[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"children-on-chronic-peritoneal-dialysis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:children-on-chronic-peritoneal-dialysis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100605885","effectiveness-of-two-icodextrin-exchanges-on-fluid-status-and-blood-pressure-control-compared-to-a-single-icodextrin-exchange-100605885",false,"NCT07168343","Effectiveness of Two Icodextrin Exchanges on Fluid Status and Blood Pressure Control Compared to a Single Icodextrin Exchange","The Effect of Two Icodextrin Exchanges on Fluid Status and Blood Pressure Control in Children on Chronic Peritoneal Dialysis","Inclusion Criteria:\n\n1. Children 5-18 years of age\n2. Receiving CAPD or CCPD for at least the preceding 4 weeks, and not likely to change from CAPD to CCPD during the study period\n3. 24-hour mean arterial pressure (MAP; measured by ambulatory blood pressure monitoring (ABPM) above the 95th percentile for age, sex, and height\n4. 24-hour urine output less than 200ml\u002Fday\n\nExclusion Criteria:\n\n1. Children under 5 years of age (as younger children are more prone to hyponatremia)\n2. Children with systolic BP \\\u003C 50th centile for age, sex, and height in the preceding 4 weeks)\n3. Children who are polyuric or those prone to hypotension (defined as \\> 2 episodes of systolic BP \\\u003C 5th centile in the 4 weeks preceding the study)\n4. Known allergy to starch\n5. Pregnant women\n6. Patients with maltose or isomaltose intolerance, glycogen storage disease, pre-existing severe lactic acidosis, uncorrectable mechanical defects that prevent effective PD or increase the risk of infection and documented loss of peritoneal function or extensive adhesions that compromise peritoneal function","ALL","5 Years","18 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"NA","Fluid overload and hypertension are prevalent in children undergoing chronic peritoneal dialysis (PD), especially in low- and middle-income countries (LMICs). These complications often lead to increased hospitalizations, higher medication use, and, in some cases, conversion to hemodialysis. Icodextrin is used to enhance ultrafiltration (UF) and reduce glucose exposure, but its effectiveness in children with a single long dwell has been inconsistent. Preliminary observations suggest that shorter, twice-daily icodextrin exchanges may improve UF and blood pressure (BP) control. However, no randomized trial has evaluated this approach in pediatric patients.",[27],"Children on Chronic Peritoneal Dialysis",[29,30,31,32],"Children","CAPD","CCPD","Icodextrin","NOT_YET_RECRUITING","2026-01-18",{"date":36,"type":37},"2026-01-21","ACTUAL",{"date":39,"type":21},"2026-02-28",{"date":41,"type":21},"2028-06-30",{"name":43,"class":44},"National University Health System, Singapore","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":18,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":45},"100603290","comparing-conventional-continuous-ambulatory-peritoneal-dialysis-prescription-c-capd-with-modified-capd-m-capd-prescription-in-children-with-end-stage-kidney-disease-from-low-resource-settings-100603290","NCT07134595","Comparing Conventional Continuous Ambulatory Peritoneal Dialysis Prescription (C-CAPD) With Modified-CAPD (M-CAPD) Prescription in Children With End-stage Kidney Disease From Low-resource Settings","A Multicenter Study Comparing Conventional Continuous Ambulatory Peritoneal Dialysis Prescription (C-CAPD) With Modified-CAPD (M-CAPD) Prescription in Delivering High Quality Goal-directed Peritoneal Dialysis in Children With End-stage Kidney Disease From Low-resource Settings: MaxED-OUT Trial","Inclusion Criteria:\n\n* CKD 5D who have been on peritoneal dialysis for at least three months.\n\nExclusion Criteria:\n\n1. Patients with BSA of ≥1.5 m2,\n2. Evidence of mechanical causes of low ultrafiltration capacity (hernia, peri-catheter, or genital leaks, pleuroperitoneal communication),\n3. Peritoneal membrane failure (encapsulating peritoneal sclerosis),\n4. Recent episode of peritonitis (within two months)\n5. Those who have been on hemodialysis before switching to PD in the last three weeks.","2 Years",{"count":55,"type":21},44,[24],"This study aims to compare modified CAPD (M-CAPD) and conventional CAPD (C-CAPD) in terms of delivering high-quality, goal-directed PD as well as avoiding resource wastage in prevalent ESKD patients aged 2 to ≤18 years using a randomized cross-over study design for one year.\n\nThis study hypothesizes that M-CAPD will have better ultrafiltration and solute clearance than C-CAPD.\n\nSpecific objectives\n\n1. To determine the ultrafiltration efficiency by measuring the following:\n\n   1. Clinical parameters: blood pressure, weight, evidence of fluid overload by the presence of edema, abnormal heart sounds (S3 gallop), lung crackles or rales, increased heart rate (tachycardia), rapid breathing (tachypnea),\n   2. Change in the number of blood pressure medications before and after the intervention,\n   3. Absolute and relative fluid overload using bioimpedance analyzer (BIA),\n   4. Mean daily ultrafiltration (UF) or Total 24-h UF,\n   5. Residual kidney function: 24-hour urine output,\n   6. Glucose exposure\n2. To determine the solute clearance adequacy by measuring the following:\n\n   1. Serum sodium, chloride, potassium, bicarbonate, serum albumin, calcium, and hemoglobin,\n   2. Phosphate clearance\n   3. Renal and peritoneal Kt\u002FVurea\n   4. Normalized protein catabolic rate (nPCR)\n3. To measure caregiver burden using a Paediatric Renal Caregiver Burden Scale (PR-CBS).",[27],[60,61,62,29,63],"M-CAPD","C-CAPD","ESKD","Low-resource settings","RECRUITING","2025-08-19",{"date":67,"type":37},"2025-08-21",{"date":69,"type":37},"2024-11-18",{"date":71,"type":21},"2026-06-30",{"name":43,"class":44}]