[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"children-only\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:children-only":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,42,70,99,127,157,181,208,234,259,278,299,324,350,379,407,437,457,474,496,526,549,570,596,623],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100642560","effect-of-task-oriented-training-with-functional-electrical-stimulation-on-balance-in-children-with-hemiparesis-100642560",false,"NCT07648511","Effect of Task Oriented Training With Functional Electrical Stimulation on Balance in Children With Hemiparesis","Inclusion Criteria:\n\n1. The age of the selected children will be ranged from 6 to 9 years.\n2. Able to follow simple instructions.\n3. Degree of spasticity is ranging from 1to 1+ according to modified Ashworth scale.\n4. The level of motor function of the children will be levels I-II according to Gross Motor Function Classification System.\n\nExclusion Criteria:\n\nThe children will be excluded if they have one or more of the following criteria:\n\n1. Visual, hearing disorders.\n2. Recent Botox injection or orthopedic surgery in the lower limb in the last 6 months before the start of the study.\n3. Any fixed deformity of lower limb.","ALL","6 Years","9 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","To investigate the efficacy of combination of task-oriented training and Functional electrical stimulation of ankle dorsiflexor muscles on:\n\n1. Strength of ankle muscles in children with hemiparesis.\n2. Balance in children with hemiparesis.",[27,28],"Hemiparesis","Children, Only","RECRUITING","2026-06-10",{"date":32,"type":33},"2026-06-15","ACTUAL",{"date":35,"type":33},"2026-04-05",{"date":37,"type":21},"2026-07-05",{"name":39,"class":40},"Cairo University","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":41},"100640614","correlation-between-toilet-sitting-position-ankle-range-of-motion-and-lower-limb-strength-in-children-100640614","NCT07576491","Correlation Between Toilet Sitting Position, Ankle Range of Motion, and Lower Limb Strength in Children","Correlation Of Different Toilet Sitting On Ankle Range Of Motion, Constipation And Lower Limb Strength In School Going Children","Inclusion Criteria:\n\n* Students age group: 6-12 year.\n* Both male and female groups\n* Normal developing children\n* Children who have been using either sitting or squatting toilet type .\n* Children's who are willing to participate and perform functional tasks.\n\nExclusion Criteria:\n\nChildren with abdominal surgery\n\n* Children with lower limb surgery\n* Children with acute or chronic disease like irritable bowel syndrome\n* Children using both toilet postures\n* Children with neurological or developmental delays affecting toilet independence like Cerebral Palsy and autism.\n* Children on medications that affect bowel movement (e.g., laxatives, opioid)","12 Years",{"count":51,"type":21},191,"OBSERVATIONAL","This study investigates the relationship between different toilet sitting styles (squat vs. western) and their effects on ankle range of motion (ROM), constipation symptoms, and lower limb strength in school-going children aged 6-12 years. With increasing urbanization, the shift from traditional squat toilets to sitting toilets may influence children's musculoskeletal development and bowel health. Squatting involves greater ankle dorsiflexion and muscle activation, which may contribute to better lower limb strength and improved bowel function compared to sitting postures.\n\nA comparative cross-sectional design will be used, including participants from public and private schools. Data on toilet usage habits will be collected along with demographic information. Ankle ROM will be measured using a goniometer, lower limb strength will be assessed through the 1-minute sit-to-stand test and standing long jump, and constipation symptoms will be evaluated using the PAC-SYM questionnaire. Data analysis will be conducted using SPSS version 26. Ethical approval will be obtained from the Research Ethics Committee of Riphah International University, Lahore.",[28],[56,57,58,59,60],"Squatting Position","Ankle Joint","Lower Extremity Strength","Constipation","Posture","2026-05-04",{"date":63,"type":33},"2026-05-08",{"date":65,"type":33},"2026-04-13",{"date":67,"type":21},"2026-08-30",{"name":69,"class":40},"Riphah International University",{"id":71,"slug":72,"hasResults":12,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":12,"sex":16,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":41},"100413513","national-bacterial-meningitis-study-in-children-and-newborns-100413513","NCT04664569","National Bacterial Meningitis Study in Children and Newborns","National Observatory of Bacterial Meningitis in Children and Newborns","Inclusion Criteria:\n\n* clinical signs of meningitis, associated with positive cerebrospinal fluid (CSF) culture and\u002For positive CSF antigen testing (Escherichia coli K1, N. meningitidis serogroups B, A, C, Y and W-135, group B streptococci, Hib, or S. pneumoniae), and\u002For positive CSF polymerase chain reaction (PCR), and\u002For positive blood culture with CSF pleocytosis (\\> 10 cells\u002FµL).\n* purpura fulminans\n\nExclusion Criteria:\n\n\\-","1 Day","18 Years",{"count":80,"type":21},10000,"Bacterial meningitis is a major cause of morbidity and mortality in childhood. Antibiotic treatment recommendations are based on epidemiological and susceptibility data. The epidemiology of bacterialméningitis has changed in recent years, mainly owing to widespread use of different conjugate vaccines. The aim of this prospective national survey is to describe epidemiology of bacteria implicated in bacterial meningitis in children.",[83,28,84,85,86,87,88,89],"Meningitis","Pneumococcal Conjugate Vaccine","Meningococcal Vaccines","H. Influenzae Vaccine","Neonatal Infection","Antibiotic Treatment","Case Fatality Rate","2026-04-23",{"date":92,"type":33},"2026-04-28",{"date":94,"type":33},"2001-01-01",{"date":96,"type":21},"2030-01-01",{"name":98,"class":40},"Association Clinique Thérapeutique Infantile du val de Marne",{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":12,"sex":16,"minAge":107,"maxAge":78,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":41},"100526293","vr-based-simulation-in-the-preparation-of-children-for-mri---mrvr-100526293","NCT06132854","VR Based Simulation in the Preparation of Children for MRI - MRVR","Efficacy of Virtual Reality Based Simulation in the Preparation of Children for Magnetic Resonance Imaging Examinations: a Randomized Clinical Trial (MRVR)","MRVR","Inclusion Criteria:\n\n1. Informed assent and parental informed consent to participate in the study.\n2. Stated willingness to participate in the intervention and to complete study questionnaires.\n3. Inpatient or outpatient at the Pediatric Center.\n4. Age 4-18 years\n5. Scheduled for MRI examination under anesthesia at the Semmelweis University.\n6. Fluent in Hungarian language\n\nExclusion Criteria:\n\n1. Severe visual impairment or hearing loss that would hinder the participation of the VR and booklet experience.\n2. In case of epilepsy, if the treating physician recommend against participation.\n3. Children with severe intellectual disability which would hinder participation in the VR group e.g. not able to follow simple instructions.\n4. Inpatients, if the treating physician indicates that the child is too unwell for the study.\n5. Face or cranial deformities, wounds on the face and head which would hinder wearing the VR headset.","4 Years",{"count":109,"type":21},288,[24],"The goal of this randomized controlled trial is to evaluate whether a virtual reality based preparation method can efficiently decrease the proportion of children requiring general anesthesia during MRI examinations.\n\nParticipants will take part in a virtual reality environment resembling an MRI before their scheduled MRI examination.\n\nResearchers will compare these children to usual care and a booklet based preparation method to see if less children need anesthesia for completing the MRI examination.",[28,113],"Anesthesia",[115,116,117,118],"MRI","Pediatrics","anesthesia","virtual reality","2026-04-22",{"date":92,"type":33},{"date":122,"type":33},"2023-11-07",{"date":124,"type":21},"2026-12-31",{"name":126,"class":40},"Semmelweis University",{"id":128,"slug":129,"hasResults":12,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":12,"sex":16,"minAge":134,"maxAge":17,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":143,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":41},"100554927","picu-related-sleep-and-circadian-dysregulation-pilot-study-100554927","NCT06505447","PICU-related Sleep and Circadian Dysregulation Pilot Study","A Three-phase Pilot Study of the Feasibility of the Measurement and Promotion of Sleep and the Circadian Rhythm in a Pediatric Intensive Care Unit","Inclusion Criteria:\n\n1. Child age 3 to 6 years old on the day of PICU admission\n2. English-speaking parent at the bedside\n3. Child expected to remain in the PICU over 24 to 48 hours\n\nExclusion Criteria:\n\n1. Child is in end-of-life care\n2. The child is receiving neuromuscular blockade for any reason\n3. Caregiver or parent not at the bedside","3 Years",{"count":136,"type":21},30,[24],"A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old. This study will also measure the feasibility of providing daytime light exposure as well as restricting all provided nutrition to during daytime hours.",[140,141,142,28],"Circadian Dysrhythmia","Sleep Disturbance","Critical Illness",[144,145,146,147],"Sleep disruption","circadian rhythm","critical care","pediatrics","2026-03-18",{"date":150,"type":33},"2026-03-23",{"date":152,"type":33},"2024-12-06",{"date":154,"type":21},"2027-01-01",{"name":156,"class":40},"State University of New York at Buffalo",{"id":158,"slug":159,"hasResults":12,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":179,"locationsCount":41},"100442629","phase-4-combined-immunosuppression-for-pediatric-crohns-disease-100442629","NCT05043870","Combined Immunosuppression for Pediatric Crohn's Disease","Combination Therapy of Infliximab and Immunosuppressives for Pediatric Crohn's Disease","Inclusion Criteria:\n\n1. 6-18 years old\n2. diagnosis of Crohn's Disease\n3. Pediatric Crohn's disease Activity Index (PCDAI)\\>30 or The Simple Endoscopic Score for Crohn Disease (SES-CD) \\>10 before treatment\n4. receiving exclusive enteral nutrition or corticosteroids as first-line treatment, Pediatric Crohn's disease Activity Index (PCDAI)\\>10 or The Simple Endoscopic Score for Crohn Disease (SES-CD)≥3 after exclusive enteral nutrition or corticosteroids\n5. The patient or legal guardian sign the informed consent documents\n\nExclusion Criteria:\n\n1. history of biological agents targeting at tumor necrosis factor (TNF)\n2. Crohn's Disease-related surgery\n3. infections\n4. tumors",{"count":165,"type":21},128,[167],"PHASE4","This is a randomized controlled trial to compare the efficacy and safety of infliximab and immunosuppressives therapy alone or in combination for pediatric Crohn's disease.",[170,171,172,28],"Crohn Disease","Infliximab","Immunosuppression","2026-03-17",{"date":175,"type":33},"2026-03-19",{"date":177,"type":33},"2022-10-10",{"date":124,"type":21},{"name":180,"class":40},"Children's Hospital of Fudan University",{"id":182,"slug":183,"hasResults":12,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":12,"sex":16,"minAge":77,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":193,"conditions":194,"keywords":198,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":202,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":41},"100419583","rsv-burden-in-outpatient-and-hospital-settings-100419583","NCT04743609","RSV Burden in Outpatient and Hospital Settings","Ambulatory Respiratory Tract Infection Survey, Burden of Respiratory Syncitial Virus in the Era of Covid-19","Oursyn","Inclusion Criteria:\n\n* children under 24 months of age (≤)\n* One of the holders of parental authority signed the consent\n* Patient affiliated to a social security scheme (Social Security or Universal Medical Coverage)\n* Acute purulent otitis media (Paradise Criteria) or otorrhea with or withitout associated bronchiolitis\n\nExclusion Criteria:\n\n* Age \\>24 months\n* Refusal by one of the parents\n* Not affiliated to a social security system\n* Maternal RSV vaccination during the pregnancy of the included child","24 Months",{"count":191,"type":21},1900,[24],"Strengthening outpatient low respiratory tract infection surveillance to document the burden of Respiratory Syncytial Virus (RSV)",[195,28,196,197],"RSV Infection","Outpatient","Otitis",[199,200,201],"RSV","children","otitis with or without concomitant bronchiolitis",{"date":175,"type":33},{"date":204,"type":33},"2021-02-08",{"date":206,"type":21},"2026-12-08",{"name":98,"class":40},{"id":209,"slug":210,"hasResults":12,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":215,"sex":16,"minAge":216,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":22,"phases":220,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":229,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":233,"locationsCount":41},"100397837","nasopharyngeal-carriage-of-s-pneumoniae-100397837","NCT04460313","Nasopharyngeal Carriage of S. Pneumoniae","Observatory of Streptococcus Pneumoniae Nasopharyngeal Carriage in Infants With Acute Otitis Media (AOM) and in Healthy Children\"","children seen on an outpatient\n\nInclusion Criteria:\n\n* both sexes\n* suffering from suppurative AOM or healthy children\n\n  * age: 6 months to 36 months for AOM\n  * age: 6 months to 15 years for healthy children\n* informed consent from parents or guardians\n* Children who haven't received antibiotic treatment within 7 days before enrollment,\n\nExclusion Criteria:\n\n* severe underlying disease,\n* inclusion in the study during the previous 12 months\n* Children with bullous myringitis cannot be included.",true,"6 Months","15 Years",{"count":219,"type":21},25760,[24],"This nasopharyngeal (NP) carriage surveillance study was requested by the European Agency for the Evaluation of Medicinal Products as a post-licensing commitment to determine whether the use of the pneumococcal conjugate vaccines (PCVs) including 7 then 13 valents (introduced in 2001 and 2010, respectively) caused a shift in the distribution of Streptococcus pneumoniae serotypes in children with acute otitis media and modified the resistance of this bacterial species to antibiotics.",[223,28,224],"Nasopharyngeal Carriage","Antibiotic Resistant Strain",[226,227,228],"Pneumococcal conjugate vaccine","Streptococcus pneumoniae","Carriage",{"date":175,"type":33},{"date":231,"type":33},"2001-09-11",{"date":124,"type":21},{"name":98,"class":40},{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":12,"sex":16,"minAge":241,"maxAge":78,"enrollmentInfo":242,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":244,"conditions":245,"keywords":247,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":41},"100423495","clinical-features-and-outcomes-of-cbp-versus-non-cbp-in-septic-children-100423495","NCT04794595","Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children","Clinical Features and Outcomes of Continuous Blood Purification Versus Non-continuous Blood Purification in Pediatric Patients With Sepsis or Septic Shock","Inclusion Criteria:\n\n* Age of 29d to 18 years old;\n* Children diagnosed with sepsis requiring blood purification.\n\nExclusion Criteria:\n\n* with a history of a duration of PICU stay \\\u003C24 h\n* active bleeding, including cerebral hemorrhage","28 Days",{"count":243,"type":21},90,"The effect of continuous blood purification (CBP) in children is unclear. Also, the timing of early application is still being explored. In this study, we need to explore the efficacy and the timing of application of CBP in children with sepsis or septic shock.",[246,28],"Sepsis",[248,249,250],"Continuous renal replacement therapy","sepsis","timing","2026-03-13",{"date":253,"type":33},"2026-03-16",{"date":255,"type":33},"2020-12-01",{"date":257,"type":21},"2026-12-30",{"name":180,"class":40},{"id":260,"slug":261,"hasResults":12,"nctId":262,"briefTitle":263,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":12,"sex":265,"minAge":17,"maxAge":49,"enrollmentInfo":266,"targetDuration":4,"studyType":22,"phases":268,"briefSummary":269,"conditions":270,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":277,"locationsCount":41},"100625916","effect-of-aerobic-exercises-versus-low-interval-training-on-cardiorespiratory-fitness-in-school-going-chlidren-100625916","NCT07428850","Effect of Aerobic Exercises Versus Low Interval Training on Cardiorespiratory Fitness in School Going Chlidren.","Inclusion Criteria:\n\n* Age 6-12\n\n  * School going children\n  * Healthy children without chronic illness\n  * Cognitive skills\n\nExclusion Criteria:\n\n* Cardiovascular disease,\n\n  * asthma,\n  * musculoskeleton disorders\n  * Children with any Physical disability\n  * Behavioural issue\n  * prior athletic training.","MALE",{"count":267,"type":21},130,[24],"Cardiorespiratory fitness (CRF), which is a key marker of heart and lung health, can be improved through regular physical activity, particularly aerobic exercises. This project aims to evaluate the effects of aerobic exercises combined with low-intensity interval training (LIIT) on the cardiorespiratory fitness of school-going children. The increasing sedentary lifestyle among children has contributed to a decline in overall physical fitness and a rise in health-related issues.Cardiorespiratory fitness is crucial for overall health and can help reduce the risk of chronic diseases from a young age.",[28],"2026-02-23",{"date":273,"type":33},"2026-02-24",{"date":275,"type":33},"2025-10-28",{"date":271,"type":21},{"name":69,"class":40},{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":12,"sex":16,"minAge":284,"maxAge":285,"enrollmentInfo":286,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":288,"conditions":289,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":41},"100540928","the-impact-of-sepsis-on-long-term-outcomes-in-critical-ill-children-with-sepsis-100540928","NCT06323226","The Impact of Sepsis on Long-term Outcomes in Critical Ill Children With Sepsis","Inclusion Criteria:\n\nWe included critically ill children with sepsis who successfully discharged from pediatric Intensive care units, age \\\u003C 16 years.\n\nWe also included age, sex, illness severity matched critically ill children as control group.\n\nExclusion Criteria:\n\nWe excluded children with underlying diseases, cancer, hematologic malignancy.","0 Years","16 Years",{"count":287,"type":21},300,"This study is conducted in critically ill children with sepsis with a five years follow-up. We aim to investigate the impact of sepsis on long-term outcomes including growth, neurodevelopment, survival rate, quality of life.",[246,28],"2026-01-19",{"date":292,"type":33},"2026-01-22",{"date":294,"type":33},"2019-01-01",{"date":296,"type":21},"2027-06-01",{"name":298,"class":40},"West China Hospital",{"id":300,"slug":301,"hasResults":12,"nctId":302,"briefTitle":303,"officialTitle":303,"acronym":4,"eligibilityCriteria":304,"healthyVolunteers":215,"sex":16,"minAge":305,"maxAge":285,"enrollmentInfo":306,"targetDuration":4,"studyType":22,"phases":308,"briefSummary":309,"conditions":310,"keywords":312,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":321,"leadSponsor":323,"locationsCount":41},"100611706","effect-of-mat-pilates-on-pain-and-postural-alignment-in-school-going-children-with-upper-crossed-syndrome-100611706","NCT07244068","Effect of Mat Pilates on Pain and Postural Alignment in School Going Children With Upper Crossed Syndrome.","Inclusion Criteria:\n\n* School going children\n* Children of the age 8-16.\n* Children having Thoracic Kyphosis angle under 20° and over 40 °,and Craniovertebral angle under 48°\n\nExclusion Criteria:\n\n* Children with systemic disorders.\n* Children with recent history of injury.\n* Physical or sensory defecit(16)","8 Years",{"count":307,"type":21},28,[24],"This randomized control clinical Trial is to evaluate the effect of mat Pilates on postural alignment and pain levels in school-going children with Upper Crossed Syndrome. The study will focus on assessing changes in head, neck, and shoulder alignment, as well as any reduction in musculoskeletal discomfort following a structured Pilates intervention in children of age 8-16.This clinical Trial will be in two groups A) Intervention group B) Control Group. From a total of 28 Participants , 14 will be performing Mat pilates and routine Physical Therapy(Group A) while the other 14 will be performing just routine Physical Therapy exercises (Group B). Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 26.00.",[28,311],"Upper Crossed Syndrome",[313,314,315,316,311],"Postural Alignment","Craniovertebral angle","Thoracic Kyphosis angle","Mat Pilates","2025-11-17",{"date":319,"type":33},"2025-11-24",{"date":275,"type":33},{"date":322,"type":21},"2026-06-16",{"name":69,"class":40},{"id":325,"slug":326,"hasResults":12,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":4,"eligibilityCriteria":330,"healthyVolunteers":215,"sex":16,"minAge":331,"maxAge":332,"enrollmentInfo":333,"targetDuration":4,"studyType":22,"phases":335,"briefSummary":338,"conditions":339,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":41},"100471389","phase-2-inhaled-isopropyl-alcohol-for-treatment-of-nausea-100471389","NCT05418244","Inhaled Isopropyl Alcohol for Treatment of Nausea","Inhaled Isopropyl Alcohol for the Treatment of Nausea in a Pediatric Emergency Department: A Open Label, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with a chief complaint of nausea or vomiting\n* Ages 7-178 years, both sexes\n* Weight ≥ 15 kg\n* Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4\u002F10\n\nExclusion Criteria:\n\n* 1\\. Require IV access\n* Inability to breathe in\u002Fout through the nose\n* Anosmia (self- or parental report)\n* Allergy to isopropyl alcohol or ondansetron\n* Current or history of alcohol abuse\n* Inability to communicate feeling nauseous\n* Inability to follow directions regarding taking deep breaths through the nose\n* Known prolonged QT interval\n* Pregnancy\n* Received antiemetics within the last 8 hours\n* Currently taking apomorphine","7 Years","17 Years",{"count":334,"type":21},84,[336,337],"PHASE2","PHASE3","To determine the efficacy of inhaled isopropyl alcohol in treating nausea\u002Fvomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.",[340,341,28],"Vomiting","Nausea","2025-10-03",{"date":344,"type":33},"2025-10-08",{"date":346,"type":33},"2022-04-20",{"date":348,"type":21},"2026-06-30",{"name":156,"class":40},{"id":351,"slug":352,"hasResults":12,"nctId":353,"briefTitle":354,"officialTitle":355,"acronym":4,"eligibilityCriteria":356,"healthyVolunteers":215,"sex":16,"minAge":331,"maxAge":357,"enrollmentInfo":358,"targetDuration":4,"studyType":22,"phases":360,"briefSummary":361,"conditions":362,"keywords":367,"overallStatus":369,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":4},"100550129","the-effect-of-virtual-reality-and-buzzy-application-on-pain-fear-and-anxiety-during-prick-test-in-children-100550129","NCT06443060","The Effect of Virtual Reality and Buzzy Application on Pain, Fear and Anxiety During Prick Test in Children","The Effect of Virtual Reality and Buzzy Application on Pain, Fear and Anxiety During Prick Test in Children: Randomized Controlled Study","Inclusion Criteria:\n\n* The child must be between the ages of 7-10\n* It will be the first time that a prick test will be applied.\n* The child can speak and understand Turkish comfortably\n* He and his family agree to participate in the study.\n* Not having used analgesic medication at least six hours ago\n\nExclusion Criteria:\n\n* The child has any diagnosed psychiatric disorder\n* Having visual, auditory or speech disorders\n* Having a chronic disease other than allergy","10 Years",{"count":359,"type":21},111,[24],"Allergy is a hypersensitivity reaction to a triggering agent. Tests used in allergy are divided into two: in vivo and in vitro. Among the in vivo tests routinely used, epidermal, intradermal and patch tests are used, and the most commonly used is the skin prick test. In order to prevent the negative effects of pain, it is important to be informed about the appropriate approach to children, newborns and babies, and effective pain management, according to their cognitive development levels. Pain management in children should be done appropriately with accurate assessment tools. This will increase the quality of life, reduce hospitalizations, shorten the length of hospital stay and reduce costs. Pain experiences experienced during childhood will cause later pain experiences to be perceived as more severe and cause anxiety and fear. Anxiety is a psychological, physiological and behavioral state that develops in response to a perceived or existing threat. Anxiety, which can also be expressed as worry or anxiety, is a emotional state that can occur in various ways, such as restlessness, tension, easy fatigue, lack of concentration, muscle tension, and sleep disturbance, in which autonomic and somatic symptoms occur in the body, without any reason.\n\nVirtual reality provides multi-sensory information as children focus on the simulated world. Virtual reality, one of the cognitive methods; It can create an environment where three-dimensional pictures or animations created on the computer can interact in people's minds. It is also defined as a distraction method created by software, which creates the feeling that users are in the environment even though they are not in the real environment, and can interact with people in the environment. When all these studies were examined, no three-group study was found comparing a distracting method with a physical method for the 7-10 age group. Additionally, there is a study that used virtual reality in the prick test, but there is no method that has been proven to be superior to virtual reality. In this study, it will be investigated whether virtual reality and buzzy applications have a reducing effect on pain, fear and anxiety compared to the control group. Virtual reality and buzzy techniques will also be compared with each other. Since no such study has been found in the literature, it is thought to contribute to the field.",[363,364,365,28,366],"Pain","Fear","Anxiety","Virtual Reality",[368,366,363,364,365],"BUZZY","NOT_YET_RECRUITING","2025-09-11",{"date":372,"type":33},"2025-09-17",{"date":374,"type":21},"2025-10-15",{"date":376,"type":21},"2025-12-15",{"name":378,"class":40},"KTO Karatay University",{"id":380,"slug":381,"hasResults":12,"nctId":382,"briefTitle":383,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":12,"sex":16,"minAge":305,"maxAge":385,"enrollmentInfo":386,"targetDuration":4,"studyType":22,"phases":388,"briefSummary":389,"conditions":390,"keywords":392,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":406},"100510222","the-effect-of-model-based-dgtal-game-on-metabolc-control-self-effcency-and-qualty-of-lfe-in-chldren-wth-type-1-dabetes-100510222","NCT05923632","The Effect Of Model-Based Dıgıtal Game On Metabolıc Control, Self-Effıcıency And Qualıty Of Lıfe In Chıldren Wıth Type 1 Dıabetes","Inclusion Criteria:\n\n* Being in the 8-13 age range,\n* Being diagnosed with T1DM at least 6 months ago,\n* Ability to read and write Turkish,\n* Ability to communicate verbally,\n* To have Internet access,\n* Computer, tablet, etc. to have and use technological tools,\n* To volunteer to participate in the study\n\nExclusion Criteria:\n\n• Having another chronic disease other than T1DM","13 Years",{"count":387,"type":21},58,[24],"This study was planned to determine the effect of model-based digital game on metabolic control, self-efficacy and quality of life in children with T1DM.",[391,28],"Type 1 Diabetes",[391,393,394,395,396,397],"Children","Digital Game","Metabolic Control","Self-efficacy","Life Quality","2025-09-10",{"date":370,"type":33},{"date":401,"type":33},"2024-11-20",{"date":403,"type":21},"2025-12-30",{"name":405,"class":40},"Abant Izzet Baysal University",2,{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":413,"eligibilityCriteria":414,"healthyVolunteers":215,"sex":16,"minAge":216,"maxAge":357,"enrollmentInfo":415,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":416,"conditions":417,"keywords":419,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":41},"100533739","normative-data-of-vestibular-and-postural-function-in-danish-children-100533739","NCT06229730","Normative Data of Vestibular and Postural Function in Danish Children","Vestibular ASsessment In Children - Balance Function in Normal Children and Specific Risk Groups (VASIC)","VASIC","Inclusion Criteria:\n\n* Children in the age of 6 months -10 years\n* Normal hearing\n* No history of dizziness or balance problems\n* Written informed consent from the parents.\n\nExclusion Criteria:\n\n* Premature birth\n* Existing or previous inner ear disease(s) or previous inner ear surgery\n* Cholesteatoma or previous middle ear surgery\n* Known or previous vestibular disorder (Vestibular schwannoma, Mb Meniere, vestibular neuritis or other known)\n* Delayed gross motor development evaluated through milestones.\n* Visual impairment to such a degree that the child is not able to maintain fixation on a dot one meter away.\n* Congenital nystagmus\n* Compromised eye muscle mobility\n* A diagnose of any neurological disease.\n* A diagnose of any psychiatric disease.\n* VEMP-electrode allergy\n* History of symptomatic head or neck trauma\n* Prescription of medicine which alters vestibular outputs (for instance sedative antihistamines)",{"count":243,"type":21},"The goal of this age-based cohort study is to provide normative data of vestibular function in the general Danish pediatric population. Thus, the investigators will be able to compare patient data with norms, allowing for more precise diagnostics. The participants will be children in the age of 6 months to 10 years, without any known hearing or balance problems. The test protocol consists of questionnaires, hearing screening and vestibular and postural assessments.",[28,418],"Vestibular Function",[420,421,393,422,423,424,425,426,427],"Vestibular dysfunction","Balance problem","Dizziness","Vestibular assessment","video Head Impulse Test","Vestibular Evoked Myogenic Potential","Computerized Dynamic Posturography","Quality of life","2025-08-21",{"date":430,"type":33},"2025-08-26",{"date":432,"type":33},"2025-06-01",{"date":434,"type":21},"2027-12",{"name":436,"class":40},"Gødstrup Hospital",{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":412,"acronym":413,"eligibilityCriteria":442,"healthyVolunteers":12,"sex":16,"minAge":216,"maxAge":357,"enrollmentInfo":443,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":444,"conditions":445,"keywords":449,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":451,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":41},"100533737","vestibular-and-postural-function-in-children-suspected-of-balance-disorders-100533737","NCT06229704","Vestibular and Postural Function in Children Suspected of Balance Disorders","Inclusion Criteria:\n\n* Children in the age of 6 months to 10 years\n* Delayed gross motor development and\u002For dizziness\u002Fbalance problems.\n* Written informed consent from the parents.\n\nExclusion Criteria:\n\n* Visual impairment to such a degree that the child is not able to maintain fixation on a dot one meter away.\n* Congenital nystagmus\n* Compromised eye muscle mobility\n* VEMP-electrode allergy\n* History of symptomatic head or neck trauma\n* Prescription of medicine which alters vestibular outputs (for instance sedative antihistamines)",{"count":136,"type":21},"The goal of this prospective cohort study is to investigate the vestibular function in children suspected of balance disorders, and to follow up on their balance progressions after rehabilitation. The main hypothesis of the study is that delayed gross motor development and symptoms of dizziness and balance problems in some children are caused by vestibular dysfunction. The investigators expect that early detection and rehabilitation by a physiotherapist will improve the balance ability for the child. The participants will be children in the age of 6 months to 10 years with delayed gross motor development and\u002For with dizziness\u002Fbalance problems. The test protocol consists of questionnaires, hearing screening and vestibular and postural assessments.",[28,446,447,448],"Vestibular Disorder","Vestibular Function Disorder","Development Delay",[420,421,393,422,423,424,425,426,450],"Delayed gross motor development",{"date":430,"type":33},{"date":453,"type":33},"2025-08-20",{"date":455,"type":21},"2028-12",{"name":436,"class":40},{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":412,"acronym":413,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":16,"minAge":134,"maxAge":357,"enrollmentInfo":463,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":465,"conditions":466,"keywords":468,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":470,"startDateStruct":471,"completionDateStruct":472,"leadSponsor":473,"locationsCount":41},"100533738","vestibular-and-postural-function-in-an-unselected-group-of-children-with-sensorineural-hearing-loss-100533738","NCT06229717","Vestibular and Postural Function in an Unselected Group of Children With Sensorineural Hearing Loss","Inclusion Criteria:\n\n* Children in the age of 3-10 years\n* Uni- or bilateral sensorineural hearing loss \\> 20 dB bone conduction pure tone average measured at frequencies 0.5, 1, 2, 4 kHz\n* Written informed consent from the parents.\n\nExclusion Criteria:\n\n* Previous inner ear surgery\n* Visual impairment to such a degree that the child is not able to maintain fixation on a dot one meter away.\n* Congenital nystagmus\n* Compromised eye muscle mobility\n* VEMP-electrode allergy\n* History of symptomatic head or neck trauma\n* Prescription of medicine which alters vestibular outputs (for instance sedative antihistamines)",{"count":464,"type":21},48,"The goal of this prospective cohort study is to investigate the vestibular function in children with unilateral or bilateral sensorineural hearing loss. The main hypothesis of the study is that abnormal vestibular test results will be found in 20-30 % of the children with sensorineural hearing loss. The participants will be children in the age of 3-10 years with sensorineural hearing loss. The test protocol consists of questionnaires and vestibular and postural assessments.",[28,446,418,467],"Sensorineural Hearing Loss",[420,421,393,469,422,423,424,425,426,427],"Hearing Loss",{"date":430,"type":33},{"date":453,"type":33},{"date":455,"type":21},{"name":436,"class":40},{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":479,"acronym":4,"eligibilityCriteria":480,"healthyVolunteers":12,"sex":16,"minAge":134,"maxAge":305,"enrollmentInfo":481,"targetDuration":4,"studyType":22,"phases":482,"briefSummary":483,"conditions":484,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":41},"100560582","a-novel-program-using-ride-on-toys-to-improve-upper-extremity-function-in-children-with-hemiplegia-100560582","NCT06579027","A Novel Program Using Ride-on Toys to Improve Upper Extremity Function in Children With Hemiplegia","A Novel, Child-friendly, Home-based Navigation Training Program Using Joystick-operated Ride-on Toys to Improve Upper Extremity Function in Children With Hemiplegia: A Pilot Study","Inclusion Criteria:\n\n* Boys and girls between the ages of 3 - 8 years\n* Diagnosed with hemiplegia by a medical doctor with clear asymmetry in upper extremity strength and control (i.e., one upper limb is clearly weaker than the other)\n* Can maintain a supported sitting position for at least 15 minutes\n\nExclusion Criteria:\n\n* Only lower limb involvement\n* Recent history (within past 6 months) of trauma or surgery or Botox\n* Uncorrected blindness\u002Fprofound visual impairment\n* Fixed deformities at wrist or hand\n* No active control in affected UE\n* Inability to follow 2-step directions\n* Weight \\> 150 lbs.",{"count":136,"type":21},[24],"The purpose of this study is to assess the feasibility and utility of 2 types of play-based training programs co-delivered by researchers and caregivers within home\u002Fcommunity settings to promote arm function among 3-to-8-year-old children with hemiplegia. Specifically, investigators will assess the feasibility of implementation and acceptance\u002Fsatisfaction associated with a researcher-caregiver co-delivered community-based training program involving either joystick-operated powered ride-on toys (SPEED training) or creative upper extremity training (CRAFT training).\n\nThe investigators will also compare the effects of these 2 types of training programs on children's arm motor function and spontaneous use of their affected arm during daily activities.",[485,486,28],"Hemiplegia","Cerebral Palsy","2025-06-04",{"date":489,"type":33},"2025-06-05",{"date":491,"type":33},"2024-09-26",{"date":493,"type":21},"2026-09-01",{"name":495,"class":40},"University of Connecticut",{"id":497,"slug":498,"hasResults":12,"nctId":499,"briefTitle":500,"officialTitle":500,"acronym":4,"eligibilityCriteria":501,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":502,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":504,"conditions":505,"keywords":510,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":41},"100451542","early-detection-of-long-term-diabetic-complications-in-children-and-adolescents-with-type-1-diabetes-100451542","NCT05159856","Early Detection of Long-term Diabetic Complications in Children and Adolescents With Type 1 Diabetes","Inclusion Criteria:\n\n* T1D\\>12 months\n* 6-18 years old prior to inclusion\n* Followed at the Pediatric Diabetes outpatient clinic at Steno Diabetes Center Copenhagen\n* Speaks and reads Danish well enough to understanding the given oral and written information.\n* There is a written consent from the guardianship holder\u002Fholders for the child.\n\nExclusion Criteria:\n\n* T1D \\\u003C 12 months\n* Known cardiovascular disease\n* Antihypertensive treatment",{"count":503,"type":21},400,"Aims: To investigate early markers of long-term diabetic complications and the association to an extended glucose metabolic profile comprising glucose control (current and past), glucose variability and insulin sensitivity in children and adolescents with type 1 diabetes (T1D).\n\nBackground: Most Danish children and adolescents with T1D do not achieve their metabolic target and are at increased risk of developing long-term diabetic complications, reducing their life expectancy and increase their morbidity rate. Hence, improved metabolic control, a better understanding of what optimal metabolic control means, combined with detailed monitoring of the first markers of long-term complications and their reversibility or lack thereof are needed.\n\nMethods: A prospectivel study of 400 children, aged 6-18 years old, with T1D\\>12 months. Early markers of long-term diabetic complications will be investigated as arterial stiffness, nerve dysfunction and nephropathy. Data on T1D onset, duration, treatment modality, self-monitoring-blood-glucose profiles, growth, weight, and pubertal status will be collected.\n\nBlood sampling will include routine tests and markers of glucose, lipid, bone, and gastrointestinal metabolism. DXA-scan, Fibroscan, bone-age, eye-examination and physical activity will be measured. Data on retrospective glucose- and lipid-profiles will be collected. The children will be offered a followup every 5 years for the next two decades.\n\nPerspectives: This study provides novel insight into the frequency of early markers of long-term diabetic complications and its association to the interplay of the pancreas, adipose, gastrointestinal and bone metabolic axis. Which can assist in identifying subgroups of children and adolescents requiring earlier in-depth screening for early markers of long-term diabetic complications, for putative interventions for prevention, hence reducing morbidity and mortality in T1D.",[506,507,28,508,509],"Diabetes Complications","type1diabetes","Diabetic Neuropathies","Arterial Stiffness",[511,512,513,514,515,516],"pediatric","arteriel stiffness","pulse wave velosity","neuropathy","type 1 diabetes","early diabetic complications","2025-05-28",{"date":519,"type":33},"2025-06-03",{"date":521,"type":33},"2022-05-03",{"date":523,"type":21},"2025-12",{"name":525,"class":40},"Steno Diabetes Center Copenhagen",{"id":527,"slug":528,"hasResults":12,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":4,"eligibilityCriteria":532,"healthyVolunteers":215,"sex":16,"minAge":533,"maxAge":134,"enrollmentInfo":534,"targetDuration":535,"studyType":52,"phases":4,"briefSummary":536,"conditions":537,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":540,"lastUpdatePostDateStruct":541,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":41},"100528175","characteristics-of-intestinal-bacteria-and-their-effects-on-growth-and-immune-function-in-children-at-high-altitude-100528175","NCT06157346","Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude","Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude in Diqing Tibetan Autonomous Prefecture, Yunnan Province","Inclusion Criteria:\n\n* Children aged 1-3 years old\n* Both men and women;\n* The child's legal guardian signed the informed consent to participate in the study.\n* The legal guardian of the child commits to follow the study procedures and cooperate with the entire study process\n\nExclusion Criteria:\n\n* Probiotics or antibiotics within 1 month\n* Associated with clinically significant abnormalities in liver and kidney function, nervous system, respiratory system, and coagulation function as determined by the investigator\n* Unstable vital signs;\n* Have other underlying medical conditions\n* Individuals deemed unsuitable for this clinical trial.","1 Year",{"count":287,"type":21},"7 Days","Microbes and the human body maintain a complex relationship of interaction and influence. Different regions, altitudes, and dietary habits have different degrees of influence on the composition of children's intestinal flora. Therefore, the development and maturation process of children's intestinal flora in plateau areas was discovered, and its relationship with children's immunity, metabolism, and growth was understood. The mechanism of action of children's intestinal flora on immunity, growth and development was further analyzed by comparing it with people in low-altitude areas, to provide a scientific basis for improving children's health in plateau areas.",[538,28,539],"Health","Gut Microbiota","2025-04-03",{"date":542,"type":33},"2025-04-04",{"date":544,"type":33},"2023-10-16",{"date":546,"type":21},"2026-08-31",{"name":548,"class":40},"Ruijin Hospital",{"id":550,"slug":551,"hasResults":12,"nctId":552,"briefTitle":553,"officialTitle":554,"acronym":4,"eligibilityCriteria":555,"healthyVolunteers":215,"sex":16,"minAge":305,"maxAge":78,"enrollmentInfo":556,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":558,"conditions":559,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":561,"lastUpdatePostDateStruct":562,"startDateStruct":564,"completionDateStruct":566,"leadSponsor":568,"locationsCount":41},"100575868","comt-and-oprm1-polymorphisms-and-their-effect-on-post-operative-pain-in-children-100575868","NCT06777875","COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children","COMT and OPRM1 Polymorphisms and Their Effect on Post-Operative Pain in Children Undergoing Orthopedic, Abdominal, Thoracic, and Plastic Surgeries.","Inclusion Criteria:\n\n* All children 8 years to 18 years\n* Undergoing orthopedic, abdominal, thoracic, and plastic surgeries\n* American Society of Anesthesiologists classification (ASA) I-II-III\n\nExclusion Criteria:\n\n* Children with schizoid personality disorders, phobias, and anxiety\n* Patients with neuropathic pain associated with surgeries requiring surgical treatment.\n* Children presented with all types of depressive disorders, atypical bipolar disorder, or a suspicion of substance abuse.\n* American Society of Anesthesiologists classification (ASA) ≥IV\n* All patients receiving regional anesthesia, local blocks, epidural and caudal blocks.",{"count":557,"type":21},200,"The goal of this observational study is to investigate whether the A118G single-nucleotide polymorphism (SNP) in the mu-opioid receptor1(OPRM1) and Catechol-O-methyltransferase (COMT) SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries.\n\nThe main question\\[s\\] it aims to answer \\[is\\]:\n\nDo OPRM1 and COMT SNPs influence postoperative pain scores in children between the ages of 8 and 18 undergoing orthopedic, abdominal, thoracic, and plastic surgeries?\n\nParticipants will be assessed for their pain scores, sedation level, the amount of postoperative analgesics received, duration of their stay in the post-anesthesia care unit, and toxicity.",[363,560,28],"Genetic Change","2025-03-14",{"date":563,"type":33},"2025-03-18",{"date":565,"type":33},"2025-03-10",{"date":567,"type":21},"2027-01-13",{"name":569,"class":40},"American University of Beirut Medical Center",{"id":571,"slug":572,"hasResults":12,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":4,"eligibilityCriteria":576,"healthyVolunteers":12,"sex":16,"minAge":577,"maxAge":285,"enrollmentInfo":578,"targetDuration":4,"studyType":22,"phases":580,"briefSummary":581,"conditions":582,"keywords":585,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":587,"lastUpdatePostDateStruct":588,"startDateStruct":590,"completionDateStruct":592,"leadSponsor":594,"locationsCount":41},"100456216","bio-impedance-monitoring-as-a-tool-to-assess-fluid-status-in-the-pediatric-surgical-patient-pedfluid-study-100456216","NCT05220709","Bio Impedance Monitoring as a Tool to Assess Fluid Status in the Pediatric Surgical Patient? (PedFluid Study)","Bio Impedance Monitoring as a Tool to Assess Fluid Status in the Pediatric Surgical Patient: Can we Measure a Fluid Shift","Inclusion Criteria:\n\n* Scheduled for elective surgery or investigation under general anesthesia\n* Day care or inpatient hospitalisation\n\nExclusion Criteria:\n\n* If sedation is needed instead of general anesthesia\n* Critically ill patients for urgent surgery\n* Patients who cannot lie still for performing correct measurements on the bio impedance monitor\n* No informed consent obtained","1 Month",{"count":579,"type":21},100,[24],"The baseline infusion rate during surgery for pediatric patients still is the 'Holliday and Segar' rule (also known as the 4\u002F2\u002F1 rule) The question arises if this rule is not outdated, since it was calculated based on the caloric need of the pediatric population, calculated for cow milk. The study tends to validate the use of bio impedance measurements for registering fluid shifts in the pediatric surgical patients.",[583,584,28],"Fluid and Electrolyte Imbalance","Body Weight Changes",[586],"bio impedance spectroscopy","2025-03-04",{"date":589,"type":33},"2025-03-05",{"date":591,"type":33},"2022-04-05",{"date":593,"type":21},"2026-05-31",{"name":595,"class":40},"University Hospital, Antwerp",{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":600,"acronym":601,"eligibilityCriteria":602,"healthyVolunteers":215,"sex":16,"minAge":78,"maxAge":603,"enrollmentInfo":604,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":606,"conditions":607,"keywords":611,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":620,"locationsCount":622},"100541756","cardiometabolic-function-in-offspring-mother-and-placenta-after-assisted-reproductive-technology-100541756","NCT06334003","Cardiometabolic Function in Offspring, Mother and Placenta After Assisted Reproductive Technology","COMPART","Inclusion Criteria:\n\nPregnant women who have either had fertility treatment at Rigshospitalet or Herlev Hospital (FET and fresh ET groups) or are scheduled for prenatal ultrasounds at Rigshospitalet or Herlev Hospital (NC group) will be screened for eligibility. Inclusion must happen before their routine ultrasound scan in 1. trimester.\n\nExclusion Criteria:\n\n* Maternal pregestational diabetes type 1 or 2\n* Non-singleton pregnancies\n* Maternal pregestational BMI \\> 35 kg\u002Fm2\n* Severe maternal co-morbidity\n* Oocyte donation","40 Years",{"count":605,"type":21},600,"The overall objective is to establish the first-of-its-kind longitudinal cohort of pregnant women, biological fathers\u002Fpartners and offspring from pregnancies achieved by frozen embryo transfer (FET), fresh-embryo transfer (fresh ET) and naturally conceived (NC) to investigate maternal cardiometabolic profiles, fetal growth patterns and placental function during pregnancy as well as metabolic and endocrine health in the offspring. Additionally, the aim is to explore genetic and epigenetic patterns in placenta, fetus and parents. As secondary objectives, the investigator group will examine telomere length and minipuberty hormones in children born after FET, fresh-ET and NC.",[608,609,28,610],"ART","IVF","Cardiovascular Disease Other",[612,613,614,609],"Frozen embryo transfer","Cardiovascular","Metabolic",{"date":616,"type":33},"2024-11-25",{"date":618,"type":33},"2024-05-17",{"date":154,"type":21},{"name":621,"class":40},"Rigshospitalet, Denmark",3,{"id":624,"slug":625,"hasResults":12,"nctId":626,"briefTitle":627,"officialTitle":628,"acronym":4,"eligibilityCriteria":629,"healthyVolunteers":215,"sex":16,"minAge":305,"maxAge":630,"enrollmentInfo":631,"targetDuration":4,"studyType":22,"phases":633,"briefSummary":634,"conditions":635,"keywords":4,"overallStatus":369,"whyStopped":4,"lastUpdateSubmitDate":637,"lastUpdatePostDateStruct":638,"startDateStruct":640,"completionDateStruct":642,"leadSponsor":644,"locationsCount":4},"100561609","a-study-on-an-educational-tool-for-the-development-of-a-tailored-dynamic-school-day-in-dutch-primary-schools-100561609","NCT06592391","A Study on an Educational Tool for the Development of a Tailored Dynamic School Day in Dutch Primary Schools.","Process Evaluation and Effectiveness Trial to Assess a Tailored Whole School Approach for a More Dynamic School Day in Dutch Primary Schools.","Inclusion Criteria:\n\nFrom participating 21 schools:\n\n* all teachers\n* a board member\n* all pupils from grade 4 - 8 (Dutch system, age 8 - 12)\n\nExclusion Criteria:\n\n\\-","99 Years",{"count":632,"type":21},980,[24],"A dynamic school day is a school day that involves regular interruptions of sedentary learning with moments of physical activity. Many Dutch primary schools have thus far not succeeded in making their school day more 'dynamic' .\n\nIn this project, the researchers will develop an educational innovation to support schools in the development of a dynamic school day that is tailored to their local context. To determine the effectiveness of the educational innovation, the researchers will study the implementation process and assess the effectiveness.\n\nThe research questions for the researcher project are:\n\n1. To what extend are school teams successful in the development and implementation of a tailored dynamic school day, and what are facilitating and hindering factors during implementation?\n2. What is the effect of the tailored dynamic school day on 8 - 12 year old pupils? Sedentary time and physical activity behavior, wellbeing and in class behavior will be assessed.",[636,28],"Physical Activity","2024-09-09",{"date":639,"type":33},"2024-09-19",{"date":641,"type":21},"2024-10",{"date":643,"type":21},"2028-01",{"name":645,"class":40},"Amsterdam University of Applied Sciences"]