[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"children-with-cerebral-palsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:children-with-cerebral-palsy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,70,92],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100540719","evaluation-of-the-effect-of-a-physical-activity-recovery-stay-100540719",false,"NCT06320496","Evaluation of the Effect of a Physical Activity Recovery Stay","Evaluation of the Effect of a Physical Activity Recovery Stay on the Physical Condition and Quality of Life of Children in a Situation of Physical Deconditioning","Inclusion Criteria:\n\n* Children with a pathology (chronic disease, rare disease or disability) in a state of deconditioning to exercise\n* Taken in charge at the CMPRE for a stay to resume physical activity\n\nExclusion Criteria:\n\n* Age under 8 and over 18\n* Patients undergoing rehabilitation during the stay\n* Patients with a significant change in their therapeutic management during the stay\n* Significant cognitive impairment preventing comprehension of instructions\n* Significant club or leisure sports activity (3x\u002Fweek)\n* Electric wheelchair\n* Non-compliance with stay (5 ½ days missed out of total stay)\n* Participation in another study during the return-to-physical-activity stay","ALL","8 Years","18 Years",{"count":20,"type":21},50,"ESTIMATED","OBSERVATIONAL","A WHO study in 2020 revealed that 81% of adolescents (aged 11-17) do not respect the recommendation of one hour of moderate physical activity per day. In the context of disability, many factors impose limits on physical activity. While the pathology itself induces limitations and restrictions (prolonged sitting time, assisted movement, etc.), organizational constraints also apply to both children and parents, who have to divide their time between work, school and therapeutic care, which is sometimes numerous and varied over the course of a single week. These limitations generate stress and fatigue, and prolonged sedentary periods lead children with chronic illnesses, rare diseases or disabilities into a process of physical deconditioning. The accumulation of sedentary time is detrimental to cardiovascular and metabolic health.\n\nTo combat this deconditioning, the 2008 National Physical Activity and Sport Plan (PNAPS) sets out the main guidelines for treatment and implementation. The plan explains that \"for patients with chronic illnesses, rare diseases or disabilities, the aim is to encourage care and guidance towards Adapted Physical Activity (APA). The attending physician will be able to identify local therapeutic education programs, rehabilitation services and \"sport-santé\" offers, to improve access for these patients to supervised local programs\". In addition, the plan suggests \"developing APA programs in healthcare establishments to enable people with chronic illnesses, rare diseases or disabilities to access health education incorporating practical sessions\".\n\nIn line with this plan, an exercise reconditioning program has been set up at our facility. This three-month stay includes children with a variety of pathologies, but with a common feature of physical deconditioning.",[25,26],"Children With Cerebral Palsy","Children With Cancer","RECRUITING","2026-05-04",{"date":30,"type":31},"2026-05-08","ACTUAL",{"date":33,"type":31},"2022-03-22",{"date":35,"type":21},"2026-09",{"name":37,"class":38},"Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":39},"100622987","remote-ischemic-conditioning-and-spinal-reflex-modulation-in-children-with-cerebral-palsy-100622987","NCT07390760","Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy","Effects of Remote Ischemic Conditioning (RIC) Combined With Balance Training on Spinal Reflex Modulation in Children With Cerebral Palsy","Inclusion Criteria:\n\n* Children diagnosed with cerebral palsy (CP) between the ages 8-17 years\n* Gross motor function classification system levels I-III\n* Mainstream in school and has sufficient cognition to follow the experiment instructions\n\nExclusion Criteria:\n\n* Children with other developmental disabilities such as autism and developmental coordination disorders\n* Children with cognitive deficits such as inability to understand and follow commands, substantially lower performance at grade level in school, and\u002For communication problems\n* Children with balance disorders such as vestibular disorders, posterior fossa tumor etc.\n* Children with known cardiorespiratory dysfunctions\n* Children with sickle cell disease\n* Children who are receiving other adjunct therapies such as transcranial magnetic stimulation, transcranial direct current stimulation, or vagal nerve stimulation\n* Presence of lower extremity condition, injury, or surgery within last three months which could compromise conditioning and training.\n* Participants who are pregnant.","17 Years",{"count":49,"type":21},16,"INTERVENTIONAL",[52],"NA","Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined with training in healthy adults and individuals with neurological conditions. Although RIC is thought to influence neuroplasticity through neural, metabolic, and humoral pathways, its effects on spinal-level mechanisms remain poorly understood. Emerging evidence indicates that neuroplastic adaptations occur not only at the cortical level but also within the spinal cord. Moreover, altered spinal reflex excitability is associated with spasticity, balance impairments, and functional limitations in children with cerebral palsy (CP), yet the role of spinal reflex modulations in response to RIC and balance training remains under expplored in this population. Therefore, this study aims to investigate the effects of RIC combined with balance training on spinal reflex modulation in children with CP.",[25],[56,57,58,59,60],"Remote Ischemic Conditioning","Cerebral Palsy","Spinal Reflex Modulation","H-reflex","Balance Training","2026-03-23",{"date":63,"type":31},"2026-03-24",{"date":65,"type":31},"2025-07-28",{"date":67,"type":21},"2026-12-31",{"name":69,"class":38},"East Carolina University",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":79,"maxAge":18,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":39},"100540703","analysis-of-trunk-and-center-of-mass-control-development-during-gait-in-children-with-cerebral-palsy-vertebral-100540703","NCT06320288","Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy (VERTEBRAL)","Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy","VERTEBRAL","Inclusion Criteria:\n\n* Children (\\\u003C 18 years) with cerebral palsy\n* GMFCS I to III\n* Independent walking with or without technical walking aids (walker, crutches, etc.)\n* Able to understand the instructions of various clinical assessments and functional explorations\n* Affiliated with a social security scheme\n\nExclusion Criteria:\n\nChildren with cerebral palsy\n\n* Neuro-orthopaedic surgery of the lower limbs or trunk within the last 12 months\n* Botulinum toxin A injections within the last 6 months\n* Therapeutic intervention targeting trunk control last 6 months\n\nTypically developing children\n\n* Surgery on lower limbs or trunk last 12 months\n* Neurological and\u002For orthopedic pathology that may influence gait",true,"18 Months",{"count":81,"type":21},270,"During the acquisition of posturokinetic abilities such as walking, postural control of the trunk is of paramount importance. Indeed, its development is strongly linked to the overall motor function of children. In cerebral palsy (CP), a term that refers to a set of motor disorders following a perinatal lesion, deficits in axial control are present from early childhood. These deficits are strongly correlated with the functional deficits observed in this population. In particular, during walking, deviations of the trunk (amplitudes, accelerations) are observed in the three planes of space. While recent literature increasingly questions the impact of trunk control deficit on the walking of children with CP, elements are still missing for a holistic understanding of the interaction between locomotor and postural disorders in children with CP. In particular, no study has focused on the deviations of trunk control and the center of mass (which is a global indicator of balance strategies) during the development and maturation of walking in children with CP. Therefore, the primary objective of this cross-sectional observational study will be to characterize the development of trunk control and center of mass during walking in children with CP.",[25],"2026-01-08",{"date":86,"type":31},"2026-01-12",{"date":88,"type":31},"2023-09-20",{"date":90,"type":21},"2028-09",{"name":37,"class":38},{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":78,"sex":16,"minAge":79,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":50,"phases":102,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":39},"100549775","trunk-activity-rehabilitation-in-young-children-with-cerebral-palsy-100549775","NCT06438432","Trunk Activity Rehabilitation in Young Children With Cerebral Palsy","Activ'Tronc","Inclusion Criteria:\n\nFor children with CP\n\n* Age between 18 months and 5 years 6 months\n* CP type: spastic paraparesis or spastic hemiparesis, GMFCS I to II\n* No or moderate retraction of the sural triceps (ankle dorsiflexion: \\> 5° on clinical examination, knee straight)\n* Sufficient level of understanding to carry out activities involving the trunk in the form of self-exercises (rehabilitation protocol), as well as clinical assessments and functional explorations.\n* Acceptance by the physiotherapist in charge of the child's follow-up to collaborate in carrying out the RAIT.\n* Affiliated with a social security scheme\n\nFor children with DT\n\n* Age between 18 months and 5 years 6 months\n* Walking acquired before age 18 months\n* Sufficient level of understanding to perform clinical assessments and functional explorations\n* Affiliated with a social security scheme\n\nExclusion Criteria:\n\nFor children with CP\n\n* Previous surgery on lower limbs less than 1 year ago\n* Botulinum toxin A injection less than 6 months ago\n* Any change in rehabilitative and\u002For orthopedic management in the last 2 months\n* Hip flessum \\> 20\n* Presence of subacute or chronic pain on standing or walking\n\nFor children with DT\n\n\\- Neurological and\u002For orthopedic disorders that may influence gait","6 Years",{"count":101,"type":21},32,[52],"Children with CP exhibit trunk control issues from early childhood, affecting their balance and gait. These issues manifest as unstable walking, increased step width, and more pronounced anterior deceleration of the sternum. Previous studies have shown that early action of the triceps surae compensates for the deficit in trunk postural control. Rehabilitation targeting the trunk has shown significant improvements in postural control and gait.\n\nThe main objective is to demonstrate that RAIT (Rehabilitation by Activities Involving the Trunk) significantly reduces the peak anterior deceleration of the sternum at the beginning of the stance phase during barefoot spontaneous walking, with an enhanced effect from prolonged RAIT duration.\n\nSecondary objectives include reducing the downward deceleration of the fifth lumbar vertebra (L5), step width, gait variability index, and improving scores on the early clinical balance scale and the global motor function evaluation.\n\nParticipants, children with spastic paraparesis or spastic hemiparesis capable of walking independently, are divided into two groups: one group continuing their usual rehabilitation for 3 months followed by RAIT for 9 months (RH-RAIT), and one group following RAIT for 12 months (RAIT-RAIT). RH involves rehabilitation exercises for lower limb muscles, while RAIT focuses on improving trunk postural control through activities involving intermediate postures.\n\nFunctional motor assessments will be conducted initially, then at 3, 6, and 12 months. These include clinical evaluations, gait analysis (step width, gait variability index, anterior foot support), and an analysis of static standing displacement using an inertial sensor placed at L5.\n\nAt M0, children with CP are expected to show higher values for deceleration peaks and gait variability indices, and lower scores on evaluation scales compared to typically developing (TD) children. After RAIT, an improvement in judgment criteria is expected: reduction in deceleration peaks, cycle width, gait variability index, anterior foot support, and an increase in scores on the ECPE and EMFG-66-SI.\n\nThis study aims to confirm that rehabilitation through trunk-involving activities is more effective than usual rehabilitation in improving postural control and gait dynamics in young children with cerebral palsy, suggesting that this approach could become a standard rehabilitation practice from early childhood.",[25],"2025-08-20",{"date":107,"type":31},"2025-08-27",{"date":109,"type":31},"2024-04-25",{"date":111,"type":21},"2026-10-31",{"name":37,"class":38}]