fruit and Vegetable Prescription","Eating Better Together: A Pilot Study","Inclusion Criteria:\n\n* Patients at the Cherokee Health Systems clinic in Cherokee Mills\n* Child age between 4 to 10 years old\n* Child BMI \\> 85th percentile\n* Child must have an adult caregiver (\\> 18 years) living in the household and be willing to participate in the program\n* Adult caregivers need to be able to read and speak English\n\nExclusion Criteria:\n\n* Not patients at the CHS Knox County Pediatric Clinic\n* A child not within the 4 to 10 years age range\n* Child BMI at or below the 85 percentile\n* Child without an adult caregiver (\\> 18 years) living in the household and not willing to participate in the program\n* Adult caregivers that are not able to read and speak English","4 Years","10 Years",{"count":91,"type":23},30,[26],"Eating Better Together is a 6-month pilot program that teaches families about healthy eating and activity and provides home deliveries of fresh fruits and vegetables from a local retail partner.",[29,95],"Obesity",[97,98],"Fruit and Vegetable Prescription","Food Security","2026-06-05",{"date":101,"type":39},"2026-06-09",{"date":103,"type":39},"2021-08-16",{"date":105,"type":23},"2026-12-28",{"name":107,"class":46},"The University of Tennessee, Knoxville",{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":18,"sex":19,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":24,"phases":119,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":47},"100507005","integrating-food-rx-with-best-feeding-practices-with-efnep-100507005","NCT05881759","Integrating Food Rx With Best Feeding Practices With EFNEP","Integrating Food Rx With Best Feeding Practices for Chronic Disease Prevention Among EFNEP Participants","Inclusion Criteria:\n\n* Living in Harris or Fort Bend counties\n* being a parent of a child 4-8 years old\n* ability to speak in English or Spanish\n* have ready access to a telephone\n* have access to the Internet with a smart phone, a tablet, a laptop, or a desktop computer\n\nExclusion Criteria:\n\n* parents of children with disabilities and\u002For those on prescription medications that affect weight and\u002For appetite\n* parents who are not able to complete self-report questionnaires","18 Years","64 Years",{"count":118,"type":23},375,[26],"To assess feasibility and acceptability of of integrating Food Rx and Best Feeding Practices with EFNEP participants via a pilot study.",[122,29,123,124],"Dietary Habits","Food Selection","Feeding Behavior","2026-06-01",{"date":127,"type":39},"2026-06-02",{"date":129,"type":39},"2024-01-15",{"date":131,"type":23},"2027-03-31",{"name":133,"class":46},"Baylor College of Medicine",{"id":135,"slug":136,"hasResults":12,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":12,"sex":19,"minAge":141,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":24,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":47},"100448927","adaptive-mechanisms-responsible-for-weight-change-in-youth-with-obesity-100448927","NCT05125822","Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity","ADMIRE","Inclusion Criteria:\n\n* 11 to less than 16 years old\n* BMI \\> 30 kg\u002Fm\\^2 or 95th BMI percentile\n* Tanner stage 2, 3, or 4\n\nExclusion Criteria:\n\n* Tanner stage 1 and 5\n* Prior bariatric surgery\n* Current or recent (\\\u003C 3 months prior to enrollment) use of anti-obesity medication(s) defined as orlistat, metformin, phentermine, topiramate, combination phentermine\u002Ftopiramate, liraglutide, and\u002For combination naltrexone\u002Fbupropion (monotherapy use of naltrexone or bupropion is not an exclusion)\n* Monogenic and hypothalamic obesity\n* Polycystic ovary syndrome (diagnosed by a physician)\n* Pregnancy or planned pregnancy\n* Current use of supplemental hormones\n* Individuals with a diagnosed eating disorder of anorexia nervosa, bulimia or binge eating disorder\n* Type 1 or 2 diabetes\n* Treatment with growth hormones\n* Thyroid disease\u002Fproblem\n* Has had cancer in the last 10 years","11 Years","15 Years",{"count":144,"type":23},260,[26],"In this study, doctors want to find out more about why people who lose weight often regain the weight that they have lost once they resume a regular diet and whether hormones might play a role in weight regain. The study is divided into two parts, called the meal replacement period and the follow-up period. The meal replacement period will consist of drinking a shake for breakfast and lunch and eating a frozen meal for dinner that is calorie controlled. Individuals will also be asked to eat two servings of fruit and three servings of vegetables each day. The study will provide the shakes and the frozen entrees, participants are asked to supply the fruits and vegetables.\n\nParticipation in this study will last for up to 35 weeks. There will be 10 in-person visits and 13 visits by phone or over Zoom over the 35 weeks.",[29],"2026-05-29",{"date":127,"type":39},{"date":151,"type":39},"2023-08-26",{"date":153,"type":23},"2028-01-01",{"name":155,"class":46},"Ann & Robert H Lurie Children's Hospital of Chicago",{"id":157,"slug":158,"hasResults":12,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":12,"sex":19,"minAge":164,"maxAge":57,"enrollmentInfo":165,"targetDuration":4,"studyType":24,"phases":167,"briefSummary":168,"conditions":169,"keywords":170,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":80},"100560922","time-restricted-eating-in-childhood-obesity-treco-100560922","NCT06583447","Time Restricted Eating in Childhood Obesity (TRECO)","Time Restricted Eating in Childhood Obesity: An Open-Label, Blinded-Endpoint, Parallel-Controlled, Randomized Clinical Trial","TRECO","Inclusion Criteria:\n\n* Age: 8-17 years.\n* Childhood obesity: BMI-z score \\> 2.\n* Agree to participate in this study and signed an informed consent form.\n\nExclusion Criteria:\n\n* Individuals who have been actively fasting for more than 12 hours\u002Fday.\n* Diabetic patients on hypoglycemic medications.\n* Individuals undergoing weight loss interventions or previous bariatric surgery.\n* Individuals with psychiatric, intellectual developmental disorders, or aphasia.\n* Individuals on appetite or weight-suppressing medications within the last three months (e.g., antipsychotics, hypnotics, weight-loss drugs, insulin).","8 Years",{"count":166,"type":23},128,[26],"The goal of this clinical trial is to learn if time-restricted eating (TRE), an alternative method of reducing energy intake which has gained popularity in recent years, works to treat obesity in children. It will also learn about the safety and long-term adherence of 12-hour TRE, in comparison to calory restricted diet (CRD) . The main questions it aims to answer are:\n\n1. Is the weight-losing effect of 12-hour TRE better than CRD?\n2. Is 12-hour TRE easier to adhere to than CRD?\n\nResearchers will compare 12-hour TRE to CRD (the primary treatment for obesity) to see if 12-hour TRE works to treat childhood obesity.\n\nParticipants will:\n\n1. Follow the 12-hour TRE or CRD diet every day for 48 weeks;\n2. Visit the clinic once every 4 weeks before 12 weeks and thereafter every 12 weeks for checkups and tests;\n3. Keep a diary of their diet, physical activity, and symptoms",[29],[29,171,172],"Calory-restricted diet","time-restricted eating","2026-05-05",{"date":175,"type":39},"2026-05-08",{"date":177,"type":39},"2024-09-28",{"date":179,"type":23},"2027-04",{"name":181,"class":46},"Xiaoyan Shi",{"id":183,"slug":184,"hasResults":12,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":188,"eligibilityCriteria":189,"healthyVolunteers":18,"sex":19,"minAge":190,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":24,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":47},"100586703","reducing-obesity-through-play-among-toddlers-tiny-steps-to-health-tshs-study-100586703","NCT06918821","Reducing Obesity Through Play Among Toddlers: Tiny Steps to Health (TSHS) Study","Reducing Obesity Through Play: A Randomized Control Trial","TSHS","Inclusion criteria:\n\n* Parents: Primary custodian (i.e., legal guardian) of a toddler, \\>18 years, have regular and frequent access to internet, fluent in English.\n* Toddlers: \\>\u002F=18 and \\\u003C\u002F=36 months of age, and walking.\n\nExclusion criteria include:\n\n* Parents or toddlers who have mental or physical conditions that would prevent engagement in nutrition, physical activity, play, or instructional activities in a group setting or families unwilling to commit to the whole program (e.g., planning to move) will be excluded because participants may be randomly assigned to group interventions where engagement in these activities will be expected.\n\n  * Parents who are not fluent in English will be excluded because this study was developed, and pilot tested on an English-speaking population. All study materials are in English, the interventions will be offered in English, and most of the surveys are not available or have been validated for non-English speaking audiences.\n  * Parents who are not willing or able to participate in parent-toddler interaction assessments via Zoom will be excluded. This assessment is an important study variable.\n* Parents who are not willing to be recorded will be excluded because all Families Understanding Nutrition and Physically Active LIfestyles (FUNPALs) Playgroup sessions will be recorded for facilitator supervision purposes, and the parent-toddler interaction assessments will be recorded for later coding.\n* Only one toddler and one parent per family will be eligible, but all children and siblings within a household will be able to attend playgroups or childcare while parents are in Healthy Toddler Parent Group (HTPG) classes.\n* Parents and toddlers who received 1 or more sessions of the FUNPALs Playgroup or the HTPG. This study will be running 1 cohort per quarter for 4 years, so it is possible that families may drop out and want to re-enroll in a later cohort or enroll when younger siblings are eligible. They will not be eligible. Also, families from the community will be invited to participate in practice sessions of FUNPALs or HTPG to train the facilitators. These families will not be eligible to participate in the study.","18 Months","36 Months",{"count":193,"type":23},300,[26],"The purpose of this study is to test various ways to help toddlers develop healthy eating and activity behaviors. Parents and toddlers, who participate in this research will be randomly assigned to either 1) continue their lifestyle behaviors for 10-weeks and then receive a health club membership for 1-month, 2) attend a health promotion playgroup together for 10 weeks, or 3) to attend an educational class for parents while toddlers are in childcare for 10-weeks. Physical measures of toddlers (height, weight, dietary intake, activity) will be collected. Parent-report surveys with questions about parenting, toddler diet, toddler temperament, food security status, demographic qualities, and satisfaction with group assignment will be collected. Last, the interactions between parents and toddlers will be observed and assessed during short play tasks via Zoom. All measures will be collected immediately upon signing up for the study (week 0), 10-weeks later (post), and 24-weeks after signing up for the study.",[29],[198,199,200,201],"toddlers","diet","physical activity","parenting","2026-04-29",{"date":173,"type":39},{"date":205,"type":39},"2025-05-17",{"date":207,"type":23},"2029-02-28",{"name":209,"class":46},"University of Houston",{"id":211,"slug":212,"hasResults":12,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":12,"sex":19,"minAge":56,"maxAge":57,"enrollmentInfo":217,"targetDuration":4,"studyType":24,"phases":219,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":228,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":80},"100580360","the-evira-study-additional-support-during-obesity-treatment-100580360","NCT06836284","The Evira Study: Additional Support During Obesity Treatment","Evaluation of a Digital Treatment Tool in Combination With Obesity Medications","Inclusion Criteria:\n\n* Patients offered liraglutide or semaglutide in accordance with the clinic's routines.\n* Aged 12-17 years at the time of inclusion.\n* The family agrees to participate in a clinical study.\n\nExclusion Criteria:\n\n* Endocrine disorders other than well-controlled hypothyroidism.\n* Severe neuropsychiatric disorders that may affect adherence to the study.\n* Eating disorder requiring treatment within the last six months before inclusion or observed during screening prior to inclusion.\n* Somatic conditions that may complicate the evaluation of treatment outcomes, such as patients on irregular oral corticosteroid treatment.\n* Hypothalamic or monogenic obesity, and genetic syndromes such as Down syndrome.\n* Patients deemed unsuitable for participation by the responsible physician.",{"count":218,"type":23},40,[26],"The goal of this clinical trial is to evaluate the effect of adding a digi-physical treatment tool as a complement to the local treatment with obesity medication in adolescents with obesity. The main question it aims to answer is:\n\n\\- Can a combination of a digi-physical treatment tool and obesity medication improve treatment outcomes for patients with obesity compared to patients treated with obesity medications alone?\n\nThis is a randomized controlled two-arm multicenter study where participants will be randomized to the intervention group (digi-physical treatment+medication) or control group (medication only). Participants will be followed for six months.",[29,222],"Treatment Adherence",[224,225,226,227],"Mobile Health","Self-Monitoring","Digital Treatment","Anti-Obesity Medication",{"date":173,"type":39},{"date":230,"type":39},"2026-02-13",{"date":232,"type":23},"2027-05-01",{"name":234,"class":46},"Karolinska Institutet",{"id":236,"slug":237,"hasResults":12,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":241,"eligibilityCriteria":242,"healthyVolunteers":18,"sex":19,"minAge":243,"maxAge":244,"enrollmentInfo":245,"targetDuration":4,"studyType":24,"phases":247,"briefSummary":248,"conditions":249,"keywords":257,"overallStatus":263,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":80},"100616125","effectiveness-of-a-10-week-multicomponent-intervention-combined-with-parent-education-on-binge-eating-behavior-in-children-and-adolescents-100616125","NCT07301541","Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents","Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents: a Randomized Controlled Trial With Long-term Follow-up","STOB","Inclusion Criteria:\n\n* Attending the camp in Hobro or Fjordmark from January 2027 to December 2027\n* 7-14 years of age at recruitment\n* Participants must have written informed consent from parent\u002Fguardian before camp to participate\n* At least one parent\u002Fguardian submit written informed consent to participate in the study with their child\n\nExclusion Criteria:\n\n* A medical condition affecting dietary intake and\u002For eating behavior\n* Taking weight loss medication\n* The parent\u002Fguardian don't understand the written informed consent\n* Participant or parent\u002Fguardian are unwilling to or unable to comply with the study protocol and instructions given by the study staff.","7 Years","14 Years",{"count":246,"type":23},200,[26],"The main purpose is to investigate the effectiveness of a 10-week multicomponent camp intervention to reduce BE behavior in children and adolescents and explore in a randomized controlled setting if a parent-based BED-intervention has any add-on effect, attenuating the development of BE behavior in this sample. The study will include an initial follow-up assessment scheduled 10-12 weeks after camp completion and plans for long-term follow-up assessments one, three and five years after inclusion.\n\nOverall, we hypothesize that the multicomponent camp intervention will effectively reduce BE behavior in children and adolescents. Furthermore, we hypothesize that participants whose parents are randomized to receive the parental BED intervention will show a lower prevalence of BE behavior one year after the camp intervention compared with children whose parents receive standard care.",[250,251,252,253,254,29,255,256],"Binge Eating Disorder","Binge Eating","Loss of Control Eating","Overweight , Obesity","Children","Screening","BED",[258,259,260,254,261,262,256,255],"Binge eating","Binge eating disorder","Lifestyle intervention","Loss of control eating","Adolescents","NOT_YET_RECRUITING","2026-04-07",{"date":266,"type":39},"2026-04-13",{"date":268,"type":23},"2027-01",{"date":270,"type":23},"2036-01",{"name":272,"class":46},"University of Aarhus",{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":18,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":280,"targetDuration":4,"studyType":24,"phases":282,"briefSummary":283,"conditions":284,"keywords":285,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":294,"completionDateStruct":296,"leadSponsor":298,"locationsCount":47},"100629809","mountain-west-prevention-research-center-core-research-project-100629809","NCT07479498","Mountain West Prevention Research Center Core Research Project","MW-PRCCRP","Inclusion Criteria:\n\nFamilies\n\nParent or legal caregiver and at least one child aged 5 to 12 years\n\nChild identified through electronic health record data from a participating clinical organization\n\nChild has had at least one clinical encounter at the participating site within the past 12 months\n\nChild has body mass index (BMI) at or above the 85th percentile for age and sex\n\nCaregiver has not opted out of receiving text communication from the clinic\n\nValid mailing address and telephone number listed in the electronic health record\n\nParents and\u002For Caregivers\n\nParent or legal caregiver of an eligible child\n\nResponsible for the child's care and able to provide consent for program participation\n\nChildren\n\nAged 5 to 12 years at time of identification\n\nMeet all criteria listed above\n\nExclusion Criteria:\n\nChild has a medical condition or contraindication that precludes participation in moderate physical activity\n\nChild has severe cognitive or physical impairment that would prevent participation in the intervention\n\nChild or family is currently participating in another structured weight management or obesity treatment program\n\nFamily opts out of receiving study-related communications",{"count":281,"type":23},600,[26],"This hybrid type 3 effectiveness-implementation sequential multiple assignment randomized trial will assess the impact of integrating population health management (PHM) strategies-text messaging and enrollment in Building Healthy Families (BHF)-for lower-income families with a child with obesity identified through electronic health record (EHR) data. BHF promotes family healthy eating, physical activity, and lifestyle behavior strategies to manage weight. The research team will partner with clinical sites (community health clinics, pediatric clinics, rural hospitals) and Community-Based Organizations (CBOs). Clinical partners will execute data-sharing agreements enabling the research team to identify eligible children and caregivers and conduct outreach via text messaging. CBO partners will deliver BHF and provide de-identified data for program evaluation. Community Implementation Teams (CITs) will complete training, surveys, interviews, learning collaborative activities, fidelity assessments, and time tracking as part of quality improvement. The BHF Action Learning Collaborative will use quarterly sessions and Plan-Do-Study-Act cycles to address recruitment, implementation, sustainability, social determinants of health, and team coordination. The research team will record sessions, conduct direct observations of BHF delivery, and take field notes to assess fidelity and adaptations. Families will be identified through EHR records and mailed a consent and authorization cover letter, postcard, QR code, and intervention information with opt-out options. Those who do not opt out will be randomized to bidirectional text messaging with one-touch response and enrollment opportunities, with or without active outreach (telephone or text) from the local CIT. Enrolled families will complete orientation, baseline assessment, and weekly group sessions with ongoing follow-up. Attendance, body weight, goals, and self-monitoring will be recorded in a CIT data portal. Families will be randomized to receive either simple text reminders or reminders with motivational and skill-building prompts matched to session topics. CITs will also connect families to food assistance programs and local resources. Each CIT will complete two cohorts over two years. The primary outcome is reach; secondary outcomes include session attendance, changes in child BMI-z scores, changes in parent or caregiver weight, and changes in adoption, implementation, and maintenance at the community level.",[29],[286,287,288,289,290],"Family Healthy Weight Program","Population Health Management","Rural","Reach","Engagement","2026-03-12",{"date":293,"type":39},"2026-03-18",{"date":295,"type":39},"2024-09-30",{"date":297,"type":23},"2029-09-29",{"name":299,"class":46},"Paul Estabrooks",{"id":301,"slug":302,"hasResults":12,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":18,"sex":308,"minAge":115,"maxAge":309,"enrollmentInfo":310,"targetDuration":4,"studyType":24,"phases":311,"briefSummary":312,"conditions":313,"keywords":320,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":80},"100628903","postnatal-exercise-to-activate-babys-brown-fat-100628903","NCT07467694","Postnatal Exercise to Activate Baby's Brown Fat","Impact of Acute Exercise and Habitual Physical Activity on Human Milk Composition and Childhood Obesity Risk","PEABaBy","Inclusion Criteria:\n\n* 18-45 y of age at the time of enrollment\n* Pre-gravid or first trimester BMI 18.5 -40 kg\u002Fm2\n* Uncomplicated singleton pregnancy\n* Intention to exclusively breastfeed for \\>3 months and, if parity \\>1, that they successfully breastfed a previous pregnancy\n* Term pregnancy (gestational age 37 to \\\u003C42 weeks)\n* Infant with birth weight \\>10th percentile of weight for gestational age\n\nExclusion Criteria:\n\n* Any obstetric contra-indication to exercise at 1 month\n* Diagnosis of uncontrolled (HbA1c \\>7%) type 1 or type 2 diabetes, or gestational diabetes managed with insulin\n* Intrauterine growth restriction\n* Pre-eclampsia or other pregnancy complications\n* Alcohol, cannabis or tobacco use\n* Known congenital metabolic, endocrine disease, or congenital illness affecting infant feeding\u002Fgrowth\n* Major fetal anomalies\n* Musculoskeletal issues that would make exercise difficult","FEMALE","45 Years",{"count":246,"type":23},[26],"The purpose of this study is to learn how exercise and physical activity during pregnancy and after pregnancy may affect the composition of breastmilk. Certain changes in breast milk after exercise may have an impact on how infants use energy. Understanding this process may improve public health recommendations for exercise during and after pregnancy. This study can help investigators learn more about how maternal exercise patterns may affect body growth and obesity risk in infants who are breastfed. This research may help identify how different factors can influence healthy weight and early development in infants.",[314,29,315,316,317,318,319],"Childhood Obesity Prevention","Physical Activity","Lactation","Breastfeeding","Pregnancy","Exercise",[316,317,321,318,319],"Breast milk","2026-03-11",{"date":291,"type":39},{"date":325,"type":39},"2025-12-01",{"date":327,"type":23},"2030-07-01",{"name":329,"class":46},"Joslin Diabetes Center",{"id":331,"slug":332,"hasResults":12,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":12,"sex":19,"minAge":338,"maxAge":56,"enrollmentInfo":339,"targetDuration":4,"studyType":24,"phases":341,"briefSummary":342,"conditions":343,"keywords":349,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":47},"100532095","early-life-intervention-in-pediatrics-supported-by-e-health-100532095","NCT06208345","Early Life Intervention in Pediatrics Supported by E-health","Early Life Intervention in Pediatrics Supported by E-health (ELIPSE I): Coaching Parents to Lower Obesity in Children. A Single-blind Randomized Controlled Parallel-group Clinical Trial.","ELIPSE-I","Inclusion Criteria:\n\n* German speaking parents\n* Any ethnic background\u002Frace\n* Children should live\u002Fgrow-up in the same household as the parental participant\n* Children with an age- and sex-matched BMI \\>97 centile according to Swiss national growth charts\n* Children who attend the outpatient weight management clinic at the Division of Pediatric Endocrinology at the University Children's Hospital Bern\n* Signed informed consent form from parent(s)\n\nExclusion Criteria:\n\n* Syndromic obesity\n* Known congenital disease affecting musculo-skeletal, cardiac or pulmonary function\n* Participation in another clinical trial targeting similar objectives","6 Years",{"count":340,"type":23},148,[26],"Childhood obesity in early life contributes to the development of specific NCDs, i.e. adult obesity. Unhealthy diet and low level of physical activity are lifestyle risk behaviors associated with chronic, systemic inflammation, which promotes the pathogenesis of NCDs. Early preventive measures to improve lifestyle behavior are of utmost importance. The aim of ELIPSE-I is to assess whether an eHealth application intervention for parents is feasible and efficacious in lowering total energy intake\u002Ftotal energy expenditure (TEI\u002FTEE) ratio in their children with BMI \\>97 centile (ELIPSE-I).",[344,29,65,345,346,347,348],"Adiposity","Non-communicable Disease","Life Style","Behavior, Eating","Behavior, Health",[344,254,262,350,351],"Prevention","eHealth","2026-02-12",{"date":354,"type":39},"2026-02-18",{"date":356,"type":39},"2024-02-16",{"date":358,"type":23},"2028-12-31",{"name":360,"class":46},"Insel Gruppe AG, University Hospital Bern",{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":18,"sex":19,"minAge":368,"maxAge":244,"enrollmentInfo":369,"targetDuration":4,"studyType":24,"phases":371,"briefSummary":372,"conditions":373,"keywords":379,"overallStatus":263,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":4},"100622884","school-meals-in-denmark-100622884","NCT07389421","School Meals in Denmark","School Meals in Denmark: Evaluation of a National School Meal Pilot Program on Children's Health, Learning and Well-being - a Natural Experiment","Inclusion Criteria:\n\n* All children attending 3rd, 4th or 7th grade in the recruited schools\n\nExclusion Criteria:\n\n* No exclusion criteria will be applied","9 Years",{"count":370,"type":23},3200,[26],"This study looks at how a national school meal program affects the health, well-being, and learning of Danish schoolchildren aged 10 to 15 years.\n\nThe study is part of the Danish National School Meal Pilot Program (2025-2028), which provides free school meals at selected public schools. Some school classes receive free school meals, while other classes do not and are used for comparison.\n\nChildren are followed for about 1.5 years. Information is collected before and after the program using simple health measurements, questionnaires about well-being, and age-appropriate cognitive tests.\n\nThe study also uses information from Danish national registers to better understand the children's background and to study longer-term outcomes related to health, education, and social conditions. In addition, the study examines whether school meal programs are cost-effective by comparing their costs with potential benefits for children and society.\n\nThe goal of the study is to find out whether free school meals can improve children's health, well-being, and learning, and help reduce social differences.",[29,374,375,376,377,378],"Childhood Obesity Pevention","Well-being\u002FQuality of Life","Diet Habits","Cognitive Abilities","Healthy",[380,381,382,199],"physical health","well-being","learning","2026-01-28",{"date":385,"type":39},"2026-02-05",{"date":387,"type":23},"2026-02-11",{"date":389,"type":23},"2029-12-31",{"name":391,"class":46},"University of Copenhagen",{"id":393,"slug":394,"hasResults":12,"nctId":395,"briefTitle":396,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":18,"sex":19,"minAge":338,"maxAge":56,"enrollmentInfo":398,"targetDuration":4,"studyType":24,"phases":400,"briefSummary":401,"conditions":402,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":47},"100558098","the-adapt-trial-adapting-evidence-based-obesity-interventions-in-community-settings-100558098","NCT06546696","The ADAPT Trial: Adapting Evidence-Based Obesity Interventions in Community Settings","Inclusion Criteria:\n\n* Child with an age ≥ 6 years and \\\u003C 12 years\n* Child body mass index ≥95th percentile for age and sex on standardized CDC growth curves\n* Index parent\u002Flegal guardian with an age ≥18 years\n* Parent and child speak English or Spanish\n* Family resides within or frequently visit selected zip codes within Middle TN surrounding the partnering community centers;\n* Have parental commitment to participate in a 6-month study;\n* Have the ability to view online trainings\n* Complete baseline data collection, including parent and child height and weight and at least 90% of baseline survey items.\n\nExclusion Criteria:\n\n* Participant child has been diagnosed with Down Syndrome, Autism, or any other developmental disorders that impact metabolism or behaviors that would preclude participation in group physical activity settings;\n* Either the participant caregiver or child is unable to participate in light to moderate physical activity;\n* Participant caregiver has a serious mental or neurologic illness that impairs ability to consent\u002Fparticipate.",{"count":399,"type":23},750,[26],"Evidence-based obesity treatment is inaccessible to most children in the United States. This lack of access is a source of health inequity, whereby children from rural and minority communities, who have the highest rates of childhood obesity, are also the least likely to receive an evidence-based intervention. Developing strategies to improve access to evidence-based obesity interventions could reduce health disparities by improving reach to these underserved communities. The premise of this study is that using a systematic framework to adapt a community-based behavioral intervention for childhood obesity that accounts for individual, family, and community factors will increase reach and effectiveness among low-income, minority, and rural populations. COACH is a multi-level obesity intervention that supports 1) the individual child through developmentally appropriate health behavior curriculum, 2) the family by directly addressing parent weight loss and engaging parents as agents of change for their children, and 3) the community by building the capacity of local community centers to offer parent-child programming. The investigators propose testing the process of adapting COACH in a cluster-randomized trial.",[29],"2025-12-10",{"date":405,"type":39},"2025-12-11",{"date":407,"type":39},"2024-10-23",{"date":409,"type":23},"2028-12-01",{"name":411,"class":46},"Vanderbilt University Medical Center",{"id":413,"slug":414,"hasResults":12,"nctId":415,"briefTitle":416,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":12,"sex":19,"minAge":418,"maxAge":419,"enrollmentInfo":420,"targetDuration":4,"studyType":422,"phases":4,"briefSummary":423,"conditions":424,"keywords":426,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":80},"100255343","whole-transcriptome-profiling-and-metabolic-phenotyping-in-children-with-rohhad-syndrome-100255343","NCT02602769","Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome","Inclusion Criteria:\n\n* Children with ROHHAD syndrome\n\nExclusion Criteria:\n\n* Children with known genetic causes of obesity","2 Years","20 Years",{"count":421,"type":23},12,"OBSERVATIONAL","Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation. There is little information about the metabolic changes that lead to the rapid onset obesity in these children. The investigators would like to study the metabolic phenotype of these children to understand the disturbances in energy balance that lead to the rapid onset obesity.",[29,425],"Morbid Obesity",[427,428,429,430],"Hypoventilation syndrome","Hypothalamic dysfunction","Autonomic dysregulation","Rapid onsey obesity","2025-10-20",{"date":433,"type":39},"2025-10-21",{"date":435,"type":4},"2015-11",{"date":437,"type":23},"2026-12",{"name":439,"class":46},"Columbia University",{"id":441,"slug":442,"hasResults":12,"nctId":443,"briefTitle":444,"officialTitle":445,"acronym":446,"eligibilityCriteria":447,"healthyVolunteers":12,"sex":19,"minAge":88,"maxAge":57,"enrollmentInfo":448,"targetDuration":4,"studyType":24,"phases":450,"briefSummary":451,"conditions":452,"keywords":455,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":458,"lastUpdatePostDateStruct":459,"startDateStruct":461,"completionDateStruct":463,"leadSponsor":465,"locationsCount":466},"100432937","a-multicenter-study-for-evaluating-a-digital-support-system-in-childhood-obesity-treatment-100432937","NCT04917601","A Multicenter Study for Evaluating a Digital Support System in Childhood Obesity Treatment","A Randomized Controlled Multicenter Study for Evaluating a Digital Support System in Childhood Obesity Treatment (EurEvira)","EurEvira","Inclusion Criteria:\n\n* Age \\>4.0 and \\\u003C17.0 years of age at inclusion\n* Obesity defined based on the International Obesity Task Force criteria iso-BMI 30 - 40 kg\u002Fm2\n* Willingness to participate in an obesity treatment clinical trial\n* Family ability to communicate in the language of the country of residence e.g. write and read messages in the mobile application\n* Parents having a smart phone and an email address\n\nExclusion Criteria:\n\n* Morbid obesity defined as iso-BMI\\>40kg\u002Fm2 independently of age\n* Endocrine disorders other than well controlled hypothyroidism\n* Metabolic disorders of importance for weight control - to be discussed\n* Treatment for depression and other psychiatric disorders during the last 6 months before inclusion\n* Pharmacological treatment of importance for weight control\n* Hypothalamic or monogenic obesity, e.g. syndromes and Mb Down\n* Severe neuropsychiatric disorders that could affect study compliance\n* Eating disorders requiring therapy during the last six months before inclusion or observed at the inclusion screening.",{"count":449,"type":23},680,[26],"Evira is a digital support system newly developed for treatment of childhood obesity. Through daily weighings at home using a special scale together with a message function in the Evira application, enabling fast and easy communication with the clinic, parents and the clinicians can easily follow the child's weight development. The purpose of this randomized controlled study is to evaluate the effect of adding Evira to the already locally used life-style treatment of childhood obesity.",[29,65,453,454],"mHealth","Personalized Medicine",[456,457],"Obesity treatment","Digital support system","2025-09-30",{"date":460,"type":39},"2025-10-06",{"date":462,"type":39},"2022-05-24",{"date":464,"type":23},"2027-12",{"name":234,"class":46},5,{"id":468,"slug":469,"hasResults":12,"nctId":470,"briefTitle":471,"officialTitle":472,"acronym":473,"eligibilityCriteria":474,"healthyVolunteers":18,"sex":19,"minAge":164,"maxAge":89,"enrollmentInfo":475,"targetDuration":4,"studyType":24,"phases":477,"briefSummary":478,"conditions":479,"keywords":480,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":80},"100607109","effectiveness-of-school-based-time-restricted-eating-for-the-prevention-and-control-of-obesity-in-children-100607109","NCT07184281","Effectiveness of School-Based Time-Restricted Eating for the Prevention and Control of Obesity in Children","Effectiveness of School-Based Time-Restricted Eating for the Prevention and Control of Obesity in Children: A Cluster-Randomized Controlled Trial","SCHOOL-TRE","Eligibility criteria for schools:\n\n1. The principal agrees to accept the randomization process and adhere to the study protocol;\n2. The total number of fourth-year students in the school must be more than 50;\n3. Schools that have not implemented or plan to implement obesity prevention interventions;\n4. Non-boarding schools, Ethnic minority schools, or specialty schools;\n5. Schools that have no clear plans to relocate or close within the next 2 years;\n\nEligibility criteria for classes:\n\n1. Class teachers are willing and actively involved in home-school liaison;\n2. Class sizes should be between 30 and 60 students;\n3. The class consists of fourth-grade students;\n4. Classes that have no clear plan to merge or cancel in the next 2 years;\n\nExclusion criteria for students:\n\nAll students in the selected classes will be the subject of the study after signing the informed consent, unless they have the following circumstances:\n\n1. Individuals with a history of heart disease, high blood pressure, diabetes, tuberculosis, asthma, hepatitis or nephritis;\n2. Individuals with secondary obesity: obesity due to endocrine disorders or side effects of medications;\n3. Individuals with abnormal growth and development, such as dwarfism, gigantism, etc;\n4. Individuals with physical deformities, including severe scoliosis, chicken breasts, claudication, significant O-leg\u002FX-shaped legs;\n5. Individuals with limited athletic ability who are unable to participate in school physical activities;\n6. Individuals who have lost weight by inducing vomiting or taking medication in the past 3 months;\n7. Individuals who have undergone prior bariatric surgery;\n8. Individuals with mental disorders or intellectual developmental disabilities, as well as aphasia;\n9. Individuals who have taken medications that affect appetite or weight within three months (e.g., antipsychotics, hypnotics, weight loss medications, insulin);\n10. Individuals who have plans to transfer within 2 years;",{"count":476,"type":23},1380,[26],"Childhood obesity has become a major global public health challenge. Obesity can not only affects children's physical and mental health during childhood but may also persist into adulthood, significantly increasing the risk of cardiovascular disease. Therefore, effective prevention and control of childhood obesity can shift the prevention window forward and promote the prevention of cardiovascular disease. Recently, time-restricted eating (TRE) has gained attention in adult studies for its feasibility, as it involves \"time control without calorie restriction,\" demonstrating weight loss effects comparable to energy restriction and higher feasibility. Here, the investigators designed a school-based cluster randomized controlled trial to investigate the effectiveness of 12-hour TRE in preventing and controlling childhood obesity. Schools were randomly assigned to either the intervention group or the control group, and participants were recruited from each school at the class level, ensuring that each group included at least 690 children. The control group received routine health education, while the intervention group received 12-hour TRE in addition to routine health education. After a 9-month intervention period (one academic year), the two groups will be compared in terms of weight management and childhood obesity prevalence.",[29,374],[481,482,172,483],"childhood obesity","school-based intervention","cluster randomized trial","2025-09-28",{"date":458,"type":39},{"date":487,"type":39},"2025-09-26",{"date":489,"type":23},"2027-07-31",{"name":491,"class":46},"Children's Hospital of Soochow University",{"id":493,"slug":494,"hasResults":12,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":18,"sex":19,"minAge":368,"maxAge":56,"enrollmentInfo":499,"targetDuration":4,"studyType":24,"phases":500,"briefSummary":501,"conditions":502,"keywords":504,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":507,"lastUpdatePostDateStruct":508,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":514,"locationsCount":47},"100607225","multidimensional-intervention-in-mexican-schoolchildren-100607225","NCT07185789","Multidimensional Intervention in Mexican Schoolchildren","Multidimensional Intervention to Improve Healthy Lifestyle Practices and Nutrition and Health Status in Mexican Schoolchildren: Development of an Intervention Platform, Randomized Clinical Trial and Scaling Proposal","Inclusion Criteria:\n\n* Fourth grade elementary schools children from schools that belong to Federal entities: Campeche, Morelos and Mexico City, with morning schedule, from 8:00 to 12:30 or extended schedule, from 8:00 to 14:00hrs.\n* For Morelos State, elementary schools will be sought to be private, with at least 1000 enrollement students, with morning schedule, from 8:00 to 12:30 or extended schedule, from 8:00 to 14:00hrs.\n\nExclusion Criteria:\n\n* Children that don´t correspond to the selected shifts.",{"count":246,"type":23},[26],"The aims is to evaluate the effects of an multidimensional intervention on the physical-built and social environment around schools and the nutritional status of the school population, through a randomized community trial, in schools in 3 states of the Mexican Republic, using anthropometric indicators, biological, psychological, behavioral and environmental.\n\nThe main questions it aims to answer are:\n\n1. What are the main risk and protective factors for overweight and obesity in the school environment and in the environments around schools in primary education schools in three states of the Mexican Republic?\n2. Is there a relationship between risky eating behaviors and the body mass index of schoolchildren?\n3. Are the strategies that are being implemented effective in reducing the presence of risk factors and increasing the presence of protective factors for overweight and obesity in the school environment and in the environments around schools?\n4. Are the strategies that are being implemented effective in reducing the presence of risk factors and increasing the protective factors for overweight and obesity in the family environment?",[29,66,503],"Childhood Overweight",[505,506],"Childhood obesity","School children","2025-09-15",{"date":509,"type":39},"2025-09-22",{"date":511,"type":39},"2023-11-07",{"date":513,"type":23},"2026-03-30",{"name":515,"class":516},"Mexican National Institute of Public Health","OTHER_GOV",{"id":518,"slug":519,"hasResults":12,"nctId":520,"briefTitle":521,"officialTitle":522,"acronym":4,"eligibilityCriteria":523,"healthyVolunteers":18,"sex":19,"minAge":524,"maxAge":525,"enrollmentInfo":526,"targetDuration":4,"studyType":422,"phases":4,"briefSummary":528,"conditions":529,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":531,"lastUpdatePostDateStruct":532,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":47},"100316634","early-childhood-obesity-programming-by-intrauterine-growth-restriction-100316634","NCT03402139","Early Childhood Obesity Programming by Intrauterine Growth Restriction","Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction","Mother-infant pairs will be recruited for this study.\n\nInclusion Criteria:\n\n* Healthy singleton term intrauterine growth restricted (IUGR) and appropriate for gestational age (AGA) infants whose mothers are followed by the Obstetric Department of Montefiore Medical Center and who deliver at the Weiler Division of Montefiore Medical Center. Infants will be classified as IUGR if birth weight is \\\u003C10th percentile for gestational age and gender based on World Health Organization (WHO) growth curves. Infants will be classified as AGA if birth weight percentile is \\>10th and \\\u003C90th percentile\n* Reproductive age women, healthy enough to achieve pregnancy\n* Deliver a single healthy live term infant at ≥37 weeks' gestational age (GA)\n* All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines\n\nExclusion Criteria:\n\n* Multiple gestation\n* Maternal depression\n* Maternal renal disease\n* History of maternal smoking in the 2nd and 3rd trimester of pregnancy\n* Maternal gestational diabetes \u002F Type 2 Diabetes (T2D)\n* Preterm birth (less than 37 weeks' gestation)\n* Known chromosomal or congenital anomaly\n* Infants in extremis\n* Low Apgar scores (Apgar score \\\u003C7 at 5 minutes of age)\n* Known congenital bacterial or non-bacterial infections\n* Known inborn errors of metabolism","1 Hour","24 Months",{"count":527,"type":23},400,"The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.",[29,530],"Epigenetics","2025-09-08",{"date":507,"type":39},{"date":534,"type":39},"2018-09-01",{"date":536,"type":23},"2028-03",{"name":538,"class":46},"Montefiore Medical Center",{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":543,"acronym":4,"eligibilityCriteria":544,"healthyVolunteers":12,"sex":19,"minAge":545,"maxAge":57,"enrollmentInfo":546,"targetDuration":4,"studyType":24,"phases":548,"briefSummary":549,"conditions":550,"keywords":551,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":558,"startDateStruct":559,"completionDateStruct":561,"leadSponsor":563,"locationsCount":80},"100566372","the-dose-trial-dose-intensity-of-behavioral-interventions-for-childhood-obesity-100566372","NCT06654323","The Dose Trial: Dose Intensity of Behavioral Interventions for Childhood Obesity","Inclusion Criteria:\n\n* BMI≥95th percentile for age and sex based on standardized CDC growth curves.\n* parent\u002Fcaregiver aged ≥ 18 years old\n* are comfortable speaking and reading English or Spanish;\n* are a patient of a participating clinical practice;\n* are able to provide written or verbal consent\u002Fassent;\n* are able to attend scheduled sessions in the 12-month study;\n* are willing to make behavioral and lifestyle changes;\n* are able to access the internet to participate in online intervention components;\n* complete baseline data collection, including child height and weight; and\n* complete at least 90% of baseline survey items no later than 14 days after the baseline visit.\n\nExclusion Criteria:\n\n* families for whom the primary care provider (PCP) or site principal investigator (PI) thinks the study and\u002For intervention is clinically\u002Fmedically inappropriate (e.g. developmental delay, disordered eating, mobility impairments, cognitive or mental difficulties);\n* participant child is taking weight management medications at the time of enrollment;\n* participant child plans to undergo bariatric surgery or another weight loss operation during the 12-month study; or\n* participant caregiver-child dyad has plans to move during the 12-month study and will no longer be a patient of a participating clinic.","5 Years",{"count":547,"type":23},900,[26],"The research team is recruiting 900 children between the ages 5-17 with obesity from Tennessee and Louisiana. The team is assigning children and their caregivers by chance to one of five groups. In the first group, 300 children and their caregivers receive 26 hours of IBT. In the second group, 300 children and their caregivers receive 13 hours of IBT. The remaining three groups of 100 children and their caregivers receive 16, 19, or 22 hours of IBT.\n\nChildren's healthcare providers, nutritionists, and social workers are providing IBT to each of the groups over six months. At the start of the study and again after one year, the research team is measuring the children's body mass index, or BMI. BMI is a measure of a person's body fat based on their height and weight. The team is also looking at the children's:\n\n* Diet\n* Exercise\n* Sleep\n* Media use\n* Quality of life",[29],[552,553,554,555,556],"Behavioral Intervention","Rural and Urban Populations","Racial and Ethnic Minority Populations","Nutrition Counseling","Community Resource Counseling","2025-09-05",{"date":531,"type":39},{"date":560,"type":39},"2025-02-20",{"date":562,"type":23},"2028-08-01",{"name":411,"class":46},{"id":565,"slug":566,"hasResults":12,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":4,"eligibilityCriteria":570,"healthyVolunteers":12,"sex":19,"minAge":88,"maxAge":338,"enrollmentInfo":571,"targetDuration":4,"studyType":24,"phases":572,"briefSummary":573,"conditions":574,"keywords":575,"overallStatus":263,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":582,"completionDateStruct":583,"leadSponsor":585,"locationsCount":47},"100602645","weight-management-program-for-obese-preschool-children-100602645","NCT07126210","Weight Management Program for Obese Preschool Children","Peking University-Family Engaged, Enhanced Diet, for Kids (PKU-FeeD)","Inclusion Criteria:\n\n* The child's primary caregivers can proficiently use smart phones.\n* Child is expected to remain in the same kindergarten for at least one year.\n* No use of antibiotics or probiotic supplements, no acute stress events (e.g., trauma or severe infection), gastrointestinal symptoms (e.g., abdominal pain, constipation, diarrhea), or vaccinations within the 3 months prior to stool sample collection.\n* Parents voluntarily agree to participate in the study and provide written informed consent.\n\nExclusion Criteria:\n\n* Obesity caused by genetic factors, diseases (e.g., endocrine disorders, central nervous system damage), or medication use.\n* History of major organ diseases, including cardiovascular, pulmonary, hepatic, or renal conditions (e.g., heart disease, hypertension, asthma).\n* Children following special diets (e.g., vegetarians).\n* Children with pathological eating disorders or medical conditions that limit physical activity.",{"count":246,"type":23},[26],"The PKU-FeeD trial is a cluster-randomized controlled trial conducted in Jinan, Shandong Province, China. This study aims to: 1) Develop and evaluate a digital health-assisted, multidisciplinary intervention for preschool children with obesity, assessing its effectiveness and cost-effectiveness. 2) Investigate how lifestyle-based interventions influence the composition and function of the gut microbiota in obese preschoolers, and elucidate the mechanisms by which these interventions may modulate gut microbiota to affect obesity-related metabolic phenotypes.",[29],[95,576,577,578,254],"Intervention","Preschool","Management","2025-08-10",{"date":581,"type":39},"2025-08-17",{"date":507,"type":23},{"date":584,"type":23},"2027-06-30",{"name":586,"class":46},"Peking University",{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":4,"eligibilityCriteria":593,"healthyVolunteers":18,"sex":308,"minAge":115,"maxAge":594,"enrollmentInfo":595,"targetDuration":4,"studyType":24,"phases":597,"briefSummary":598,"conditions":599,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":601,"lastUpdatePostDateStruct":602,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":608,"locationsCount":47},"100325253","maternal-smoking-cessation-and-pediatric-obesity-prevention-100325253","NCT03514602","Maternal Smoking Cessation and Pediatric Obesity Prevention","Pilot Study on Pediatric Obesity Prevention by Maternal Smoking Cessation in Pregnancy and Lactation","Inclusion Criteria:\n\n1. Able to read, understand, and speak English.\n2. Are 18-39 years old\n3. Are less than 20 weeks of gestation\n4. Have a singleton pregnancy\n5. Currently smoking one or more cigarettes per day, based on self-report.\n6. Currently smoking biochemically verified by a level of 1 or higher in urine cotinine test (i.e., \\>100ng\u002FmL cotinine concentration).\n7. Willing to try to quit or reduce smoking by behavioral intervention\n8. Willing to monitor smoking status by breath carbon monoxide and saliva cotinine.\n9. Willing to provide breath, saliva, and urine samples to test smoking status\n10. With low household income (meeting federal income eligibility guidelines for the Special Supplemental Nutrition Program for Women, Infants, and Children) and\u002For low education level (≤12 years). These disadvantaged pregnant women are very likely not to quit spontaneously, and thus need extra intervention most.\n11. Currently living in Erie County or Niagara County; don't plan to move out of these two counties during the current pregnancy.\n\nExclusion Criteria:\n\n1. Previous history of major chronic disease or blood clotting disorders such as cancer, thyroid disorders, heart disease, kidney disease\n2. Depression or have been diagnosed with depression or post-partum depression at any time\n3. In treatment for Axis 1 disorders that prevent them following smoking cessation interventions","39 Years",{"count":596,"type":23},48,[26],"The objective of this study is to test the effect of smoking cessation in pregnancy or in lactation on preventing rapid infant adiposity gain. Investigators propose a randomized, controlled experiment among smoking pregnant women from 1st prenatal care visit through 6 months of postpartum period. Two-phase randomization will be applied to separate the effects of smoking cessation in two different critical periods (i.e., pregnancy and lactation) on infant adiposity gain. Investigators will first randomly assign 40 smoking pregnant women into either the multicomponent intervention (N=30) or the education-only control group (N=10). The multicomponent intervention group will receive education and counseling, monitoring and feedback, contingent financial incentives, and family support, while the control group will receive education only. At the end of pregnancy, investigators will further randomize successful quitters (estimated N=20) from the multi-component intervention group into either the continuous multi-component intervention group in lactation (N=10) or the education-only control group (N=10). All women and their newborns will be followed from enrollment to 6 months postpartum. The key outcomes include maternal smoking abstinence confirmed by urine-cotinine and infant gain in weight-for-length z-score. Specific Aim 1 is to examine the effects of maternal smoking cessation intervention in pregnancy on infant gain in weight-for-length z-score from birth to 6 months. Specific Aim 2 is to examine the effect of maternal smoking abstinence intervention in lactation and infant post-weaning gain in weight-for-length z-score among the women who have successfully quit smoking in pregnancy.",[29,600,318],"Smoking, Cigarette","2025-07-25",{"date":603,"type":39},"2025-07-30",{"date":605,"type":39},"2015-07-01",{"date":607,"type":23},"2026-12-31",{"name":609,"class":46},"State University of New York at Buffalo",{"id":611,"slug":612,"hasResults":12,"nctId":613,"briefTitle":614,"officialTitle":614,"acronym":615,"eligibilityCriteria":616,"healthyVolunteers":12,"sex":19,"minAge":338,"maxAge":141,"enrollmentInfo":617,"targetDuration":4,"studyType":24,"phases":619,"briefSummary":620,"conditions":621,"keywords":622,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":626,"lastUpdatePostDateStruct":627,"startDateStruct":629,"completionDateStruct":631,"leadSponsor":632,"locationsCount":47},"100597358","national-childhood-obesity-prevention-programme-be-fit-24-100597358","NCT07057453","National Childhood Obesity Prevention Programme BE FIT 24","BE FIT 24","Inclusion Criteria:\n\n* Age: 6-11 years\n* BMI: Between the 90th and 97th percentile\n* Signed consent to participate in the project and GDPR\n\nExclusion Criteria:\n\n* Children with a BMI between the 90th and 97th percentile with an associated chronic disease requiring continuous pharmacological treatment",{"count":618,"type":23},1000,[26],"The project is a national, prospective, multicenter, interventional pilot project of early detection of childhood overweight and the prevention of obesity in the Czech Republic.\n\nThe main goal of the project is to methodically prepare, implement and evaluate a pilot project that will verify the suitability of the proposed procedure of early detection of childhood overweight and the prevention of obesity and setting up and testing new methods and implementation into the system of health care.",[29],[623,624,625],"Early detection","Overweight","Fitness bracelets","2025-07-04",{"date":628,"type":39},"2025-07-09",{"date":630,"type":39},"2024-11-19",{"date":607,"type":23},{"name":633,"class":516},"Institute of Health Information and Statistics of the Czech Republic",{"id":635,"slug":636,"hasResults":12,"nctId":637,"briefTitle":638,"officialTitle":638,"acronym":639,"eligibilityCriteria":640,"healthyVolunteers":18,"sex":19,"minAge":338,"maxAge":56,"enrollmentInfo":641,"targetDuration":4,"studyType":24,"phases":643,"briefSummary":644,"conditions":645,"keywords":648,"overallStatus":263,"whyStopped":4,"lastUpdateSubmitDate":658,"lastUpdatePostDateStruct":659,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":47},"100597682","cities-for-better-health-childhood-obesity-prevention-initiative-in-japan-100597682","NCT07061665","Cities for Better Health Childhood Obesity Prevention Initiative in JAPAN","CBH COPI JAPAN","Inclusion Criteria:\n\n* Children aged 6 to 12 years who are currently enrolled in one of the public elementary schools located within the 22 participating Junior High School District clusters in Chiba City.\n* The parent or legal guardian of each child must provide written informed consent prior to participation.\n* Parents or legal guardians must have sufficient Japanese language proficiency to understand study procedures, complete questionnaires, and provide accurate information during the study.\n* Children must be physically and cognitively capable of participating in school- and community-based activities involved in the intervention.\n* Participants must not have any medical conditions that would preclude safe participation in routine physical activities promoted by the intervention.\n\nExclusion Criteria:\n\n* Children whose parents or legal guardians fail to provide complete informed consent.\n* Families who withdraw consent at any point during the study period.\n* Children who independently express refusal to participate, even with parental consent.\n* Children with serious physical, psychological, or developmental disorders that prevent them from participating safely in the program's activities.\n* Families planning to relocate outside of Chiba City during the study period, making follow-up assessment infeasible.",{"count":642,"type":23},2200,[26],"The goal of this interventional study is to prevent childhood obesity in children aged 6-12 years in Chiba City, Japan. The main questions it aims to answer are:\n\n* Does the multi-component intervention for environments around children reduce the BMI z-score of children aged 6-12 years after one and two years?\n* Does the multi-component intervention for environments around children improve the health-related quality of life (assessed by KIDSCREEN-10) of children aged 6-12 years after one and two years?\n\nResearchers will compare school clusters receiving the intervention to control clusters to see if the intervention package promotes healthy eating, increases physical activity, improves health-related quality of life, and reduces obesity prevalence.\n\nParticipants will:\n\n* Attend elementary schools within participating clusters (either the intervention or control group).\n* Have baseline data collected, with follow-up assessments after one year and two years.\n* Potentially participate in school-based programs (nutrition education, physical activity promotion) and community-based initiatives (park activation, supermarkets) if in an intervention cluster.\n* Have their physical activity and dietary behavior assessed through self-report questionnaires.",[646,647,315,95,29],"Quality of Life (QOL)","Nutrition",[649,505,650,651,200,652,653,654,655,656,657],"BMI","Japan","Chiba city","nutrition","health equity","community intervention","randomized controlled trial","KIDSCREEN-10","Diet Quality Questionnaire","2025-07-02",{"date":660,"type":39},"2025-07-11",{"date":662,"type":23},"2025-07",{"date":664,"type":23},"2027-09",{"name":666,"class":46},"Chiba University",{"id":668,"slug":669,"hasResults":12,"nctId":670,"briefTitle":671,"officialTitle":671,"acronym":672,"eligibilityCriteria":673,"healthyVolunteers":18,"sex":19,"minAge":338,"maxAge":4,"enrollmentInfo":674,"targetDuration":4,"studyType":24,"phases":676,"briefSummary":677,"conditions":678,"keywords":4,"overallStatus":263,"whyStopped":4,"lastUpdateSubmitDate":679,"lastUpdatePostDateStruct":680,"startDateStruct":682,"completionDateStruct":684,"leadSponsor":686,"locationsCount":47},"100572094","leveraging-interactive-digital-technology-to-increase-access-to-family-based-behavioral-treatment-for-childhood-obesity-100572094","NCT06728800","Leveraging Interactive Digital Technology to Increase Access to Family-Based Behavioral Treatment for Childhood Obesity","FBT 2","Inclusion Criteria:\n\n* must be youth between the ages of 6 and 18\n* must have a body mass index (BMI) percentile greater than or equal to the 95th BMI percentile for age and sex\n* must have one caregiver participate, who is at least 18 years of age and lives with the child at least 50% of the time.\n\nExclusion Criteria:\n\n* co-morbid disorders that contraindicate weight loss (e.g., eating disorder).",{"count":675,"type":23},140,[26],"The primary goal of this SBIR Direct to Phase II is to expand upon the existing training platform to create an \"all-in-one\" digital product, FBT 2.0, that offers an integrated suite of intervention components, including (a) dynamic, personalized, self-paced program for children and parent\u002Fcaregivers; (b) e-training and ongoing support for interventionists; and (c) family engagement and monitoring tools for interventionists. Investigators will create a comprehensive, e-learning digital intervention with engaging, interactive, and personalized online tools for youth and their parents\u002Fcaregivers that are integrated into the broader interventionist platform.",[29],"2025-04-25",{"date":681,"type":39},"2025-04-29",{"date":683,"type":23},"2025-10-01",{"date":685,"type":23},"2026-04-30",{"name":687,"class":688},"3-C Institute for Social Development","INDUSTRY"]